Astronauts launch to the space station after sidelined by Boeing's troubled Starliner
The U.S.-Japanese-Russian crew of four rocketed from NASA's Kennedy Space Center. They'll replace colleagues who launched to the space station in March as fill-ins for NASA's two stuck astronauts.
Their SpaceX capsule should reach the orbiting lab this weekend and stay for at least six months.
Zena Cardman, a biologist and polar explorer who should have launched last year, was yanked along with another NASA crewmate to make room for Starliner's star-crossed test pilots.
The botched Starliner demo forced Butch Wilmore and Suni Williams to switch to SpaceX to get back from the space station more than nine months after departing on what should have been a weeklong trip. Ensuring their safe return 'meant stepping aside,' Cardman said before her launch.
'Every astronaut wants to be in space. None of us want to stay on the ground, but it's not about me,' said Cardman, the flight commander. Even after launch, 'things can change at the last minute, so I'll count myself very fortunate when the hatch opens' to the space station.
NASA's Mike Fincke — Cardman's co-pilot — was the backup for Wilmore and Williams on Starliner, making those three still the only ones certified to fly it. Fincke and Japan's Kimiya Yui, former military officers with previous spaceflight experience, were training for Starliner's second astronaut mission. With Starliner grounded until 2026, NASA switched the two to the latest SpaceX flight.
Rounding out the crew is Russia's Oleg Platonov. The former fighter pilot was pulled a few years ago from the Russian Soyuz flight lineup because of an undisclosed health issue that he said has since been resolved.
On hand for the first launch attempt on Thursday, NASA's new acting administrator, Transportation Secretary Sean Duffy, met with Roscosmos director general Dmitry Bakanov, an invited guest. The two discussed future collaboration, then left town after thick clouds forced a last-minute delay.
'What we learn on these missions is what's going to get us to the moon and then from the moon to Mars, which is I think the direction that NASA has to be,' Duffy said in a NASA interview. 'There's critical real estate on the moon. We want to claim that real estate for ourselves and our partners.'
To save money in light of tight budgets, NASA is looking to increase its space station stays from six months to eight months, a move already adopted by Russia's space agency. SpaceX is close to certifying its Dragon capsules for longer flights, which means the newly launched crew could be up there until April.
NASA is also considering smaller crews — three astronauts launching on SpaceX instead of the typical four — to cut costs.
As for Starliner, NASA is leaning toward launching the next one with cargo before flying another crew.
Engineers are still investigating the thruster failures and helium leaks that bedeviled Starliner following liftoff. Time is running out as NASA looks to abandon the aging space station by 2030. An air leak on the Russian side of the station remains unresolved after years of patching.
'I am not in the least worried' about the leak, which is localized, Platonov said earlier this month.
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
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Biomea Fusion Reports Second Quarter 2025 Financial Results and Corporate Highlights
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('Biomea' or 'Biomea Fusion' or 'the Company') (Nasdaq: BMEA), a clinical-stage diabetes and obesity company, today reported its financial results for the second quarter ended June 30, 2025, and provided a business update. 'In the second quarter, we presented clinical and preclinical results with icovamenib that support its unique role as a novel, potentially first-in-class investigational agent for the treatment of type 2 diabetes as well as in obesity, while further strengthening our BMF-650 program with robust data in non-human primates,' said Mick Hitchcock, Ph.D., Interim Chief Executive Officer and Board Member of Biomea Fusion. 'At ADA 2025, we showed in preclinical models that our menin inhibitor, icovamenib, in combination with low-dose semaglutide not only drove superior glycemic control but also considerably boosted weight reduction, while fully preserving lean mass and outperforming semaglutide alone. Furthermore, icovamenib promoted myotube health and reduced drug-induced atrophy in a human cell model, highlighting its potential to support muscle health. We look forward to engaging with FDA and further evaluating icovamenib in this patient setting. Our next-generation investigational GLP-1 RA, BMF-650, showed encouraging results in a 28-day study in obese cynomolgus monkeys, achieving up to 15% weight reduction and robust dose-dependent appetite suppression. These findings reinforce BMF-650's potential as an oral GLP-1 RA. With these clinical advances and the completion of our $42.8 million equity financing, we now have the necessary resources to advance these high-priority diabetes and obesity programs.' Second Quarter Highlights: Icovamenib (Oral Small Molecule Menin Inhibitor for T2D and Type 1 Diabetes (T1D)) Three presentations at ADA 2025 highlighted the therapeutic potential of icovamenib across multiple aspects of metabolic health: In patients with T2D not achieving glycemic targets, icovamenib demonstrated durable HbA1c reduction and enhanced beta-cell function three months subsequent to the dosing period, particularly in severe insulin deficient patients enrolled in its Phase II trial; icovamenib was well tolerated across the dosing arms. In a Zucker Diabetic Fatty (ZDF) rat model of T2D, treatment of icovamenib in combination with low-dose semaglutide delivered superior metabolic benefits compared to low-dose semaglutide alone: 60% lower fasting blood glucose and 50% lower glucose OGTT AUC Greater HbA1c decline of >1% by Day 28 and >2% by Day 39 Greater improvement in insulin sensitivity with a 75% lower HOMA-IR (marker of insulin resistance) 2-fold increase in C-peptide to glucose ratio indicating enhanced beta cell function Superior appetite suppression with a 10% greater body weight reduction than low-dose semaglutide alone The observed body weight loss was primarily due to fat mass reduction with complete preservation of lean mass Icovamenib also promoted healthy myotube morphology and diminished drug-induced atrophy in ex vivo human myotube cultures. 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Initiation of Phase II study of icovamenib in T2D patients currently uncontrolled on a GLP-1 based therapy in the second half of 2025. Preliminary data from the Phase II COVALENT-112 study in T1D anticipated in the second half of 2025. BMF-650 (Next-generation Oral Small Molecule GLP-1 RA for Obesity) Submission of the IND application for BMF-650 is planned for the second half of 2025. Phase I study initiation in obese, otherwise healthy volunteers anticipated by late 2025, pending regulatory clearance. Second Quarter 2025 Financial Results Cash, Cash Equivalents, and Restricted Cash: As of June 30, 2025, the Company had cash, cash equivalents and restricted cash of $56.6 million. The Company expects its cash, cash equivalents, and restricted cash to be sufficient to fund planned operating activities into the second half of 2026. 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This decrease in external costs was partially offset by an increase of $0.7 million in other external costs related to consultants, advisors and other professional services to support our clinical studies. Personnel-related expenses decreased by $5.5 million, including stock-based compensation, due to a decrease in headcount. General and Administrative (G&A) Expenses: G&A expenses were $4.7 million for the three months ended June 30, 2025, compared to $7.1 million for the same period in 2024. The decrease of $2.4 million is primarily driven by a decrease of $1.9 million related to personnel-related expenses, including stock-based compensation, due to a decrease in headcount and a decrease of $0.4 million related to professional and legal services. G&A expenses were $11.5 million for the six months ended June 30, 2025, compared to $14.4 million for the same period in 2024. 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These statements may be identified by words such as 'aims,' 'anticipates,' 'believes,' 'could,' 'estimates,' 'expects,' 'forecasts,' 'goal,' 'intends,' 'may,' 'plans,' 'possible,' 'potential,' 'seeks,' 'will,' and variations of these words or similar expressions that are intended to identify forward-looking statements. Any such statements in this press release that are not statements of historical fact, including statements regarding the expected benefits resulting from the implementation of the cost saving measures and potential ability to fund key value drivers; clinical and therapeutic potential of our product candidates and development programs, including icovamenib, BMF-500, and BMF-650, the potential of icovamenib as a treatment for T1D and T2D, the potential of BMF-650 as a treatment for diabetes and obesity; our research, development and regulatory plans; the mechanism of action of our product candidates and development programs; the progress and initiation of our ongoing and upcoming clinical trials, including our Phase I/II COVALENT-111 study of icovamenib in T2D, our Phase II COVALENT-112 study of icovamenib in T1D, and our planned IND submission for the BMF-650 program; the anticipated availability of data from our clinical trials; our planned interactions with regulators, and the timing of such events; and our expected cash runway may be deemed to be forward-looking statements. We intend these forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Exchange Act and are making this statement for purposes of complying with those safe harbor provisions. Any forward-looking statements in this press release are based on our current expectations, estimates and projections only as of the date of this release and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, including the risk that preliminary or interim results of preclinical studies or clinical trials may not be predictive of future or final results in connection with future clinical trials and the risk that we may encounter delays in preclinical or clinical development, patient enrollment and in the initiation, conduct and completion of our ongoing and planned clinical trials and other research and development activities. These risks concerning Biomea Fusion's business and operations are described in additional detail in its periodic filings with the U.S. Securities and Exchange Commission ('SEC'), including its most recent periodic report filed with the SEC and subsequent filings thereafter. Biomea Fusion explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law. Contact: Meichiel Jennifer WeissSr. Director of Investor Relations and Corporate Development mweiss@ BIOMEA FUSION, INC. Condensed Statement of Operations and Comprehensive Loss (Unaudited) (in thousands, except share and per share data) Three Months Ended Six Months Ended June 30, June 30, 2025 2024 2025 2024 Operating expenses: Research and development (1) $ 16,566 $ 31,825 $ 39,463 $ 65,601 General and administrative (1) 4,710 7,073 11,525 14,356 Total operating expenses 21,276 38,898 50,988 79,957 Loss from operations (21,276 ) (38,898 ) (50,988 ) (79,957 ) Interest and other income, net 536 1,622 986 3,620 Net loss and comprehensive loss $ (20,740 ) $ (37,276 ) $ (50,002 ) $ (76,337 ) Net loss per common share, basic and diluted $ (0.51 ) $ (1.03 ) $ (1.29 ) $ (2.12 ) Weighted-average number of shares used to compute basic and diluted net loss per common share 40,630,403 36,043,561 38,639,834 35,966,965 (1) Includes stock-based compensation as follows (non-cash operating expenses): Three Months Ended Six Months Ended June 30, June 30, 2025 2024 2025 2024 Research and development $ 1,568 $ 2,448 $ 3,488 $ 4,994 General and administrative 1,005 2,392 2,254 4,868 Total stock-based compensation expense $ 2,573 $ 4,840 $ 5,742 $ 9,862 BIOMEA FUSION, INC. 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