Nature Publication Shows Mission Bio's Tapestri ® Platform Enables Real-Time, Single-Cell Tracking of Precancerous Clones Using Natural Epigenetic Markers
Lineage tracing holds the potential to explain how premalignant conditions like clonal hematopoiesis of indeterminate potential (CHIP) and myelodysplastic syndrome (MDS) can progress into hematologic cancers, and how cancerous subclones persist in relapse. Traditional methods for lineage tracing can be complex, low-throughput, or even harmful to normal cellular function. In the paper, titled "Clonal tracing with somatic epimutations reveals dynamics of blood aging," EPI-clone utilizes natural epigenetic patterns that are highly stable over long time scales.
Using Mission Bio's Tapestri Platform for high-throughput multi-omics measurement, researchers successfully captured hundreds of clonal differentiation trajectories across 230,358 single cells in both mouse and human hematopoiesis, with dual readout of epimutational barcodes and cell state information.
'EPI-clone provides insights into clonal selection during aging, potentially guiding the development of personalized, preventative treatments for diseases like cancers,' said Velten. 'The scale of our findings could only have been enabled by Tapestri, which allowed us simultaneous observation of single-cell genotype, phenotype, and clone.'
'The impressive results of this study are a first step toward truly identifying, and therefore understanding, how certain clones contribute to cancer progression before they expand,' said Adam Sciambi, Chief Technology Officer at Mission Bio. 'We look forward to continued collaboration with the CRG team and others as we support the use of the Tapestri Platform's unique capabilities to make novel discoveries that change the course of disease understanding and treatment.'
In aging mice, the researchers found that low output of old hematopoietic stem cells (HSCs) is restricted to a small number of expanded clones, while many functionally young clones persist in old age. In human aging, the team showed that clones associated with known clonal hematopoiesis (CH) mutations are part of a broader spectrum of age-related clonal expansions, with and without known driver mutations, displaying similar lineage biases. The results also showed that clonal complexity declines with age, leading to oligoclonal blood production.
To learn more about Tapestri and its ability to provide single-cell DNA + protein analysis at unmatched resolution, please visit missionbio.com/products/platform/.
About Mission Bio
Mission Bio is a leading life science company, specializing in the advancement of single-cell DNA and multiomics analysis. The company's Tapestri Platform is unique in its capabilities, offering an unparalleled level of granularity and precision that is critical for complex research areas such as cancer studies, pharmaceutical development, and advanced cell and gene therapies. Unlike traditional methods such as bulk sequencing, Tapestri provides a level of precision that opens the door for more tailored and effective treatment strategies. Researchers globally depend on Tapestri to identify rare cell populations, understand mechanisms of therapeutic resistance and response, and establish key quality metrics for next-generation medical treatments. Founded in 2014, Mission Bio has secured investment from firms including Mayfield Fund, Novo Growth, Cota Capital, and Agilent Technologies. With the Tapestri Platform, Mission Bio is setting the standard in the field, contributing significantly to the progress of personalized medicine and targeted therapies. To learn more about Mission Bio and the Tapestri Platform, please visit missionbio.com.
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