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The keto flu, or carb flu, is used to describe symptoms often experienced by those beginning a keto diet. Here's what the keto flu is, why it happens…
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Associated Press
37 minutes ago
- Associated Press
Kennedy names 8 vaccine committee replacements, including COVID shot critic
NEW YORK (AP) — U.S. Health Secretary Robert F. Kennedy Jr. on Wednesday named eight new vaccine policy advisers to replace the panel that he abruptly dismissed earlier this week. They include a scientist who researched mRNA vaccine technology and transformed into a conservative darling for his criticisms of COVID-19 vaccines, and a leading critic of pandemic-era lockdowns. Kennedy's decision to 'retire' the previous 17-member panel was widely decried by doctors' groups and public health organizations, who feared the advisers would be replaced by a group aligned with Kennedy's desire to reassess — and possibly end — longstanding vaccination recommendations. The new appointees to the Advisory Committee on Immunization Practices include Dr. Robert Malone, the former mRNA researcher who emerged as a close adviser to Kennedy during the measles outbreak. Malone, who runs a wellness institute and a popular blog, rose to popularity during the COVID-19 pandemic as he relayed conspiracy theories around the outbreak and the vaccines that followed. He has appeared on podcasts and other conservative news outlets where he's promoted unproven and alternative treatments for measles and COVID-19. He has claimed that millions of Americans were hypnotized into taking the COVID-19 shots. He's even suggested that those vaccines cause a form of AIDS. He's downplayed deaths related to one of the largest measles outbreaks in the U.S. in years. Other appointees include Dr. Martin Kulldorff, a biostatistician and epidemiologist who was a co-author of the Great Barrington Declaration, an October 2020 letter maintaining that pandemic shutdowns were causing irreparable harm. Dr. Cody Meissner, a former ACIP member, also was named. Kennedy made the announcement in a social media post on Wednesday. The committee, created in 1964, makes recommendations to the director of the Centers for Disease Control and Prevention. CDC directors almost always approve those recommendations on how Food and Drug Administration-cleared vaccines should be used. The CDC's final recommendations are widely heeded by doctors and determine the scope of vaccination programs. ___ Associated Press reporter Amanda Seitz contributed to this report. ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
CNN
an hour ago
- CNN
LA protest weapons, extreme winter weather, protein in coffee: Catch up on the day's stories
👋 Welcome to 5 Things PM! Forgetting things is frustrating, but humans aren't designed to remember everything. An expert offers five tips to improve your memory of the important things. Here's what else you might have missed during your busy day: 1️⃣ Weapon watch: To quell protests in Los Angeles, police have used 'less lethal' weapons to minimize fatalities, prevent permanent injuries and decrease property damage — but that does not mean they are harmless. Here's a look at the equipment authorities have used. 2️⃣ A deep freeze: A new study found the collapse of a critical system of Atlantic Ocean currents could bring extreme weather, with winter temperatures plunging to around minus 55 degrees Fahrenheit in some cities. This interactive map helps visualize the impacts across the globe. 3️⃣ Love over looks: Natasha Burns, a 6-foot-5-inch-tall model, found her now (shorter) husband on Tinder. But as dating apps allow paying users to set height preferences for potential partners, is it getting in the way of finding true love? 4️⃣ Gains in your cup of joe: Starbucks is testing a new banana flavored protein cold foam at five US locations. Revising the menu and starting to bake some pastries fresh in store is all a part of the CEO's plan to expand into the wellness sector and reverse sagging sales. 5️⃣ Living off the land: Celebrities and influencers have transformed the image of farm living from backbreaking labor and mucked-up boots to romantic cottage dresses, sunlit ranches and tablescaping. A new wave of luxury resorts is capitalizing on the agrarian rebrand. GET '5 THINGS' IN YOUR INBOX CNN's 5 Things newsletter is your one-stop shop for the latest headlines and fascinating stories to start and end your busy day. Sign up here. 😋 Epic eats: In Japan, 7-Eleven stores are known for taking snacks to the next level. CNN's Hanako Montgomery got a behind-the-scenes look at how one of its tasty treats is made. • Newsom and California confront Trump with a potential blueprint for Democrats• More than a dozen lawmakers tied to stock trades, transactions ahead of Trump's early tariff pause• Brian Wilson, music icon and creative force behind The Beach Boys, dead at 82 💰 That's how much a rare Labubu — the toys that have taken the world by storm — sold for at an auction in Beijing. 🐊 The Crocodile Guardian: In recent years, the population of Jamaica's 28 species of crocodiles has declined because of illegal hunting, habitat loss and pollution. One man has made it his life's mission to change that. 🏈 He's still got it: At 41, Aaron Rodgers is the oldest quarterback in the NFL after signing a deal with the Pittsburgh Steelers last week. He said the decision to keep playing was 'best for my soul.' 🎮 Nintendo says the Switch 2 hit the highest global sales of any of its consoles in the first few days of its release. How many have been sold?A. 3.5 millionB. 87 millionC. 4.9 millionD. 33 million⬇️ Scroll down for the answer. 🧠 Future forward: From climate change to migration, acclaimed academic Lesley Lokko hopes to inspire a new generation of 'dynamic thinkers' through studio sessions that explore architecture's role in global issues. 👋 We'll see you tomorrow.🧠 Quiz answer: A. Nintendo sold 3.5 million Switch 2 consoles in the first four days of its release.📧 Check out all of CNN's newsletters. 5 Things PM is produced by CNN's Chris Good, Meghan Pryce, Kimberly Richardson and Daniel Wine.
Medscape
an hour ago
- Medscape
Taletrectinib Approved for NSCLC
The FDA has approved taletrectinib (Ibtrozi, Nuvation Bio) for locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) in first- and later-line settings, regardless of prior ROS1 tyrosine kinase inhibitor (TKI) exposure. Taletrectinib is considered a next-generation ROS1 TKI to distinguish it from two first-generation products already on the US market: crizotinib and entrectinib. A third ROS1 TKI approved in 2023, repotrectinib, is also a next-generation medicine. Like repotrectinib, FDA granted taletrectinib a breakthrough therapy designation. Compared with crizotinib and entrectinib, Nuvation Bio data suggests taletrectinib has greater brain penetration, lower incidence of neurologic adverse events, less likelihood of resistance, and other benefits, plus a possible safety and efficacy edge over next-generation rival repotrectinib. 'Taletrectinib will likely become the preferred treatment option for advanced ROS1+ NSCLC,' commented Thomas E. Stinchcombe, MD, an associate editor at the Journal of Clinical Oncology , in the 'Context' section of his journal's publication of a pooled analysis of Nuvation Bio's two approval studies, TRUST-I and TRUST-II, in April. Taletrectinib was originally developed in China and was approved there in Jan 2025 for the same indication granted by FDA. The company plans a US launch in mid-2025, they stated in a press release. About 2% of NSCLC patients have ROS1-positive disease, and about a third of them present with brain metastases. ROS1-positive patients have an oncogenic rearrangement in the ROS1 gene, which leads to an abnormal ROS1 fusion protein that drives cancer growth. ROS1 TKIs block the protein's activity. The drug's approval was based on results of TRUST-I and TRUST-II, phase 2, single-arm, open label studies in ROS1-positive NSCLC patients treated with oral taletrectinib 600 mg once daily until progression, unacceptable toxicity, death, or consent withdrawal. Of the 273 subjects in the pooled analysis, 93.8% had stage IV disease, 33.7% had brain metastases, and 27.1% had received chemotherapy. TRUST-I included Chinese subjects who were either new to TKIs or who had received crizotinib. TRUST-II included patients from North America, Europe, and Asia who were TKI-naive or who had been treated with crizotinib or entrectinib. The efficacy population included 157 patients (103 in TRUST-I; 54 in TRUST-II) who were naive to treatment with a ROS1 TKI and 113 patients (66 in TRUST-I; 47 in TRUST-II) who had received one prior ROS1 TKI. Patients may have received prior chemotherapy for advanced disease. For treatment-naive patients, the overall response rate (ORR) was 90% in TRUST-I and 85% in TRUST-II, with 72% and 63% of responders having a duration of response (DOR) of at least a year, respectively. For TKI-pretreated patients, ORR was 52% in TRUST-I and 62% in TRUST-II, with 74% and 83% of responders having a DOR of at least 6 months, respectively. Among 13 patients with a G2032R mutation, which triggers resistance to first generation ROS1 TKIs, eight (61.5%) had a response to taletrectinib. In a safety analysis with 352 patients, the most frequent treatment-emergent adverse events with taletrectinib were gastrointestinal problems (88%) and elevated aspartate aminotransferase (72%) and alanine aminotransferase (68%). Neurologic adverse events included dizziness (21%) and dysgeusia (15%). Overall, 33% of patients had grade 3 or higher treatment-related adverse events. Treatment-emergent adverse events led to discontinuation in 7% of patients. There were three treatment-related deaths due to abnormal hepatic function, liver failure, and pneumonia. Prescribing information for taletrectinib includes warnings and precautions for hepatotoxicity, interstitial lung disease/pneumonitis, QTc interval prolongation, hyperuricemia, myalgia with creatine phosphokinase elevation, skeletal fractures, and embryo-fetal toxicity. The recommended taletrectinib dose is 600 mg orally once daily on an empty stomach until disease progression or unacceptable toxicity. Taletrectinib pricing was not available, but fourteen 160 mg capsules of rival repotrectinib — the initial 2-week supply with daily dosages doubling afterwards — is $7,666.97, according to
