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KAYTUS Unveils KSManage V2.0, Quadrupling Data Center O&M Efficiency

KAYTUS Unveils KSManage V2.0, Quadrupling Data Center O&M Efficiency

Yahoo14-04-2025

KSManage V2.0 delivers a one-stop intelligent data center solution, featuring centralized management of 5,000+ IT device models, with one-click fully automated batch configuration
SINGAPORE, April 14, 2025--(BUSINESS WIRE)--KAYTUS, a leading provider of end-to-end AI server and liquid cooling solutions, has announced the release of KSManage V2.0, its next-generation data center management platform. The upgraded platform offers broad compatibility with over 5,000 mainstream IT device models, enabling seamless integration across diverse environments. With one-click fully automated batch configuration, KSManage V2.0 boosts management efficiency by up to four times. Leveraging advanced AIOps capabilities, the platform achieves a fault diagnosis accuracy rate of over 98% and reduces energy consumption by 20%. These enhancements significantly optimize operations and maintenance (O&M) for scaled data centers, empowering sustainable and intelligent infrastructure management.
With the rapid advancement of cloud computing and AI applications, data centers have scaled at an unprecedented pace—from just over a hundred devices to tens of thousands. This explosive growth presents significant challenges for operations and maintenance (O&M), particularly in managing vast arrays of heterogeneous servers, storage systems, and network equipment. KSManage is purpose-built to address these complexities, delivering intelligent and efficient data center O&M. It tackles key pain points such as the difficulty of managing diverse hardware, low operational efficiency, and inconsistent infrastructure performance. By ensuring reliable, streamlined, and intelligent infrastructure operations, KSManage enables enterprises to focus entirely on driving their core business innovation.
Centralized Management, All-in-One Integrated Platform
A major challenge in scaled data centers is the management of heterogeneous devices across multiple vendors and models—each with its own management interfaces and protocols. While open-source tools offer basic functionality, their decentralized approach often leads to fragmented resource allocation and increased operational complexity. KSManage V2.0 addresses this with a unified, enterprise-grade platform designed to streamline O&M. It supports a wide range of IT devices from different vendors, offering compatibility with over 5,000 models of servers, storage systems, and network devices. Through standardized interfaces and protocols, KSManage V2.0 enables centralized, out-of-band management of heterogeneous infrastructure at scale—greatly simplifying operations while enhancing efficiency and control.
KSManage V2.0 delivers significant upgrades in data center monitoring and management, with enhanced capabilities across health monitoring, performance tracking, inspection management, and network testing tools. These improvements enable granular, component-level health monitoring, a comprehensive view of performance metrics, and customizable inspection workflows—offering a more precise and intelligent monitoring experience.
The platform supports both 2D and 3D global visualization, allowing users to monitor key resource metrics such as power consumption, temperature, and capacity in real time. This enhanced visibility empowers operators to proactively track infrastructure status and optimize management efficiency. In addition, KSManage V2.0 can generate customized visual analytics reports within minutes, simplifying data analysis and accelerating data-driven decision-making.
Fully Automated Batch Upgrades, Quadrupling Operational Efficiency
Server configuration low efficiency remains a major challenge in scaled data centers, where manual firmware upgrades are time-consuming, complex, and prone to human error. To address this, KSManage V2.0 introduces one-click automated batch upgrades, significantly simplifying workflows and boosting O&M efficiency. Complementing this capability, KAYTUS has launched the KSManage Repo, a centralized firmware repository that hosts the latest updates for KAYTUS servers. After registration and entry of device serial numbers (SNs), customers can connect to the official image repository to automatically detect and retrieve the most up-to-date firmware versions in real time. Leveraging both in-band and out-of-band communication channels, KAYTUS servers support full-stack firmware batch upgrades and automated configuration—including BMC, BIOS, CPLD, FRU, NICs, drives, and more—either online or via batch downloads. This automation ensures optimal device performance and delivers up to a 400% increase in maintenance efficiency.
AIOps for Enhanced Reliability and Energy Efficiency
Scaled data centers often face challenges related to infrastructure stability and excessive energy consumption. Manual monitoring lacks the responsiveness needed for real-time device analysis, while open-source management tools are frequently plagued by security risks, instability, and limited functionality—resulting in delayed fault detection, slow incident resolution, and potential business disruptions. Additionally, insufficient visibility into energy usage contributes to elevated power usage effectiveness (PUE). KSManage V2.0 addresses these issues through built-in AIOps capabilities, integrating intelligent operations throughout the entire lifecycle of fault prediction, alarm reporting, and diagnostics. The platform not only enhances fault response time and system stability but also provides real-time energy consumption tracking, including carbon emissions monitoring. This enables data centers to optimize energy efficiency and supports sustainable, eco-friendly operations aligned with green IT initiatives.
Intelligent Prediction and Rapid Diagnosis. KSManage V2.0 takes predictive maintenance and fault diagnosis to the next level with advanced AI-powered capabilities. It supports drive failure prediction up to 15 days in advance, while its memory failure prediction accuracy has improved by 30%. In the event of a fault, AI algorithms are leveraged for both performance and capacity prediction, enabling proactive and informed decision-making. Designed for scaled data centers, KSManage V2.0 can process real-time, billion-level O&M data within seconds, and respond to thousands of alarms in under five seconds. It employs an innovative ETF (Event-Trigger-Free) threshold-free alarm algorithm, achieving an impressive alarm accuracy rate of 95.26%. For diagnostics, KSManage V2.0 actively and passively monitors metric data and collects logs to quickly detect and accurately pinpoint faults—delivering a diagnostic accuracy rate exceeding 98%. These capabilities significantly improve operational resilience and reduce downtime across complex IT environments.
Comprehensive Energy Management for Sustainable Operations. KSManage V2.0 delivers robust energy consumption management across a wide range of data center infrastructure—including AI and general-purpose servers, storage systems, network equipment, cooling units, lighting, and power supply devices. Tailored to meet diverse business needs, KSManage V2.0 offers a variety of power consumption control strategies, enabling dynamic workload-based energy adjustments and visual tracking of carbon emissions. By intelligently managing workloads to maintain peak efficiency and avoiding no-load or overload conditions, the platform reduces overall energy consumption by 15% to 20%. In addition, KSManage V2.0 provides predictive energy analytics based on historical data trends, enabling data centers to proactively plan operational and energy strategies. This minimizes the risk of under- or over-supply of energy and supports sustainable, eco-friendly operations aligned with long-term carbon reduction goals.
KSManage has been successfully deployed across a wide range of industries, including cloud service providers (CSPs), finance, and telecommunications. In one notable case involving a leading e-commerce platform in Turkey, KSManage effectively addressed critical operational challenges such as inefficient firmware upgrades, error-prone configurations, and slow OS deployments. By automating the management of over 3,000 servers, KSManage reduced firmware upgrade time by 70%, increased configuration accuracy to 99.8%, and enabled the daily deployment of up to 500 servers. These improvements translated into an 80% boost in overall O&M efficiency and a 40% reduction in hardware failure rates.
About KAYTUS
KAYTUS is a leading provider of end-to-end AI and liquid cooling solutions, delivering a diverse range of innovative, open, and eco-friendly products for cloud, AI, edge computing, and other emerging applications. With a customer-centric approach, KAYTUS is agile and responsive to user needs through its adaptable business model. Discover more at KAYTUS.com and follow us on LinkedIn and X.
View source version on businesswire.com: https://www.businesswire.com/news/home/20250414326624/en/
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Media contact media@kaytus.com

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QIAGEN and Incyte Announce Precision Medicine Collaboration to Develop Companion Diagnostics for Patients With Mutant CALR-expressing Myeloproliferative Neoplasms (MPNs)
QIAGEN and Incyte Announce Precision Medicine Collaboration to Develop Companion Diagnostics for Patients With Mutant CALR-expressing Myeloproliferative Neoplasms (MPNs)

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QIAGEN and Incyte Announce Precision Medicine Collaboration to Develop Companion Diagnostics for Patients With Mutant CALR-expressing Myeloproliferative Neoplasms (MPNs)

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The panel will be validated using the next-generation sequencing (NGS) technology and the Illumina NextSeq 550Dx platform as part of QIAGEN's partnership with Illumina (NASDAQ: ILMN) to leverage its NGS diagnostic platforms for patient testing by laboratories worldwide. QIAGEN will support regulatory submission processes and market access activities across the United States, European Union and Asia-Pacific regions. Myeloproliferative neoplasms are a group of diseases representing about 40% of hematological malignancies, characterized by chronic accumulation of different mature blood cell types in blood. Identifying genomic aberrations in clinically relevant biomarkers like CALR are shown to be key, especially in MPNs. Incyte is at the forefront of developing novel therapies, including INCA033989 for patients with mutCALR ET or MF, that target only malignant cells, sparing normal cells. The use of companion diagnostics helps guide clinicians in making treatment decisions that can lead to better patient outcomes. 'Following our presentation of positive, late-breaking data from our first-in-class mutCALR-targeted antibody at EHA, we are excited to announce this partnership with QIAGEN, which will facilitate CALR testing for patients with MPNs on a global basis. The development of companion diagnostics for mutCALR, coupled with the potential for new medicines to selectively target disease-initiating cells, is a critical step toward changing the course of disease in patients with ET and MF,' said Pablo J. Cagnoni, M.D., President and Head of Research and Development, Incyte. 'As a partner, QIAGEN has the proven expertise in companion diagnostics development and approvals needed to support our ongoing work and commitment to transforming the treatment of patients with CALR-mutant MPNs.' 'Together with Incyte we are building a multimodal companion diagnostic using a powerful technology like next-generation sequencing to facilitate highly accurate testing for several blood cancer genes at once,' said Jonathan Arnold, Vice President and Head of Partnering for Precision Diagnostics at QIAGEN. 'This new partnership strengthens our role in offering companion diagnostics for the growing number of biomarkers being discovered in onco-hematology and maximizing the clinical utility of the diagnostic for payor and patient benefit, thus supporting the work of innovative, science-driven companies like Incyte to improve patient outcomes.' About Mutations in Calreticulin (mutCALR) Calreticulin (CALR) is a protein involved in the regulation of cellular calcium levels and normal protein production. 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Automation solutions bring these processes together into seamless and cost-effective workflows. QIAGEN serves over 500,000 customers globally in Life Sciences (academia, pharma R&D and industrial applications, primarily forensics) and Molecular Diagnostics for clinical healthcare. As of March 31, 2025, QIAGEN employed approximately 5,700 people in over 35 locations worldwide. For more information, visit QIAGEN is a pioneer in precision medicine and the leader in collaborating with pharmaceutical and biotechnology companies to develop companion diagnostics, having more than 30 master collaboration agreements with global pharmaceutical and biotechnology companies to develop and commercialize diagnostic tests. QIAGEN's offering to these companies encompasses technologies ranging from polymerase chain reaction (PCR), near-patient testing and digital PCR (dPCR) to next-generation sequencing (NGS), and sample types from liquid biopsy to tissue. It also spans disease areas from cancer to non-oncology diseases such as neurodegenerative, inflammatory, and metabolic diseases – including 16 FDA-approved PCR-based companion diagnostics. For more information about QIAGEN's efforts in precision medicine please visit About Incyte A global biopharmaceutical company on a mission to Solve On., Incyte follows the science to find solutions for patients with unmet medical needs. Through the discovery, development and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Oncology and Inflammation & Autoimmunity. Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe and Asia. For additional information on Incyte, please visit or follow us on social media: LinkedIn, X, Instagram, Facebook, YouTube. QIAGEN Forward-Looking Statement Certain statements in this press release may constitute forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. These statements, including those regarding QIAGEN's products, development timelines, marketing and / or regulatory approvals, financial and operational outlook, growth strategies, collaborations and operating results - such as expected adjusted net sales and adjusted diluted earnings - are based on current expectations and assumptions. However, they involve uncertainties and risks. These risks include, but are not limited to, challenges in managing growth and international operations (including the effects of currency fluctuations, regulatory processes and logistical dependencies), variability in operating results, commercial development for our products to customers in the Life Sciences and clinical healthcare, changes in relationships with customers, suppliers or strategic partners; competition and rapid technological advancements; fluctuating demand for QIAGEN's products due to factors such as economic conditions, customer budgets and funding cycles; obtaining and maintaining regulatory approvals for our products; difficulties in successfully adapting QIAGEN's products into integrated solutions and producing these products; and protecting product differentiation from competitors. Additional uncertainties may arise from market acceptance of new products, integration of acquisitions, governmental actions, global or regional economic developments, natural disasters, political or public health crises, and other "force majeure" events. There is also no guarantee that anticipated benefits from restructuring programs and acquisitions will materialize as expected. For a comprehensive overview of risks, please refer to the 'Risk Factors' contained in our most recent Annual Report on Form 20-F and other reports filed with or furnished to the U.S. Securities and Exchange Commission. Incyte Forward-Looking Statements Except for the historical information set forth herein, the matters set forth in this press release, including statements regarding the potential for Incyte's mut-CALR targeted antibody (INCA033989) to provide a potential treatment option for patients with ET or MF, contain predictions, estimates and other forward-looking statements. These forward-looking statements are based on Incyte's current expectations and subject to risks and uncertainties that may cause actual results to differ materially, including unanticipated developments in and risks related to: unanticipated delays; further research and development and the results of clinical trials possibly being unsuccessful or insufficient to meet applicable regulatory standards or warrant continued development; the ability to enroll sufficient numbers of subjects in clinical trials; determinations made by the FDA, EMA, and other regulatory authorities; the efficacy or safety of Incyte and its partners' products; the acceptance of Incyte and its partners' products in the marketplace; market competition; sales, marketing, manufacturing and distribution requirements; and other risks detailed from time to time in our reports filed with the U.S. Securities and Exchange Commission, including our annual report on Form 10-K and our quarterly report on Form 10-Q for the quarter ended March 31, 2025. 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Positive Late-Breaking Data for Incyte's First-in-Class mutCALR-targeted therapy INCA033989 in Essential Thrombocythemia Presented at EHA2025
Positive Late-Breaking Data for Incyte's First-in-Class mutCALR-targeted therapy INCA033989 in Essential Thrombocythemia Presented at EHA2025

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Positive Late-Breaking Data for Incyte's First-in-Class mutCALR-targeted therapy INCA033989 in Essential Thrombocythemia Presented at EHA2025

WILMINGTON, Del.--(BUSINESS WIRE)--Incyte (Nasdaq:INCY) today announced the first clinical data from two studies evaluating the safety, tolerability and efficacy of INCA033989, a novel, first in class, Incyte-discovered, targeted monoclonal antibody in patients with mutant calreticulin (mutCALR)-expressing myeloproliferative neoplasms (MPNs). These data – featured today in the Late-Breaking Oral Session (#LB4002) at the European Hematology Association 2025 (EHA2025) Congress in Milan, Italy – focus on the dose escalation portion of the studies in patients with high risk essential thrombocythemia (ET) who are resistant/intolerant to prior cytoreductive therapy. 'These findings, and the further development of INCA033989, offer the potential to significantly transform the treatment of patients with CALR-mutant MPNs," said Pablo J. Cagnoni, M.D., President, Head of Research and Development, Incyte. Share The studies evaluated the safety and efficacy of INCA033989 in patients with ET as measured by hematologic response and reduction in mutCALR variant allele frequency (VAF). Results as of April 4, 2025, showed rapid and durable normalization of platelet counts across all dose levels, with a trend toward improved responses in higher doses (>400 mg), in patients with ET treated with INCA033989. Notably, 86% of patients at doses 400 mg and above achieved a complete or partial hematologic response, with the majority (82%) of patients achieving complete response. Eighty-nine (89) percent of evaluable patients (34/38) showed a reduction in mutCALR VAF from baseline. A partial molecular response (>50% VAF reduction) was observed in 21% of evaluable patients (8/38) after only 3 cycles of treatment. An exploratory study using single-cell DNA (scDNA) sequencing showed that INCA033989 directly targets and reduces cells carrying mutCALR. This reduction was seen in early blood-forming (CD34-positive) cells and cells in the myeloid-erythroid (ME) lineage. At the same time, there was a clear increase in healthy (wild-type CALR) cells, suggesting that the treatment supports the return of normal blood production. Bone marrow biopsies further confirmed these effects showing fewer megakaryocytes with mutCALR protein and a notable increase in megakaryocytes without mutCALR protein. Together, these findings demonstrate the selectivity of INCA033989, allowing for normalization of healthy hematopoiesis and disease modification. 'The late-breaking data presented today highlight the impact of INCA033989, a novel agent that selectively targets mutant CALR, to inhibit and eliminate cancer-causing cells in patients with essential thrombocythemia (ET), while sparing healthy cells and normalizing healthy blood production," said Pablo J. Cagnoni, M.D., President, Head of Research and Development, Incyte. 'These findings, and the further development of INCA033989, offer the potential to significantly transform the treatment of patients with CALR-mutant myeloproliferative neoplasms (MPNs).' The results (N=49) showed that INCA033989 was well tolerated across all dose cohorts (24 to 2,500 mg), with no dose-limiting toxicities observed. Only one (1) patient discontinued treatment, and only one (1) dose reduction due to treatment-emergent adverse events (TEAEs) was observed. No infusion interruptions due to TEAEs were reported, and a maximum tolerated dose was not reached. Forty-two (42) patients across the dose cohorts reported a TEAE. The most common TEAEs were fatigue (26.5%) and upper respiratory tract infection (20.4%), all of which were Grade ≤2. Thirteen (13) patients had Grade >3 TEAEs, with transient asymptomatic lipase increase as the most common (6%). 'mutCALR is the second most common oncogenic driver of MPNs, yet the therapeutic landscape lacks a targeted agent for mutCALR expressing MPNs. Currently, ET treatments aim to prevent vascular complications and improve symptoms but are limited by toxicity and tolerability issues,' said John Mascarenhas, M.D., Professor of Medicine at the Icahn School of Medicine at Mt. Sinai and Director, Center of Excellence for Blood Cancers and Myeloid Disorders, The Tisch Cancer Institute. 'These data support the hypothesis that INCA033989 has the potential not only to normalize platelet counts and provide rapid and durable hematologic responses – but to induce molecular responses, which could potentially change the natural history of the disease.' Additional data from the INCA033989 study in patients with myelofibrosis will be submitted for presentation at a future medical meeting. Discussions with regulatory authorities are planned with the goal to initiate a Phase 3 study by early 2026. 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Estimates of the prevalence of MPNs vary, but analysis of claims data suggests there may be as many as 200,000 people in the U.S. living with the most prevalent MPNs: myelofibrosis, polycythemia vera or essential thrombocythemia (ET). 1 About Mutations in Calreticulin (mutCALR) Calreticulin (CALR) is a protein involved in the regulation of cellular calcium levels and normal protein folding. Somatic, or non-inherited, DNA mutations in the CALR gene (mutCALR) can result in abnormal protein function and lead to the development of myeloproliferative neoplasms (MPNs), 2 a closely related group of clonal blood cancers in which the bone marrow functions abnormally, overproducing blood cells. 3,4 Among two types of MPNs, essential thrombocythemia (ET) and myelofibrosis (MF), mutCALR drives 25-35% of all cases. 2,3 There are approximately 60,000 patients in the U.S. and Europe with mutCALR positive ET. 5 Incyte is at the forefront of developing novel therapies for patients with mutCALR ET or MF that target only malignant cells, sparing normal cells, including INCA033989, a first-in-class, mutCALR-specific therapy. 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These forward-looking statements are based on Incyte's current expectations and subject to risks and uncertainties that may cause actual results to differ materially, including unanticipated developments in and risks related to: further research and development and the results of clinical trials possibly being unsuccessful or insufficient to meet applicable regulatory standards or warrant continued development; the ability to enroll sufficient numbers of subjects in clinical trials and the ability to enroll subjects in accordance with planned schedules; determinations made by the FDA, EMA and other regulatory agencies; Incyte's dependence on its relationships with and changes in the plans of its collaboration partners; the efficacy or safety of Incyte's products and the products of Incyte's collaboration partners; the acceptance of Incyte's products and the products of Incyte's collaboration partners in the marketplace; market competition; unexpected variations in the demand for Incyte's products and the products of Incyte's collaboration partners; the effects of announced or unexpected price regulation or limitations on reimbursement or coverage for Incyte's products and the products of Incyte's collaboration partners; sales, marketing, manufacturing and distribution requirements, including Incyte's and its collaboration partners' ability to successfully commercialize and build commercial infrastructure for newly approved products and any additional products that become approved; greater than expected expenses, including expenses relating to litigation or strategic activities; variations in foreign currency exchange rates; and other risks detailed in Incyte's reports filed with the Securities and Exchange Commission, including its annual report on form 10-K and our quarterly report on Form 10-Q for the quarter ended March 31, 2025. Incyte disclaims any intent or obligation to update these forward-looking statements.

Embracing Powertrain Diversity, GWM Continues to Enhance Clean Diesel Capabilities for Off-Roading
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Business Wire

time6 hours ago

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