logo
Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs

Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs

Mail & Guardian30-05-2025
Reabetswe Pitere
Name of faculty and department: Institute for Cellular and Molecular Medicine, and Department of Oral and Maxillofacial Pathology, Faculty of Health Sciences, University of Pretoria
Picture of the researcher: see attached
Name of 1st author: Reabetswe Pitere
Email of 1st author:
Name of additional Authors: Reabetswe R. Pitere, Marlene B. van Heerden, Michael S. Pepper and Melvin A. Ambele
Submitting authority – Faculty of Health Sciences
Name of 'submitter' – Prof Flavia Senkubuge, Dean of the Faculty of Health Sciences (they ask for the dean's details)
Email of 'submitter' –
For the full paper see below:
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Life Esidimeni families urge swift prosecution of those responsible
Life Esidimeni families urge swift prosecution of those responsible

The Herald

time6 hours ago

  • The Herald

Life Esidimeni families urge swift prosecution of those responsible

The Life Esidimeni families have expressed concern that almost 10 years after the deaths of 144 mental healthcare users and more than a year since an inquest judgment into their deaths, there is still no decision on the prosecution of those responsible. The patients who died were among the 1,711 mentally ill people who were transferred from Life Esidimeni facilities in 2015 and 2016 to ill-prepared non-governmental organisations. The families on Tuesday met the National Prosecuting Authority (NPA), represented by acting director of public prosecutions Marika Jansen van Vuuren. The families said the meeting followed years of delays in the decision to prosecute those responsible for the deaths. The NPA told the families it had received a legal opinion that recommended prosecution of former Gauteng health MEC Qedani Mahlangu and former director of mental health Dr Makgabo Manamela. 'However, the legal opinion recommends prosecutions for the deaths of only two people: Mr Terence Chaba and Ms Virginia Machpelah,' the families said. The NPA informed the families that a team of prosecutors had been formed to assess both the legal opinion and the extensive evidence already presented at the inquest to make a final decision on prosecution. The meeting this week comes after the NPA announced last year it was in the process of making a thorough, well-informed decision on the matter. The announcement last year was made in response to a demand for justice and accountability for Life Esidimeni victims made by public interest law centre Section27. The families said a decision to criminally prosecute all those whose actions caused the deaths was what they had demanded all along. 'In this regard we feel vindicated and welcome the NPA's movement towards a decision. However, almost 10 years after the deaths and over a year since the inquest judgment, there is still no decision on prosecution, even after a legal opinion.' They said by limiting accountability to only two deaths, it felt as if the NPA was sending a message that the other 142 deaths did not matter, and said that was not justice. 'It reflects a failure to honour the pain of the families and the dignity of those who died. It amounts to protecting those responsible, rather than holding them fully accountable.' The families said they believed there was overwhelming evidence that had been presented in multiple formal processes to charge more people. These included the health ombudsman's report in 2017 which exposed the gross human rights violations, unlawful transfers and neglect that led to the tragedy. There was also an arbitration presided over by former deputy chief justice Dikgang Moseneke who found that the government had acted unlawfully, recklessly and with disregard for human life. Moseneke ordered compensation for families while affirming the state's liability. The families said the inquest presided over by judge Mmonoa Teffo established in July last year that there was prima facie evidence linking Mahlangu and Manamela to multiple unlawful deaths, highlighting systemic negligence and criminal liability. 'Taken together, these processes, combined with the unrelenting calls from and evidence provided by families over nearly a decade, constitute an undeniable body of evidence.' The families demanded that the NPA immediately consider not only the inquest judgment and legal opinion but the mountain of evidence that formed part of the inquest record, including from the arbitration, and recognise the urgent need for a prosecution that reflected the full scale of the tragedy. TimesLIVE

How booming elephant numbers are reshaping SA's savanna trees
How booming elephant numbers are reshaping SA's savanna trees

The Herald

time6 hours ago

  • The Herald

How booming elephant numbers are reshaping SA's savanna trees

Venter said: 'This can potentially lead to long-term population declines or local extirpations of trees that need to be large to reproduce, such as the marula. 'From observation, 10 years ago there were quite a few large marula trees on Madikwe and most are dead now.' Prof Herve Fritz, of NMU's Sustainability Research Unit and REHABS International Research Laboratory, said: 'What the study offers is more precise information as to what to monitor in ecosystems where the architecture and type of modification of trees is a critical indicator of change, in addition to the effect on or disappearance of specific iconic trees. 'The concern is that there are signs at Madikwe that we are getting close to a serious change in the ecosystem.' Referring to the 85 elephants that died at the reserve during the drought in 2024, Venter said some people argued that if you let nature take its course and a number of elephants died when the habitat deteriorated, then the ecosystem would, in time, restore balance. 'The problem with this is an ethical issue. 'When you are dealing with the confined system of a fenced reserve, where the elephants cannot migrate as they would have done historically, it is morally questionable to allow them to starve to death. 'The hard truth is that the 85 elephants that died don't even make a dent in the elephant population at Madikwe, where there are too many for the reserve. 'Hunting is definitely not an option. Ethics and politics aside, you cannot control this number of elephants with hunting. 'Contraception will help and translocation to far larger areas with low elephant densities is an option, but it is a major operation that is also limited to how long elephants can remain in the transport truck — generally limited to a distance of ±1,000km.' Expanding protected areas was often flagged as a solution, Venter said. For the past 30 years, Madikwe and the Pilanesberg Game Reserve planned to connect the two reserves and create a wildlife area of more than 200,000ha, but they had achieved only a ±7,000ha expansion as they encountered various challenges, including landowners who did not want to sell and communities who could not agree to combine their areas. Several reserves, including Madikwe, were established in the 1990s and are approaching 40 years old. Most introduced the big five and Madikwe brought in about 250 elephants. In 1995, the government put a moratorium on elephant culling. Madikwe's large founder population grew, and it now faces an acute ecological crisis caused by decades of indecision on elephant management. 'Madikwe offers a strong example of what can happen in other enclosed protected areas if populations and ecosystems are not carefully managed,' Fritz said. 'The evidence from this research provides some ecological foundation for urgent, science‑based management decisions with targeted interventions to prevent further habitat collapse and animal suffering.' The Herald

Unsafe and substandard. Is that what public healthcare in SA looks like?
Unsafe and substandard. Is that what public healthcare in SA looks like?

Mail & Guardian

time2 days ago

  • Mail & Guardian

Unsafe and substandard. Is that what public healthcare in SA looks like?

'Unsupervised, unstructured, non-standardised, unsafe and altogether substandard.' This is what was said about the care at two public hospitals in the Northern Cape last year. But is the way quality is measured a fair test? (Delwyn Verasamy) 'Unsupervised, unstructured, non-standardised, unsafe and altogether substandard.' This is how the Two later died and one was left with permanent brain damage. In the same week as the ombud's report, politicians' comments about the 'alarming number' of patients who Mention the This is where the The basic idea is that inspectors visit clinics and hospitals, run through a long list of requirements that have to be met, award a score for each one and then write up a report to say whether quality is up to scratch. If so, a certificate of compliance — valid for four years — is issued; if not, the facility is re-inspected later and, if still not in the clear, it gets a written warning. But, says Susan Cleary, a health economist and head of the School of Public Health at the University of Cape Town, the measures defined in these scorecards make it 'almost impossible' for an establishment to pass the test. Scoring a facility's service quality according to measures they have little control over is unfair, she says. 'The last thing you want to do is give people a job that's impossible to do.' Yet, given the way the inspection system tests whether a facility complies with each of the 'Is it then really a question of what the quality of service is,' she asks, 'or is it a question of what is being measured?' In a series of analyses, we're diving into the OHSC's inspection reports to get a sense of what the benchmarks are — and what they say about the state of affairs at clinics, community health centres (CHCs) and hospitals. In this first story, we're looking only at the public health sector — not because we think things are perfect in private establishments, but because with And as with getting universal health coverage in place, we have to start somewhere. Come with us as we look at the numbers. The lay of the land South Africa has 3 741 public health facilities, of which about 90% are clinics and CHCs. Hospitals make up the remaining 10%. Because the different facilities offer different services, the detailed list of requirements they have to meet doesn't look the same for each place — although they all have to adhere to the same broad set of 23 standards. For example, four For this reason, one day is budgeted for Counting and compliance Between 2019 and 2023, the OHSC inspected 3 093 public health facilities — about 83% of the total to be assessed. Scores for the last 17% — 648 facilities — are still outstanding. (The latest inspection results Getting to every health facility in the country is a mammoth task. For example, 734 inspections in 2023 works out to two a day — and with But the task seems even more overwhelming when the compliance rate is added into the mix. In 2022 (the latest year for which results are available), only four out of 10 public facilities passed the test and so have to be re-inspected later, meaning that the backlog builds. To be rated as compliant, a facility has to get full marks for a set of so-called non-negotiable measures — things the It's an unfeasible system, Cleary says. 'I think that's a large part of what's happened to our public sectors. [People] get given unfunded mandates all the time. But just because a standard has been set unrealistically high, it doesn't mean that [service] quality is terrible; it may simply mean that hitting the bar is unaffordable given the money or staff available.' Star struck or star stuck? If we convert public health facilities' compliance rates to a star rating — like you'd give a service provider on an online review — no province got more than three stars in 2022. Looking at these results, it seems that, at best, three out of five facilities would make the cut — and it happens only in Gauteng. In KwaZulu-Natal and the Western Cape, chances are that every second facility might meet the OHSC's list of requirements, with the other provinces struggling to get more than one out of five facilities compliant. In fact, in the Northern Cape and Limpopo, so few of the inspected facilities could pass the assessments that their scores wouldn't even translate to a single star. But these are the results on paper — and likely give a warped picture of what is happening in practice because of the way performance is measured. A trimmed list of requirements — 'something that 90–95% of facilities can actually meet' — could give a more realistic view, says Cleary. This doesn't mean compromising on quality, but rather that decision-makers have to think more carefully about what the priorities really are. 'It's partly a matter of 'cutting your coat according to your cloth',' she says and working from there to improve step by step — with the money to make it happen. Says Cleary: 'We have to let go of this idea that we can have everything and that it all has to be perfect otherwise it's not good enough.' Stats that are shocking Something like the non-negotiable measures in the OHSC's scorecards could give a fairer idea of what healthcare quality really looks like. These are three things a clinic has to have in place to make the grade; the same three things in the emergency, obstetrics and clinical services units of a CHC and eight things in a hospital. They cover only statements related to handling a medical emergency, having a system in place for supplying lifesaving medical gas (like oxygen) to patients and getting patients' consent the right way. Viewing the quality of public healthcare from this angle really does paint a shocking picture — and could give decision-makers a concrete place to start to get to grips with claims of inadequate service. In 2022, only two provinces — Gauteng and the Western Cape — managed to have these minimum lifesaving measures in place in at least seven out of 10 clinics and CHCs and half the district hospitals inspected. (We didn't include regional hospitals in our analysis because at most two of these were assessed in a province. A score of, say, 50% would therefore not have been a fair reflection of reality.) In two other provinces — Mpumalanga and North West — half of either clinics or CHCs met these minimum requirements. The other provinces didn't come close. The health ombud's investigation Looking only at these measures, the This story was produced by the . Sign up for the .

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store