Conference MDAngle: ASCO 2025 Advanced NSCLC
Preconference Considerations
ASCO 2025: Previewing Therapeutic Updates in Advanced NSCLC
Dr Preeshagul notes how excitement is building around new therapies for advanced NSCLC at ASCO 2025, especially for KRAS G12C, EGFR exon 20 insertions, and HER2 alterations, with several promising studies such as LOXO-RAS-20001 and zipalertinib monotherapy drawing attention. Emerging HER2-targeted small molecules such as zongertinib and BAY 2927088 are also being closely watched for their potential central nervous system activity. Additionally, antibody-drug conjugates such as those in the TROPION-Lung02 trial are generating interest for their potential roles across treatment lines. Quick Clinical Takeaways
Coming soon: Dr Preeshagul highlights new data and progress regarding advanced NSCLC immediately following ASCO. How Will My Patients Benefit?
Coming soon: Reflections from Dr Preeshagul on how new data from ASCO will affect her patients with advanced NSCLC. Image 1: Memorial Sloan Kettering Cancer Center
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Health Line
18 minutes ago
- Health Line
The Link Between Ibuprofen and Ulcers
Long-term ibuprofen use can increase your risk of bleeding and ulcers in your stomach and intestines. If you take ibuprofen regularly, you can take steps to prevent peptic ulcers and protect stomach health. Peptic ulcers are slow-healing sores that can develop in your stomach lining, the beginning or top part of your small intestines (duodenum), or your esophagus. If you have a peptic ulcer, you'll usually experience some degree of abdominal pain. This pain can range from mild to severe and tends to come and go. Some people describe this pain as dull, while for others, it has more of a burning sensation. You might feel this pain anywhere from your belly button to your chest. Other symptoms include: Peptic ulcers can develop for a few reasons. One common cause is the frequent use of nonsteroidal inflammatory drugs (NSAIDs), including ibuprofen (Advil), naproxen (Aleve), and aspirin. Another is infection. Read on to learn how ibuprofen affects your stomach and what you can do to lower your risk of ulcers. Can ibuprofen cause stomach ulcers? Your body produces hormones called prostaglandins, which help heal tissue damage and injury, play a role in ovulation and labor, and help gut muscles contract and relax. These hormones also benefit your stomach in two main ways. They help repair and heal any damage to the lining of your stomach. They also protect your stomach from damage through the production of stomach mucus, which helps counter the effects of the stomach acid that helps break down your food. Stomach acid is very strong — strong enough to wear down your teeth and bones. If your body doesn't produce enough prostaglandins, this acid can easily damage your stomach lining. This is where ibuprofen and other NSAIDs can pose a danger. If you have an infection or injury, your body produces prostaglandins to help you heal. In some cases, though, your body may produce too much of these hormones. High levels of prostaglandins can lead to pain, swelling, and other inflammation. Ibuprofen relieves these symptoms by reducing the amount of prostaglandins your body can produce. But over time, the drop in prostaglandins can leave your stomach more vulnerable to damage. Ulcers don't develop overnight You probably won't develop an ulcer after taking ibuprofen for a few days in a row. Still, regular doses of ibuprofen daily for weeks or months will increase your chances of developing a peptic ulcer. take ibuprofen with other NSAIDs take ibuprofen with some other medications, such as corticosteroids, blood thinners, serotonin-norepinephrine reuptake inhibitors (SNRIs), or selective serotonin reuptake inhibitors (SSRIs) have a history of stomach ulcers have an H. pylori infection are older than 65 have three or more servings of alcohol a day smoke cigarettes Reducing your risk Most people can safely take ibuprofen to relieve short-term symptoms, such as fever, menstrual cramps, or body aches and pains. When taking ibuprofen or any other medication, you can reduce your risk of unwanted side effects by reading the label and following the directions closely. These tips can also help lower your chances of developing an ulcer: Take the smallest possible dose: Does your medication bottle say, 'Take 1 to 2 tablets every 4 to 6 hours?' It never hurts to start with one tablet and pay attention to your symptoms before taking more. Avoid taking too many doses: When taking ibuprofen around the clock to relieve pain that remains for a few days, like menstrual cramps, it may help to set a timer for each dose. If you take your next dose too soon, you may take more ibuprofen than planned and exceed the daily recommendation. Take ibuprofen for no more than a few days at a time: If you have persistent fever, aches, or other symptoms, it may be worth asking your healthcare professional about other options for treating your pain. Keep in mind, too, that NSAIDs to treat migraine pain and other headaches could lead to medication overuse headaches. Medications that help prevent peptic ulcers Many people take ibuprofen regularly to treat arthritis and other conditions that cause chronic pain and inflammation. If you need to take an NSAID long term, consider asking your doctor about medication to help protect against ulcers. The following medications could make a difference: proton pump inhibitors (PPIs), which help lower stomach acid production H2 blockers, which also help lower stomach acid production misoprostol, which helps boost the production of stomach mucus These medications may not work well for everyone and may cause some side effects, including constipation and diarrhea. Also, long-term use of PPIs may increase your risk of fractures and infection. Your care team can offer more guidance on whether these medications are a good option for you. Bottom line Most people won't get an ulcer from taking ibuprofen occasionally, especially when sticking to the dosing directions on the label. Taking several doses of ibuprofen a day for a few weeks or longer may raise your risk of peptic ulcers, especially if you take other NSAIDs at the same time. If you use ibuprofen to manage ongoing pain and inflammation, a good next step involves asking a doctor about medications that can lower your ulcer risk. They can also offer more guidance on other options for pain relief.
Yahoo
an hour ago
- Yahoo
Teen TikTok skin care craze may be harmful — and expensive, study finds
Get inspired by a weekly roundup on living well, made simple. Sign up for CNN's Life, But Better newsletter for information and tools designed to improve your well-being. When Ayva Peña got a phone at age 10, her interest in skin care skyrocketed. At first, she bonded over it with her mother, Giselle Peña. Together, they would have spa days with face masks and take occasional shopping trips to try out new products. But when the Rhode Island mother found a $300 anti-aging face cream in Ayva's medicine drawer, it gave her pause. 'I got very upset. … She's 15 years old,' Peña said. 'It says it makes your skin ageless, improves fine lines, wrinkles and firmness. I was like, 'This is not for you, girl.'' Peña is among a growing number of parents concerned about how content on social media platforms is influencing children and teens into trying out elaborate, often age-inappropriate skin care products. Now, a study published Monday in the journal Pediatrics may confirm those parents' worries. After analyzing beauty routines from 100 TikTok videos by content creators ages 7 through 18, researchers found an average of 11 potentially irritating active ingredients among their regimens, many of which carry a risk of developing skin allergies and increased sun sensitivity. Only a quarter of the lengthy product lists contained sunscreens, however. 'The majority of (children) featured in these videos didn't have any visible acne. They had perfect, clear skin,' said Dr. Molly Hales, the first study author and a board-certified dermatologist in the department of dermatology at Northwestern University's Feinberg School of Medicine. 'For many of them, the harms probably outweigh any potential benefits.' Between the dozens of daily serums, moisturizers, toners and cleansers featured in the videos, the average routine was six steps long, costing about $168 — with some more than $500 — for one month's worth of product, according to the study. 'When you have kids waking up at 5:30 in the morning on a school day to have enough time to layer on these complicated regimens, I think it becomes less about health and more (about) pursuing an idea of beauty that is unrealistic and problematic,' said Hales, who is also a postdoctoral research fellow at Feinberg. The findings raise serious ethical questions about how social media content influences young people in their everyday lives, she added A TikTok spokesperson, noting that this type of content is 'common across all media,' said the platform is only for users ages 13 and older, and any creators suspected to be under 13 are removed. Additionally, they said that TikTok works with third-party doctors and experts in adolescent development to implement safeguarding policies. Most of the studied skin care routines lacked a form of sunscreen but contained products that could increase sun sensitivity and risk of skin cancer, the authors found. Common active ingredients found in recommended skin products were alpha hydroxy acids or AHAs, mild chemical exfoliants that help remove top layers of skin cells, Hales said. While they have the intended effect of evening skin tone and creating a more youthful appearance, they are known to make the skin more vulnerable to the sun's ultraviolet rays. 'I would recommend daily sunscreen use for all ages and regimens, but especially for those using these (AHAs),' Hales said. 'It's a necessary step to prevent permanent skin damage.' Those AHAs, as well as vitamin-based ingredients such as niacinamide, are also considered potential irritants, carrying side effects such as redness and dryness, especially with overuse. 'In many cases, the girls may not have realized they were applying the same active ingredient again and again, which just increases the risk of irritation,' said Dr. Tara Lagu, senior study author and adjunct lecturer of medicine and medical social sciences at Feinberg. More than half the products contained fragrance — a common cause of allergic contact dermatitis — and 20 other inactive ingredients that are known allergens, according to the study. 'Misinformation is a big issue on social media, but especially for these content creators younger than 18,' said Dr. Sonal Shah, a board-certified dermatologist in Cleveland and director of pediatric dermatology at University Hospitals Rainbow Babies & Children's Hospital. Shah was not involved in the study. 'These are sources that perhaps don't have a scientific background and are not well read in the science behind a lot of these products, how they work, or what risks they carry,' Shah said, adding that there are board-certified dermatologists on TikTok that could offer more credible advice. Other concerning trends Shah has seen in her practice, but were not mentioned in the study, include mechanical exfoliants, such as scrubbing wands or cleansers containing plastic microbeads, which are often too rough for facial skin. The study also noted that many of the creators were offering tips relevant to those with lighter complexions, which may exclude the unique skin care considerations of darker complexions while perpetuating harmful ideals of 'brighter' skin associated with whiteness. Both Shah and Hales recommend children under 18 who are not dealing with acne use a gentle cleanser with no active ingredients, paired with a fragrance-free moisturizer and a daily mineral sunscreen. In general, children will not benefit from anti-aging products that promise to boost skin elasticity or eliminate fine lines, Shah said. In these young ages, collagen production is at the highest it will ever be. As children reach puberty, however, they may produce more acne-causing hormones. In those cases, Shah recommends adding an over-the-counter product with salicylic acid or a low percentage of benzoyl peroxide. 'Their skin care does not have to be complicated and does not have to be very expensive,' Shah said. Parents 'can talk to a board-certified dermatologist or pediatric dermatologist if there are skin concerns that are significant or don't respond to over-the-counter treatment.' Ultimately, if parents are concerned about their child's skin care regimen, they should talk about it, said Jennifer Harriger, a professor of psychology at Pepperdine University who studies childhood development, in a statement. 'I think that it is always best to have open conversations with children about the messages they see on social media as well as their own intentions behind purchasing particular skincare products,' said Harriger, who was not involved in the study. It's also important to keep an open mind, understanding the social dimension of youth beauty and wellness content, Hales said. 'These videos show a kind of playful self-expression that's very appealing to this age group,' Hales said. 'These are girls who are just starting to develop their own sense of independent identity, how they present (themselves) in the world, their gender identity, and in many cases what it means to be a girl in our society.'
Washington Post
an hour ago
- Washington Post
Unsubstantiated 'chemtrail' conspiracy theories lead to legislation proposed in US statehouses
BATON ROUGE, La. — As Louisiana Rep. Kimberly Landry Coates stood before her colleagues in the state's Legislature she warned that the bill she was presenting might 'seem strange' or even crazy. Some lawmakers laughed with disbelief and others listened intently, as Coates described situations that are often noted in discussions of 'chemtrails' — a decades-old conspiracy theory that posits the white lines left behind by aircraft in the sky are releasing chemicals for any number of reasons, some of them nefarious. As she urged lawmakers to ban the unsubstantiated practice, she told skeptics to 'start looking up' at the sky. 'I'm really worried about what is going on above us and what is happening, and we as Louisiana citizens did not give anyone the right to do this above us,' the Republican said. Louisiana is the latest state taking inspiration from a wide-ranging conspiratorial narrative, mixing it with facts, to create legislation. Tennessee Gov. Bill Lee signed a similar measure into law last year and one in Florida has passed both the House and the Senate. More than a dozen other states, from New York to Arizona, have introduced their own legislation. Such bills being crafted is indicative of how misinformation is moving beyond the online world and into public policy. Elevating unsubstantiated theories or outright falsehoods into the legislative arena not only erodes democratic processes, according to experts, it provides credibility where there is none and takes away resources from actual issues that need to be addressed. 'Every bill like this is kind of symbolic, or is introduced to appease a very vocal group, but it can still cause real harm by signaling that these conspiracies deserve this level of legal attention,' said Donnell Probst, interim executive director of the National Association for Media Literacy Education. Louisiana's bill , which is awaiting Republican Gov. Jeff Landry's signature, prohibits anyone from 'intentionally' injecting, releasing, applying or dispersing chemicals into the atmosphere with the purpose of affecting the 'temperature, weather, climate, or intensity of sunlight.' It also requires the Department of Environmental Quality to collect reports from anyone who believes they have observed such activities. While some lawmakers have targeted real weather modification techniques that are not widespread or still in their infancy, others have pointed to dubious evidence to support legislation. Discussion about weather control and banning 'chemtrails' has been hoisted into the spotlight by high-profile political officials, including Health Secretary Robert F. Kennedy Jr. and U.S. Rep. Marjorie Taylor Greene. Recently, Marla Maples, the ex-wife of President Donald Trump, spoke in support of Florida's legislation. She said she was motivated to 'start digging' after seeing a rise in Alzheimer's. Asked jokingly by a Democratic state senator if she knew anyone in the federal government who could help on the issue, Maples smiled and said, 'I sure do.' Chemtrail conspiracy theories, which have been widely debunked and include a myriad of claims, are not new. The publication of a 1996 Air Force report on the possible future benefits of weather modification is often cited as an early driver of the narrative. Some say that evidence of the claims is happening right before the publics' eyes, alleging that the white streaks stretching behind aircrafts reveal chemicals being spread in the air, for everything from climate manipulation to mind control. Ken Leppert, an associate professor of atmospheric science at the University of Louisiana Monroe, said the streaks are actually primarily composed of water and that there is 'no malicious intent behind' the thin clouds. He says the streaks are formed as exhaust is emitted from aircrafts, when the humidity is high and air temperature is low, and that ship engines produce the same phenomenon. A fact sheet about contrails , published by multiple government agencies including NASA and the Environmental Protection Agency, explains that the streaks left behind by planes do not pose health risks to humans. However, the trails, which have been produced since the earliest days of jet aviation, do impact the cloudiness of Earth's atmosphere and can therefore affect atmospheric temperature and climate. Scientists have overwhelmingly agreed that data or evidence cited as proof of chemtrails 'could be explained through other factors, including well-understood physics and chemistry associated with aircraft contrails and atmospheric aerosols,' according to a 2016 survey published in the journal Environmental Research Letters. In the survey of 77 chemists and geochemists, 76 said they were not aware of evidence proving the existence of a secret large-scale atmospheric program. 'It's pure myth and conspiracy,' Leppert said. While many of the arguments lawmakers have used to support the chemtrails narrative are not based in fact, others misrepresent actual scientific endeavors, such as cloud seeding; a process by which an artificial material — usually silver iodide — is used to induce precipitation or to clear fog. 'It's maybe really weak control of the weather, but it's not like we're going to move this cloud here, move this hurricane here, or anything like that,' Leppert said. Parker Cardwell, an employee of a California-based cloud seeding company called Rainmaker, testified before lawmakers in Louisiana and asked that an amendment be made to the legislation to avoid impacts to the industry. The practice is an imprecise undertaking with mixed results that isn't widely used, especially in Louisiana, which has significant natural rainfall. According to Louisiana's Department of Agriculture and Forestry, a cloud seeding permit or license has never been issued in the state. While presenting Louisiana's bill last week, Coates said her research found charts and graphics from the National Oceanic and Atmospheric Administration on spraying the air with heavy metals to reflect sunlight back into space to cool the Earth. The Consolidated Appropriations Act of 2022 directed the Office of Science and Technology Policy, with support from NOAA, to develop an initial governance framework and research plan related to solar radiation modification, or SRM. A resulting report , which Coates holds up in the House session, focuses on possible future actions and does not reflect decisions that had already been made. SRM 'refers to deliberate, large-scale actions intended to decrease global average surface temperatures by increasing the reflection of sunlight away from the Earth,' according to NOAA . It is a type of geoengineering. Research into the viability of many methods and potential unintended consequences is ongoing, but none have actually been deployed. In recent years, misinformation and conspiratorial narratives have become more common during the debates and committee testimonies that are a part of Louisiana's lawmaking process. And while legislators say Louisiana's new bill doesn't really have teeth, opponents say it still takes away time and focus from important work and more pressing topics. State Rep. Denise Marcelle, a Democrat who opposed Louisiana's bill, pointed to other issues ailing the state, which has some of the highest incarceration, poverty, crime, and maternal mortality rates. 'I just feel like we owe the people of Louisiana much more than to be talking about things that I don't see and that aren't real,' she said. ___ Associated Press writers Kate Payne in Tallahassee, Florida, and Jack Dura in Bismarck, North Dakota, contributed to this story.
