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Health Rounds: RSV can boost seniors' heart risks

Health Rounds: RSV can boost seniors' heart risks

Reuters4 days ago
July 24 (Reuters) - (This is an excerpt of the Health Rounds newsletter, where we present latest medical studies on Tuesdays and Thursdays. To receive the full newsletter in your inbox for free sign up here.)
Older adults hospitalized for respiratory syncytial virus (RSV) face an elevated risk of developing heart failure and a dangerous heart rhythm problem, a Canadian study found.
The risk for heart failure was seen even in individuals without a history of heart problems, researchers reported in the Journal of the American Geriatrics Society, opens new tab.
The researchers reviewed data on more than 100,000 adults aged 65 and older hospitalized in Ontario between 2011 and 2020 for either RSV, influenza, urinary tract infection, or a fracture.
The proportion of patients with a subsequent cardiovascular event was 18.5% after an RSV-related hospitalization, compared to 17.7%, 12.1% and 8.4% after hospitalizations for influenza, urinary tract infection, or fracture, respectively.
In comparisons of patients who were closely matched according to demographics and risk factors, heart failure (10%–11%) was the most common outcome for RSV patients, occurring in 10% to 11%. Next most common was the heart rhythm disorder atrial fibrillation, occurring in 5% to 6% of RSV patients.
The risk for those outcomes, as well as for heart attack, 'was at least two to three times higher in patients with a pre-existing cardiovascular condition compared to those without,' the researchers also said.
'Our findings reinforce the importance of RSV vaccination in older adults and suggest that monitoring for signs of heart disease following an RSV illness may be pragmatic,' study leader Chris Verschoor of Health Sciences North Research Institute in Sudbury, Ontario, said in a statement.
Sending dye through the small intestine to look for blockages has been sparing a significant proportion of patients from needing to undergo surgery, a new study shows.
The dye, Gastrografin from Bracco Diagnostics Inc., is administered to symptomatic patients before an X-ray or CT scan so that surgeons can see the location and severity of any so-called adhesive small bowel obstructions.
Researchers reviewed nationwide data on more than 20,000 patients with suspected small bowel obstruction managed in two periods - 2012 to 2016, before Gastrografin was widely used for this purpose, and 2019 to 2023, when using Gastrografin to visualize intestinal blockages was a standard of care.
They found nearly a 45% decrease in surgeries for small bowel obstruction in the Gastrografin era, from 13,257 to 7,333.
Small bowel obstruction accounts for 15% of hospital admissions in the U.S., with about 20% of cases needing surgery to reconstruct the intestine, the researchers said. The resulting healthcare costs total over $3 billion each year.
Despite better small bowel obstruction outcomes overall, post-surgery mortality increased from 4.4% to 5.9% after use of the dye became standard, and reoperations within 30 days rose from 4.7% to 6.2% - likely because surgeries were probably more complex in the later era, the researchers said.
Gastrografin testing had weeded out patients with relatively mild obstructions who ultimately didn't need surgery, they added.
'Previously, patients who had a relatively mild adhesive small bowel obstruction would have been operated on, as we didn't have an alternative option,' study leader Dr. Robert McLoughlin from the University of Connecticut School of Medicine in Farmington said in a statement.
'This meant that in the post-Gastrografin era, the surgeries were more complex and challenging, hence the increased morbidity and mortality.'
Still, because surgeons have gotten better at managing patients after surgery for small bowel obstructions, patients in the Gastrografin group averaged 6 days in the hospital, versus about 10 days for patients treated before the Gastrografin era, the researchers reported in the Journal of Surgical Research, opens new tab.
The current study was not designed to prove that any of the outcomes were the result of Gastrografin use, the article pointed out.
McLoughlin recalled that during a discussion with a younger colleague about managing small bowel obstructions, he mentioned that when he was in training, surgeons operated 'on a lot more' of these patients.
That recollection prompted the current study, he said.
(To receive the full newsletter in your inbox for free sign up here)
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Extraordinary satellite images show huge crowds descending on aid trucks as UN claims Gaza is ‘on the brink of full-scale famine' amid mounting blame game
Extraordinary satellite images show huge crowds descending on aid trucks as UN claims Gaza is ‘on the brink of full-scale famine' amid mounting blame game

Daily Mail​

time2 hours ago

  • Daily Mail​

Extraordinary satellite images show huge crowds descending on aid trucks as UN claims Gaza is ‘on the brink of full-scale famine' amid mounting blame game

New satellite images show masses of starving Palestinians rushing to American-backed aid distribution point to pick up food and water. Photos taken by PlanetLabs shows innumerable Gazans gathering just over a kilometre away from a Gaza Humanitarian Foundation aid site in Khan Younis, Gaza's second city. They can be seen crowding around roughly 15 aid trucks that have been let into Gaza by Israel, as the Strip is entering a 'worst-case scenario' famine the world's main nutrition monitor warned. Rival aid efforts have sparked a war of words, pitting Israel, the US and the GHF against the UN, international aid groups and dozens of governments from around the world. Some have accused Israel of deliberately starving Gaza's civilian population. The Integrated Food Security Phase Classification Initiative (IPC) said that air drops over Gaza will not be enough to avert the 'humanitarian catastrophe.' 'The worst-case scenario of famine is now unfolding in the Gaza Strip,' said the UN-backed group of organisations, used as a monitor to gauge malnutrition. 'Immediate, unimpeded' humanitarian access into Gaza was the only way to stop rapidly rising 'starvation and death', it said. The IPC issued their warning 'alert' after days of aid groups sounding the alarm over hunger-related deaths in Gaza. Israel imposed a total blockade on Gaza on March 2 after ceasefire talks broke down. In late May, it began allowing a small trickle of aid to resume, amid warnings of a wave of starvation. The IPC said its latest data shows that 'famine thresholds' have been reached in 'most of the Gaza Strip'. Hunger-related deaths of young children, it said, were rising fast. 'Over 20,000 children have been admitted for treatment for acute malnutrition between April and mid-July, with more than 3,000 severely malnourished.' Children under the age of five were dying of hunger, 'with at least 16 reported deaths since 17 July', IPC said. 'Mounting evidence shows that widespread starvation, malnutrition, and disease are driving a rise in hunger-related deaths,' it said Tuesday. Israel and the US accuse Hamas of stealing aid - which they deny - and the UN of failing to prevent it. The US says it has not seen evidence of mass aid diversion in Gaza by Hamas. Israeli prime minister Benjamin Netanyahu said there is no policy of starvation in Gaza, and no starvation per se. Donald Trump diverged from Mr Netanyahu's comments on Monday, insisting there is 'real starvation' in Gaza. Asked if he agreed with Mr Netanyahu that it was a 'bold-faced lie' to say Israel was fuelling hunger, he said: 'I don't children look very real starvation stuff.' On Monday night, Mr Netanyahu's office said that Israel would work with aid groups, the US and Europe to ensure 'large amounts of humanitarian aid flows' into Gaza. Israel said that 120 aid trucks had entered Gaza from crossings on Sunday, and that Jordan and the UAE had airdropped 28 packages of food. The GHF said it had delivered more than 95 million meals directly to Palestinians in Gaza in total. But on Monday, the Hamas-run health ministry in Gaza said a further 14 people had died from malnutrition over the past 24 hours, bringing the total to 147 since the start of the war, according to the ministry. It added today that more than 60,000 people have been killed since the war started. Israel has said that Hamas is using a so-called 'famine narrative' for leverage in ceasefire talks, which broke down last week as the US and Israel left talks in Doha, suggesting a cynical 'lack of desire to reach a ceasefire' from Hamas. Hamas responded with incredulity and insisted it did want to continue negotiations. Hamas leader Khalil Al-Hayya then said on Monday there was 'no point in continuing negotiations' under current conditions. A source close to Hamas told CNN: 'After the Israeli side withdrew from the negotiations, Hamas is considering reversing the flexibility it had shown regarding the timeline for releasing the 10 living Israelis captives.' Until talks resume, Gaza's 2.1 million population remains in dire need of aid. A former British soldier in Gaza shared chaotic and unsettling scenes of civilians rushing to collect aid from a distribution site as essentials continued to trickle into the beleaguered Palestinian enclave. Andrew Fox, a former British Army airborne officer, shared a series of clips from the Gaza Humanitarian Foundation (GHF) site in Rafah, describing an 'influx of hungry Gazans coming to get their aid'. The video was shared on social media in the early hours of Tuesday morning, after Israel said on Sunday it would halt military operations for 10 hours a day in parts of the Gaza Strip and allow new aid corridors. Mr Fox's dispatch from Rafah offers a rare insight into the coordination of aid deliveries in the Gaza Strip. Journalists are pushing to be allowed in and out of the enclave and say reporting from the enclave is nearing 'extinction' with local reporters facing 'threat of starvation'. 'The flow of people just keeps coming,' Mr Fox said, reporting from the sidelines of the crowd in the first few minutes of opening. The initial influx was mostly young men, he said, who were ordered to dismount from motorbikes to avoid injuries. Within 20 minutes, he said, they were starting to see more women and children arrive to claim essentials held in reserve. After 45 minutes, the aid had mostly been depleted. Mr Fox said the team had used smoke and flashbang grenades to 'encourage the last of the male crowd out of the site' to allow the team to hand out aid held in reserve for women and children. Mr Fox described GHF cardboard boxes, which he said were enough to buy one kilogram (2.2lbs) of flour in the barter economy. Increasingly, he said, Palestinians were taking empty boxes and wooden pallets to be used as firewood, with Gaza facing blackouts. 'No live rounds at all have been fired,' he said. Women and young people could be seen leaving the site with aid, waving and gesturing towards the camera. The GHF, a US-backed private aid operation supported by Israel, has faced pressure in recent days after the UN reported that Israeli forces had killed more than 1,000 Palestinians seeking food aid, mostly near distribution points. Israel accused Hamas of instigating chaos near the aid sites. It said its troops had only fired warning shots, and that they do not deliberately shoot civilians. The GHF has accused Hamas of massive aid theft in defending its distribution model. An internal US government analysis found no evidence of systematic theft of US-funded humanitarian supplies by Hamas, challenging the rationale Israel and the US give for backing the aid operation, as reported by Reuters last week. Mr Fox described the challenging environment facing locals as they waited to start distributing aid in Rafah. 'The terrain here is as destroyed as has been reported in the media. It's no lie. The place is wrecked. These people do need food. They do need feeding. They need the aid that these teams are bringing to them. 'This is really, really hot. There is water on site but people are still struggling for the very basics of life, and GHF are here to try and at least alleviate some of that suffering.' He wrote in a July 24 blog that while aid was entering Gaza, 'the grim truth is that supply is not the same as access'. 'Gaza's crisis is mainly a result of distribution collapse and governance issues, worsened by Hamas's tactics and the paralysis of traditional aid channels.' In testimonies shared with MailOnline, International Rescue Committee (IRC) staff inside Gaza described harrowing scenes. 'People are collapsing in the streets from emaciation... I saw a child digging through a pile of trash for food. He found nothing,' said IRC staffer Abdelraheem Hamad. 'The sound of children crying from hunger never stops. Every day, people knock on our doors asking for food. Not money — just bread,' said staffer Rania Al Shrehi. The leading international authority on food crises said in a new alert Tuesday that the 'worst-case scenario of famine is currently playing out in the Gaza Strip', predicting 'widespread death' without immediate action. The Integrated Food Security Phase Classification, or IPC, said Gaza has teetered on the brink of famine for two years, but recent developments have 'dramatically worsened' the situation, including 'increasingly stringent blockades' by Israel. The IPC is a global initiative that partners with 21 aid groups, international organizations, and UN agencies, and assesses the extent of hunger suffered by a population. The alert, still short of a formal famine declaration, follows an outcry over images of emaciated children in Gaza and reports of dozens of hunger-related deaths after nearly 22 months of war. While international pressure led Israel over the weekend to announce measures to deliver more aid, the United Nations and Palestinians on the ground say little has changed, and desperate crowds continue to overwhelm and unload delivery trucks before they can reach their destinations. 'Formal famine declarations always lag reality,' David Miliband, head of the International Rescue Committee aid group, said in a statement ahead of the IPC alert. 'By the time that famine was declared in Somalia in 2011, 250,000 people - half of them children under 5 - had already died of hunger. By the time famine is declared, it will already be too late,' he said. 'In the coming days, thousands of Gaza's children will either be rescued — or allowed to die. That is the choice before us.' The conflict between Israel and Gaza continued as aid agencies scrambled to deliver essentials. The sun sets over Gaza, ravaged by war, as seen from the Israeli side of the border, July 28 Gaza's civil defence said Tuesday that Israeli air strikes killed at least 30 Palestinians, including women and children, in the central Nuseirat district. Civil defence agency spokesman Mahmud Basal said the strikes were carried out overnight and into the morning and 'targeted a number of citizens' homes' in the Nuseirat refugee camp. The war in Gaza began on October 7, 2023, when Hamas killed 1,200 people in southern Israel and took some 250 hostages, according to Israeli tallies.

Number of Palestinians killed in Israel-Hamas war passes 60,000, ministry says
Number of Palestinians killed in Israel-Hamas war passes 60,000, ministry says

Glasgow Times

time4 hours ago

  • Glasgow Times

Number of Palestinians killed in Israel-Hamas war passes 60,000, ministry says

The ministry, part of the Hamas-run government, said the death toll has climbed to 60,034, with another 145,870 people wounded since the Hamas attack on October 7 2023. It did not say how many were civilians or militants, but has said women and children make up around half of the dead. The ministry is staffed by medical professionals. The United Nations and other independent experts view its figures as the most reliable count of casualties. An Israeli armoured personnel carrier returns from inside the northern Gaza Strip (Ariel Schalit/AP) Israel's offensive has destroyed vast areas of Gaza, displaced around 90% of the population and caused a catastrophic humanitarian crisis, with experts warning of famine. As international organisations warn of a 'worst-case scenario of famine', Israel continued to strike the Gaza Strip, killing at least 70 Palestinians in the past day, according to local hospitals. More than half were killed while attempting to access aid, hospitals said, and includes a rising toll from a deadly incident on Monday as people attempted to access aid from a truck convoy passing through the southern Gaza Strip. Local hospitals said they received the bodies of an additional 33 people who were killed by gunfire around an aid convoy in southern Gaza on Monday, bringing the total from the single incident to 58. The Israeli military did not comment on the shooting. Israel says it only targets militants and takes extraordinary measures to avoid harming civilians. It blames civilian deaths on Hamas because the militants operate in populated areas. The military said it targeted Hamas military infrastructure over the past day including rocket launchers, weapons storage facilities and tunnels. An additional seven Palestinians were killed while attempting to access aid near the American and Israeli-backed Gaza Humanitarian Fund (GHF) site in central Gaza, according to local hospitals. Neither GHF nor the Israeli military commented on the shooting, but the Israeli military has said in the past it only fires warning shots if troops feel threatened and GHF has said their contractors have not fired at civilians. Humanitarian aid is airdropped to Palestinians over Gaza City (Jehad Alshrafi/AP) Air strikes also targeted tents hosting displaced people in the central city of Nuseirat, killing 30 people, including 12 children and 14 women, according to Al-Awda hospital. The strikes come as international organisations continue to warn about the dire humanitarian situation in Gaza, which has teetered on the brink of famine for two years. Recent developments have 'dramatically worsened' the situation, according to a report by the Integrated Food Security Phase Classification (IPC). Hamas-led militants killed some 1,200 people, mostly civilians, in the attack that sparked the war, and abducted another 251. They are still holding 50 captives, around 20 believed to be alive, after most of the rest were released in ceasefires or other deals. The war took a major turn in early March when Israel imposed a blockade, barring the entry of all food, medicine, fuel and other goods. Weeks later, Israel ended a ceasefire with a surprise bombardment and began seizing large areas of Gaza, measures it said were aimed at pressuring Hamas to release more hostages. At least 8,867 Palestinians have been killed since then. Israel eased the blockade in May, but UN agencies say it has not allowed nearly enough aid to enter and that they have struggled to deliver it because of Israeli restrictions and the breakdown of law and order. An alternative Israeli-backed system run by an American contractor has been marred by violence and controversy.

‘Game-changing' new Alzheimer's drug could slow progression of disease
‘Game-changing' new Alzheimer's drug could slow progression of disease

The Independent

time5 hours ago

  • The Independent

‘Game-changing' new Alzheimer's drug could slow progression of disease

An Alzheimer's drug that clears away plaque build-up in the brain could slow progression of the disease and delay the onset of symptoms, early trials have shown. There is currently no cure for the disease, which can severely affect memory and impact people's ability to carry out daily tasks, and the medicines available can only reduce symptoms. But a new drug called Trontinemab is showing promising results, the Alzheimer's Association International Conference in Toronto was told. The drug has been tested on a small number of patients, but 49 out of 54 with early-stage Alzheimer's showed signs of improvement within 28 weeks during a trial, according to Roche, the pharmaceutical company behind the drug. Researchers said 91 per cent of the participants showed a reduction in clusters of protein on their brains, known as amyloid plaques – a key marker of Alzheimer's. Alzheimer's is thought to be caused by an abnormal build-up of this protein around brain cells, while another protein called tau forms tangles within brain cells. These can interrupt the chemical messengers responsible for sending signals between brain cells, according to the NHS. The new drug was found to reduce amyloid proteins to a level so low that scan results on patients taking it for seven months were considered to be 'amyloid negative'. It is thought that the clearance of plaques slows down the progression of the disease and delays the onset of symptoms. 'Alzheimer's disease represents one of the greatest challenges in healthcare today, and tackling it requires early detection and effective therapeutics,' Dr Levi Garraway, chief medical officer of Roche, said. He added: 'Trontinemab is designed to target a key driver of Alzheimer's disease biology more effectively in the brain. Combining new treatment avenues with advanced diagnostics may enable earlier and potentially more effective intervention.' Professor Sir John Hardy, the chairman of molecular biology of neurological disease at University College London's Institute of Neurology, who was not involved in the trial, told The Telegraph the drug was a 'massive improvement' and works faster than other Alzheimer's drugs on the market. 'There is no doubt this could be game-changing. We hope that if we can use these drugs to people early, we can halt the progression of disease, even before people have symptoms. Now we need to see the size of the clinical effect,' he said. However, the drug does have some side effects, with five participants of 149 (3 per cent) suffering from lesions or swelling in their brains after taking it. But all the participants recovered, and it was considered to be safer than other Alzheimer's drugs that have resulted in 17 per cent of participants experiencing similar side effects. The final part of the trial, which will test the drug on a large number of patients, is yet to be carried out. But if it is successful, health bodies in the UK will need to decide whether it is cost-effective enough to use on the NHS. An estimated 982,000 people are living with some form of dementia, including Alzheimer's, in the UK, with the disease most common in people over the age of 65. But more than a third of people with the condition do not have a diagnosis. The number of those with the disease is expected to rise to 1.4 million by 2040, according to the Alzheimer's Society.

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