Ultra-processed foods tied to 124,000 premature deaths over 2 years in U.S., study finds
ST. PAUL, Minn., April 28 (UPI) -- A study released Monday links a total of more than 124,000 preventable, premature deaths in the United States over two years to adverse health affects from consuming ultra-processed foods.
The study's Brazilian authors also analyzed data on ultra-processed food consumption from seven other countries, concluding that premature deaths tied to unhealthy diets are a growing global phenomenon calling for coordinated international action.
In addition to the nearly 125,000 premature U.S. deaths for 2017 and 2018, the study, published in the American Journal of Preventative Medicine, also estimated that more than 25,000 Brazilians died prematurely during those years because of poor health outcomes tied to ultra-processed foods.
The researchers' statistical model also showed more than 17,000 such deaths in Britain during 2018 and 2019 and another 17,000 in Mexico during a single year, 2016.
Similarly, Canada had more than 7,700 premature deaths attributed to ultra-processed foods in 2016, the authors estimated, while Australia recorded 3,277 in 2016, Colombia had 2,813 in 2015 and Chile tallied 1,874 in 2010.
Ultra-processed foods, or UPFs, generally are defined as those that include mass-produced ingredients that can't be made at home, such as preservatives, emulsifiers and sweeteners. They often contain added fats, starches, sugars, salts and hydrogenated oils extracted from other foods.
Sugary drinks, sweets and chocolates, pizzas, hamburgers, chicken nuggets and other highly popular food items are defined as UPFs under the NOVA food classification system. High consumption of these foods has been associated with many different diseases, including cardiovascular disease, obesity, diabetes, some types of cancer and depression.
By 2018, UPFs already made up more than half of the total dietary energy consumed in high-income countries such as the United States, Canada and Britain, and between one-fifth and one-third of total dietary energy in middle-income countries such as Brazil, Mexico and Chile, according to a University of São Paulo study.
The topic is receiving renewed attention due to the agenda of U.S. Health and Human Services Secretary Robert F. Kennedy Jr., who is focusing on the perceived dangers of UPFs during his "Make American Healthy Again" tour this month.
To calculate their numbers, the study's authors developed a comparative risk assessment looking at dietary share of UPFs and all-cause mortality in each country.
They then employed a statistical model to estimate the percentage of all premature preventable deaths due to the consumption of UPFs, tapping studies from many countries and the landmark Global Burden of Disease report of 2021, according to lead author Eduardo A.F. Nilson, a nutrition researcher at the University of São Paulo.
They determined the percentage of UPF-attributable premature deaths vary from 4% in countries with lower UPF consumption to almost 14% in countries with the highest UPF consumption such as the United States and Britain.
Nilson told UPI that while it wasn't much of a surprise the United States has the highest percentage of UPF-associated premature deaths, he noted the trajectory of U.S. deaths has stabilized in recent years while they continue to rise in low- and middle-income nations such as Brazil, Chile and Colombia.
"Our findings on the attributable deaths to UPF in low- and middle-income countries shows that UPFs are replacing traditional fresh and minimally processed foods ,and that this may increase deaths from non-communicable diseases associated with unhealthy dietary patterns," Nilson said in emailed comments.
"These countries are already facing accelerated nutritional and epidemiological transitions and the replacement of traditional diets by UPFs is increasing especially among low income families, reinforcing the challenges of the double burden of malnutrition."
Global food systems have made UPFs more available and affordable in all countries, triggering changes in diets all over the world as well as new heath problems that "demand policy responses by national governments" the Brazilian researcher said.
UPF consumption "represents a global priority, and it requires more than consumer education because food choices are determined by many factors beyond consumers, mostly related to the food environment," Nilson said.
"Food choices are influenced by price, availability, information and other factors and education by itself is insufficient to ensure healthy diets. Therefore, we need to make healthy dietary behaviors easier and more accessible and affordable."
He added: "This means implementing fiscal and regulatory policies, including subsidies to fresh and minimally processed foods, taxation of UPFs -- as is already done for sugar-sweetened beverages in some countries -- improving front-of-pack food labelling, regulating food marketing and regulating food sales in settings such as schools, workplaces and hospitals, for example."
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Robert F. Kennedy Jr.'s warning about mitochondria slipped in between the anti-vaccine junk science and the excoriation of pharmaceutical drugs as 'the No. 3 killer in our country.' He was speaking in 2023 to Joe Rogan, elaborating on the dangers of Wi-Fi—which no high-quality scientific evidence has shown to harm anyone's health—and arguing that it causes disease by somehow opening the blood-brain barrier, and by degrading victims' mitochondria. The mention of mitochondria—the tiny structures that generate energy within our cells—was brief. Two years later, mitochondrial health is poised to become a pillar of the MAHA movement, already showing up in marketing for supplements and on podcasts across the 'manosphere.' Casey Means, President Donald Trump's newest nominee for surgeon general, has singled out the organelle as the main casualty of the modern American health crisis. 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Even one laser-light skin treatment promises to 'recharge failing mitochondria.' The enzyme CoQ10 is popular right now as a supplement for mitochondrial function, as is NAD, a molecule involved in mitochondria's production of energy. NAD IV drips are especially beloved by celebrities such as Gwyneth Paltrow, Kendall Jenner, and the Biebers. These supplements are generally thought to be safe, and some preliminary research shows that NAD supplementation could help patients with Parkinson's or other neurodegenerative diseases, and that CoQ10 could benefit people with mitochondrial disorders. Patients whose symptoms are clearly caused or made worse by deficiencies in a specific vitamin, such as thiamine, can benefit from supplementing those vitamins, Mootha said. But little research explores how these supplements might affect healthy adults. In Good Energy, as well as on her website and in podcast appearances, Casey Means promotes a number of supplements for mitochondrial health. She also recommends that people wear continuous glucose monitors—available from her company, Levels Health, for $184 a month—to help prevent overwhelming their mitochondria with too much glucose. (According to Macleod, glucose levels are only 'a very indirect measure' of mitochondrial activity.) As with so many problems that wellness influencers harp on, the supposed solution to this one involves buying products from those exact same people. At best, all of this attention to mitochondria could lead Americans to healthier habits. Much of the advice in Good Energy echoes health recommendations we've all heard for decades; getting regular exercise and plenty of fiber is good guidance, regardless of anyone's reasons for doing so. Switching out unhealthy habits for healthy ones will likely even improve your mitochondrial health, Jaya Ganesh, a mitochondrial-disease expert at Icahn School of Medicine at Mount Sinai, told me. After all, 'if you consistently beat your body up with unhealthy habits, everything is going to fall sick,' Ganesh said. But the mitochondrial approach to wellness carries risks, too. For patients with genetically caused mitochondrial disease, lifestyle changes might marginally improve some symptoms, Ganesh said, but attempting to cure such conditions with supplements and a healthy diet alone could be dangerous. Means also calls out medications—including antibiotics, chemotherapy, antiretrovirals, statins, and high-blood-pressure drugs—for interfering with mitochondria. Macleod told me that statins really do affect mitochondria, as do some antibiotics. (The latter makes sense: Mitochondria are thought to have evolved from bacteria more than a billion years ago.) That's no reason, though, to avoid any of these medications if a doctor has determined that you need them. And yet, a whole chapter of Good Energy is dedicated to the idea that readers should mistrust the motives of their doctors, who the authors say profit by keeping Americans sick. The book is less critical of the ways the wellness industry preys on people's fears. Zooming in on mitochondria might offer a reassuringly specific and seemingly scientific explanation of the many real ills of the U.S. population, but ultimately, Means and MAHA are only helping obscure the big picture.
