Long-Term Use of Metformin May Prevent AMD in Diabetes
The study was led by Alexander T. Hong of the Keck School of Medicine of the University of Southern California in Los Angeles. It was published online Aug. 11, 2025, in Ophthalmology Retina . LIMITATIONS:
Due to its retrospective design, the study could not show if taking metformin was actually protecting against AMD. There may have been coding errors and missing information as electronic health records data were used. The cohort analysis only included patients with annual health encounters for 5 years prior to the second eye care visit, potentially excluding those who changed institutions or had gaps in care. DISCLOSURES:
The study was partly supported by grants from the National Eye Institute, Research to Prevent Blindness, Inc, and All May See Foundation, Inc. One author disclosed receiving consulting fees and having personal financial interests with certain organizations unrelated to this study.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication. Lead image: The National Institute of Health
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