Shefali Jariwala's Death Raises Alarms Over Glutathione Injection Risks; Expert Answers

News18

01-07-2025

Last Updated:
Shefali Jariwala's sudden death has sparked urgent conversations around the risks of unregulated glutathione injections and the dangers of low blood pressure after IV treatments
The sudden and tragic death of actress-model Shefali Jariwala at the age of 42 has raised serious concerns about the safety of unregulated cosmetic treatments, particularly intravenous (IV) glutathione injections. While the official cause of death is yet to be confirmed, early reports suggest the possibility of cardiac arrest, potentially triggered by low blood pressure following a glutathione and Vitamin C injection administered on an empty stomach.
In light of the incident, medical experts are sounding the alarm about the growing misuse of IV anti-ageing and skin-lightening treatments in non-clinical settings. Dr Sarita Sanke, Head of Cosmetology and Dermatology, Yashoda Cosmetic Boutique, Yashoda Superspeciality Hospital, Kaushambi, shares critical insights into the safe use of glutathione.
'The principle behind using Glutathione in skin lightening lies in its ability to decrease melanin production, thereby lightening the skin and reducing hyper pigmentation. Glutathione is available in multiple forms, oral supplements, topical applications, and intravenous (IV) injections and each has its own safety and efficacy profile," says Dr Sanke.
She explains that oral glutathione especially in sublingual or effervescent dissolvable forms is considered among the safest options. It offers moderate skin-lightening effects with limited side effects and is generally well tolerated. Similarly, topical formulations may help improve skin tone and texture, although their effectiveness can vary.
'Intravenous glutathione, although known for its fast-acting results, carries serious safety risks, including the potential for anaphylactic reactions and liver toxicity. These risks are compounded by the absence of standardized dosing protocols and limited long-term safety data," she warns. As a result, IV glutathione should be approached with extreme caution and always under medical supervision.
1000–2000 mg per day for the first 3 months.
500 mg daily as a maintenance dose thereafter.
Do not exceed 2000 mg per day, and avoid prolonged continuous use.
IV administration (only under medical supervision):
1200–1800 mg per week for 4–6 weeks.
Maintenance dose of 600–1200 mg per week.
'Always consult a healthcare provider before starting glutathione, especially if you are on other medications," she adds. 'The long-term systemic effects are not yet fully understood, so caution is advised with extended use. Watch for potential side effects such as low blood pressure or allergic reactions, particularly with IV use."
Shefali Jariwala's death serves as a sobering reminder of the hidden risks involved in unmonitored cosmetic therapies. While beauty trends continue to drive demand for rapid results, experts like Dr Sanke stress the need for medical oversight, proper dosage, and a deep understanding of what our bodies can safely handle.