
Shefali Jariwala's Death Raises Alarms Over Glutathione Injection Risks; Expert Answers
Shefali Jariwala's sudden death has sparked urgent conversations around the risks of unregulated glutathione injections and the dangers of low blood pressure after IV treatments
The sudden and tragic death of actress-model Shefali Jariwala at the age of 42 has raised serious concerns about the safety of unregulated cosmetic treatments, particularly intravenous (IV) glutathione injections. While the official cause of death is yet to be confirmed, early reports suggest the possibility of cardiac arrest, potentially triggered by low blood pressure following a glutathione and Vitamin C injection administered on an empty stomach.
In light of the incident, medical experts are sounding the alarm about the growing misuse of IV anti-ageing and skin-lightening treatments in non-clinical settings. Dr Sarita Sanke, Head of Cosmetology and Dermatology, Yashoda Cosmetic Boutique, Yashoda Superspeciality Hospital, Kaushambi, shares critical insights into the safe use of glutathione.
'The principle behind using Glutathione in skin lightening lies in its ability to decrease melanin production, thereby lightening the skin and reducing hyper pigmentation. Glutathione is available in multiple forms, oral supplements, topical applications, and intravenous (IV) injections and each has its own safety and efficacy profile," says Dr Sanke.
She explains that oral glutathione especially in sublingual or effervescent dissolvable forms is considered among the safest options. It offers moderate skin-lightening effects with limited side effects and is generally well tolerated. Similarly, topical formulations may help improve skin tone and texture, although their effectiveness can vary.
'Intravenous glutathione, although known for its fast-acting results, carries serious safety risks, including the potential for anaphylactic reactions and liver toxicity. These risks are compounded by the absence of standardized dosing protocols and limited long-term safety data," she warns. As a result, IV glutathione should be approached with extreme caution and always under medical supervision.
1000–2000 mg per day for the first 3 months.
500 mg daily as a maintenance dose thereafter.
Do not exceed 2000 mg per day, and avoid prolonged continuous use.
IV administration (only under medical supervision):
1200–1800 mg per week for 4–6 weeks.
Maintenance dose of 600–1200 mg per week.
'Always consult a healthcare provider before starting glutathione, especially if you are on other medications," she adds. 'The long-term systemic effects are not yet fully understood, so caution is advised with extended use. Watch for potential side effects such as low blood pressure or allergic reactions, particularly with IV use."
Shefali Jariwala's death serves as a sobering reminder of the hidden risks involved in unmonitored cosmetic therapies. While beauty trends continue to drive demand for rapid results, experts like Dr Sanke stress the need for medical oversight, proper dosage, and a deep understanding of what our bodies can safely handle.

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Hindustan Times
43 minutes ago
- Hindustan Times
Cardiologist warns against anti ageing injections post Shefali Jariwala death, plastic surgeon reveals if they even work
Shefali Jariwala's untimely death at 42 has come as a shock and raised concerns over cosmetic procedures like anti-ageing injections. The Kaanta Laga fame actor and model died on June 27 in Mumbai. The exact cause of her death is still under investigation. However, multiple reports suggest that Shefali's death might be linked to low blood pressure, cardiac arrest, and gastric issues, potentially triggered by an anti-ageing injection she took on an empty stomach. In the light of Shefali Jariwala's death, a cardiologist and plastic surgeon talk about anti-ageing injections, if they actually work, what are the risks of taking them, and more.(Representative picture: Freepik) Also Read | Shefali Jariwala death: Doctors warn skin lightening glutathione injections aren't without risk or 'severe side effects' In an interview with HT Lifestyle, Dr Jyoti Kusnur, consultant, interventional cardiologist, Manipal Hospital, Goa, and Dr Karthik Shrinivas Tallam, senior consultant, plastic and reconstructive surgery, Manipal Hospital Varthur, talked about anti-ageing injections – if they actually work, what are the risks of taking them, and more. No proven research substantiates existence of 'anti-ageing therapies' According to Dr Kusnur, a cardiologist, 'There is no proven research in medical literature substantiating the existence of any 'anti-ageing therapies'; however, several beauty consultants claim cosmetic benefits by administering different compounds.' Certain additives in anti-ageing injections may cause allergic reactions or anaphylaxis, causing blood pressure to fall to dangerous levels, thereby precipitating a cardiac arrest. The cardiologist stressed that these injections cover a diverse range of substances, like Botox, which has been used for wrinkle treatment for many years. As for Shefali, speculations are rife that she took Glutathione injections for anti-ageing treatment. 'Any therapy which is not medically supervised or indicated is best avoided. In the absence of any verified data relating to the formulation and production of these substances, as well as their therapeutic effects on the human body, it would be very difficult to ascertain the damage they cause. In this instance, certain additives might have caused allergic reactions or anaphylaxis, causing blood pressure to fall to dangerous levels, thereby precipitating a cardiac arrest,' Dr Kusnur explained. 'Debatable whether such treatments will work for everyone' Dr Karthik Shrinivas Tallam, a plastic surgeon, agrees that it is debatable whether anti-ageing treatments work for everyone, and advises people to ask a professional before getting the treatments done. Giving examples of a few anti-ageing treatments, Dr Shrinivas said: Anti-ageing treatments can be IV injections, skin or subcutaneous injections. Anti-ageing injections given by an IV are glutathione injections. These injections act as an antioxidant. Oxidation of cells leads to ageing; hence, antioxidants will slow the ageing of the cells. He added, 'Studies have not shown any increase in life span due to such treatments, but people do get lightening of skin colour and a glow in the skin due to such treatments. So, it is debatable whether such treatments will work for everyone.' The plastic surgeon warned, 'Skin and subcutaneous injections are fillers and Botox. All of these are safe and tested. Some individuals do get reactions like allergy and anaphylaxis, which can be fatal. Treatments done by certified physicians at a standard hospital will have the least risks, as all of these risks will be assessed prior to the procedure, although the costs will be higher. Always get the procedures done at a certified hospital which has other specialities to take care of in case of an untoward event or complication.' Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.
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First Post
an hour ago
- First Post
Shefali Jariwala death: Why you should not take medicines on an empty stomach
Shefali Jariwala's unexpected passing due to cardiac arrest at the age of 42 came as a shock. While the exact cause of her death is still under investigation, many reports point towards her taking medications and Vitamin C IVs on an empty stomach on the day of her death. How dangerous is this practice? read more Shefali had been using anti-ageing injections for some time, reportedly under medical supervision. However, taking them while fasting is extremely risky, expoerts warn. Image courtesy: X Shefali Jariwala's unexpected passing at the age of 42 came as a shock to most. The Bollywood actress and model, best known as the 'Kaanta Laga Girl', collapsed at home in Mumbai on June 27. Her husband, actor Parag Tyagi, rushed her to Bellevue Hospital in Mumbai on a Friday night, where she was declared brought dead. While the exact cause of her death is still under investigation, initial reports suggest a suspected cardiac arrest, possibly linked to the combination of medications she had taken while fasting. STORY CONTINUES BELOW THIS AD While the exact cause of death is still under investigation, the incident has sparked conversations about the risks of consuming medication on an empty stomach, especially when combined with fasting and cosmetic treatments. Here's what we know What happens when you take medicines on an empty stomach Taking medication without food can have serious consequences. When the stomach is empty, its lining is more exposed and sensitive, which means certain medications, especially anti-inflammatory drugs, steroids, and even some supplements, can cause irritation or worse. Dr Rituja Ugalmugle, consultant in internal medicine at Wockhardt Hospitals, Mumbai Central, told The Indian Express that taking medicine without food can lead to a number of side effects. 'Low blood pressure, dizziness, fainting, or even cardiac complications' can occur, she warned, particularly when medications like antihypertensives or heart drugs are involved. It's not just about discomfort or nausea. In some cases, the absorption of the medicine is too fast, especially when taken on an empty stomach. This can trigger a sudden drop in blood pressure, shivering, fainting spells, or irregular heart activity. These symptoms are even more likely when several medications are taken at once—a condition known as polypharmacy. According to an Dr Narander Singla, lead consultant in internal medicine at CK Birla Hospital, Delhi, noted that when multiple medications or injections are combined, especially without food, the body can become overwhelmed. The effects can be sudden and dangerous. This appears to align with the events in Shefali Jariwala 's case. According to an NDTV report, she was fasting for a puja on the day she collapsed. She had taken an anti-ageing injection earlier in the afternoon and reportedly followed it with her usual medications later that evening—again, all on an empty stomach. STORY CONTINUES BELOW THIS AD A police official told PTI, 'Her blood pressure dropped drastically, and she began shivering, following which family members rushed her to the hospital.' The hidden risks of supplements & anti-ageing injections According to police sources, Shefali had been using anti-ageing injections for some time, reportedly under medical supervision. These treatments often include ingredients like glutathione, collagen boosters, or vitamin-based antioxidants, administered intravenously or intramuscularly. Close friend and actor Pooja Ghai told The Indian Express that Shefali had taken a Vitamin C IV drip on the day she died. 'It's a very normal IV. We all take Vitamin C. Some pop it as a tablet, and others opt for a drip. She did take an IV drip that day.' While these treatments are commonly marketed as wellness or beauty boosters, doctors caution that they aren't always risk-free, especially during fasting. Without adequate hydration or food, even something as standard as a Vitamin C infusion could put pressure on the cardiovascular system. While these treatments are commonly marketed as wellness or beauty boosters, doctors caution that they aren't always risk-free, especially during fasting. Image for Representation. Pixabay Dr Rahul Mehrotra, Chief of Non-Invasive & Clinical Cardiology at Artemis Hospitals, told TOI that high-dose vitamin C (30 g or more via IV) can lower blood pressure by relaxing the blood vessels. 'This is usually harmless, but if the patient is fasting or dehydrated, the blood pressure can drop dangerously, leading to fainting, dizziness, or worse,' he said. STORY CONTINUES BELOW THIS AD Dr Ugalmugle added that food acts as a natural buffer. 'For many medications, taking them with meals improves tolerability and safety by moderating how quickly they enter the bloodstream.' What you should keep in mind Always follow medical guidance Consult a doctor before starting any medication, supplement, or cosmetic treatment, especially injections like vitamin C or glutathione Never take medication on an empty stomach Without food, absorption and effects can be unpredictable. Always read labels and check whether a light snack or meal is needed. Be cautious with supplements Supplements and cosmetic injections can have a potent effect. Long-term or unsupervised use can be risky, so consult a healthcare practitioner. Know your health risks People with heart conditions, hypertension, or fainting history should be particularly careful with fasting, medications, or cosmetic therapies. With input from agencies

Time of India
2 hours ago
- Time of India
SHEFALI JARIWALA'S TAKE ON BOTOX SPARKS DEBATE AFTER HER DEATH
Following the sudden and tragic death of actress and dancer Shefali Jariwala, a past interview where she openly endorsed Botox and skin treatments has resurfaced and gone viral. In the clip, Shefali confidently states she's 'pro-Botox' and believes there's nothing wrong with wanting to look good, as long as it's done responsibly with the right doctors. She emphasized that everyone, including celebrities, wants to feel confident in their appearance and shouldn't be judged for enhancing their looks. Her words, delivered with conviction, are now sparking fresh conversations on beauty standards, self-care, and the pressure of aging gracefully in the public eye. Read More