
How much junk food did you eat? A new test may soon tell
Counting how much ultra-processed food someone eats has always relied on diet questionnaires and personal honesty.But researchers at the US National Institutes of Health (NIH), the world's largest medical research body, may have found a more objective way: by reading it in your blood and urine.In a new study published in PLOS Medicine, scientists have developed what they call a poly-metabolite score, a biomarker-based tool that can estimate how much of a person's energy comes from ultra-processed foods.advertisement
These include packaged snacks, soft drinks, ready-to-eat meals, and other industrially manufactured calorie-dense products and nutrient-poor products.This could be a breakthrough for nutrition research, which has long struggled with the inaccuracies of self-reported diet data.'The limitations of self-reported diet are well known. With metabolomics, we can get closer to an objective measure of food intake and also understand how diet may be impacting health," said Dr Erikka Loftfield, lead investigator and researcher at the National Cancer Institute.ALL ABOUT THIS SCOREThe NIH team looked at blood and urine samples for 12 months from two different groups: one observational study of 718 older US adults, and one clinical trial where 20 participants were fed two different diets, one high (80%) and one completely free (0%) of ultra-processed foods, each for two weeks.advertisementThe researchers found hundreds of tiny substances in the blood and urine, called metabolites, that were linked to how much ultra-processed food a person ate.Using machine learning, they created a special score called a poly-metabolite score that could tell how processed a person's diet was.These scores clearly showed the difference between when someone was eating mostly processed food and when they weren't, the study authors noted.WHY THIS MATTERSThe health risks of diets high in ultra-processed foods such as obesity, type 2 diabetes, and even some cancers are well documented.But quantifying how much people actually eat is tricky, especially when relying on memory-based food logs or questionnaires. People could forget, under-report, or misjudge portion sizes.This biomarker-based tool could make large-scale population studies more reliable and help uncover stronger links between diet and disease.LIMITATIONS OF THE SCOREWhile the findings are promising, researchers caution that the current results are based mostly on older American adults.The scores still need to be validated in more diverse populations with different eating habits and levels of ultra-processed food intake.Besides this, the study didn't check whether these scores are linked to diseases like cancer or diabetes. That's something the scientists want to study next, to see if people with higher scores (meaning they eat more ultra-processed food) are more likely to get these illnesses.advertisementFor now, though, the study marks a step toward more precise nutrition science and maybe one day, doctors won't need to ask what you eat.Your body might already have the answer.

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Indian Express
2 hours ago
- Indian Express
From no hope to a potential cure for a deadly blood cancer
A group of 97 patients had longstanding multiple myeloma, a common blood cancer that doctors consider incurable, and faced a certain, and extremely painful, death within about a year. They had gone through a series of treatments, each of which controlled their disease for a while. But then it came back, as it always does. They reached the stage where they had no more options and were facing hospice. They all got immunotherapy, in a study that was a last-ditch effort. A third responded so well that they got what seems to be an astonishing reprieve. The immunotherapy developed by Legend Biotech, a company founded in China, seems to have made their cancer disappear. And after five years, it still has not returned in those patients — a result never before seen in this disease. These results, in patients whose situation had seemed hopeless, has led some battle-worn American oncologists to dare to say the words 'potential cure.' 'In my 30 years in oncology, we haven't talked about curing myeloma,' said Dr. Norman Sharpless, a former director of the National Cancer Institute who is now a professor of cancer policy and innovation at the University of North Carolina School of Medicine. 'This is the first time we are really talking seriously about cure in one of the worst malignancies imaginable.' The new study, reported Tuesday at the annual conference of the American Society of Clinical Oncology and published in The Journal of Clinical Oncology, was funded by Johnson & Johnson, which bought Legend Biotech. The 36,000 Americans who develop multiple myeloma each year face an illness that eats away at bones, so it looks as though holes have been punched out in them, said Dr. Carl June, of the University of Pennsylvania. Bones collapse. Dr. June has seen patients who lost six inches in height. 'It's a horrible, horrible death,' Dr. June said. 'Right now advanced myeloma is a death sentence.' (Dr. June has immunotherapy patents that are owned by his university.) There have been treatment advances that increased median survival from two years to 10 over the past two decades. But no cures. Dr. Peter Voorhees of the Atrium Health Levine Cancer Institute in North Carolina and the Wake Forest University School of Medicine, who is lead researcher for the newly published study, said patients usually go through treatment after treatment until, ultimately, the cancer prevails, developing resistance to every class of drug. They end up with nothing left to try. The Legend immunotherapy is a type known as CAR-T. It is delivered as an infusion of the patient's own white blood cells that have been removed and engineered to attack the cancer. The treatment has revolutionized prospects for patients with other types of blood cancer, like leukemia. Making CAR-T cells, though, is an art, with so many possible variables that it can be hard to hit on one that works. And it can have severe side effects including a high fever, trouble breathing and infections. Patients can be hospitalized for weeks after receiving it. But Legend managed to develop one that works in multiple myeloma, defying skeptics. The Chinese company gained attention for its CAR-T eight years ago when it made extravagant claims, which were met by snickers from American researchers. Johnson & Johnson, though, was looking for a CAR-T to call its own. So, said Mark Wildgust, an executive in the oncology section of the American drug giant, the company sent scientists and physicians to China to see if the claims were true. 'We went site by site to look at the results,' he said. The company was convinced. It bought Legend and began testing the treatment in patients whose myeloma had overcome at least one standard treatment. Compared with patients who had standard treatment, those who had the immunotherapy lived longer without their disease progressing. The immunotherapy received regulatory approval in that limited setting and is sold under the brand name Carvykti. The study did not determine whether this difficult treatment saved lives. The new study took on a different challenge — helping patients at the end of the line after years of treatments. Their immune systems were worn down. They were, as oncologists said, 'heavily pretreated.' So even though CAR-T is designed to spur their immune systems to fight their cancer, it was not clear their immune systems were up to it. Oncologists say that even though most patients did not clear their cancer, having a third who did was remarkable. To see what the expected life span would be for these patients without the immunotherapy, Johnson & Johnson looked at data from patients in a registry who were like the ones in its study — they had failed every treatment. They lived about a year. For Anne Stovell of New York, one of the study patients whose cancer disappeared, the result is almost too good to be true. She says she went through nine drugs to control her cancer after it was diagnosed in 2010, some of which had horrendous side effects. Each eventually failed. Taking the Legend CAR-T was difficult — she said she had spent nearly three weeks in the hospital. But since that treatment six years ago, she has no sign of cancer. She said it was still difficult for her to believe her myeloma is gone. A new ache — or an old one — can bring on the fear. 'There's that little seed of doubt,' she said. But in test after test, the cancer has not reappeared. 'It's a relief for me every year to get a bone marrow biopsy,' she said. Myeloma experts applauded the results. Like treatments for many other cancers, treatments for multiple myeloma come with a high price. The drugs are 'hideously expensive,' Dr. June said, costing more than $100,000 a year. The total cost over the years can be millions of dollars, Dr. June said, usually paid by insurers, 'and it doesn't even cure you.' CAR-T is expensive too. Carvykti's list price is $555,310. But it is a one-time treatment. And, more important, the hope is that perhaps by giving it earlier in the course of the disease, it could cure patients early on. Johnson & Johnson is now testing that idea. Dr. Kenneth Anderson, a myeloma expert at Dana-Farber Cancer Institute who was not involved with the study, said that if the treatment is used as a first-line treatment, 'cure is now our realistic expectation.' That, at least, is the hope, Dr. Sharpless said. And for those like the patients in the new study who are living at least five years — so far — without disease, the outcome 'really is eye-popping,' Dr. Sharpless said. 'That's getting to a point where you wonder if it will ever come back,' he added. Gina Kolata reports on diseases and treatments, how treatments are discovered and tested, and how they affect people.


Mint
2 hours ago
- Mint
Who was Shigeo Nagashima? Japan's baseball icon 'Mr Pro Baseball' dies at 89
Shigeo Nagashima, a popular name in Japan's baseball fraternity, is no more. He passed away at a hospital in Tokyo, while battling pneumonia, according to a statement by Yomiuri Giants, his former baseball team. Nagashima was 89 when he died. Nagashima was one of the most popular baseball players in the 60s and 70s, and had played in 2,186 games, hitting an eye-popping 444 home runs. He had won nine straight titles in that glory period of his career, and was also nicknamed "Mr. Giants". Nagashima had given society 'bright dreams and hopes', a government spokesperson was quoted as saying upon the former baseball icon's death, as reported by the BBC. Meanwhile, Shohei Ohtani, who is regarded currently as one of the most popular baseballers in Japan, posted pictures of himself with Nagashima on Instagram. Ohtani wrote in the caption of his post,"May your soul rest in peace." Ohtani currently plays for the LA Dodgers, an American professional baseball team based in Los Angeles. Nagashima's ability on the field, coupled with his charm, made him one of the most popular baseball stars during his heyday. He was also one of the icons of the developing economy and confidence in the Asian country. Nickname Mr Pro Baseball, Nagashima is also known for hitting a winning home run at a professional baseball game attended by the Japanese emperor, back in the year 1959. Interestingly, it was the first-ever game that the Japanese emperor attended. Nagashima retired after a 17-year-long playing career, but not before winning the Central League batting title six times. After his retirement in 1974, he also led the Giants to two Japan Series titles as the team manager. The country's chief cabinet secretary, Yoshimasa Hayashi also commented about the passing away of the sporting star of the 60s. "He left so many brilliant records in the world of professional baseball for many years and gave bright dreams and hopes to society as a national star," Hayashi said, according to BBC.


Time of India
2 hours ago
- Time of India
Donald Trump's USA may witness massive exodus of scientists, biggest beneficiary will be China, warns report
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