Israel, Iran launch more barrages as Israel aims to wipe out Tehran's nuclear program
By Alexander Cornwell, Parisa Hafezi and Steve Holland
TEL AVIV/DUBAI/WASHINGTON (Reuters) -Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.
Air raid sirens sounded in Tel Aviv and Jerusalem, the country's two largest cities before dawn, sending residents rushing into shelters. The military said its air defence systems were operating, seeking to intercept Iranian missiles.
"In the last hour, dozens of missiles have been launched at the state of Israel from Iran, some of which were intercepted," the Israeli military said.
It said rescue teams were operating at a number of locations across the country where fallen projectiles were reported, without commenting on casualties.
Several explosions were heard in the Iranian capital Tehran, the semi-official Tasnim news agency reported.
Israeli media said a suspected missile came down in Tel Aviv, and a Reuters witness heard a loud boom in Jerusalem. It was unclear whether Iranian strikes or Israeli defensive measures were behind the activity.
Iran's Fars news agency said Tehran launched a third wave of airstrikes on Saturday after two salvos on Friday night.
Those were in response to Israel's attacks on Iran early on Friday against commanders, nuclear scientists, military targets and nuclear sites.
Israel's ambulance service said 34 people were injured on Friday night in the Tel Aviv area, most with minor injuries. Police later said one person had died.
The U.S. military helped shoot down Iranian missiles headed for Israel on Friday, two U.S. officials said. Israel's military said Iran fired fewer than 100 missiles on Friday and that most were intercepted or fell short. Several buildings in and around Tel Aviv were hit.
The Israeli strikes on Iran throughout the day and the Iranian retaliation raised fears of a broader regional conflagration, although Iran's allies Hamas in Gaza and Hezbollah in Lebanon have been decimated by Israel.
TRUMP SAYS: NOT TOO LATE
Iran's state news agency IRNA said Tehran launched hundreds of ballistic missiles at Israel after Israel blasted Iran's huge Natanz underground nuclear site and killed its top military commanders. Iran says its nuclear programme is only for peaceful purposes.
Israeli officials said it may be some time before the extent of damage at Natanz was clear. Western countries have long accused Iran of refining uranium there to levels suitable for a bomb rather than civilian use.
The above-ground pilot enrichment plant at Natanz has been destroyed, U.N. nuclear watchdog chief Rafael Grossi told the Security Council on Friday. He said the U.N. was still gathering information about Israeli attacks on two other facilities, the Fordow fuel enrichment plant and at Isfahan.
Iran's Supreme Leader Ayatollah Ali Khamenei accused Israel of starting a war. A senior Iranian official said nowhere in Israel would be safe and revenge would be painful.
Iran's U.N. envoy Amir Saeid Iravani said 78 people, including senior military officials, were killed in Israel's strikes on Iran and more than 320 people were wounded, most of them civilians.
He accused the U.S. of being complicit in the attacks and said it shared full responsibility for the consequences.
Israel's U.N. envoy Danny Danon said intelligence had confirmed that within days Iran would have produced enough fissile material for multiple bombs. He called Israel's operation "an act of national preservation."
Iran has long insisted its nuclear programme is for civilian purposes only. The U.N. nuclear watchdog concluded this week that it was in violation of its obligations under the global non-proliferation treaty.
U.S. President Donald Trump said it was not too late for Tehran to halt the Israeli bombing campaign by reaching a deal on its nuclear programme.
Tehran had been engaged in talks with the Trump administration on a deal to curb its nuclear programme to replace one that Trump abandoned in 2018. Tehran rejected the last U.S. offer.
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The Grim Reality of the Conflict in Iran
A damaged residential building in Tehran, Iran, on June 13, 2025. Credit - Middle East Images—AFP/Getty In the early hours of Friday morning, Israel launched a sweeping military campaign against Iran. The ongoing operation, which was reportedly planned to unfold over several days, is targeting a list of nuclear and military facilities, as well as senior regime officials, that grows longer by the hour. Iran has thus far retaliated with drones and a substantial missile barrage that could see Israel expand its targeting further still. In a region that has seen endless bloodshed since Hamas's October 2023 attacks, the grim reality is that things may get much worse before they get even worse. Under the Islamic Republic that took power in 1979, enmity toward Israel has been a core ideological tenet of Iranian foreign policy and a key driver in its regional policy. Over decades, their rivalry played out mainly through indirect actions by Iran and by covert operations from Israel. That dynamic changed last year. In April and again in October, the two sides engaged in direct hostilities, with Iran twice launching massive missile salvoes largely repelled by Israeli and allied air defenses. After the second strike, which came shortly after Israel severely degraded the upper ranks of Hizbollah in Lebanon—the most powerful of Iran's proxies—Israel targeted Iranian air defences and missile production facilities, facing little resistance or response. But while Iran's regional power projection was diminishing and its arsenal of missiles and drones twice proved largely ineffective, a third concern—a nuclear threat which Israel considered existential—was still growing. Tehran had been steadily expanding the scale and scope of its nuclear activity ever since President Donald Trump withdrew from the Iran Nuclear Deal during his first term; President Joe Biden's Administration sought and failed to revive it. In March, Trump announced that he had reached out to Iran's leadership to negotiate a new deal, and his administration conducted five rounds of talks in Muscat and Rome in attempts to reach one. For Iran, which sought sanctions relief for its embattled economy, the success of negotiations with the U.S. hinged on concessions it has long opposed: Dismantling its nuclear program altogether or even ceasing the domestic enrichment of uranium. For Israel, eliminating, rather than merely restricting, the production of fissile material that could be used to fuel a weapon has been paramount. For President Trump, the prospect of a military strike by Israel seems a means of strengthening Washington's hand in a diplomatic agreement in which he still remains interested. But at the moment, the question may be less a matter of whether diplomacy can succeed than how grievously the situation could escalate. The worst-case scenarios are dire: A cycle of Israeli and Iranian counterstrikes that draw in the U.S., Iran's non-state allies, and regional states, cause grievous harm to civilians on all sides, and inject profound uncertainty into global markets. Over time, Iran's regime could attempt to reconstitute its nuclear activity from the rubble, only with an explicit aim of fashioning a weapon in the shortest possible time as a means of deterrence in the future. Another disastrous scenario is that the regime in Tehran falls and there is a protracted war for power and chaos or an even harder line regime armed with nuclear weapons. Is there a path out of this deepening crisis? Perhaps, though not a particularly promising one. Trump's stated objective—even as the fire is exchanged in two directions—remains a deal with Iran, and Tehran could offer concessions on the stipulation that it also involve an immediate cessation of hostilities with Israel. Were Iran to concede on its red lines in an effort to stave off greater destruction, perhaps Trump would be keen enough to avert a widening conflagration to also press Israel into ending the escalation cycle as well. Iran's government has previously demonstrated that when facing particularly inauspicious circumstances, especially those that might threaten the very foundations of the regime itself, it can make concessions necessary for its survival. But facing perhaps the gravest crisis it has faced since the eight-year-long war with Iraq in the 1980s, it may end up doubling down to the detriment of its people and the region. Contact us at letters@
