Daily oral GLP-1 pill could be just as effective as weekly shots: Drugmaker
Eli Lilly said Thursday that the company's orforglipron pill can offer up to an average of 27.3 pounds of weight loss, according to results from two of its Phase 3 trials that included more than 3,000 overweight or obese adults.
"With orforglipron, we're working to transform obesity care by introducing a potential once-daily oral therapy that could support early intervention and long-term disease management, while offering a convenient alternative to injectable treatments," Kenneth Custer, an executive vice president and president of Lilly Cardiometabolic Health, said in a statement. "With these positive data in hand, we are now planning to submit orforglipron for regulatory review by year-end and are prepared for a global launch to address this urgent public health need."
This is a developing story. Please check back for updates.
Solve the daily Crossword
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
4 minutes ago
- Yahoo
Measles outbreak that sickened more than 700 declared over in Texas
A measles outbreak in Texas that infected more than 700 people has officially been declared over, state health officials announced on Monday. The outbreak was the largest in the state in more than 30 years and led to the deaths of two unvaccinated school-aged children. Health officials declared the outbreak over after more than 42 days without a new case, a cut-off based on the time between when a person is exposed to when they get sick. MORE: Measles cases in US over 4.5 times higher than all of last year In late January, a cluster of cases was reported in western Texas near Gaines County -- near the border with New Mexico -- which had one of the lowest vaccination rates in the state. A total of 762 cases were recorded with more than two-thirds of infections among children, according to the Texas Department of State Health Services (DSHS). Nearly 100 people were hospitalized. Infections spread to other parts of the state as well as New Mexico, where another unvaccinated person died after contracting measles. "I want to highlight the tireless work of the public health professionals across the state who contributed to the containment of one of the most contagious viruses," Dr. Jennifer Shuford, commissioner of the DSHS, said in a press release. "We arrived at this point through a comprehensive outbreak response that included testing, vaccination, disease monitoring and educating the public about measles through awareness campaigns." Texas health officials warned that the state is likely to experience additional cases this year given ongoing outbreaks in other parts of the U.S. and the world. "The end of this outbreak is certainly encouraging, but measles remains one of the most contagious viruses we face, and continued vigilance is critical given ongoing outbreaks both in the U.S. and globally," said Dr. John Brownstein, an epidemiologist and ABC News medical contributor. Nationally, over 1,350 cases of measles have been reported across at least 40 states, according to the Centers for Disease Control and Prevention (CDC). It is the highest number of measles cases seen in the U.S. since 1992. MORE: Amid growing Texas outbreak, how contagious is measles? The virus was declared eliminated by health officials in 2000 after a full year of no continuous spread, but declining vaccination rates have led to a growing number of outbreaks annually, experts say. An estimated 92% of cases nationally this year are unvaccinated or have unknown vaccination status. "Vaccination rates in many communities remain far too low, leaving large pockets of children vulnerable to measles and other preventable diseases -- and that's why we're likely to continue seeing outbreaks," Brownstein said. The 2024-2025 school year had a record number of non-medical vaccine exemptions, with an estimated 286,000 kindergarteners attending school without documentation of receiving the shot that protects against measles, according to CDC data. "Measles isn't happening in isolation -- we're seeing a broader resurgence of vaccine-preventable diseases, from pertussis to polio threats, which underscores the urgent need to maintain high vaccination coverage and public trust in immunization," Brownstein added. The measles, mumps and rubella (MMR) vaccine is recommended for children in the U.S. to receive after their first birthday, followed by a second dose in between ages four and six. Two doses of the vaccine have been shown to be 97% effective against infection. Solve the daily Crossword
Yahoo
4 minutes ago
- Yahoo
Woman who is a quadruplet becomes 1st-time mom to quintuplets
A Texas woman became a first-time mom to not just one but five babies at once when she gave birth to quintuplets two months ago. "It's surreal, scary at the same time, because it's zero to five, immediate. It's an instant family, but it's beautiful," Theresa Troia of El Paso told ABC News. What makes Troia's story even more interesting is that the 36-year-old is a quadruplet herself. Troia has three brothers, Joseph Troia, Matthew Troia and Thomas Troia. "To me, the normal is multiples, you know, because I don't obviously know any different, but it was nice growing up and always having a sibling there," Theresa Troia said. Troia said she's excited to care for her quintuplets and live out her dream of being a mom. Family that welcomed quintuplets now expecting another baby "My mom passed away 10 years ago, so I haven't been able, you know, I can't talk to her about it, but now, I get to see what it was for her, which I think is a beautiful thing," said Troia. Troia, a nurse consultant, said she didn't undergo any fertility treatments and is no longer in a relationship with her former partner but learned she would be having quintuplets in January. She said that although she experienced bleeding during her first trimester, her pregnancy overall went "great." "I didn't have any nausea, vomiting, cravings, anything like that. I didn't have any swelling. So I was really lucky," Troia said. Couple welcomes quintuplets after years of infertility During the pregnancy, Troia and her care team learned that two of the quintuplets -- Isabella and Viviana -- were identical monochorionic-diamniotic or Mo-Di twins, meaning they shared a placenta but were in separate amniotic sacs. Troia delivered her quintuplets -- Kyla Rose, Joseph Anthony, Jaxon Thomas, Viviana Lily, and Isabella Gianna -- via cesarean section on June 3 at Las Palmas Medical Center. One of Troia's doctors, Dr. Aaron Poole, an OB-GYN and maternal-fetal medicine specialist with HCA Healthcare's Las Palmas Del Sol Healthcare, told ABC News that the Troia babies happen to be the first set of quintuplets born at the El Paso hospital. "The birth of Las Palmas Del Sol Healthcare's first set of quintuplets is a rare and special moment, and we're proud to have provided the high-level of care necessary to support Theresa and her babies from delivery through recovery," Poole said in a statement. "Bringing five newborns safely into the world took thoughtful planning and close coordination, demonstrating the expertise and commitment our maternal and neonatal teams bring to every patient," Poole added. "Our Level III [neonatal intensive care unit] at Las Palmas Medical Center is equipped to manage high-risk, complex pregnancies with around-the-clock care, experienced specialists and advanced technology. We are honored to be part of Theresa's story and to welcome some of El Paso's newest residents." The quintuplets were born at 28 weeks and one day. Ten weeks later, three of the siblings -- Kyla, Isabella and Jaxon -- have gone home from the hospital NICU. "They're all doing great and they're all growing," Troia said. "You would never know that they were premature babies or quintuplets, because they're doing so, so good. They're so healthy." Solve the daily Crossword
Yahoo
4 minutes ago
- Yahoo
Measles outbreak at the center of record US case numbers officially over, Texas says
The outbreak at the epicenter of measles cases reaching a multi-decade high in the U.S. has officially ended, according to Texas health authorities. The Texas Department of State Health Services (DSHS) declared the outbreak centered in West Texas over as of Monday, Aug. 18, saying that it had been more than 42 days, or two incubation periods, since a new case was reported in the counties that previously showed ongoing transmission. As of Aug. 5, the Centers for Disease Control and Prevention (CDC) has reported a total of 1,356 confirmed measles cases across 40 states since the beginning of the year, resulting in three confirmed deaths and 171 hospitalizations. The majority of those cases, 92%, were in people who were unvaccinated or had unknown vaccine status. In Texas, 762 cases were confirmed in total as of Aug. 18, with more than two-thirds occurring in children. More than 94% of cases were in unvaccinated people, according to state DSHS data. Two school-aged children, a 6-year-old and an 8-year-old, died in the state during the outbreak. Texas county at center of largest outbreak in over 20 years Gaines County accounted for more than 54%, or 414, of total Texas cases, many of which were focused in the tight-knit Mennonite community in the area, as previously reported by USA TODAY. Gaines, which has three school districts that are all public, had an abnormally high conscientious (non-medical) vaccine exemption rate of 13.6% in grades K-12 for the 2023-2024 school year, one of the highest in Texas, state health data shows. This was more than five times the statewide average of 2.5%. While Gaines was ground zero, 32 outbreaks (defined as three or more related cases) were recorded across states by the CDC this year, as compared to 16 outbreaks in 2024. Outside of Texas, many pockets of infection were concentrated in nearby states, including New Mexico and Kansas. Measles is a vaccine-preventable disease that had been considered eradicated in the United States as of 2000, meaning there was no spread and new cases were those contracted only from abroad. But vaccinations have declined, resulting in a growing number of states no longer reporting rates consistent with herd immunity, and infections have returned. The last outbreak of a similar scale occurred in 2019, when 1,274 cases were confirmed across the country. What is measles and how do you get it? Measles is a highly contagious, vaccine-preventable disease caused by a virus that primarily, and most severely, afflicts children. According to the World Health Organization, it infects the respiratory tract before spreading throughout the body. The virus is one of the most contagious infectious diseases; so contagious, in fact, that 90% of unvaccinated people who are exposed end up contracting it. Additionally, 1 in 5 of those people end up hospitalized, according to the CDC. The MMR vaccine (measles, mumps and rubella) protects against measles with a 97% efficacy rate and is typically given to children as part of the regular vaccine course at ages 12 to 15 months for the first dose and ages 4 to 6 for the second. What are the symptoms of measles? According to the CDC, measles symptoms appear seven to 14 days after contact with the virus and typically include high fever, cough, runny nose and watery eyes. Measles rashes appear three to five days after the onset of the first symptoms. Other signs and symptoms of measles include: Reddish-brown rash that can spread across the entire body When the rash appears, a person's fever may spike to more than 104 degrees Fahrenheit High fever Cough Runny nose and sneezing Red, watery eyes Loss of appetite, diarrhea Koplik spots, tiny white spots that may appear inside the mouth two to three days after symptoms begin Small raised bumps may also appear on top of the flat red spots (the spots may become joined together as they spread from the head to the rest of the body) This article originally appeared on USA TODAY: Texas declares measles outbreak over after more than 700 state cases Solve the daily Crossword
