U.S. and El Salvador presidents ‘thumbing their nose' at Supreme Court, says lawyer
The U.S. Supreme Court has upheld a judge's order that the Trump administration facilitate the return of a Maryland man who was mistakenly deported to El Salvador, but neither country's president seems interested in getting Kilmar Abrego Garcia home. During a visit to the White House on Monday, El Salvador President Nayib Bukele said: 'How can I smuggle a terrorist into the United States?" As It Happens host Nil Kӧksal spoke to Nicole Hallett, director of the Immigrants' Rights Clinic at the University of Chicago Law School.
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Winnipeg Free Press
32 minutes ago
- Winnipeg Free Press
It's not the time to cave on booze boycotts
Opinion A good measure of the true strength of your intentions is how much you're willing to sacrifice to stand up for what you believe. That should be the case even more when what you're sacrificing is essentially a luxury. You should, after all, be able to hold out a good long time without compromising your principles when what you're giving up is not even a necessity. Well, two Canadian premiers have demonstrated that the strength of their convictions is as shallow as a shot glass. MIKAELA MACKENZIE / FREE PRESs fileS Shelves emptied of American alcohol at a Liquor Mart. Remember when many provinces halted their sales of U.S. alcohol products in response to trade action by the American government? You should — it was, after all, only a little over three months ago that Alberta Premier Danielle Smith was saying this about U.S. tariffs: 'This economic attack on our country, combined with Mr. Trump's continued talk of using economic force to facilitate the annexation of our country, has broken trust between our two countries in a profound way… It is a betrayal of a deep and abiding friendship.' A deep betrayal, all right. As of this week, both Alberta and Saskatchewan began purchasing U.S. alcohol products again. The halt in sales had been a clear and decisive multimillion-dollar message to American producers that Canadians weren't going to put up with the endless tariff follies of U.S. President Donald Trump. With plenty of other domestic and global options, we could no doubt put up with the absence of American wine, beer and bourbon. The boycott threatened US$1.1 billion in American wine sales alone, and U.S. spirits producers have said the boycotts were worse than tariffs. It was a strong message to the U.S. that trade is a two-way street. But a boycott — even of a luxury item that will still face a retaliatory tariff of 25 per cent by the Canadian government — is only as strong as its weakest link. And the governments of Alberta and Saskatchewan, always proud chest-thumpers of the innate toughness of good western folk, have proven to be that weakest link. Heaven forbid the Jack Daniels or Maker's Mark bourbon wouldn't be there to flow for the Calgary Stampede. Meanwhile, Alberta's move was swiftly welcomed by the United States' ambassador to Canada, Peter Hoekstra, who couldn't resist taking a social media victory lap, saying on X/Twitter: 'Very glad to see that Albertans can once again enjoy a cold U.S. beer or glass of wine. Thanks to Premier @ABDanielleSmith for your leadership in removing this barrier to fair and reciprocal trade.' Hoekstra's comments have to be read as a bitter little joke: the fact is that the capricious introduction of tariffs across a broad range of Canadian products by Trump is what built the current barriers 'to fair and reciprocal trade.' (If Hoekstra couldn't see the backhander he was delivering for the insult it truly was, then perhaps the carefully wrought world of diplomacy should not be his trade.) Wednesdays Columnist Jen Zoratti looks at what's next in arts, life and pop culture. Alberta seems quite willing to be the butt of that joke: last Friday, Alberta's Service Alberta and Red Tape Reduction Minister Dale Nally said the sales were being restarted to show a 'renewed commitment to open and fair trade' with the U.S. The United States has shown, of course, not one single iota of renewed commitment to anything like open and fair trade. Let's hope that customers in Alberta and Saskatchewan will continue to make the point that their governments don't have the strength to deliver, and continue to boycott American products until American producers can make their own case to their politicians about the damage done by trade wars. If not? Raise a glass to capitulation. And just wait for the next Trumpian punishment to be dealt out to America's former closest neighbour. Because it will come.
Japan Forward
an hour ago
- Japan Forward
AI Tool 'KIBIT': A Game Changer in New Drug Development
このページを 日本語 で読む The COVID-19 pandemic reminded the world of the importance of drug discovery. However, modern drug discoveries require massive financial investment. Meanwhile, the use of artificial intelligence for AI drug discovery is gaining attention as a way to control soaring pharmaceutical prices. And a Japanese-made AI tool named 'KIBIT' is about to open up a new stage in this field. President Donald Trump issued executive orders in April and May mandating the reduction of domestic drug prices in the United States. Accompanying White House fact sheets refer to the high cost Americans pay for prescriptions, which is 2.78 times higher than the OECD average. Prescription costs are also 3.47 times higher than in Japan. Trump sees these high costs to consumers as a serious issue. In Japan, a national drug pricing system sets medication prices, enabling access to affordable treatments due to governmental oversight. In contrast, US pharmaceutical companies can set prices freely. This often results in higher charges than in other countries. Following his May 12 executive order, Trump stated that his orders would cut prices by 59% to as much as 90% to align with the levels of other countries. This could potentially result in significant revenue losses for the pharmaceutical industry. In the case of Japan, major pharmaceutical companies such as Takeda Pharmaceutical Company Limited and Astellas Pharma Inc earn over 30% of their revenue from the US. According to his comments, the President could impose additional tariffs on foreign-manufactured drugs if prices are not reduced. In the search for new drugs and treatments (Screenshot, ©FRONTEO Inc) One major reason for rising drug prices is the increasing cost of research and development. The average R&D spending by Japanese pharmaceutical companies rose from ¥30.2 billion JPY ($298.7 million USD) in 1993 to 163.3 billion ($1.13 billion) in 2019 — a 5.4-fold increase over 26 years. US companies saw an even sharper rise, from $841 million (¥121.1 billion) to $7.449 billion (¥1.0725 trillion). That marked an 8.8-fold increase. Moreover, investing in R&D doesn't guarantee success. The probability of developing a successful drug in Japan dropped from 1 in 13,000 two decades ago to 1 in 23,000 recently. Despite the increasing costs, results are scarce. Consequently, the R&D-to-revenue ratio rose from about 10% in 1993 to around 18% in 2019 in both countries. Introducing KIBIT. (Screenshot ©FRONTEO Inc) AI is being eyed as a solution to reduce R&D costs by dramatically cutting time and expenses. Drug development involves four stages: Basic research & target identification Compound optimization Preclinical trials and Clinical trials. Many AI vendors are involved in drug discovery. In particular, they focus on reducing costs in the third (preclinical) and fourth (clinical) stages. However, most companies have yet to tackle the critical first stage — target identification. Introducing KIBIT. (Screenshot, ©FRONTEO Inc) The first enterprise to address this initial stage is the Japanese company FRONTEO. Utilizing its proprietary natural language processing AI engine KIBIT, the company analyzes vast medical and pharmaceutical literature to generate innovative drug ideas that researchers may not have considered. Human thinking is inherently biased. The more experienced a researcher is, the more difficult it becomes to identify novel molecular targets. Stated another way, the bias of experience often blocks new ideas. KIBIT, however, is free from such biases. It identifies new molecular targets that might be effective against specific diseases. To do so, it analyzes vast amounts of academic literature. It can even derive specific hypotheses. Furthermore, KIBIT can identify and suggest highly disease-relevant target molecules that are not explicitly mentioned in the literature. This significantly enhances drug discovery potential. How KIBIT works. (Screenshot, ©FRONTEO Inc) Only a few countries have the capacity to develop new drugs. In 2024, among newly approved pharmaceuticals in Japan, the US, and Europe, the US led with 143 products. Japan followed with just 12, roughly equal to the United Kingdom's 10. According to the statistics "Nationalities of companies creating the top 100 drugs in the world by sales (2022),": United States – 52 United Kingdom – 10 Switzerland – 9 Germany – 8 Denmark – 8 Japan – 7 Most countries, other than the US, struggle to produce blockbuster drugs. In this context, hopes are high for FRONTEO's KIBIT. If it can consistently generate innovative new drugs efficiently, it may help deliver affordable medicines to those in need, without Mr Trump's intervention. FRONTEO's AI drug discovery service, utilizing KIBIT, is already being adopted by several major pharmaceutical companies. Those leveraging KIBIT to create new drugs could become game changers in the industry. This article is contributed by FRONTEO Inc, a supporting member of JAPAN Forward. (Read the report in Japanese.) Author: FRONTEO Inc. このページを 日本語 で読む
Winnipeg Free Press
2 hours ago
- Winnipeg Free Press
Los Angeles imposes downtown curfew as protests against Trump's immigration crackdown continue
LOS ANGELES (AP) — Los Angeles leaders imposed a downtown curfew through Wednesday morning to deal with protests against President Donald Trump's immigration crackdown, while the governor accused him of drawing a 'military dragnet' across the nation's second-largest city with his escalating use of the National Guard. Democratic Gov. Gavin Newsom asked a court to put an emergency stop to the military helping federal immigration agents, with some guardsmen now standing in protection around agents as they carried out arrests. He said it would only heighten tensions and promote civil unrest. The judge chose not to rule immediately, giving the administration several days to continue those activities before a hearing Thursday. The change moves troops closer to engaging in law enforcement actions like deportations as Trump has promised as part of his administration's immigration crackdown. The Guard has the authority to temporarily detain people who attack officers but any arrests ultimately would be made by law enforcement. Trump has activated more than 4,000 National Guard members and 700 Marines over the objections of city and state leaders, though the Marines have not yet been spotted in Los Angeles and Guard troops have had limited engagement with protesters. They were originally deployed to protect federal buildings. As the curfew went into effect Tuesday night, a police helicopter flew over downtown federal buildings that have been the center of protests and ordered people to leave the area. Riot police on horses and foot surrounded a group of a few hundred that had gathered in the area, shouting: 'Move!' Most of the protesters scattered, with some regrouping and refusing orders to disperse. Officials said the curfew was necessary to stop vandalism and theft by agitators looking to cause trouble. Demonstrations have spread to other cities nationwide, including Dallas and Austin, Texas, Chicago and New York, where a thousand people rallied and multiple arrests were made. In Texas, where police in Austin used chemical irritants to disperse several hundred demonstrators Monday, Republican Gov. Greg Abbott's office said Texas National Guard troops were 'on standby' in areas where demonstrations are planned, Abbott spokesperson Andrew Mahaleris said Tuesday evening. Guard members were deployed to San Antonio, according to assistant police chief Jesse Salame. He said he did not know how many were sent or details on the deployment. LA mayor puts curfew in place Los Angeles Mayor Karen Bass declared a local emergency on the fifth day of protests and said the curfew will run from 8 p.m. Tuesday until 6 a.m. Wednesday. She said it was expected to last for several days. 'We reached a tipping point' after 23 businesses were looted, Bass said during a news conference Tuesday. The curfew covers a 1 square mile (2.5 square kilometer) section of downtown that includes the area where protests have occurred since Friday. The city of Los Angeles encompasses roughly 500 square miles (nearly 2,300 square kilometers). The curfew doesn't apply to residents who live in the designated area, people who are homeless, credentialed media or public safety and emergency officials, according to Los Angeles Police Chief Jim McDonnell. McDonnell said 'unlawful and dangerous behavior' had been escalating since Saturday. 'The curfew is a necessary measure to protect lives and safeguard property following several consecutive days of growing unrest throughout the city,' McDonnell said. Trump says he's open to using Insurrection Act Trump left open the possibility of invoking the Insurrection Act, which authorizes the president to deploy military forces inside the U.S. to suppress rebellion or domestic violence or to enforce the law in certain situations. It's one of the most extreme emergency powers available to a U.S. president. 'If there's an insurrection, I would certainly invoke it. We'll see,' he said from the Oval Office. Later the president called protesters 'animals' and 'a foreign enemy' in a speech at Fort Bragg ostensibly to recognize the 250th anniversary of the U.S. Army. Trump has described Los Angeles in dire terms that Bass and Newsom say are nowhere close to the truth. In a public address Tuesday evening, Newsom called Trump's actions the start of an 'assault' on democracy. 'California may be first, but it clearly will not end here. Other states are next,' he said. Newsom warned people against inciting violence, but urged them to stand up to the president's actions. 'What Donald Trump wants most is your fealty, your silence. To be complicit in this moment,' he said. 'Do not give it to him.' The protests began Friday after federal immigration raids arrested dozens of workers in Los Angeles. Protesters blocked a major freeway and set cars on fire over the weekend, and police responded with tear gas, rubber bullets and flash-bang grenades. The demonstrations have been mostly concentrated downtown in the city of 4 million. Thousands of people have peacefully rallied outside City Hall and hundreds more protested outside a federal complex that includes a detention center where some immigrants are being held following workplace raids. Despite the protests, immigration enforcement activity has continued throughout the county, with city leaders and community groups reporting ICE present at libraries, car washes and Home Depots. School graduations in Los Angeles have increased security over fears of ICE action and some have offered parents the option to watch on Zoom. McDonnell said that police had made 197 arrests on Tuesday, including 67 who were taken into custody for unlawfully occupying part of the 101 freeway. Several businesses were broken into Monday, though authorities didn't say if the looting was tied to the protests. The vast majority of arrests have been for failing to disperse, while a few others were for assault with a deadly weapon, looting, vandalism and attempted murder for tossing a Molotov cocktail. Seven police officers were reportedly injured, and at least two were taken to a hospital and released. Defense Secretary Pete Hegseth suggested Tuesday that the use of troops inside the U.S. will continue to expand. The Pentagon said deploying the National Guard and Marines costs $134 million. ___ Baldor and Copp reported from Washington. Associated Press writers Dorany Pineda and Christopher Weber in Los Angeles, Amy Taxin in Orange County, California, John Seewer in Toledo, Ohio, Jim Vertuno in Austin, Texas, Hallie Golden in Seattle, and Greg Bull in Seal Beach, California, contributed to this report.
