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Senator Chuck Schumer taken to hospital as DC struggles with heatwave

Senator Chuck Schumer taken to hospital as DC struggles with heatwave

Fox News15 hours ago

Senate Minority Leader Chuck Schumer, D-N.Y., was taken to the hospital in Washington Wednesday for dehydration, his office said, as the region continues to experience another day of scorching heat.
"Leader Schumer was at the Senate gym this morning and got lightheaded," Schumer's office told Fox News. "Out of an abundance of caution, he went to the hospital to be treated for dehydration and is now back at work in the Capitol."
Temperatures in Washington D.C., were expected to reach into the high 90s as parts of the East Coast experienced a heatwave.
"Extreme Heat Alert for DC: Until 8PM Today. Daytime temperatures will feel like 105°F or hotter. Drink water. Stay cool," the Washington D.C. Homeland Security & Emergency Management posted on X.
Officials have warned people to take precautions to prevent heat-related illness.
Schumer's office said the senator wanted to remind everyone "to drink some water and stay out of the heat."

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Semaglutide Benefits Adults With Type 1 Diabetes + Obesity
Semaglutide Benefits Adults With Type 1 Diabetes + Obesity

Medscape

time41 minutes ago

  • Medscape

Semaglutide Benefits Adults With Type 1 Diabetes + Obesity

CHICAGO — Once-weekly semaglutide improved glycemia and reduced weight without increasing hypoglycemia in adults with type 1 diabetes (T1D) and obesity, new research presented at the American Diabetes Association (ADA) 85th Scientific Sessions found. The study results were simultaneously published in NEJM Evidence . 'Semaglutide was effective in lowering or improving time in range, without increasing time below range; it produced weight loss of at least 5%; and it was very safe,' said lead investigator Viral N. Shah, MD, professor of medicine and director of diabetes clinical research at the Center for Diabetes and Metabolic Diseases, Indiana University, Indianapolis. 'We didn't find any difference in severe hypoglycemia between semaglutide and a placebo, and we did not find any [diabetic ketoacidosis] in the entire study,' Shah told Medscape Medical News . 'I think the results are very encouraging, and I hope that industry will take it on and do a regulatory approval trial for semaglutide in type 1,' he added. Over a Third Met Composite Endpoint The 26-week ADJUST-T1D randomized clinical trial investigated semaglutide vs placebo in 72 adults with T1D and obesity (BMI ≥ 30) who were using automated insulin delivery (AID) systems. The trial was investigator-initiated and funded by Breakthrough T1D, not Ozempic manufacturer Novo Nordisk, although the company did provide the drug. A total of 72 patients were randomized 1:1 to receive once-weekly semaglutide, up to 1 mg, or placebo for 26 weeks. Participants had a mean age of 40 years, a mean diabetes duration of 23 years, a mean baseline A1c of 7.8, BMI 35, and body weight 102 kg. Two thirds were using the Tandem Control IQ AID system. The primary endpoint was a composite of continuous glucose monitoring (CGM)-based time in range 70-180 mg/dL of > 70%; time below 70 mg/dL of < 4%; and ≥ 5% weight reduction. A total of 13 of the 36 (36.1%) in the semaglutide group vs zero in the placebo group met the composite endpoint. The between-group difference was 36 percentage points ( P < .001). Semaglutide treatment was associated with a nearly eightfold better chance of achieving the primary outcome (odds ratio, 7.77). Among the secondary outcomes, A1c reductions from baseline to week 26 were 0.7 with semaglutide vs 0.4 with placebo; increased percent time in range was 11.1% vs 2.3%; reductions in CGM mean glucose were 15.7 mg/dL vs 3.6 mg/dL; and reductions in percentage time above 180 mg/dL were 11.1% vs 2.7%. All of those differences were significant, Shah reported. The percentage of time spent below 70 mg/dL from baseline was low and the change from baseline didn't differ significantly between the two groups, 0.1% vs 0.4%. Body weight change at 26 weeks were reductions of 9.2 kg vs 0.4 kg, and BMI drops were 3.3 vs 0.2. Those differences were also significant, Shah said. Daily insulin requirements from baseline to week 26 were reduced significantly by 22.3 units per day with the semaglutide group compared to the placebo group. A total of 57 gastrointestinal events were reported by 19 patients in the semaglutide group vs 13 gastrointestinal events were reported by 9 patients in the placebo group. Two from each group experienced severe hypoglycemia. There were no diabetic ketoacidosis events in either group. The number of people who discontinued the trial early due to persistent gastrointestinal adverse events was three in the placebo group vs two in the semaglutide group. 'Prohibitively Expensive for Those With T1D' Asked to comment, Nicholas B. Argento, MD, senior clinical endocrinologist and diabetes technology director at the Maryland Endocrine and Diabetes Center, Columbia, Maryland, said that the trial 'was small but showed the benefit of using adjunctive therapy in T1D.' There is an 'unmet need' in patients with T1D with a high BMI and suboptimal glycemic control, he told Medscape Medical News Despite proven cardiorenal benefits of both GLP-1 agonists and SGLT2 inhibitors in type 2 diabetes, 'none are approved for use in T1D, which means that they are generally not covered by insurance.' These medications 'end up being prohibitively expensive for those withT1D to access,' Argento noted. But there is no reason to believe we would not see similar benefits in those with T1D, who have a very high cardiorenal risk, he said. 'ADJUST-T1D shows that T2D agents like semaglutide can definitely benefit T1Ds with no safety concerns.' For the time being, Shah pointed to this section of the ADA Standards of Care that was just added in the 2025 edition: A diagnosis of type 1 diabetes does not preclude also having features classically associated with type 2 diabetes (eg, insulin resistance, obesity, and other metabolic abnormalities), and until more precise subsets are used in clinical practice, it may be appropriate to categorize such an individual as having features of both type 1 and type 2 diabetes to facilitate access to appropriate treatment (eg, glucagon-like peptide 1 receptor agonist [GLP-1 RA] or sodium–glucose cotransporter 2 [SGLT2] inhibitor therapies for potential weight and other cardiometabolic benefits) and monitoring systems. 'We use that language from the Standards of Care in prior authorization,' Shah told Medscape Medical News . Independent Industry Consultant Charles Alexander, MD, told Medscape Medical News , 'This small study is very encouraging but unlikely to lead to [US Food and Drug Administration] approval for semaglutide in T1D. In contrast, two much larger currently recruiting global studies of tirzepatide in T1D NCT06914895 and NCT06962280 are more likely to lead, if successful, to FDA approval.' Shah received research support from, does consulting, speaking, and/or serves on advisory boards for Alexion, Novo Nordisk, Dexcom, Enable Bioscience, Zucara Therapeutics, Lilly, Breakthrough T1D, NIH, Insulet, Tandem Diabetes Care, Medtronic, Ascensia Diabetes Care, Embecta, Sanofi, Sequel Med Tech, Biomea Fusion, Lumosfit, and Genomelink. Argento has consulted or been on advisory boards for Eli Lilly Diabetes, Dexcom, DiabeLoop, ConvaTec, and Senseonics and served on the speakers' bureaus for Boehringer-Ingelheim, Dexcom, Eli Lilly Diabetes, MannKind, Novo Nordisk, Xeris, and Zealand Pharmaceuticals. Alexander had no disclosures.

Mifepristone Improves A1C in T2D With Hypercortisolism
Mifepristone Improves A1C in T2D With Hypercortisolism

Medscape

time42 minutes ago

  • Medscape

Mifepristone Improves A1C in T2D With Hypercortisolism

CHICAGO — Mifepristone treatment improved glycemic control and led to weight loss and a reduction of waist circumference in patients with poorly controlled type 2 diabetes (T2D) and hypercortisolism, according to new data from the CATALYST trial. Results from the prevalence phase of the study, presented last year, indicated that 24% (253) of the 1055 patients enrolled had hypercortisolism, as determined by dexamethasone suppression test. The figure was surprising, as the expected prevalence was 8%. The current data were presented at the American Diabetes Association (ADA) 85th Scientific Sessions and simultaneously published in Diabetes Care . 'These findings demonstrate a potentially promising treatment solution' for these patients, who are often frustrated with their diabetes care, said study author John Buse, MD, PhD, Verne S. Caviness Distinguished Professor of Medicine at the University of North Carolina School of Medicine, Chapel Hill, North Carolina, in a press release. The CATALYST Trial: Latest Results In the second phase of CATALYST, individuals who had abnormal cortisol suppression were offered the opportunity to take part in a randomized trial of mifepristone, a medication that reduces the effects of cortisol. It is currently FDA approved for the treatment of elevated blood glucose in patients with hypercortisolism and prediabetes or T2D. The trial took place at 36 sites in the US. A total of 136 patients with T2D (A1c of 7.5%-11.5%, who were on multiple medications) and hypercortisolism were randomized 2:1 to mifepristone (300-900 mg once daily; 91 patients) or placebo (45 patients) for 24 weeks, with stratification by presence/absence of an adrenal imaging abnormality. Almost 40% of the patients were women, and the mean age was 63 years. The mean A1c was 8.55%, and mean BMI was 33.3. Twenty-eight percent of participants had adrenal imaging abnormalities. The medication reduced A1c by 1.5% (95% CI, -1.79 to -1.14). For those taking placebo, A1c declined 0.2% from 8.41% to 8.36% (95% CI, -0.56 to 0.27). Within the first 12 weeks, 30% of those taking mifepristone reduced or discontinued fast-acting insulin compared to 11% of those taking placebo. And half reduced or discontinued long-acting insulin compared to 13% of those taking placebo. 'As their A1c came down, they didn't need the insulin,' Buse told reporters at a press conference at the meeting. Patients taking mifepristone also lost 4.4 kg of body weight and had a 5.2 cm (2.05 in) reduction in waist circumference from baseline. However, almost 50% of those taking mifepristone discontinued due to adverse events compared to just 18% of those taking placebo. A total of 62% of patients on mifepristone reported having treatment-related adverse events, said Buse, adding that people on mifepristone primarily experience glucocorticoid withdrawal syndrome or hypokalemia. Mifepristone 'is a challenging drug to use,' he said, and 'it's important to set expectations appropriately with patients about steroid withdrawal symptoms and how to manage them.' CATALYST already demonstrated that hypercortisolism was likely a culprit in almost a quarter of patients with poorly controlled diabetes, and screening with a dexamethasone suppression test is relatively easy, said Buse. The treatment phase of CATALYST showed 'that identifying and addressing hypercortisolism is a novel path to improving diabetes care in millions of people worldwide,' he added. The CATALYST investigators 'believe that there's sufficient evidence now to suggest guideline changes at the American Diabetes Association and other international health organizations.' This study was funded by Corcept Therapeutics. Buse disclosed serving on an advisory panel/as a consultant for Altimmune, Antag Therapeutics, Amgen, APstem Therapeutics, Aqua Medical, AstraZeneca, Boehringer Ingelheim, CeQur, Corcept Therapeutics, Dexcom, Eli Lilly, embecta, GentiBio, Glyscend, Insulet, Medtronic MiniMed, Mellitus Health, Metsera, Novo Nordisk, Pendulum Therapeutics, Praetego, Stability Health, Tandem Diabetes Care, Terns Pharmaceuticals, Vertex Pharmaceuticals, and Zealand Pharma; and having stocks/shares in Glyscend, Mellitus Health, Metsera, Pendulum Therapeutics, Praetego, and Stability Health.

9 Best Foods for Headaches and Migraines, According to Dietitians and Doctors
9 Best Foods for Headaches and Migraines, According to Dietitians and Doctors

CNET

time44 minutes ago

  • CNET

9 Best Foods for Headaches and Migraines, According to Dietitians and Doctors

Our diet can significantly impact our health, which is why it's important to ensure it's balanced. Certain foods can also be incorporated to target specific parts of the body or medical conditions, like headaches and migraines. "The most important thing I tell patients is that migraines are highly individualized," says Dr. Nicholas Church, a board-certified member of the American Board of Family Medicine and the American Academy of Family Physicians. "What helps one person may not help another, and what's a trigger for one might be therapeutic for someone else." A holistic approach is best for headaches and migraines because hydration, exercise, sleep and stress can all play a role in this head pain. That's why Church advises patients to keep a "headache diary" to track these factors, including the foods they eat or avoid, to see if they notice any triggers. Though no one food or change to your diet will cure you of headaches or migraines completely, they may help provide relief. These are the foods experts recommend. 1. Omega-3-rich foods like flaxseed "I recommend omega-3-rich fish, such as salmon, mackerel and sardines," says Church. "These fish are high in anti-inflammatory fats (EPA and DHA), which can reduce inflammation throughout the body, including in the vascular system and brain." Citing a 2021 randomized controlled trial, Church explains that because migraines are believed to involve inflammatory and vascular changes in the body, omega-3 fatty acids may help reduce their frequency or intensity when eaten regularly. "The study's findings also align with earlier data showing that omega-3s help regulate prostaglandins, which play a role in headache inflammation," says Church. Prostaglandins are hormone-like substances that impact bodily functions like inflammation, pain and menstrual cramps. Fatty fish also contain vitamin D, coenzyme Q10 and B vitamins like riboflavin, which support healthy brain metabolism. Kiran Campbell, a registered dietitian nutritionist at MyNetDiary, also mentions a 2024 meta-analysis revealing that omega-3 fatty acids can reduce the frequency, duration and severity of migraines. She adds that plant-based sources include chia seeds, walnuts, flaxseed and algae oil. Example foods: salmon, mackerel, sardines, chia seeds, walnuts, flaxseed and algae oil Chia and flax seeds are great sources of omega-3s. mikroman6/Getty Images 2. Magnesium-rich foods like kale Daniel Redwood, the director of Human Nutrition and Functional Medicine at the University of Western States, explains, "Attention to the potential importance of magnesium in migraine grew in prominence with the discovery (Ramadan, 1989) that people with migraines had lower levels of this mineral in their red blood cells, serum and brain tissue." Dr. Paul Daidone, medical director at True Self Recovery, seconds this, stating that food rich in magnesium -- like pumpkin seeds, spinach and avocado -- may reduce the severity and occurrence of migraines. He cites a 2022 study examining the potential connection between magnesium deficiency and migraine, which describes how magnesium deficiency is implicated in migraine attacks due to processes like cortical spreading depression, oxidative stress, neurotransmitter imbalance and electrolyte imbalance. "Although clinical evidence of the acute dietary magnesium deficiency as a direct migraine trigger remains limited, scientists are investigating the involvement of intra- and extracellular magnesium levels in migraine pathogenesis," Daidone explains. Dr. Schonze Del Pozo, a board-certified internal medicine physician and medical director at East Sacramento Concierge, states that many of the patients she sees for headaches and migraines are deficient in magnesium. She also cites a 2012 study in the Journal of Neural Transmission entitled "Why all migraine patients should be treated with magnesium." As a result, she recommends a healthy diet of magnesium-rich dark leafy greens like spinach, kale, broccoli and Swiss chard. Example foods: pumpkin seeds, spinach and avocado, kale, broccoli and Swiss chard 3. Ginger "Many swear by ginger as a way to help with migraines," states Dr. Maria Knöbel, a general practitioner and medical director of Medical Cert UK. "Studies have proven that ginger reduces nausea and can decrease the inflammation that leads to migraine pain. Ginger has helped patients during my practice, whether they take it as ginger tea or in supplement form." She references a 2014 study that found ginger powder to be as effective as the medication sumatriptan in treating acute migraine attacks, but with fewer side effects. Ginger tea may be especially beneficial because, Knöbel states, "It's important to drink enough water, as well as eat ginger. Drinking enough water might stop your migraine from getting any worse." Church also recommends ginger because it contains natural anti-inflammatory compounds like gingerol. "I've had patients find relief from migraines or migraine-related nausea using ginger tea, powder or chews," he explains. A 2019 study also found that 400mg of ginger extract, in addition to 100mg of the non-steroidal anti-inflammatory drug ketoprofen, may help treat migraine attacks. Ginger tea combines the benefits of ginger with the hydration of water.4. Nuts and seeds like walnuts "Another group of foods I recommend are nuts and seeds, including almonds, pumpkin seeds, sunflower seeds and walnuts," Church states. "Like leafy greens, these are rich in magnesium, and some also provide vitamin E, which has been shown to help with menstrual migraines and migraines with aura." A 2015 study reflected this. Example foods: almonds, pumpkin seeds, sunflower seeds and walnuts 5. Cinnamon "Cinnamon contains a high amount of antioxidants that may also reduce headache frequency," Campbell explains. "Stir it into your morning oatmeal or tea, or bake it into muffins and breads." She cites a randomized, double-masked, placebo-controlled 2020 trial, stating, "Studies suggest that cinnamon supplementation may lower inflammation, cutting down on migraine frequency, severity and duration." The antioxidants in cinnamon may help treat headaches and migraines. FreshSplash/Getty Images 6. Foods rich in vitamin B2, like eggs "A well-known [1998] randomized controlled trial found that 400 mg of riboflavin daily significantly reduced migraine frequency and severity over a three-month period," Church says. Though this high dose usually comes from supplementation, riboflavin-rich foods support the same metabolic processes in migraine prevention. These foods can include eggs, dairy and lean meats. "Riboflavin is essential for mitochondrial energy production, and many researchers believe that migraines stem in part from dysfunction in energy metabolism within brain cells," Church adds. Redwood adds, "There exists a small but promising body of research on the effectiveness of some nutritional supplements for migraines, especially riboflavin (vitamin B2), coenzyme Q10 and magnesium. The first research-based indicator of riboflavin's potential as a migraine treatment appeared in a small 1946 article by a medical physician, published in the Canadian Medical Association Journal, which reported dramatic effectiveness from what would now be considered low-dose B2 supplements." A 2022 systematic review and meta-analysis found that supplementation of 400mg/day of vitamin B2 for three months affected the duration, frequency and pain score of migraine attacks. Example foods: Eggs, dairy and lean meats 7. Turmeric Curcumin is the active compound in turmeric and, according to Campbell, is "high in antioxidant power and shines especially when paired with omega-3s." To add it to your diet, consider sprinkling it into smoothies, curries or teas. Campbell references a randomized, double-masked, placebo-controlled 2021 trial that concluded, "Present findings revealed that n-3 fatty acids and curcumin co-supplementation can be suggested as a promising new approach in migraine headache management." However, more studies are needed. When combined with omega-3s, turmeric may help with migraine headache management. Rawlstock/Getty Images 8. Whole grains like oats Church mentions that whole grains like quinoa, brown rice and oats may also be beneficial since they "provide a steady release of glucose, preventing blood sugar crashes that can trigger headaches, and are good sources of fiber, B vitamins and trace minerals." He cites a 2023 cross-sectional study of 12,710 participants with all data collected from a 1999-2004 National Health and Nutrition Examination Survey. It found that for every 10 grams of fiber added to the diet, there was an 11% reduction in the odds of having severe headaches or migraines. "By providing magnesium, iron, and B vitamins, whole grains support brain health, oxygen delivery and a stable glucose supply, which are all relevant to migraine prevention," concludes Church. A 2023 comprehensive review also found that curcumin is a promising candidate for preventing and controlling migraines due to its anti‑inflammatory, antioxidative, anti-protein aggregate and analgesic effects. However, additional studies are needed. Example foods: quinoa, brown rice and oats 9. Water-rich foods like watermelon Dr. Kimberly Idoko, a developmental neurobiologist and board-certified neurologist, reveals that dehydration can also trigger headaches, which is why staying hydrated can significantly improve migraine treatments. "Water-rich foods like cucumber, watermelon and citrus fruits also help you stay hydrated," adds Church. To prevent dehydration-caused headaches or migraines, enjoy more water-rich foods like watermelon. Anucha Muphasa/500px/Getty Images Foods that may trigger headaches or migraines Chocolate, cheese and alcohol: "In one [2007] study of over 500 migraine sufferers, 44% reported at least one food as a trigger. Among the most common triggers were chocolate, cheese and alcohol, " reveals Dr. Adam Lowenstein, a board-certified plastic surgeon who runs the Migraine Surgery Specialty Center. Gluten: "Gluten can be a highly inflammatory food substance, especially among those who are prone to sensitivities or gluten allergy," explains Trista Best, a registered dietitian at The Candida Diet, environmental health specialist and adjunct nutrition professor. "This inflammation causes a host of health conditions, including migraines." When it comes to caffeine, moderation is "The most fascinating study I've seen on the role of nutrition in the treatment of headaches (Hering-Hanit and Gadoth, 2003) was published in Cephalalgia, the premier headache journal. Over a 5-year period, doctors at a neurology clinic in Israel treated 36 children and adolescents (average age 9) with severe daily or near-daily headaches who drank an average of 11 quarts of cola drinks per week," says Redwood. "At the end of a gradual withdrawal period (because too speedy a withdrawal can trigger even worse headaches), 33 of these 36 young people were headache-free, a truly stunning result. Nearly all cola drinks contain substantial amounts of caffeine (Chou and Bell, 2007)." Note: 11 quarts of cola per week is extreme, and the average person doesn't consume this much caffeine. Moderate caffeine intake is still OK, according to Amelia Ti, a registered dietitian and diabetes educator in New York City who is also part of CNET's medical review board. However, when it comes to caffeine, Church notes, "Caffeine, used strategically, can enhance the absorption of pain relievers and constrict dilated blood vessels in the brain, which may ease migraine pain. This is why many over-the-counter headache medications include it. Studies have shown that 40–100 mg of caffeine (the amount in a small cup of coffee or strong tea) can reduce migraine or tension headache pain. But, chronic overuse can lead to rebound headaches, so moderation is key." Added sugars and highly processed foods: "Research has shown that people following a 'Western' diet, which includes substantial amounts of added sugars and other highly processed foods, are at greater than average risk for developing migraines, while the risk is significantly lower than average for those following a healthier diet," states Redwood. download (1) Dr. Joseph Mercola, a board-certified family physician and author of Your Guide to Cellular Health, adds that in addition to incorporating foods rich in specific nutrients like magnesium and B vitamins, you'll want to eliminate triggers like processed foods that contain nitrates, MSG, added sugars or yeast.

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