EnteroBiotix Presents Positive IBS-C Data at Digestive Disease Week® 2025
Ph2b trial in IBS-C initiating in H2 2025 to confirm efficacy
Glasgow, Scotland – 6 May 2025. EnteroBiotix Limited ('EnteroBiotix'), a biopharmaceutical company developing best-in-class therapies for gut health, today presented positive data from its TrIuMPH Phase 2a trial evaluating EBX-102-02, the Company's next-generation oral full-spectrum microbiome product, in patients with irritable bowel syndrome with constipation (IBS-C) at Digestive Disease Week® (DDW) 2025, taking place 3–6 May in San Diego, USA.
The multicentre, randomised, double-blind, placebo-controlled TrIuMPH trial evaluated the safety, tolerability, and efficacy of EBX-102-02 in 122 patients with moderate to severe irritable bowel syndrome with constipation (IBS-C) or diarrhoea (IBS-D). Participants were randomised 2:1 to receive 8 capsules of EBX-102-02 on Day 1 and Day 7 or matched placebo, with follow-up through Week 6. Data presented at DDW focused on the IBS-C cohort; results from the IBS-D cohort are expected in Q2 2025.
EBX-102-02 was well tolerated, with adverse events primarily mild, self-limiting, and gastrointestinal in nature. Patients receiving EBX-102-02 showed clinically meaningful improvements and favourable trends compared to placebo across multiple endpoints, including the IBS Symptom Severity Score (IBS-SSS), abdominal pain, stool consistency, straining severity, average weekly complete bowel movements, PAC-SYM, and IBS Quality of Life (IBS-QoL). Improvements were observed as early as Week 1 and were sustained through follow-up.
Shotgun metagenomic sequencing demonstrated robust strain engraftment, with the microbiome profiles of treated patients shifting toward the composition of the EBX-102-02 product.
Highlights from the TrIuMPH trial presented at DDW 2025 included: IBS-SSS: Patients receiving EBX-102-02 showed greater improvement in IBS-SSS than placebo across all measured timepoints, with mean reductions of 78 points compared to 53 in the placebo group by Week 7.
Patients receiving EBX-102-02 showed greater improvement in IBS-SSS than placebo across all measured timepoints, with mean reductions of 78 points compared to 53 in the placebo group by Week 7. Abdominal Pain: Mean abdominal pain severity dropped by 14.1 points in the EBX-102-02 group compared to 9.3 in the placebo group by Week 7. There was an improvement in the number of days with reported abdominal pain, with a 2.0 day reduction in the EBX-102-02 compared to 1.1 day reduction in the placebo group at Week 7.
Mean abdominal pain severity dropped by 14.1 points in the EBX-102-02 group compared to 9.3 in the placebo group by Week 7. There was an improvement in the number of days with reported abdominal pain, with a 2.0 day reduction in the EBX-102-02 compared to 1.1 day reduction in the placebo group at Week 7. Bristol Stool Form: The weekly average number of stools classified as hard (BSFS 1 or 2) fell from 69% to 30% in the EBX-102-02 group compared to a decrease from 67% to 54% with placebo by Week 3.
The weekly average number of stools classified as hard (BSFS 1 or 2) fell from 69% to 30% in the EBX-102-02 group compared to a decrease from 67% to 54% with placebo by Week 3. Complete Bowel Movement Frequency : Patients receiving EBX-102-02 experienced greater improvement in complete bowel movements than those on placebo, with an average increase of over one bowel movement per week in 4 out of 6 follow-up weeks, compared to 2 out of 6 weeks in the placebo group.
: Patients receiving EBX-102-02 experienced greater improvement in complete bowel movements than those on placebo, with an average increase of over one bowel movement per week in 4 out of 6 follow-up weeks, compared to 2 out of 6 weeks in the placebo group. Microbiome Shift Toward Product Composition: Faecal microbiota profiles in the EBX-102-02 group shifted toward the composition of the drug product and this effect persisted through Week 7.
Dr. James McIlroy MBChB, CEO of EnteroBiotix, commented: 'These positive data in EBX-102-02 for IBS-C represent a significant milestone for EnteroBiotix and for the broader field of microbiome-based therapeutics. EBX-102-02 was well tolerated and demonstrated consistent, clinically meaningful improvements across multiple IBS symptoms and measurements of quality of life. The observed microbial engraftment reinforces our confidence our full-spectrum approach. We look forward to advancing EBX-102-02 into a Ph2b trial later this year and were pleased to discuss these data with our Scientific Advisory Board during the Conference.'
About EnteroBiotix
EnteroBiotix is a clinical-stage biotechnology company developing microbiome-based therapeutics for irritable bowel syndrome (IBS) and other gastrointestinal and hepatic indications. Using its proprietary platform technology, EnteroBiotix creates next-generation therapies with differentiated characteristics designed to restore and enhance gut microbiome function. The company has established independent control over the supply chain for its drug formulations, with MHRA licensed manufacturing capabilities, and a donor programme called Number2®.
About EBX-102-02
EBX-102-02 is a next-generation, full-spectrum microbiome therapeutic composed of a high-diversity consortium of gut-derived microbes. Manufactured using the Company's proprietary AMPLA™ technology, EBX-102-02 has a robust stability profile and is formulated as an off-white, odourless powder encapsulated into oral capsules. It is designed to deliver rapid, well-tolerated, and effective symptom relief for diseases associated with gut microbiome dysfunction, including irritable bowel syndrome (IBS).
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A Week In Minneapolis On A $187,000 Joint Income
Welcome to Money Diaries where we are tackling the ever-present taboo that is money. We're asking real people how they spend their hard-earned money during a seven-day period — and we're tracking every last dollar. Today: a research and development engineer who has a $187,000 joint income and who spends some of her money this week on home furniture. Occupation: Research and development engineer Industry: Medical device Age: 26 Location: Minneapolis, MN Salary: $95,000 Joint Income/Financial Setup: My husband C. and I share finances. Our household income is $187,000. Assets: 401(k): ~$39,000; C.'s 401(k) and Roth IRA: ~$70,000; savings accounts: ~$56,000; investments: ~$20,000; home equity: ~$96,000. Debt: $364,000 (mortgage). Paycheck Amount (Biweekly): $4,399 Pronouns: She/her Monthly Expenses Housing Costs: $3,213 Loan Payments: We have no formal loans other than the home mortgage. I owe my parents ~$7,000 for part of my education. Gym Membership: $25 Netflix: $9 Was there an expectation for you to attend higher education? Did you participate in any form of higher education? If yes, how did you pay for it? I was a good student in high school so I kind of naturally ended up in honors classes and AP classes. Once I was in that group I was never presented with options other than college. In hindsight I think I should have considered trade schools, but I didn't really know that was an option at the time. When the time came my parents and I agreed to split all college costs 50/50. I had some money saved from working in high school and graduation gifts so that's how I paid my half at first. When I ran out of money my parents decided to give me an interest-free loan where they would give me money as I needed and continuously tally it up. I've paid bits off over the last few years but they insist they don't want us to pay them back until we're 'established in life'. Now that we've bought our house, I think it might be time to pay them back. Growing up, what kind of conversations did you have about money? Did your parent(s) educate you about finances? My dad worked in banking, so he told my brother and I bad money management things he'd seen so that we would know what not to do. He was very good about setting us up for success later in life like getting us credit cards/loans that he managed so we could start off with good credit scores. What was your first job and why did you get it? My first job was babysitting for spending money. Did you worry about money growing up? I was occasionally (incorrectly) worried about money just because my parents kind of made a big deal over spending any money. I know now that it was never a concern, it was just something they commented on a lot. I think they were trying to show us real world money management but it came off a different way than I think they intended to. Do you worry about money now? My husband and I are fortunate enough to have pretty stable jobs and a good emergency fund but I still worry about money because I'm generally a worrier. At what age did you become financially responsible for yourself and do you have a financial safety net? I would say I wasn't financially responsible for myself until I graduated college. I was still paying my own bills and whatnot in college but it wasn't until I moved into my first apartment by myself that I really felt like I was on my own. If anything catastrophic were to happen I'm sure my parents or my husband's parents would help financially. Do you or have you ever received passive or inherited income? If yes, please explain. My grandparents gave each of their grandchildren their inheritance ($10,000) ahead of their passing because they knew that all of them were in a spot in their life where they could really use it. We're very grateful and used the money toward our house down payment. 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I recently did a pretty massive health overhaul where I lost 70lbs, so I try to only eat snacks when I'm actually hungry. Even then I try to start with fruit and eat something more substantial only if the fruit doesn't do the trick. My husband C. likes a 5:30 p.m. or 6 p.m. dinner, so this also makes sure I'm hungry around the same time. 5 p.m. — We're having a home energy assessment done to see if our new (to us) home is energy efficient. C. was there to let them in but I'm late. The findings are surprisingly good!! I learn we don't need new windows after all (and you really only need to replace windows if they're actually broken). We should plan that we'll need a new water heater soon (the energy efficient one they recommend is $3,000) and to get more insulation in the attic (they quote this at $7,500). We'll have to weigh this against the other projects we want to do. The city pays for half of the $100 visit and C. swipes his card for the other half. $50 6 p.m. — Once the energy people leave we make dinner. Dinner is a pasta salad with ranch dressing made from blended cottage cheese, a little mayo, and buttermilk. After dinner, I decide I need whipped cream for the pound cake my in-laws left with us when they came over yesterday. We run to the grocery store to buy it. $6.99 7 p.m. — We eat cake when we get home. A big storm was supposed to roll through so we don't have any plans for tonight. We end up not even getting rain so we could have gone for a walk or something. I prep some overnight oats for breakfast tomorrow and then lay around the house all night. Daily Total: $56.99 Day Two: Tuesday 7:30 a.m. — Wake up, shower, get ready, make espresso. I try to do as little as possible in the mornings before work. I have to feed our youngest cat every morning since we haven't gotten an automatic feeder for her yet. 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The Breakdown Conclusion 'Other than all the home purchases, this was a pretty normal spend week for us. I'm sure we'll have a few more weeks like this as we continue to buy stuff for the house, but I think we'll be back to our normal no-frills spending in a month or so.' Money Diaries are meant to reflect an individual's experience and do not necessarily reflect Refinery29's point of view. Refinery29 in no way encourages illegal activity or harmful behavior. The first step to getting your financial life in order is tracking what you spend — to try on your own, check out our guide to managing your money every day. For more Money Diaries, click here. We've updated our Money Diaries submission process: You can now submit your Money Diary via our online form or by sending us a bit of information about you and your financial situation to moneydiary@ We pay $150 for each published diary. Apologies but we're not able to reply to every email. 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