Palm Springs fertility clinic bombing: How disaster was averted
Source: CNN
Christy Holstege, the former mayor of Palm Springs who is 18 weeks pregnant, was playing with her pre-schooler in their living room Saturday morning when a blast reverberated through her neighborhood and a plume of smoke began to grow on the horizon. It didn't take long for word to reach her that the building ablaze was the local fertility clinic.
Panic gripped Holstege as she thought of her last remaining embryo stored inside the clinic and her concern deepened as she considered the safety of the staff that had carried her family through the last five years of in-vitro fertilization treatment – first with her son and again this year.
Through a fortuitous turn of events, the usually bustling American Reproductive Center was completely empty when a car exploded outside the clinic Saturday, blowing a gaping hole in the side of the building and severing the power supply of the lab where thousands of embryos and other specimens are stored.
For miles around the blast zone, Coachella Valley families held the babies and toddlers conceived at ARC. Alongside hopeful would-be parents, they worried for the immediate fate of their remaining embryos in the clinic, and for the long-term safety of the reproductive center, which authorities believe was targeted in an act of domestic terrorism.
Mothers Sophie and Simone Bain-Tohl were hosting a party full of fellow parents when they heard news of the attack. The room grew somber as they surrounded a play mat full of wriggling babies – two of them conceived by IVF – and realized every person in the room either had embryos stored at ARC or knew someone who does.
Though the frozen embryos at the clinic would remain cold without electricity, a set of embryos being incubated would be irreversibly damaged if power was not restored within hours.
But at the scene of the explosion, a firefighter began to hatch a risky plan to protect future families, including that of a fellow first responder.
Firefighters initially rushed to tamp down the blaze caused by the explosion and ensure no victims were inside. But the crumbling building soon began to shift and bomb squad technicians became concerned about a possible secondary device that could put first responders at risk.
When Deputy Fire Chief Greg Lyle arrived an hour after the blast, first responders had been ordered to get out of the still smoking building until a bomb squad could assess the scene.
Clinic director Dr. Maher Abdallah, who was able to access clinic security cameras before the power went out, reported that the embryo lab appeared intact, but Lyle was not convinced. Itching to help, he and the other firefighters began considering how they could ensure the embryo incubators and cryogenic tanks were secure.
'So I went over to the lead FBI investigator, and kind of pitched a crazy scheme to him, fully expecting him to say no,' Lyle said.
The scheme: Lyle would venture alone into the still standing part of the building, which contained unknown risk of structural collapse, a secondary explosion or additional fires, to find the lab and assess the status of the embryos.
'This is a crazy plan, and if anybody's going to get hurt, the only thing that I would be able to be comfortable with is that it would be me,' he said. 'I just had a gut feeling it had to be me.'
The FBI agent, identified by the city police chief as Agent Chris Meltzer, embraced the plan under one condition: Meltzer would accompany Lyle.
Together, the pair headed into the building, cautiously navigating blown-out door frames, crumbling drywall and several inches of standing water, likely from a water main break or fire sprinklers. They eventually spotted a room stacked with what appeared to be cryogenic tanks.
'We thought initially that maybe we could go in and just grab it and go. But it was obvious there was too much (equipment) – too big, too bulky, too heavy,' Lyle said. 'So we determined the only thing we could do would be restore power to this stuff.'
Quickly, they realized the backup generators had failed, and it became increasingly clear they alone would not be able to restore the electricity. The pair picked their way back out of the building to assemble a team of firefighters, police and bomb squad personnel to address the outage.
'It took them a while, but they were successful,' Lyle said.
The team's heroic initiative likely saved the incubating embryos, Abdallah said. An hour or two longer without power could have had tragic consequences.
Unbeknownst to Lyle, the ARC lab houses embryos belonging to the wife of one of his own firefighters, who sent Lyle a message thanking him for preserving his family's future.
'It kind of hit home there. I didn't even know,' Lyle said. The firefighter's wife is among the patients with appointments early this week.
Yet, in order to continue ongoing treatment for patients, it would take a second team effort to keep the delicate process moving forward.
Most Saturdays, Abdallah and his staff are flitting between patient rooms and laboratories, sterilizing equipment, checking on growing embryos and walking hopeful parents through the arduous process of in vitro fertilization.
But through a series of inexplicable events, the clinic was completely empty on Saturday when the car exploded outside.
Abdallah had spontaneously decided to visit family. Two other weekend employees had been called away. And the clinic, just days before, had rescheduled a procedure that would have required 12 employees to be in the office at the time of the explosion.
'So many things happened to protect our staff,' Abdallah said. 'It's just really a miracle.'
Though shaken by the bombing, Abdallah and his staff have been seeking solace in each others' presence and their shared determination to continue operating the clinic.
The attack, though unsuccessful, delivered a seismic shock to patients and violated a space that many feel is far more intimate than just a medical clinic; It's the venue where their families were formed and precious possibilities are stored.
'I went there every week for the last 12 weeks, sometimes twice a week,' Holstege said. 'That is my home, my medical home.'
As the only fertility clinic within a 100-mile radius, ARC stores thousands of embryos, eggs and sperm specimens for patients from Palm Springs to as far as Asia and the Middle East, Abdallah said.
Several families who depend on ARC for fertility services described a profound level of care from the clinic's staff, who have made late-night calls to share test results, scheduled extra ultrasounds for nervous mothers and held patients in their arms during moments of both grief and joy.
'ARC is a place where we went to build our family and holds so much more than just a clinic. It's a place of vulnerability and hope and tenderness, and the staff there is just incredible,' said Sophie Bain-Tohl, whose four-month-old son was conceived at ARC.
Though Bain-Tohl and her wife plan to keep their embryos at ARC, the attack has left them with a lingering fear for the safety of their embryos, which they hope will one day provide them with a daughter.
'Our sense of safety is shattered by something like this,' Simone Bain-Tohl said. 'It's such an absurd event that you never really think it's going to happen, especially to a place that's tied to so much hope and vulnerability.'
Investigators say the 25-year-old bombing suspect, who was killed in the blast, had 'nihilistic ideations' and intentionally targeted the IVF facility – a reality that Holstege and other patients are having difficulty coming to terms with.
'Why would someone do this? Who could do this? This is a place of hope and creating life,' said Holstege.
For some patients with appointments in the days following the explosion, halting treatment is simply not an option, Abdallah explained. The window for egg retrieval and embryo transfer is very tight and delaying care would mean starting the entire process over again – risking time and money many couples do not have.
Less than 24 hours after the bombing, Abdallah was formulating a plan to continue providing time-sensitive treatment to these patients, which required retrieving their valuable medical records from inside the most heavily damaged part of the clinic.
Again, a crew of fire personnel and other law enforcement entered the compromised building.
'We needed a team of people to kind of bucket brigade all these folders out of the building,' Lyle said. Abdallah also asked them to haul out two brand new ultrasound machines.
'I was just really amazed at the risk they're willing to take, and how they just work so well together,' the clinic director said.
As the clinic races to rebuild, Abdallah is determined to continue providing care. On Monday, his staff saw patients in a room loaned to them by a fellow physician.
But the emotional trauma experienced by his patients and staff is not lost on Abdallah, whose office is holding a news conference Thursday to update the community on its plans for 'moving forward with strength and renewed purpose.'
'The patients who have embryos, a lot of them regard those embryos as children,' he said. 'They go through so much to get to that point where their embryos are frozen. They need a lot of reassurance to know that their embryos are safe.'
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CBS News
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- CBS News
A woman's heart suddenly stopped. Two passing nurses saved her life.
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ASCO Report of Pioneering Treatment of Lymphopenia with Significant Overall Survival Benefit in Advanced Pancreatic Cancer
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The ASCO Annual Meeting 2025 materials from ImmunityBio can be found below: Association of lymphopenia rescue and CA19-9 levels with overall survival following IL-15 superagonist N-803 and PD-L1 t-haNK chemo-immunotherapy for 3rd line or greater metastatic pancreatic Text: Poster PDF: About the Cancer BioShield™ Platform The Cancer BioShield platform is a first-in-class immunotherapy strategy designed to restore immune competence by reversing lymphopenia—the loss of functional immune cells caused by cancer itself and by conventional treatments such as chemotherapy, radiation and immunotherapy. At its core is ANKTIVA® (nogapendekin alfa inbakicept-pmln), an IL-15 agonist approved for BCG-unresponsive non-muscle-invasive bladder cancer CIS with or without papillary disease, activates and proliferates natural killer (NK) cells and CD4+ and CD8+ T cells, restoring lymphocyte levels critical for immunosurveillance, immunogenic cell death, and long-term tumor control. 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Unlike anemia and neutropenia, which have FDA-approved treatments like EPO and Neupogen, no therapy previously existed to treat this immune cell depletion. Lymphopenia weakens the immune system, increases infection risk, and is linked to early death across many cancer types5. Low Absolute Lymphocyte Count (ALC) is a recognized poor prognostic marker. ANKTIVA® is the first approved therapy to restore lymphocyte levels by activating and expanding NK and T cells—without increasing immunosuppressive T regulatory cells7. More information on lymphopenia could be found on Twitter/X @DrPatSoonShiong articles here: References: Ray-Coquard I, et al. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res. 2009 Jul 1;69(13):5383-91. doi: 10.1158/ Epub 2009 Jun 23. PMID: 19549917; PMCID: PMC2775079. Chen D, et al. Absolute Lymphocyte Count Predicts Abscopal Responses and Outcomes in Patients Receiving Combined Immunotherapy and Radiation Therapy: Analysis of 3 Phase 1/2 Trials. Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):196-203. doi: 10.1016/ Epub 2020 Feb 7. Pike LRG, et al. The Impact of Radiation Therapy on Lymphocyte Count and Survival in Metastatic Cancer Patients Receiving PD-1 Immune Checkpoint Inhibitors. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):142-151. doi: 10.1016/ Epub 2018 Sep 15. PMID: 30227198. Lee, Y.J., et al. Peripheral lymphocyte count as a surrogate marker of immune checkpoint inhibitor therapy outcomes in patients with non-small-cell lung cancer. Sci Rep 12, 626 (2022). Ménétrier-Caux C., et al. Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: an opportunity for combination with Cytokines? J Immunother Cancer. 2019 Mar 28;7(1):85. doi: 10.1186/s40425-019-0549-5. PMID: 30922400; PMCID: PMC6437964. Templeton AJ, et al. Prognostic role of neutrophil-to-lymphocyte (NLR) ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014 May 29;106(6):dju124. doi: 10.1093/jnci/dju124. PMID: 24875653. FDA ANKTIVA Label, April 2024 - About ImmunityBio ImmunityBio is a vertically-integrated biotechnology company developing next-generation therapies and vaccines that bolster the natural immune system to defeat cancers and infectious diseases. The Company's range of immunotherapy and cell therapy platforms, alone and together, act to drive and sustain an immune response with the goal of creating durable and safe protection against disease. Designated an FDA Breakthrough Therapy, ANKTIVA is the first FDA-approved immunotherapy for non-muscle invasive bladder cancer CIS that activates natural killer cells, T cells, and memory T cells for a long-duration response. The Company is applying its science and platforms to treating cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies that we believe sharply reduce or eliminate the need for standard high-dose chemotherapy. These platforms and their associated product candidates are designed to be more effective, accessible, and easily administered than current standards of care in oncology and infectious diseases. For more information, visit (Founder's Vision) and connect with us on X (Twitter), Facebook, LinkedIn, and Instagram. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, such as statements regarding clinical trial data and potential results and implications to be drawn therefrom, the expectation that the EAP described herein will enable access to ANKTIVA for patients across all solid tumor types who have exhausted first-line therapy including chemo, radiation or immunotherapy, the RMAT designation as previously reported and potential results therefrom and regulatory submissions in connection therewith, the belief that ALC levels and NLR levels obtained from a CBC are predictors of clinical benefit and outcomes relating to overall survival, the belief that improving ALC levels and NLR levels correlates with enhanced overall survival and clinical benefit, the belief that reversal of lymphopenia correlates with improved survival, clinical trial and expanded access program enrollment, data and potential results to be drawn therefrom, anticipated components of ImmunityBio's Cancer BioShield platform, the development of therapeutics for cancer and infectious diseases, potential benefits to patients, potential treatment outcomes for patients, the described mechanism of action and results and contributions therefrom, potential future uses and applications of ANKTIVA alone or in combination with other therapeutic agents for the prevention or reversal of lymphopenia, potential future uses and applications of ANKTIVA alone or in combination with other therapeutic agents across multiple tumor types and indications and for potential applications beyond oncology, potential regulatory pathways and the regulatory review process and timing thereof, the application of the Company's science and platforms to treat cancers or develop cancer vaccines, immunotherapies and cell therapies that has the potential to change the paradigm in cancer care, and ImmunityBio's approved product and investigational agents as compared to existing treatment options, among others. Statements in this press release that are not statements of historical fact are considered forward-looking statements, which are usually identified by the use of words such as "anticipates," "believes," "continues," "goal," "could," "estimates," "scheduled," "expects," "intends," "may," "plans," "potential," "predicts," "indicate," "projects," "is," "seeks," "should," "will," "strategy," and variations of such words or similar expressions. Statements of past performance, efforts, or results of our preclinical and clinical trials, about which inferences or assumptions may be made, can also be forward-looking statements and are not indicative of future performance or results. Forward-looking statements are neither forecasts, promises nor guarantees, and are based on the current beliefs of ImmunityBio's management as well as assumptions made by and information currently available to ImmunityBio. Such information may be limited or incomplete, and ImmunityBio's statements should not be read to indicate that it has conducted a thorough inquiry into, or review of, all potentially available relevant information. Such statements reflect the current views of ImmunityBio with respect to future events and are subject to known and unknown risks, including business, regulatory, economic and competitive risks, uncertainties, contingencies and assumptions about ImmunityBio, including, without limitation, (i) risks and uncertainties regarding the FDA regulatory submission, filing and review process and the timing thereof, (ii) whether the RMAT designation will lead to an accelerated review or approval, of which there can be no assurance, (iii) risks and uncertainties regarding commercial launch execution, success and timing, (iv) risks and uncertainties regarding participation and enrollment and potential results from the expanded access clinical investigation program described herein, (v) whether clinical trials will result in registrational pathways and the risks, (vi) whether clinical trial data will be accepted by regulatory agencies, (vii) the ability of ImmunityBio to continue its planned preclinical and clinical development of its development programs through itself and/or its investigators, and the timing and success of any such continued preclinical and clinical development, patient enrollment and planned regulatory submissions, (viii) potential delays in product availability and regulatory approvals, (ix) ImmunityBio's ability to retain and hire key personnel, (x) ImmunityBio's ability to obtain additional financing to fund its operations and complete the development and commercialization of its various product candidates, (xi) potential product shortages or manufacturing disruptions that may impact the availability and timing of product, (xii) ImmunityBio's ability to successfully commercialize its approved product and product candidates, (xiii) ImmunityBio's ability to scale its manufacturing and commercial supply operations for its approved product and future approved products, and (xiv) ImmunityBio's ability to obtain, maintain, protect, and enforce patent protection and other proprietary rights for its product candidates and technologies. More details about these and other risks that may impact ImmunityBio's business are described under the heading "Risk Factors" in the Company's Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on March 3, 2025, and the Company's Form 10-Q filed with the SEC on May 12, 2025, and in subsequent filings made by ImmunityBio with the SEC, which are available on the SEC's website at ImmunityBio cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date hereof. View source version on Contacts ImmunityBio Contacts: Investors Hemanth Ramaprakash, PhD, MBA ImmunityBio, Inc. +1 Media Sarah Singleton ImmunityBio, Inc. +1 Sign in to access your portfolio
Yahoo
an hour ago
- Yahoo
Cardiologists are begging you to never practice this mid-morning habit
Are you tired in the mid-morning? Experts advise not to reach for the caffeine. A second or third cup of coffee may not have the effect you hope it will. The stimulant can raise cortisol levels, which naturally dip around 10 or 11 a.m. Cortisol is the body's main stress hormone. It can also regulate inflammation and blood pressure and boost energy. But, high cortisol doesn't necessarily equate to high energy. 'Cortisol can be high and we can feel tired or low energy, like when we wake up. Or it can be low and we can feel high energy like the mid-morning. If I had to equate cortisol levels with something, it would be irritation,' Calm's Dr. Chris Mosunic said in a statement. Regardless, caffeine raises cortisol, 'potentially amplifying sympathetic tone," Dr. Marschall Runge told Parade. "[This] may heighten blood pressure or heart rate more than if caffeine is consumed earlier,' the cardiologist said. The sympathetic nervous system is a network of nerves that helps your body activate its 'fight-or-flight' response. Caffeine can raise sympathetic nerve activity and blood pressure. Previous research has shown people who drink coffee on a regular basis don't see that rise in blood pressure. "Until now we have attributed the cardiovascular effects of coffee to caffeine, but we found non-coffee drinkers given decaffeinated coffee also display these effects," Dr. Roberto Corti, a cardiologist at University Hospital in Zurich, explained in 2002. Some groups are especially vulnerable to mid-morning caffeine, according to Runge. They include people with anxiety disorders, those with a slower caffeine metabolism, women during their period or perimenopause, people with hypertension or prehypertension, individuals with a slow CYP1A2 gene variant, and people with known cardiovascular risks. If any of these groups repeatedly consume a second cup or an empty stomach during this period of day, they could see negative cumulative effects, he warned. "Repeated stimulation might stress the system over time," Runge warned. But, moderate caffeine use 'doesn't increase cardiovascular risk' and there are major benefits to drinking coffee. A recent study found it helped women age better. Between two to four cups of coffee a day should be safe. An eight-ounce cup contains close to 100 milligrams of caffeine. The U.S. Food and Drug Administration recommends no more than 400 milligrams of caffeine daily for adults. Notably, decaffeinated coffees are not caffeine free and everyone responds to caffeine differently. Beyond that — especially on an empty stomach — risks may increase. 'When your cortisol levels stay elevated, you're at an increased risk for weight gain, diabetes, heart problems and other health concerns,' dietitian Anthony DiMarino said. Eat well and regularly. Talk a short walk and make sure to stay hydrated — with water! "Dehydration often mimics fatigue," Runge noted.