TriLink BioTechnologies® and Quantoom Biosciences Sign License and Supply Agreement for CleanCap® mRNA Capping Technology
SAN DIEGO--(BUSINESS WIRE)-- TriLink BioTechnologies (TriLink®), a Maravai® LifeSciences company (NASDAQ: MRVI) and global provider of life science reagents and services, has signed a non-exclusive License and Supply Agreement with Quantoom Biosciences, a full-stack RNA partner for mRNA- and saRNA-based vaccines and therapeutics. Under the agreement, Quantoom will have access to TriLink's CleanCap® mRNA capping technology for integration in its Ntensify® (sa)mRNA production platform to help accelerate the RNA production process and make life-saving therapeutics and vaccines more accessible to patients worldwide.
"Strengthening global health against infectious diseases requires strong industry partnerships," said Becky Buzzeo, Chief Commercial Officer at Maravai.
TriLink's CleanCap technology produces optimal 5′ cap structures with over 95% efficiency, creating a co-transcriptional capping solution that dramatically improves mRNA yield and process time when compared to legacy capping methods. Under this agreement, TriLink will supply its patented CleanCap technology for use in Quantoom's (sa)mRNA production platform, allowing customers to benefit from the industry's leading capping technology to develop their unique (sa)mRNA drugs using the Ntensify platform through clinical development phases.
"Strengthening global health against infectious diseases requires strong industry partnerships," said Becky Buzzeo, Chief Commercial Officer at Maravai. "We're excited for the Quantoom production platform to incorporate TriLink's CleanCap reagents, a proven mRNA capping technology to deliver essential therapeutics and vaccines to nations with limited resources."
Since its debut in 2017, TriLink's CleanCap capping technology has transformed the mRNA capping industry and is used in the majority of all approved COVID-19 mRNA and saRNA vaccines.
'We are committed to making the RNA technology more accessible and scalable, and this partnership with TriLink is a key step toward that goal," said José Castillo, CEO of Quantoom Biosciences. "By integrating CleanCap analogs into our platform, we can further empower researchers and manufacturers to develop life-saving vaccines and therapeutics for communities in need."
About TriLink BioTechnologies
TriLink BioTechnologies, a Maravai LifeSciences company, is a global leader in nucleic acid and mRNA solutions. TriLink delivers unrivaled chemical and biological experience, CDMO services, and high-quality readymade and custom materials, including its patented CleanCap® mRNA capping technology. Pharmaceutical leaders, biotech disruptors, and world governments depend on TriLink to meet their greatest challenges, from delivering the COVID-19 vaccine at warp speed, to empowering innovative treatments in oncology, infectious diseases, cardiology, and neurological disorders, to enabling future pandemic response plans. For more information about TriLink, visit trilinkbiotech.com
About Maravai LifeSciences
Maravai is a leading life sciences company providing critical products to enable the development of drug therapies, diagnostics and novel vaccines. Maravai's companies are leaders in providing products and services in the fields of nucleic acid synthesis and biologics safety testing to many of the world's leading biopharmaceutical, vaccine, diagnostics, and cell and gene therapy companies.
For more information about Maravai LifeSciences, visit www.maravai.com.
About Quantoom Biosciences
Quantoom Biosciences is a full-stack RNA partner for mRNA- and saRNA-based vaccines and therapeutics. Its N-Force TM toolbox relies on 3 core elements to turn any antigen into a (sa)mRNA-LNP drug product: Ncode TM for sequence design and optimization, Ntensify ® for RNA production and Ncapsulate ® for RNA-LNP formulation. Launched in 2023, the Ntensify solution enables fully integrated, scalable RNA production by combining processes, equipment, reagent mixes, and disposables and has gained global adoption, being recognized for performance and ease-of-use. Beyond technology, Quantoom Biosciences assists its partners by providing extensive enabling solutions, ranging from strategic R&D partnerships to sequence design & optimization.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
an hour ago
- Yahoo
Lululemon Athletica Inc (LULU) Q1 2025 Earnings Call Highlights: Strong Revenue Growth and ...
Total Revenue: Increased 7% or 8% on a constant currency basis to $2.4 billion. Gross Margin: Increased 60 basis points to 58.3%. Earnings Per Share (EPS): $2.60, ahead of expectations. Share Repurchases: $430 million worth of stock repurchased. Net Income: $315 million. Operating Income: $439 million or 18.5% of net revenue. Cash and Cash Equivalents: Approximately $1.3 billion. Store Count: Ended the quarter with 770 stores globally. Comparable Sales: Increased 1% overall. Regional Revenue Growth: Americas: Increased 3% or 4% in constant currency. China Mainland: Increased 21% or 22% in constant currency. Rest of World: Increased 16% or 17% in constant currency. Warning! GuruFocus has detected 3 Warning Signs with BRZE. Release Date: June 05, 2025 For the complete transcript of the earnings call, please refer to the full earnings call transcript. Lululemon Athletica Inc (NASDAQ:LULU) reported a 7% increase in total revenue for Q1 2025, or 8% on a constant currency basis, reaching $2.4 billion. Gross margin improved by 60 basis points to 58.3%, driven by lower product costs and improved markdowns. The company continued its share repurchase program, buying back $430 million of stock, demonstrating confidence in its long-term prospects. Revenue in China Mainland increased by 22% in constant currency, showcasing strong growth in this key market. Lululemon Athletica Inc (NASDAQ:LULU) maintained its full-year revenue guidance, expecting 7% to 8% growth, indicating confidence in its strategic initiatives. The U.S. market showed only a 2% revenue growth, with consumers remaining cautious and intentional about their buying decisions. The company anticipates a 110 basis point decrease in gross margin for the full year due to increased tariffs. SG&A expenses increased to 39.8% of net revenue, up from 38.1% last year, driven by FX revaluation losses. Operating margin decreased to 18.5% from 19.6% in Q1 2024, reflecting increased costs and strategic investments. Lululemon Athletica Inc (NASDAQ:LULU) expects a decline in operating margin by approximately 160 basis points for the full year, primarily due to tariffs and increased markdowns. Q: Can you expand on the mitigation efforts for tariffs and what you're thinking about regarding price increases and diversifying sourcing? Also, any category trends in the U.S. business with the newness offered? A: Meghan Frank, CFO, explained that the mitigation efforts include strategic price increases on a small portion of the assortment and pursuing efficiency actions in sourcing. Calvin McDonald, CEO, noted that the newness is balanced across activity and lifestyle categories, with strong responses to new products like the Daydrift trouser and Align No Line. Q: Could you elaborate on the comp drivers and any updates on the progression of the quarter? A: Meghan Frank, CFO, stated that there was a decline in store traffic, particularly in the U.S., but conversion trends remained consistent, and there was an uptick in average dollars per transaction. The progression from April into May showed no material changes. Q: Why not do more with price to offset tariffs, and is the bigger disconnect between top and bottom line mostly due to tariffs? A: Meghan Frank, CFO, confirmed that the decline in operating margin guidance is driven by the net impact of tariffs, with some offsets from pricing and supply chain efficiencies. There are no meaningful changes in expense posture, and strategic pricing is being considered based on elasticities. Q: Can you elaborate on the slight increase in markdowns now contemplated in the full-year outlook? A: Meghan Frank, CFO, mentioned that markdowns were down 10 basis points in Q1, but given consumer confidence and macroeconomic concerns, a slight increase in markdowns is anticipated for the second half of the year, in the range of 10 to 20 basis points above last year. Q: Given the success of new launches, what are your thoughts on returning the U.S. business to sustainable comp growth? A: Calvin McDonald, CEO, expressed confidence in the newness and innovation, noting that the U.S. consumer remains cautious. The company is gaining market share in the premium activewear segment, and the newness is resonating well with consumers. For the complete transcript of the earnings call, please refer to the full earnings call transcript. This article first appeared on GuruFocus. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
an hour ago
- Yahoo
Docusign Inc (DOCU) Q1 2026 Earnings Call Highlights: Strong Revenue Growth and Strategic Shifts
Revenue: $764 million, up 8% year over year. Subscription Revenue: $746 million, up 8% year over year. Gross Margin: Non-GAAP gross margin at 82.3%. Operating Margin: Non-GAAP operating margin at 29.5%, a 100-basis point improvement year over year. Free Cash Flow: $228 million, representing a 30% margin. Billings: $740 million, up 4% year over year. Net Retention Rate: Increased to 101% from 99% in Q1 2025. Customers: Over 1.7 million total customers, with 10% year-over-year growth. Large Customers: 1,123 customers spending over $300,000 annually, a 6% increase year over year. International Revenue: 28% of total revenue, grew 10% year over year. Non-GAAP EPS: $0.90, up from $0.82 last year. GAAP EPS: $0.34, up from $0.16 last year. Share Buybacks: $183 million repurchased in Q1, with $1.4 billion in repurchase authorization available. Warning! GuruFocus has detected 5 Warning Signs with BBCP. Release Date: June 05, 2025 For the complete transcript of the earnings call, please refer to the full earnings call transcript. Docusign Inc (NASDAQ:DOCU) reported strong Q1 financial performance with revenue of $764 million, an 8% growth year-over-year, surpassing expectations. The company achieved a 30% free cash flow margin, supporting continued share repurchases and authorizing an additional $1 billion in buybacks. Docusign Inc (NASDAQ:DOCU) introduced new AI-powered capabilities across the agreement lifecycle, enhancing its Intelligent Agreement Management (IAM) platform. The IAM platform has become the fastest-growing offering in Docusign Inc (NASDAQ:DOCU)'s history, with over 10,000 customers and significant international growth. Gross retention and dollar net retention improved year-over-year, indicating strong customer retention and engagement. Billings growth ended slightly below guidance due to lower-than-expected early renewals, attributed to timing rather than demand. The company experienced a reduction in early renewals sooner than anticipated, impacting Q1 billings. Docusign Inc (NASDAQ:DOCU) faces challenges in expanding its enterprise business, with a focus on replicating its commercial success. International revenue growth was impacted by lower-than-expected expansion rates, particularly in EMEA. The company is undergoing foundational go-to-market changes, which have introduced some short-term disruption. Q: Can you explain the go-to-market transition and its impact on early renewals and billings growth? A: Allan Thygesen, CEO, explained that changes were made to sales compensation to encourage reps to hold deals in the quarter, which led to lower early renewals than anticipated. This was expected to occur over the year but happened predominantly in Q1. Despite this, the business remains healthy with strong IAM progress, and revenue outlook is maintained or increased. Q: How do you feel about the broader health of the business and the IAM upsell opportunity? A: Allan Thygesen, CEO, expressed confidence in the IAM upsell opportunity, noting strong product market fit in the commercial segment and good adoption internationally. The core eSignature business remains healthy with improving dollar net retention and consumption metrics, indicating a positive trajectory. Q: What gives you confidence in the second half billings growth acceleration? A: Allan Thygesen, CEO, stated that the company always assumed an acceleration in the second half, driven by the scaling of the commercial business globally. The assumption of low early renewals in Q1 is expected to be maintained, and the enterprise contribution is expected to grow more significantly in fiscal '27 and beyond. Q: How are the go-to-market changes affecting sales capacity and IAM adoption? A: Allan Thygesen, CEO, explained that changes were made to allow sales reps to focus on higher-value prospects by moving customers to a self-serve model, freeing up capacity without expanding the team. This is expected to lead to larger deals and more enterprise-type sales motions, with early positive results. Q: Can you provide context on IAM's impact on subscription book of business and its pricing strategy? A: Blake Grayson, CFO, noted that IAM is becoming a larger share of new deals and is primarily an upsell opportunity for existing customers. The pricing reflects the additional value provided, and customers are willing to pay a premium for the enhanced features and capabilities. For the complete transcript of the earnings call, please refer to the full earnings call transcript. This article first appeared on GuruFocus. Sign in to access your portfolio
Yahoo
an hour ago
- Yahoo
ServiceTitan Inc (TTAN) Q1 2026 Earnings Call Highlights: Record Revenue Growth and Strategic ...
Gross Transaction Volume (GTV): $17.7 billion, up 22% year over year. Total Revenue: $215.7 million, up 27% year over year. Subscription Revenue: $162.7 million, up 29% year over year. Usage Revenue: $45.3 million, up 22% year over year. Platform Revenue: $208 million, up 27% year over year. Professional Service Revenue: $7.7 million. Net Dollar Retention: Greater than 110% for the quarter. Platform Gross Margin: 79.7%, an improvement of over 300 basis points year over year. Total Gross Margin: 73.6%, up 390 basis points year over year. Operating Income: $16.2 million, with a record operating margin of 7.5%, an improvement of 560 basis points year over year. Free Cash Flow: Negative $22.3 million, better than negative $24.6 million for the prior-year first quarter. Q2 Revenue Guidance: $228 million to $230 million. Q2 Operating Income Guidance: $17 million to $18 million. Full Year 2026 Revenue Guidance: $910 million to $920 million. Full Year 2026 Operating Income Guidance: $54 million to $59 million. Release Date: June 05, 2025 For the complete transcript of the earnings call, please refer to the full earnings call transcript. ServiceTitan Inc (NASDAQ:TTAN) reported a 29% year-over-year growth in subscription revenue and a 27% increase in total revenue. The company achieved record operating margins, improving by 560 basis points year-over-year. ServiceTitan Inc (NASDAQ:TTAN) successfully launched several large strategic accounts, both residential and commercial, during the quarter. The company is seeing strong adoption of its Pro products, which are contributing significantly to subscription revenue growth. ServiceTitan Inc (NASDAQ:TTAN) is making significant progress in expanding its enterprise capabilities and entering new markets, such as commercial and roofing. ServiceTitan Inc (NASDAQ:TTAN) reported a negative free cash flow of $22.3 million for the quarter. The company faces potential risks from economic uncertainties, including tariffs and supply chain inflation, which could impact customer growth. There is a dependency on weather patterns for Q2 performance, which introduces variability in revenue outcomes. ServiceTitan Inc (NASDAQ:TTAN) is still in the early stages of penetrating the commercial market, indicating a long path to full market capture. The company has to manage the timing of expenses carefully, as Q1 expenses were more favorable than in prior years, which may not be sustainable. Q: How might tariffs impact ServiceTitan's business, particularly in terms of equipment servicing opportunities and transaction volumes? A: Ara Mahdessian, CEO, explained that while tariffs could lead to supply chain inflation, ServiceTitan's customers have historically managed to pass through rising costs. The company remains prudent in forecasting Gross Transaction Volume (GTV) due to macroeconomic uncertainties. Q: Can you elaborate on the stacking S-curve strategy and its role in driving growth? A: Vahe Kuzoyan, President, emphasized the company's focus on enterprise, commercial, Pro products, and roofing as the primary areas of growth. While there are additional opportunities, the current focus remains on these key areas to drive durable growth. Q: What seasonal trends does ServiceTitan typically observe in the first half of the year, and how do Pro products contribute to growth? A: Dave Sherry, CFO, noted that Q2 is seasonally strong due to trades like HVAC and landscaping, making it sensitive to weather. Pro products are the fastest-growing segment, significantly contributing to subscription revenue growth. Q: What progress has ServiceTitan made in the commercial sector, and what is the current penetration rate? A: Ara Mahdessian highlighted successful commercial go-lives and ongoing development of project management capabilities. Vahe Kuzoyan added that the company is still in the early stages of penetrating the commercial market, with significant opportunities ahead. Q: How does ServiceTitan approach entering new trades, and are there opportunities beyond the current focus areas? A: Vahe Kuzoyan stated that while there are broader verticals that could use ServiceTitan, the company prioritizes focused areas like enterprise and commercial. Opportunistic deals are considered if there's a high degree of conviction in their success. Q: How does ServiceTitan plan to leverage AI and digital agents to drive efficiencies for customers? A: Vahe Kuzoyan explained that AI is integrated across the platform to automate tasks and enhance productivity, particularly in back-office operations and fieldwork, providing a competitive advantage. Q: What impact do home equity loan applications have on ServiceTitan's business, and is there potential for larger projects? A: Vahe Kuzoyan noted that increased home equity loan applications could drive more home projects, but the magnitude of impact is uncertain at this point. Q: What factors contributed to the strong gross margin performance in Q1, and what can be expected going forward? A: Dave Sherry attributed the gross margin improvement to scale and product selection, with a significant portion due to customer success management reclassification. Margins are expected to remain stable throughout the year. For the complete transcript of the earnings call, please refer to the full earnings call transcript. This article first appeared on GuruFocus.
