logo
Mounjaro weight loss jab: All you need to know

Mounjaro weight loss jab: All you need to know

Yahoo4 hours ago

GPs in England will be able to prescribe weight loss jabs for the first time on the NHS on Monday, as the health service begins its mass rollout.
Some 220,000 people with the 'greatest need' are expected to receive Mounjaro, also known as tirzepatide and made by Lilly, through the NHS over the next three years.
Here the PA news agency takes a look at the drug and the rollout.
– How does tirzepatide work?
Tirzepatide, or Mounjaro, is an antidiabetic drug which lowers blood sugar levels and slows down how quickly food is digested.
It makes you feel fuller for longer and therefore less hungry.
If the jab is recommended by a healthcare professional, those using it will need to eat a balanced, reduced-calorie diet and to exercise regularly while taking it, according to the NHS website.
– Who might be eligible for the drug?
In the first year of the programme, the drug will be offered to people with a body mass index (BMI) score of more than 40 who have at least four other health problems linked to obesity, such as type 2 diabetes; high blood pressure; heart disease; and obstructive sleep apnoea.
It was previously only accessible to patients through a special weight loss service, to severely obese people who also suffer from a range of other health problems.
Estimates suggest around 1.5 million people in the UK are already taking weight loss drugs, which may have been prescribed through specialist weight loss services or via private prescription.
– How would it be administered?
The drug is usually delivered through a self-administered weekly injection which a doctor or nurse will show patients how to use, the NHS website says.
– Who cannot take tirzepatide?
Mounjaro is not recommended for those who are pregnant or planning to get pregnant, breastfeeding or have certain health conditions, according to the NHS.
For those taking the contraceptive pill and using tirzepatide, the NHS recommends using an additional method of contraception, such as a condom, for the first four weeks of treatment and for four weeks after each dose increase as the contraceptive pill may not be absorbed by the body during this time.
– What are the potential side effects?
Potential side effects of tirzepatide include nausea, vomiting, diarrhoea and constipation, according to the National Institute for Health and Care Excellence.

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Colorectal cancer isn't an 'old person's disease,' advocates warn. A stage 4 cancer survivor shares 5 things you should never do if you want to avoid the disease
Colorectal cancer isn't an 'old person's disease,' advocates warn. A stage 4 cancer survivor shares 5 things you should never do if you want to avoid the disease

Yahoo

timean hour ago

  • Yahoo

Colorectal cancer isn't an 'old person's disease,' advocates warn. A stage 4 cancer survivor shares 5 things you should never do if you want to avoid the disease

Colorectal cancer is a serious health risk for many Canadians — including people under age 50. More than 25,200 people were diagnosed with colorectal cancer in 2024, making it the fourth most commonly diagnosed cancer in Canada last year. Now, advocates want all provinces and territories to lower the screening age for the disease to 45. "Our objective is to ensure that young Canadians do not ignore the signs and symptoms just because of their age and that they are aware of their family medical history and risk level, as we call on our provincial and territorial health ministries to lower the screening age for colorectal cancer throughout the country to 45," Barry Stein, president and CEO of Colorectal Cancer Canada, explains in a press release on Tuesday. This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Contact a qualified medical professional before engaging in any physical activity, or making any changes to your diet, medication or lifestyle. The non-profit adds that colorectal cancer might be perceived as an "old person's disease," but shares that early-onset colorectal cancer is on the rise and that cancer doesn't care about your age. Most new cases still occur in people age 50 and above, but Canadians born after 1980 are two to two-and-a-half times more likely to be diagnosed with colorectal cancer before age 50 compared to earlier generations. According Colorectal Cancer Canada, 26 people die from the illness everyday on average, with around 69 people receiving a diagnosis daily. For 2024, it was estimated that 9,400 Canadians died from colorectal cancer, making up 11 per cent of all cancer deaths last year. View this post on Instagram A post shared by Colorectal Cancer Canada (@coloncanada) Colorectal cancer cancer grows more slowly than some other cancer and can stay in the colon or rectum for months or even years. If left untreated, it can spread to other parts of the body, but if found early, colorectal cancer can often be cured. This is why Stein points out that colorectal cancer can be preventable through lifestyle choices, awareness of symptoms and early screening. In 1995, while juggling the demands of his legal career, Stein began noticing various concerning symptoms. Those included blood in his stool, migraines, abdominal pain and nausea, which he dismissed as related to stress. "I was turning 41 at the time and had no idea what cancer even was," Stein recalls in a previous interview with Yahoo Canada. "People didn't say that word so much in 1995, let alone colorectal cancer. These were symptoms that came and went, so I ignored them." It wasn't until he finally had a fecal occult blood test and colonoscopies that the diagnosis hit: Stage IV colorectal cancer, which had spread to his liver and lungs. Still, Stein stresses a person's health doesn't have to get to this point; he shares five things Canadians should and shouldn't do to help prevent colorectal cancer. Unexplained changes in bowel habits, blood in the stool, persistent abdominal pain, unexplained weight loss or fatigue should never be symptoms you ignore. These signs might also be linked to other gastrointestinal conditions, including ulcers, Crohn's disease or hemorrhoids, according to the Colorectal Cancer Canada website. That means "just because you have these symptoms doesn't mean you have colon cancer," Stein adds. "But they are a reason to be checked out." Regular screenings are important because colorectal cancer often develops from precancerous polyps, or growths in the colon or rectum. Catching and removing these polyps early can prevent them from becoming cancerous. Starting at age 50, you should undergo routine fecal occult blood tests and colonoscopies. Even though everybody has the right to get screened starting at age 50, the Canadian Partnership Against Cancer states the "screening participation rate across the country is still below the national target of 60 per cent." Despite this, Colorectal Cancer Canada highlights that the screening guidelines have effectively reduced cancer rates in those over age 50, demonstrating their life-saving potential. However, there is a rise in cases among younger adults, particularly those with a family history of colorectal cancer, Stein notes. These individuals are often diagnosed at a later stage because they are not getting screened and health-care professionals may not suspect cancer at a young age. If you're under 50 and experiencing related symptoms, or have a family history of colorectal cancer or polyps, you may need to start screening early. "Speak to your doctor about your personal testing plan," the organization advises. The Foods That Fight Cancer program by Colorectal Cancer Canada recommends eating a diet rich in whole grains, fruits and vegetables. These foods are high in fibre, which helps keep the digestive system healthy and can lower the risk of colorectal cancer. In addition to these foods, the program advises limiting the intake of processed meats and red meat, which are associated with a higher risk of colorectal cancer. It also recommends reducing the amount of alcohol and sugary beverages you drink. Highly processed foods should be minimized as well. By making these dietary changes, the risk of developing colorectal cancer can be minimized, Stein points out. Incorporate regular exercise into your routine, as physical inactivity is a significant risk factor for colorectal cancer. Stein highlights, "Having a sedentary lifestyle, in other words, being a couch potato, is a risk factor." Staying active not only helps maintain a healthy weight but also reduces the risk of colorectal cancer. According to Colorectal Cancer Canada, regular physical activity can lower the risk by improving bowel function and reducing inflammation. Discuss your family history of colorectal cancer with a health-care provider so you understand the risk. If you have a first-degree relative — such as a parent, sibling or child — who's had colorectal cancer, your risk is higher. Shared genetics and lifestyle factors contribute to this increased risk, according to Colorectal Cancer Canada. Moreover, genetic syndromes like Lynch syndrome (hereditary nonpolyposis colorectal cancer) can elevate your risk further. People with Lynch syndrome are more likely to develop colorectal cancer, often at a younger age. Other inherited conditions, like familial adenomatous polyposis (FAP), which causes numerous polyps in the colon and rectum, also heighten the risk. "Your age and generic history of your family are risk factors that you can't control," Stein says, adding the goal is to focus on what can be controlled, like eating healthier foods and exercising. Prevention is often more straightforward than treatment, which can be invasive and challenging. As Stein states, "it's so much easier to prevent something (than to treat it)." "All you have to do is get a kit, poop in your toilet, send it to the lab with a little stick and you find out if it's positive," Stein explains. If it does turn out positive, you would then go for a colonoscopy so that the polyp can be located. "If there is a polyp, they remove it and you catch the cancer early. Otherwise, you go through what I went through, which is quite challenging, to say the least. And at worst, people die." By focusing on early screening and prevention, potential issues can be caught early before developing into cancer, ultimately saving lives and reducing the burden of treatment.

Why nightmares could make you age faster and die sooner
Why nightmares could make you age faster and die sooner

Yahoo

time2 hours ago

  • Yahoo

Why nightmares could make you age faster and die sooner

Frequent nightmares are linked to premature ageing and increase the risk of an early death, according to a new study. Adults who report weekly nightmares are more than three times likely to die before the age of 70 compared to those who rarely or never experience them, researchers found. The study found nightmares to be a 'stronger predictor of premature death' than smoking, obesity, poor diet, and low physical activity. The scientists warned the findings should be treated as a 'public health concern', but said people can reduce nightmares by managing stress. The team, led by Dr Abidemi Otaiku of the UK Dementia Research Institute, and Imperial College London, analysed data from 2,429 children aged eight to 10 and 183,012 adults aged 26 to 86 over a period of 19 years. The research, presented at the European Academy of Neurology (EAN) Congress this month, found that nightmares disrupt both sleep quality and duration, which impairs the body's overnight cellular restoration and repair ability. The combined impacts of chronic stress and disrupted sleep are likely to contribute to the accelerated ageing of our cells and bodies. Dr Otaiku said, 'Our sleeping brains cannot distinguish dreams from reality. That's why nightmares often wake us up sweating, gasping for breath, and with our hearts pounding – because our fight-or-flight response has been triggered. This stress reaction can be even more intense than anything we experience while awake.' He said: 'Nightmares lead to prolonged elevations of cortisol, a stress hormone closely linked to faster cellular ageing. For those who frequently experience nightmares, this cumulative stress may significantly impact the ageing process.' He added: 'Given how common and modifiable nightmares are, they should be taken far more seriously as a public health concern.' Researchers found that children and adults who had frequent nightmares also exhibited faster ageing. This accounted for approximately 40 per cent of those who had a higher risk of early death. Dr Otaiku said this was the first study to show nightmares can predict faster biological ageing and earlier mortality, even after accounting for other health issues. Even monthly nightmares were linked to faster ageing and increased mortality compared to those who had no nightmares. and the links were consistent across all ages, sexes, ethnicities, and mental health statuses. 'The good news is that nightmares can be prevented and treated,' said Dr Otaiku. Simple measures, such as maintaining good sleep hygiene, managing stress, seeking treatment for anxiety or depression and not watching scary films can be effective in reducing nightmares, he said.

Could Ketamine on the NHS help treat severe depression?
Could Ketamine on the NHS help treat severe depression?

Yahoo

time2 hours ago

  • Yahoo

Could Ketamine on the NHS help treat severe depression?

Ketamine is increasingly known as a party drug which is linked to serious health problems, even fatalities. But there is growing interest in Scotland in its potential to treat severe depression. One NHS Lothian psychiatrist hopes to set up a clinic by the end of the year offering the Category B drug as an alternative to electroconvulsive therapy (ECT), a treatment that involves sending an electric current through the brain. Prof Andrew McIntosh thinks it could offer another alternative to patients with the most hard-to-treat depression. The move comes after a private clinic in Lanarkshire began offering ketamine assisted therapy to clients with treatment-resistant depression last summer. The Eulas clinic in Hamilton opened under licence from Healthcare Improvement Scotland in September and charges £6,000 for a programme of four intravenous ketamine infusions and a course of psychotherapy. Ketamine is a medical anaesthetic and while it is not licensed for the routine treatment for depression, it can be used 'off-label' by doctors and psychiatrists. Alex, who recently moved to Scotland from the United States, is one of 12 people being treated at the clinic. She has experienced periods of depression and anxiety and says she turned to ketamine assisted therapy when traditional treatments didn't help. "I was crying all day long while I was working, and was very resistant to doing anything new," the 40-year-old said. Ketamine, which is illegal on the streets, has nevertheless been used as a recreational drug for years because of its detached, dream-like effects. "I definitely had a psychedelic experience," Alex said. "You would see images, kind of feel like you're floating sometimes. "If you're reclined, you might feel like you're floating into different spaces for example. Or like you're going down a waterslide." Alex believes the infusions made her more receptive to psychotherapy. "I think it makes it more palatable almost," she says. "You may see an image and you'll remember this image and then you'll talk to your therapist and they'll say: 'That's interesting, why do you think you saw that? What does that represent to you?" Alex had already tried ketamine therapy in the United States before being treated in Scotland and thinks it should be more widely available here. "Before, I was really depressed," she said "Now I feel like I'm doing pretty well. I am active, I am trying new things, traveling again, kind of getting back to the person I felt like I used to be." Sean Gillen, the director of the Eulas clinic, says patients must have a diagnosed condition and be assessed by a psychiatrist to qualify for treatment. He admits the cost of ketamine assisted therapy may be out of reach for many and hopes it will soon be available on the NHS. "You're dealing with psychiatrists, anaesthetists, psychotherapists – these are real professional people and they need to be paid," he said. "Most people don't have that kind of money and that's why we'd like to enter a partnership with the NHS." Ketamine is licensed as an anaesthetic but has hit the headlines for its recreational use. It can cause serious and sometimes permanent damage to the bladder, alongside a range of other complications if misused. It was linked to the death of RuPaul's Drag Race UK star The Vivienne earlier this year. And a coroner found Friends actor Matthew Perry died of the 'acute effects of ketamine' in 2023. Esketamine, a form of ketamine taken as a nasal spray, has been approved for the treatment for moderate to severe treatment-resistant depression in Scotland but intravenous ketamine has not, though it can be prescribed 'off-label'. The Royal College of Psychiatrists has previously urged caution over the use of ketamine therapy but it is due to publish a new report on psychedelics later this year, with updated information on ketamine. Andrew McIntosh, a professor of psychiatry at the University of Edinburgh and an NHS psychiatrist, hopes to set up a ketamine clinic at the Royal Edinburgh Hospital by the end of the year. It would be offered to patients with the most hard-to-treat depression, as an alternative to ECT. He said: "Even after taking multiple antidepressants and multiple different treatments, there's a small number of people who don't respond very well to any of those treatments, so ketamine gives them additional hope and it's been shown to be effective. "And it's an extra thing we could be doing to help our patients that is not currently available widely in Scotland." Prof McIntosh said it is not clear exactly how ketamine works to treat depression. He said: "Some people think it's because the brain becomes more plastic, more able to adapt. "Some people think it's because it alters the connections between different parts of the brain. "I think it's fair to say we don't fully understand how all the pieces of the jigsaw fit together and why it's effective, although we know it's very effective." He said the ketamine used to treat depression is very different to what people might take illegally. "The ketamine that's given in clinical services is going to be a very pure form of the drug," he said. "It's going to be given under very controlled circumstances, and we are going to know that it's only the drug that's in the preparation, it's not the other things that are sometimes taken by people who use it recreationally. "The dose of the drug that is given for depression is also far, far lower than people use recreationally, so we think the risks of that are much, much lower than they are when it's taken in the community." NHS Lothian said it was considering the use of intravenous ketamine as an alternative to ECT, but no decision had been made. Tracey Gillies, executive medical director at NHS Lothian, said recent international studies suggested that the use of IV ketamine may be a cost-effective alternative to ECT. She said the introduction of any new service had to be carefully considered, with patient safety and cost factors among those to be managed. Dr Anna Ross, a lecturer in health and social policy at the University of Edinburgh and co-founder of Scottish Psychedelic Research Group, has carried out research with the Eulas clinic. She is interested in the potential for ketamine to treat depression and addiction problems but believes psilocybin, a Category A drug found in so-called magic mushrooms, could be more effective. She said: "I've been involved in drugs policy and drugs using communities now for about 20 years, and ketamine in and of itself has not been a substance I've known to be a positive substance as such, but it's really come to the fore in the UK because we don't have access to psilocybin. "So therefore clinics like the Eulas clinic and NHS facilities are starting to look at ketamine because it already has a scheduling and it can already be used for psychedelic therapy." A Scottish government spokesman said: "Decisions on whether to prescribe a medicine are a matter for the prescribing clinician based on individual patient need and in consultation with the patient, informed by advice and guidance about the medicine."

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store