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BBC News
31 minutes ago
- BBC News
The world is getting hotter – this is what it is doing to our brains
As heatwaves become more intense with climate change, scientists are racing to understand how extreme heat changes the way our brains work. When Jake was five months old, he had his first tonic-clonic seizure, his little body stiffening and then jerking rapidly. "It was extremely hot, he had overheated and we witnessed what we thought would be the scariest thing we would ever see," says his mother, Stephanie Smith. "Unfortunately, it wasn't." Seizures began to crop up often in hot weather. As soon as the stifling, humid days of summer would arrive, the family would resort to all kinds of cooling methods and a fierce battle to keep the seizures at bay would ensue. Following a genetic test at the age of 18 months, Jake was diagnosed with Dravet Syndrome, a neurological condition that includes a form of epilepsy and affects around one in 15,000 children. Seizures are often accompanied by intellectual disability and a range of comorbidities such as autism and ADHD, as well as difficulties with speech, mobility, eating and sleep. Heat and sudden temperature changes can bring on a seizure. Jake is now 13 years old, but has endured countless seizures with the turn of the weather, his mother says. "Increasingly hot summers and heatwaves are adding to the burden of living with this already devastating condition," says Smith. Dravet Syndrome is just one of many neurological diseases that are exacerbated by higher temperatures, says Sanjay Sisodiya of University College London and a pioneer in the field of climate change's impact on the brain. A neurologist who specialises in epilepsy, he frequently heard from patients' families that they had more troubles during heatwaves. "And I thought to myself, of course, why shouldn't climate change also affect the brain? After all, so many processes in the brain are involved in how the body copes with heat." As he dug into the scientific literature, he discovered a range of neurological conditions that are made worse by rising heat and humidity, including epilepsy, stroke, encephalitis, multiple sclerosis, migraine, along with a number of others. He also discovered that the effects of climate change on our brains are already becoming visible. During the 2003 European heatwave, for example, about 7% of the excess deaths involved direct neurological problems. Similar figures were also seen during the 2022 UK heatwave. So, as the world warms due to climate change, what can we expect the effect on our brains to be? The human brain is, on average, rarely more than 1C (1.8F) higher, on average, than our core body temperature. Yet our brains – as one of the more energy-hungry organs in our bodies – produce a fair amount of their own heat when we think, remember and respond to the world around us. This means our bodies have to work hard to keep it cool. Blood circulating through a network of blood vessels helps to maintain its temperature, whisking away excess heat. This is necessary because our brain cells are also extremely heat sensitive. And the function of some of the molecules that pass messages between them are also thought to be temperature dependent, meaning they stop working efficiently if our brains get too hot or too cold. "We don't fully understand how the different elements of this complicated picture are affected," says Sisodiya. "But we can imagine it like a clock, where all the components are no longer working together properly." Although extreme heat alters how everyone's brains work – it can, for example, adversely affect decision making and lead to people taking greater risks – those with neurological conditions are often the most severely affected. This is for many reasons. For example, in some diseases, perspiration may be impaired. "Thermoregulation is a brain function and can be disrupted, if certain parts of the brain are not functioning properly," says Sisodiya. In some forms of multiple sclerosis, for instance, the core body temperature appears to be altered. In addition, some drugs that treat neurological and psychiatric conditions such as schizophrenia affect temperature regulation, leaving those taking them more vulnerable to heatstroke, or hyperthermia as it is known medically, and at a greater risk of heat-related death. Heatwaves – and elevated nighttime temperatures especially – can affect people's sleep, affecting our mood and potentially worsening the symptoms of some conditions. "For many people with epilepsy, poor sleep can increase the risk of having seizures," says Sisodiya. Evidence suggests that hospital admissions and mortality rates among people with dementia also increase during heatwaves. Part of this may be due to age – older people are less able to regulate their body temperature – but their cognitive impairment may also mean they are less able to adapt to extreme heat. They may not drink enough, for example, or forget to close the windows, or go out into the heat when they shouldn't. Rising temperatures have also been linked to an increase in stroke incidents and mortality. In one study that analysed stroke mortality data from 25 countries, researchers found that out of 1,000 deaths from ischemic stroke, the hottest days contributed two excess deaths. "That may not seem like a lot," says Bethan Davies, a geriatrician at University Hospitals Sussex, in the UK. "But given that there are seven million deaths from strokes a year worldwide, heat may well be contributing to over 10,000 additional stroke deaths per year." She and her co-authors warned that climate change is likely to exacerbate this in years to come. A disproportionate share of the burden of heat-related stroke will be in middle- and low-income countries, which are already most affected by climate change and experience the highest rates of stroke. "Rising temperatures will exacerbate health inequalities both between and within countries and social groups," says Davies. A growing body of evidence suggests that older people as well as those with a low socioeconomic position are at an increased risk for heat-related mortality. A hotter world is also harming the neurodevelopment of the very youngest. "There is a link between extreme heat and bad pregnancy outcomes such as premature births," says Jane Hirst, professor of global women's health at Imperial College London in the UK. One recent systematic review of the scientific research found that heatwaves are associated with a 26% increase in preterm births, which can lead to neurodevelopmental delays and cognitive impairments. "However, there is a lot we do not know," adds Hirst. "Who is most vulnerable and why? Because clearly, there are 130 million women who have babies every year, a lot of them in hot countries, and this does not happen to them." Excessive heat due to climate change may also put additional strain on the brain, leaving it more vulnerable to damage that can lead to neurodegenerative diseases. Heat also affects the barrier that normally protects the brain, making it more permeable and increasing the risk that toxins, bacteria and viruses can cross over into our brain tissue. This could become more important as temperatures increase, as so too will the spread of mosquitos that transmit viruses that can cause neurological disease, such as Zika, chikungunya and dengue. "The Zika virus can affect foetuses and cause microcephaly," says Tobias Suter, a medical entomologist at the Swiss Tropical and Public Health Institute. "Rising temperatures and milder winters mean that the mosquito breeding season begins earlier in the year and ends later." (Read David Cox's story on how the US's mosquito season is already changing.) Heatwaves are capable of influencing a whole range of factors, from the electrical firings of the nerve cells to suicide risk, climate anxiety and even the stability of medication for neurological conditions. But exactly how rising temperatures affect our brains are still being investigated by scientists. Heat affects people in very different ways – some thrive in hot weather, others find it unbearable. "Different factors might be relevant for this differential sensitivity, and one of them may be genetic susceptibility," says Sisodiya. Genetic variants could influence the structures of proteins that might render some people more vulnerable to the impacts of climate change. "There may be thermo-latent phenotypes that will only become apparent when those environmental pressures are sufficient to bring them out," he says. "What we're seeing today in people with neurological disorders could become relevant for people without neurological disorders as climate change progresses." There are still other questions that remain to be answered too. For example, is it the maximum temperature, is it the length of a heatwave or the nighttime temperature that has the greatest impact? It may well differ for each person or by neurological condition. But identifying who is at risk and why will be crucial to developing strategies to protect the most vulnerable. These could include early warning systems or insurance to compensate day labourers for lost wages due to extreme heat. "The era of global warming has ended, the era of global boiling has arrived," UN Secretary-General Antonio Guterres announced, when July 2023 was confirmed to be the hottest month on record. Climate change is here and it is intensifying. The era of the hot brain is just beginning. -- For trusted insights into better health and wellbeing rooted in science, sign up to the Health Fix newsletter, while The Essential List delivers a handpicked selection of features and insights. For more science, technology, environment and health stories from the BBC, follow us on Facebook and Instagram.
BBC News
31 minutes ago
- BBC News
Instagram sisters from Birmingham raising neurodiversity awareness
Two sisters have been supporting people living with neurodiversity and helping educate others through their new training company. Iveta Pudilova, 23, discovered she was neurodivergent after sister Vera was diagnosed with autism."I grew up non-verbal. I couldn't speak until I was about five years old and even now I experience verbal shutdown. So verbal communication can be a really difficult challenge, Iveta said. In 2019, Vera started documenting her experiences through drawings and reflections on Instagram. Iveta helped and the Birmingham sisters went on to found the National Neurodiversity Training company last year. By May, the company had delivered neurodiversity training to seven organisations and 350 people, helping them to understand how to better support is an umbrella term that includes a number of conditions including ASD, attention-deficit hyperactivity disorder (ADHD) and dyslexia. Iveta told the BBC her sister Vera's Instagram reflections were not intended to go viral, but her take on life soon gained traction. She explained her sister is "a very creative person" who made "content illustrations about her experience of being diagnosed... to connect with other autistic people". Iveta joined her and added: "We started an e-commerce [initiative], selling communication products like badges and cards, because a lot of neurodivergent people are non verbal." 'More productive' Badges and cards have helped neurodivergent people express themselves in public. One design reads: "I wear noise-cancelling headphones but I can still hear you."Iveta said they started e-commerce work "to empower other neurodivergent people".However, she added "the lack of neurodiversity awareness and support is impacting everyone, including companies, and so we transitioned to delivering neurodiversity training". Their company now works with organisations including the NHS and is behind training delivered in tech firms, universities and local project, in partnership with Birmingham Newman University and the NHS, involved training psychological and wellbeing practitioners to better support autistic patients. 'Looking to leave' "What we found is that neurodiverse teams are about 30% more productive when they have the right support," Iveta said. "But 50% of neurodivergent staff are... looking to leave their employer because of a lack of support."She said in the work with the NHS, they addressed "diagnostic bias", which she explained was essentially when a practitioner diagnosing someone "might have personal biases". The company was invited to deliver staff training "on recognising their own biases, addressing them, but then also tailoring their therapy services and support to their autistic patients". Iveta added: "In the last year we've seen kind of the corporate world take up neurodiversity a lot more because there's more demand both internally, and [from] society pressures." Follow BBC Birmingham on BBC Sounds, Facebook, X and Instagram.
Daily Mail
31 minutes ago
- Daily Mail
Britons to receive Elon Musk's brain chips in new clinical trial - as paralysed woman reveals the implant's shocking effects
British patients are set to receive Elon Musk 's Neuralink brain chips as part of the first UK clinical trial. Neuralink is partnering with University College London Hospitals Trust and Newcastle Hospitals for the project, the company said in an announcement. Seven participants who cannot walk will be fitted with an implant about the size of a 10p coin, allowing them to control a smartphone with their mind. Those living with paralysis due to conditions such as spinal cord injuries and a nervous system disease called amyotrophic lateral sclerosis qualify for the study, the company revealed in a post on X. This comes after a paralysed woman in the US revealed the shocking effect the brain implant has already had on her life. Audrey Crews, who has been paralysed since she was 16, became one of five people in the US who have already been implanted with the brain chip. Speaking on X, Ms Crews revealed how she was now able to write her signature for the first time since losing the use of her legs and arms in a car accident. Ms Crews said: 'I tried writing my name for the first time in 20 years. I'm working on it.' Neuralink's N1 Chip, known as a brain-computer-interface (BCI), is a small implant which links the human brain to a computer through 128 threads thinner than a human hair. Each thread contains 1,000 electrodes, which are inserted into the surface of the brain to read spikes in electrical activity. Those signals are recorded and sent to a computer, which converts them into commands for common devices such as moving a cursor or clicking. According to Neuralink, the chip can 'restore digital autonomy to individuals with severe paralysis by enabling them to control devices with their thoughts '. Participants in the UK trial will have their implants inserted by a robotic surgeon at London's UCLH National Hospital for Neurology and Neurosurgery. Professor Harith Akram, a consultant neurosurgeon at University College London and chief investigator for the study, said the trial 'represents a major milestone in the development of brain-computer interface technology, with the potential to transform the lives of people living with severe neurological disorders worldwide.' After resolving safety concerns flagged by the US Food and Drug Administration, Neuralink began US clinical trials in 2023. Noland Arbaugh, 30, a quadriplegic from Arizona, became the first person to receive the Neuralink brain chip. The implant allowed Mr Arbaugh to write, play chess, and even enjoy complicated video games. Although many of the electrodes became disconnected from Mr Arbaugh's brain, Neuralink enabled him to maintain control by improving the software that reads brain signals. Similarly, Ms Crews has shared how receiving the brain implant has restored a level of autonomy she had long considered lost. At the age of 16, Ms Crews was severely injured in a car accident, which damaged the C4 and C5 vertebrae in her neck, leaving her a quadriplegic with no feeling in her arms and legs. However, after being implanted with the N1 chip in July, Ms Crews has shared her renewed ability to use a computer. In her posts on X following the surgery, Crews revealed how she has been able to draw pictures, write words, scroll with a mouse, and use a keyboard all through the power of her mind. Responding to the positive feedback she's received on social media, Crews said she felt liberated, and she's even started taking requests on what to draw next as the pictures act as practice for her while using the implant. 'Imagine your pointer finger is left click and the cursor [movement] is with your wrist, without physically doing it. Just a normal day using telepathy,' she explained while showing off her latest drawings. Mr Musk also replied to a post about Crews' story, saying: 'She is controlling her computer just by thinking. Most people don't realize this is possible.' The first female Neuralink patient noted that the BCI won't give her the ability to walk again or regain any movement in her limbs, but she is hoping this breakthrough will allow her to write a book about her journey. 'I've been a quadriplegic since the age of 16, so I have lots to tell,' Crews explained. Mr Musk, the CEO of SpaceX and Tesla, co-founded Neuralink in 2016 with a group of neuroscience, engineering, and robotics experts. Their goal was to merge human intelligence with artificial intelligence, treat brain disorders and potentially enhance human capabilities. The billionaire said in June that the chip technology had made 'an incredible amount of progress'. But he emphasised the company's cautious approach, adding: 'The reason we're not moving faster than we are is because we're taking great care with each individual to make sure we never miss - and, so far, we haven't.' Elon Musk's Neuralink is working to link the human brain with a machine interface by creating micron-sized devices. Neuralink was registered in California as a 'medical research' company in July 2016, and Musk has funded the company mostly by himself. It is working on what Musk calls the 'neural lace' technology, implanting tiny brain electrodes that may one day upload and download thoughts. The technology is initially planned to be used to help people suffering from severe degenerative brain disorders such as ALS, but it could have wider uses in years to come.
