
Evolving face of Hepatitis
Hepatitis refers to inflammation of the liver, a condition that can range from mild and self-limiting to severe and life-threatening. It is most commonly caused by viral infections — hepatitis A, B, C, D, and E viruses. However, this condition can also result from alcohol misuse, certain
medications, autoimmune disorders, or metabolic conditions.
Hepatitis A and E are typically short-term infections spread through contaminated food or water, while hepatitis B and C can become chronic, silently damaging the liver over years and leading to fibrosis (scarring of the liver), cirrhosis (permanent scarring), liver failure, or liver cancer if untreated. Globally, hepatitis B and C account for a majority of chronic liver disease and liver-related deaths.
Despite the availability of vaccines (Hepatitis A and B have vaccines) and highly effective treatments, a large proportion of those infected remain unaware of their condition due to the absence of symptoms in the early stages and lack of awareness about preventive measures.
India is now facing a silent liver health crisis driven by a convergence of metabolic, viral, and alcohol-related causes; many of which remain undiscovered until advanced stages. A growing number of hepatitis cases are being diagnosed with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). This condition is largely driven by sedentary lifestyles, poor diets, obesity, and type 2 diabetes — all hallmarks of modern urban living. MASLD represents a spectrum — from simple fat accumulation in the liver to more advanced inflammation and scarring, and eventually liver cancer.

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Time of India
4 hours ago
- Time of India
Liver cancer: 3 in 5 cases are preventable, experts reveal what we're doing wrong and how obesity is fueling the crisis
A new global study published in The Lancet has revealed a startling yet hopeful fact, three in five liver cancer cases are preventable. That's over 60% of all liver cancer diagnoses worldwide. As reported by The Times of India (TOI), experts are now calling for urgent action to tackle the root causes of the disease, particularly rising obesity, alcohol consumption, and viral hepatitis. The study comes at a critical time. In 2020 alone, more than 905,000 people were diagnosed with liver cancer and over 830,000 died of it. With liver disease on the rise across the world, researchers say the situation could get even worse unless global prevention strategies are put in place. Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program Published by The Lancet Oncology Commission, the report warns that if no major action is taken, liver cancer cases are expected to nearly double by 2050, from around 870,000 in 2022 to 1.52 million, with deaths rising to 1.37 million in the same period. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Join new Free to Play WWII MMO War Thunder War Thunder Play Now Undo However, the experts offer a silver lining. According to their findings, at least 60% of liver cancer cases are linked to modifiable risk factors, including chronic viral hepatitis (hepatitis B and C), alcohol use, and metabolic dysfunction-associated steatotic liver disease (MASLD), a long-term condition where fat builds up in the liver. A more severe form of MASLD, known as MASH, is expected to cause 35% more liver cancer cases by 2050. What are the leading causes of liver cancer? As quoted by TOI, Prof Hashem B El-Serag, from Baylor College of Medicine (USA), said, 'Liver cancer was once thought to occur mainly in patients with viral hepatitis or alcohol-related liver disease. However, today rising rates of obesity are an increasing risk factor... largely due to the rise in cases of excess fat around the liver.' Live Events He added that routine screening and early lifestyle interventions, especially among individuals with obesity, diabetes, or heart disease, could help reduce the risk. A shift in the disease's global pattern Experts pointed out a shift in what's causing liver cancer globally. MASLD now affects nearly a third of the global population, and although not everyone with MASLD will develop liver cancer, those who do often have the more severe MASH condition. More than 40% of liver cancer cases globally occur in China, largely due to high rates of hepatitis B. Meanwhile, Africa is expected to see the sharpest rise in new cases and deaths by 2050 due to population growth and ageing. What can be done The Commission has outlined a series of recommendations. These include: Expanding hepatitis B vaccine coverage Promoting healthier diets and lifestyle changes Public health policies to reduce alcohol use Introducing sugar taxes and clear food labelling According to The Lancet study, reducing liver cancer incidence by just 2–5% annually could prevent between 9 to 17 million cases and save up to 15 million lives by 2050. 'The time to act is now' As quoted by TOI, Prof Jian Zhou from Fudan University, Chair of the Commission, stressed, 'Liver cancer is one of the most challenging cancers to treat... Without urgent action, we risk seeing close to a doubling of cases and deaths over the next quarter of a century.' Prof Stephen Chan, first author of the report from the Chinese University of Hong Kong, added, 'As three in five cases of liver cancer are linked to preventable risk factors, there is a huge opportunity for countries to act and save lives.' And finally, Prof Valérie Paradis from Beaujon Hospital in France said, 'There is an urgent need to raise awareness... With joint and continuous efforts, many liver cancer cases can be prevented, and both survival and quality of life for patients can be considerably improved.'


Economic Times
4 hours ago
- Economic Times
Liver cancer: 3 in 5 cases are preventable, experts reveal what we're doing wrong and how obesity is fueling the crisis
Synopsis A recent Lancet study reveals that 60% of liver cancer cases are preventable, urging immediate action against rising obesity, alcohol consumption, and viral hepatitis. With diagnoses exceeding 905,000 in 2020, experts warn of a potential doubling of cases by 2050 without intervention. Liver cancer (Representative image) A new global study published in The Lancet has revealed a startling yet hopeful fact, three in five liver cancer cases are preventable. That's over 60% of all liver cancer diagnoses worldwide. As reported by The Times of India (TOI), experts are now calling for urgent action to tackle the root causes of the disease, particularly rising obesity, alcohol consumption, and viral study comes at a critical time. In 2020 alone, more than 905,000 people were diagnosed with liver cancer and over 830,000 died of it. With liver disease on the rise across the world, researchers say the situation could get even worse unless global prevention strategies are put in by The Lancet Oncology Commission, the report warns that if no major action is taken, liver cancer cases are expected to nearly double by 2050, from around 870,000 in 2022 to 1.52 million, with deaths rising to 1.37 million in the same the experts offer a silver lining. According to their findings, at least 60% of liver cancer cases are linked to modifiable risk factors, including chronic viral hepatitis (hepatitis B and C), alcohol use, and metabolic dysfunction-associated steatotic liver disease (MASLD), a long-term condition where fat builds up in the liver. A more severe form of MASLD, known as MASH, is expected to cause 35% more liver cancer cases by quoted by TOI, Prof Hashem B El-Serag, from Baylor College of Medicine (USA), said, 'Liver cancer was once thought to occur mainly in patients with viral hepatitis or alcohol-related liver disease. However, today rising rates of obesity are an increasing risk factor... largely due to the rise in cases of excess fat around the liver.' He added that routine screening and early lifestyle interventions, especially among individuals with obesity, diabetes, or heart disease, could help reduce the risk. Experts pointed out a shift in what's causing liver cancer globally. MASLD now affects nearly a third of the global population, and although not everyone with MASLD will develop liver cancer, those who do often have the more severe MASH condition. More than 40% of liver cancer cases globally occur in China, largely due to high rates of hepatitis B. Meanwhile, Africa is expected to see the sharpest rise in new cases and deaths by 2050 due to population growth and ageing. The Commission has outlined a series of recommendations. These include: Expanding hepatitis B vaccine coverage Promoting healthier diets and lifestyle changes Public health policies to reduce alcohol use Introducing sugar taxes and clear food labelling According to The Lancet study, reducing liver cancer incidence by just 2–5% annually could prevent between 9 to 17 million cases and save up to 15 million lives by quoted by TOI, Prof Jian Zhou from Fudan University, Chair of the Commission, stressed, 'Liver cancer is one of the most challenging cancers to treat... Without urgent action, we risk seeing close to a doubling of cases and deaths over the next quarter of a century.'Prof Stephen Chan, first author of the report from the Chinese University of Hong Kong, added, 'As three in five cases of liver cancer are linked to preventable risk factors, there is a huge opportunity for countries to act and save lives.'And finally, Prof Valérie Paradis from Beaujon Hospital in France said, 'There is an urgent need to raise awareness... With joint and continuous efforts, many liver cancer cases can be prevented, and both survival and quality of life for patients can be considerably improved.' Disclaimer: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.


Time of India
5 hours ago
- Time of India
Diseases caused by fatty liver: A guide to health risks and complications
Fatty liver disease, including non‑alcoholic fatty liver disease (NAFLD) or metabolic dysfunction‑associated steatotic liver disease (MASLD), occurs when fat accumulates in liver cells, often without obvious symptoms initially. Over time, this condition can progress to more serious diseases such as non‑alcoholic steatohepatitis (NASH/MASH), fibrosis, cirrhosis, and even hepatocellular carcinoma (liver cancer). Beyond liver‑specific conditions, fatty liver also increases risks of systemic diseases, including cardiovascular disease, type 2 diabetes, chronic kidney disease, and extrahepatic malignancies like colorectal cancer. From fatty liver to liver cancer: Health complications caused by fatty liver 1. Liver-specific diseases Non‑Alcoholic Steatohepatitis: When simple fat accumulation triggers inflammation and liver-cell injury, fatty liver may evolve into NASH (now often referred to as metabolic dysfunction-associated steatohepatitis, MASH), which amplifies the risk of scarring (fibrosis) and complications Fibrosis, cirrhosis, and liver failure: Persistent inflammation may lead to fibrosis and, over the years, irreversible cirrhosis, characterised by liver shrinkage, impaired function, jaundice, ascites, and possible liver failure requiring transplantation Liver cancer: Patients with NASH or cirrhosis have a notably higher risk of hepatocellular carcinoma, even sometimes in the absence of cirrhosis 2. Cardiovascular and metabolic diseases Cardiovascular Disease (CVD): Although fatty liver is a liver-related condition, most deaths in affected individuals stem from cardiovascular disease. NAFLD/MASLD promotes systemic inflammation, hypertension, and atherosclerosis, doubling the risk of heart attacks and strokes Type 2 diabetes & insulin resistance: Fatty liver impairs glucose regulation, contributing to insulin resistance and type 2 diabetes, which in turn exacerbates liver fat and inflammation, a vicious cycle Metabolic syndrome & dyslipidemia: NAFLD is closely linked to metabolic syndrome and abnormal lipid profiles, high triglycerides, high LDL, low HDL, which negatively impact overall metabolic health and cardiovascular risk 3. Extrahepatic complications beyond the liver Chronic Kidney Disease (CKD): The metabolic and inflammatory effects of NAFLD increase the risk of kidney damage. Advanced liver fibrosis is independently associated with kidney dysfunction and elevated cardiovascular and mortality risks. Extrahepatic malignancies: Individuals with NAFLD have an increased incidence of certain cancers beyond the liver, especially colorectal cancer, as well as possibly breast and prostate cancers related to fibrosis status Hormonal and endocrine disorders: Fatty liver is associated with endocrine imbalances such as polycystic ovarian syndrome (PCOS), hypothyroidism, and growth hormone deficiency, often due to common pathways involving insulin resistance and inflammation Other conditions Fatty liver patients may also be prone to gastroesophageal reflux disease (GERD), obstructive sleep apnea, periodontitis, and psychological dysfunction, reflecting multisystem involvement Also read | Symptoms of fatty liver on skin: What you should know