
Data Center Power Infrastructure Market Analysis Report 2025: Focus on Power Supply Architecture, AI Specific Data Center Requirements, Cloud Infrastructure, GaN Applications
DUBLIN--(BUSINESS WIRE)--May 21, 2025--
The 'Data Center Power Infrastructure Market - A Global and Regional Analysis: Focus on Power Supply Architecture, AI Specific Data Center Requirements, Cloud Infrastructure, GaN Applications' report has been added to ResearchAndMarkets.com's offering.
The Global Data Center Power Infrastructure Market is expanding rapidly as organizations modernize their IT environments, add AI-specific workloads, and adopt cloud and hyperscale designs.
By 2025, data centers will increasingly prioritize energy-efficient power distribution and supply architectures to handle higher rack densities, mitigate costs, and comply with sustainability mandates. Innovations in GaN-based power solutions, DC distribution, and advanced packaging (e.g., 3D stacking) are reshaping how data centers manage and convert power.
Looking further ahead, the drive to accommodate specialized compute (GPU servers, HPC clusters) will intensify the need for robust, flexible power systems. As more operators adopt green energy sources and push for low-PUE (Power Usage Effectiveness) targets, advanced power conversion and distribution solutions become critical to staying competitive and meeting environmental goals.
Trend in the Market
A prominent trend is the rise of distributed and modular power architectures, particularly in AI-oriented facilities. As compute density grows, data centers adopt local or 'pod-level' power distribution models that minimize loss, simplify scaling, and accommodate diverse workload demands.
Driver in the Market
Soaring AI and HPC workloads spur higher rack densities, intensifying the need for efficient, high-capacity power solutions. Operators expand power capacity at both the rack and infrastructure levels, adopting next-gen technologies like GaN-based converters to sustain performance and control energy costs.
Restraint in the Market
Complex integration and higher upfront expenses can slow adoption. Advanced power architecture (e.g., fully DC distribution) requires re-engineering data hall designs, staff training, and robust maintenance procedures, leading some operators to delay or opt for incremental upgrades over radical shifts.
Opportunity in the Market
Emerging edge data centers and specialized HPC facilities provide a fertile ground for adoption of cutting-edge power infrastructure. As computing moves closer to users (for low-latency services), smaller data centers will need robust, efficient power and distribution solutions customized for limited footprints and unique site conditions. Suppliers offering modular, future-proof architectures can capture these underserved segments.
Regional Overview
Companies Featured
Key Topics Covered:
1. Markets: Industry Outlook
1.1 Data Center Trends: Current and Future Impact Assessment
1.1.1 Data Center Capacities: Current and Future
1.1.1.1 Retrofitting and Brownfield Projects
1.1.1.2 Green Field projects and New Installation
1.1.1.3 Cloud Infrastructure Deployment
1.1.1.3.1 Colocation VS Hyperscale
1.1.1.3.2 AI Workloads
1.1.2 Data Center Power Consumption Scenario
1.1.3 Other Industrial Trends
1.1.3.1 HPC Cluster Developments
1.1.3.2 Blockchain Initiatives
1.1.3.3 Super Computing
1.1.3.4 5G and 6G Developments
1.1.3.5 Impact of Server/Rack Density
1.1.4 Data Center Deployment Market
1.1.4.1 Market by Components
1.1.4.1.1 IT Infrastructure
1.1.4.1.1.1 General Servers
1.1.4.1.1.2 Accelerated or GPU Servers
1.1.4.1.1.3 Storage Systems
1.1.4.1.1.4 Network Infrastructure
1.1.4.1.2 Data Center Physical Infrastructure
1.1.4.1.2.1 UPS Systems and Backup Generators
1.1.4.1.2.2 Electrical Systems
1.1.4.1.2.3 Cooling Equipment
1.1.4.1.2.4 Data Center Management software
1.2 R&D Review
1.2.1 Patent Filing Trend by Country, by Company
1.3 Stakeholder Analysis
1.3.1 Use Case
1.3.2 End User and Buying Criteria
1.4 Market Dynamics Overview
1.4.1 Market Drivers
1.4.2 Market Restraints
1.4.3 Market Opportunities
2. Data Center Power Infrastructure Market (By Application)
2.1 Application Segmentation
2.2 Application Summary
2.3 Data Center Power Infrastructure Market (by Data Center Type)
2.3.1 Hyperscale Data Centers
2.3.2 Colocation and Retail Data Centers
2.3.3 Enterprise Data Centers
2.3.4 Others
2.4 Data Center Power Infrastructure Market (by Application)
2.4.1 Conventional and Non-AI Data Centers
2.4.2 AI Data Centers
3. Data Center Power Infrastructure Market (by Product)
3.1 Product Segmentation
3.2 Product Summary
3.3 Data Center Power Infrastructure Market (by Power Supply Architecture)
3.3.1 Market by Distribution
3.3.1.1 Centralized
3.3.1.2 Distributed
3.3.2 Market by Power Supply
3.3.2.1 Rack Level
3.3.2.1.1 AC-DC
3.3.2.1.2 DC-DC
3.3.2.2 Infrastructure Level
3.3.2.2.1 AC Supply
3.3.2.2.2 DC Supply (not yet used at infrastructure level)
3.3.3 Market by Component
3.3.3.1 Power Supply
3.3.3.1.1 AC/DC and DC/DC Converters
3.3.3.1.2 Multi-Phase Voltage Regulator Modules (VRMs)
3.3.3.1.3 Hot-Swap Power Modules
3.3.3.1.4 Digital Power Control Units
3.3.3.2 Power Distribution and Management
3.3.3.2.1 Power Distribution Units (PDUs)
3.3.3.2.2 Intelligent/Metered PDUs
3.3.3.2.3 Busbar and Busway Systems
3.3.3.2.4 Automatic Transfer Switches (ATS)
3.3.3.2.5 Switchgear
3.4 GaN-Based Power Solutions for Data Centers
3.4.1 Transistors
3.4.2 Modules
3.4.3 Power ICs
3.4.4 Key Players and Their Products
3.5 Component-Level Technology Integration
3.5.1 Advanced Packaging (3D Packaging, SiP, TSV)
3.5.1.1 3D Stacking and Through-Silicon Vias (TSVs)
3.5.1.2 System-in-Package (SiP) Implementations for Servers
3.5.1.3 High-Density Modules for Compute-Intensive Racks
3.5.1.4 Package-Level Thermal Dissipation Considerations
3.5.2 Integrated Power Modules on PCB
3.5.3 On-Chip/On-Board Interconnects
3.5.4 Thermal Interface and EMI/EMC Components
3.5.5 Adoption by Integration Level
3.5.5.1 SoC vs. SiP Adoption Rates in Data Centers
3.5.5.2 Growth Projections for 3D Packaging Technologies
4. Data Center Power Infrastructure Market (by region)
4.1 Data Center Deployment Market (by Region)
4.2 North America
4.2.1 Regional Overview
4.2.2 Driving Factors for Market Growth
4.2.3 Factors Challenging the Market
4.2.4 Application
4.2.5 Product
4.2.6 U.S.
4.2.6.1 Data Center Trends and Capex
4.2.6.2 Market by Application
4.2.6.3 Market by Product
4.2.7 Canada
4.2.8 Mexico
4.3 Europe
4.4 Asia-Pacific
4.5 Rest-of-the-World
5. Markets - Competitive Benchmarking & Company Profiles
5.1 Next Frontiers
5.2 Geographic Assessment
5.3 Company Profiles
5.3.1 Overview
5.3.2 Top Products/Product Portfolio
5.3.3 Top Competitors
5.3.4 Target Customers
5.3.5 Key Personnel
5.3.6 Analyst View
5.3.7 Market Share
For more information about this report visit https://www.researchandmarkets.com/r/ba67vw
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Copyright Business Wire 2025.
PUB: 05/21/2025 07:07 AM/DISC: 05/21/2025 07:06 AM
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About TROPION-Lung02 TROPION-Lung02 is an ongoing global, open-label, six-cohort phase 1b trial evaluating the safety and efficacy of DATROWAY at two dose levels (4 mg/kg and 6 mg/kg) in combination with Merck's anti-PD-1 therapy KEYTRUDA ® (pembrolizumab; 200 mg) with or without four cycles of platinum chemotherapy (carboplatin or cisplatin) in patients with previously untreated or pretreated locally advanced or metastatic NSCLC without actionable genomic alterations (e.g., EGFR, ALK, ROS1, NTRK, BRAF, RET, MET or other known AGAs). Participants with tumors that harbor KRAS mutations are eligible for this study. The primary endpoints of TROPION-Lung02 are dose-limiting toxicities and treatment-emergent adverse events. Secondary endpoints include ORR, DoR, PFS as assessed by investigator, overall survival, pharmacokinetics and anti-drug antibodies for DATROWAY and pembrolizumab. TROPION-Lung02 is one of three clinical trials along with the phase 3 TROPION-Lung07 and TROPION-Lung08 trials in a collaboration and supply agreement between Daiichi Sankyo, AstraZeneca and Merck (known as MSD outside of the United States and Canada) to evaluate the combination of DATROWAY and pembrolizumab. TROPION-Lung02 enrolled 145 patients in Asia, Europe and North America. For more information visit KEYTRUDA ® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. About TROPION-Lung04 TROPION-Lung04 is an ongoing global, open-label, 15-cohort phase 1b trial evaluating the safety and efficacy of DATROWAY (4 mg/kg or 6 mg/kg) in combination with immunotherapy (durvalumab, rilvegostomig or volrustomig) with or without up to four cycles of carboplatin in patients with advanced or metastatic NSCLC without actionable genomic alterations. Participants with tumors that harbor KRAS mutations are eligible for this study. Patients enrolled in the cohorts evaluating durvalumab were previously untreated or had received one or fewer lines of systemic chemotherapy without concomitant immunotherapy. The primary endpoints of TROPION-Lung04 are safety and tolerability. Secondary endpoints include ORR, DCR, duration of response and progression-free survival as assessed by investigator. Rilvegostomig is AstraZeneca's PD-1/TIGIT bispecific antibody. The TIGIT component of rilvegostomig is derived from the clinical-stage anti-TIGIT antibody, COM902, developed by Compugen Ltd. (Nasdaq/TASE: CGEN). TROPION-Lung04 will enroll more than 370 patients in Asia, Europe and North America. For more information visit About NeoCOAST-2 NeoCOAST-2 is a global, randomized, multicenter, open-label, multi-arm phase 2 platform trial conducted by AstraZeneca evaluating the efficacy and safety of durvalumab in multiple novel combinations, before and after surgery, in patients with resectable, early-stage (stage IIA-IIIB) NSCLC. The dual primary endpoints of NeoCOAST-2 are antitumor activity of neoadjuvant treatment assessed by pCR and the safety and tolerability of neoadjuvant and adjuvant treatment. Secondary endpoints include event-free survival, disease-free survival and ORR as determined by investigator using RECIST version 1.1, OS, feasibility of surgery, and mPR determined by central blinded independent pathologist review. NeoCOAST-2 will enroll approximately 630 patients in Asia, Europe and North America. For more information visit About Non-Small Cell Lung Cancer Nearly 2.5 million lung cancer cases were diagnosed globally in 2022. 1 NSCLC is the most common type of lung cancer, accounting for about 87% of cases. 2 While most NSCLC cases are diagnosed in the advanced setting, between 25 to 30% of diagnoses occur in the early stage of the disease. 3,4 Despite improvements in treatment for early-stage NSCLC, patients may experience disease recurrence even after complete tumor resection with or without treatment with adjuvant therapy. 5,6,7 For patients with advanced NSCLC without actionable genomic alterations, immunotherapy with or without platinum-based chemotherapy is the standard first-line treatment. While these medicines have improved outcomes in the first-line metastatic setting, most patients experience disease progression. 8,9,10 TROP2 is a protein broadly expressed in the majority of NSCLC tumors. 11 There is currently no TROP2 directed ADC approved in the U.S. for the treatment of lung cancer. 12,13 About DATROWAY DATROWAY (datopotamab deruxtecan; datopotamab deruxtecan-dlnk in the U.S. only) is a TROP2 directed ADC. Designed using Daiichi Sankyo's proprietary DXd ADC Technology, DATROWAY is one of six DXd ADCs in the oncology pipeline of Daiichi Sankyo, and one of the most advanced programs in AstraZeneca's ADC scientific platform. DATROWAY is comprised of a humanized anti-TROP2 IgG1 monoclonal antibody, developed in collaboration with Sapporo Medical University, attached to a number of topoisomerase I inhibitor payloads (an exatecan derivative, DXd) via tetrapeptide-based cleavable linkers. DATROWAY is approved in more than 30 countries for the treatment of adult patients with unresectable or metastatic HR positive, HER2 negative (IHC 0, IHC 1+ or IHC 2+/ISH-) breast cancer who have received prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease based on the results from the TROPION-Breast01 trial. About the DATROWAY Clinical Development Program A comprehensive global clinical development program is underway with more than 20 trials evaluating the efficacy and safety of DATROWAY across multiple cancers, including NSCLC, triple negative breast cancer and HR positive, HER2 negative breast cancer. The program includes eight phase 3 trials in lung cancer and five phase 3 trials in breast cancer evaluating DATROWAY as a monotherapy and in combination with other anticancer treatments in various settings. About the Daiichi Sankyo and AstraZeneca Collaboration Daiichi Sankyo and AstraZeneca entered into a global collaboration to jointly develop and commercialize ENHERTU ® in March 2019 and DATROWAY in July 2020, except in Japan where Daiichi Sankyo maintains exclusive rights for each ADC. Daiichi Sankyo is responsible for the manufacturing and supply of ENHERTU and DATROWAY. About the ADC Portfolio of Daiichi Sankyo The Daiichi Sankyo ADC portfolio consists of seven ADCs in clinical development crafted from two distinct ADC technology platforms discovered in-house by Daiichi Sankyo. The ADC platform furthest in clinical development is Daiichi Sankyo's DXd ADC Technology where each ADC consists of a monoclonal antibody attached to a number of topoisomerase I inhibitor payloads (an exatecan derivative, DXd) via tetrapeptide-based cleavable linkers. The DXd ADC portfolio currently consists of ENHERTU, a HER2 directed ADC, and DATROWAY, a TROP2 directed ADC, which are being jointly developed and commercialized globally with AstraZeneca. Patritumab deruxtecan (HER3-DXd), a HER3 directed ADC, ifinatamab deruxtecan (I-DXd), a B7-H3 directed ADC, and raludotatug deruxtecan (R-DXd), a CDH6 directed ADC, are being jointly developed and commercialized globally with Merck & Co., Inc, Rahway, NJ, USA. DS-3939, a TA-MUC1 directed ADC, is being developed by Daiichi Sankyo. The second Daiichi Sankyo ADC platform consists of a monoclonal antibody attached to a modified pyrrolobenzodiazepine (PBD) payload. DS-9606, a CLDN6 directed PBD ADC, is the first of several planned ADCs in clinical development utilizing this platform. Ifinatamab deruxtecan, patritumab deruxtecan, raludotatug deruxtecan, DS-3939 and DS-9606 are investigational medicines that have not been approved for any indication in any country. Safety and efficacy have not been established. DATROWAY U.S. Important Safety Information Indication DATROWAY ® is a Trop-2-directed antibody and topoisomerase inhibitor conjugate indicated for the treatment of adult patients with unresectable or metastatic, hormone receptor (HR)-positive, HER2-negative (IHC 0, IHC 1+, or IHC 2+/ISH−) breast cancer who have received prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease. Contraindications None. Warnings and Precautions Interstitial Lung Disease/Pneumonitis DATROWAY can cause severe, life-threatening, or fatal interstitial lung disease (ILD) or pneumonitis. In TROPION-Breast01, ILD/pneumonitis occurred in 4.2% of patients treated with DATROWAY, including 0.5% of patients with Grade 3-4 ILD/pneumonitis, and 0.3% with fatal ILD/pneumonitis. Six patients (1.7%) permanently discontinued DATROWAY due to ILD/pneumonitis. The median time to onset of ILD/pneumonitis was 3.5 months (range: 1.2 months to 10.8 months). Patients were excluded from TROPION-Breast01 for a history of ILD/pneumonitis requiring treatment with steroids or for ongoing ILD/pneumonitis. Monitor patients for new or worsening respiratory symptoms indicative of ILD/pneumonitis (eg, dyspnea, cough, fever) during treatment with DATROWAY. For asymptomatic (Grade 1) ILD/pneumonitis, consider corticosteroid treatment (eg, ≥0.5 mg/kg/day prednisolone or equivalent). For symptomatic ILD/pneumonitis (Grade 2 or greater), promptly initiate systemic corticosteroid treatment (eg, ≥1 mg/kg/day prednisolone or equivalent) and continue for at least 14 days followed by gradual taper for at least 4 weeks. Withhold DATROWAY in patients with suspected ILD/pneumonitis and permanently discontinue DATROWAY if Grade ≥2 ILD/pneumonitis is confirmed. Ocular Adverse Reactions DATROWAY can cause ocular adverse reactions including dry eye, keratitis, blepharitis, meibomian gland dysfunction, increased lacrimation, conjunctivitis, and blurred vision. In TROPION-Breast01, ocular adverse reactions occurred in 51% of patients treated with DATROWAY. Seven patients (1.9%) experienced Grade 3 ocular adverse reactions, including dry eye, keratitis, and blurred vision. The most common (≥5%) ocular adverse reactions were dry eye (27%), keratitis (24%), blepharitis and increased lacrimation (8% each), and meibomian gland dysfunction (7%). Patients with clinically significant corneal disease were excluded from TROPION-Breast01. The median time to onset for ocular adverse reactions was 2.1 months (range: 0.03 months to 23.2 months). Of the patients who experienced ocular adverse reactions, 45% had complete resolution; 9% had partial improvement (defined as a decrease in severity by one or more grades from the worst grade at last follow up). Ocular adverse reactions led to permanent discontinuation of DATROWAY in 0.8% of patients. Advise patients to use preservative-free lubricant eye drops several times daily for prophylaxis. Advise patients to avoid use of contact lenses unless directed by an eye care professional. Refer patients to an eye care professional for an ophthalmic exam including visual acuity testing, slit lamp examination (with fluorescein staining), intraocular pressure, and fundoscopy at treatment initiation, annually while on treatment, at end of treatment, and as clinically indicated. Promptly refer patients to an eye care professional for any new or worsening ocular adverse reactions. Monitor patients for ocular adverse reactions during treatment with DATROWAY, and if diagnosis is confirmed, dose delay, dose reduce, or permanently discontinue DATROWAY based on severity. Stomatitis DATROWAY can cause stomatitis, including mouth ulcers and oral mucositis. In the TROPION-Breast01 study, stomatitis occurred in 59% of patients treated with DATROWAY, including 7% of patients with Grade 3-4 events. Median time to first onset was 0.7 months (range: 0.03 months to 8.8 months). Stomatitis led to interruption of DATROWAY in 1.9%, dosage reductions in 13%, and permanent discontinuation in 0.3% of patients. In patients who received DATROWAY, 38% used a mouthwash containing corticosteroid for management or prophylaxis of stomatitis/oral mucositis at any time during the treatment. Advise patients to use a steroid-containing mouthwash for prophylaxis and treatment of stomatitis. Instruct the patient to hold ice chips or ice water in the mouth throughout the infusion of DATROWAY. Monitor patients for signs and symptoms of stomatitis. If stomatitis occurs, increase the frequency of mouthwash and administer other topical treatments as clinically indicated. Based on the severity of the adverse reaction, withhold, dose reduce, or permanently discontinue DATROWAY. Embryo-Fetal Toxicity Based on its mechanism of action, DATROWAY can cause embryo-fetal harm when administered to a pregnant woman because the topoisomerase inhibitor component of DATROWAY, DXd, is genotoxic and affects actively dividing cells. Advise patients of the potential risk to a fetus. Advise female patients of reproductive potential to use effective contraception during treatment with DATROWAY and for 7 months after the last dose. Advise male patients with female partners of reproductive potential to use effective contraception during treatment with DATROWAY and for 4 months after the last dose. Adverse Reactions The safety of DATROWAY was evaluated in 360 patients with unresectable or metastatic HR-positive, HER2-negative (IHC 0, IHC 1+ or IHC 2+/ISH−) breast cancer who received at least one dose of DATROWAY 6 mg/kg in TROPION-Breast01. DATROWAY was administered by intravenous infusion once every three weeks. The median duration of treatment was 6.7 months (range: 0.7 months to 16.1 months) for patients who received DATROWAY. Serious adverse reactions occurred in 15% of patients who received DATROWAY. Serious adverse reactions in >0.5% of patients who received DATROWAY were urinary tract infection (1.9%), COVID-19 infection (1.7%), ILD/pneumonitis (1.1%), acute kidney injury, pulmonary embolism, vomiting, diarrhea, hemiparesis, and anemia (0.6% each). Fatal adverse reactions occurred in 0.3% of patients who received DATROWAY and were due to ILD/pneumonitis. Permanent discontinuation of DATROWAY due to an adverse reaction occurred in 3.1% of patients. Adverse reactions which resulted in permanent discontinuation of DATROWAY in >0.5% of patients included ILD/pneumonitis (1.7%) and fatigue (0.6%). Dosage interruptions of DATROWAY due to an adverse reaction occurred in 22% of patients. Adverse reactions which required dosage interruption in >1% of patients included COVID-19 (3.3%), infusion-related reaction (1.4%), ILD/pneumonitis (1.9%), stomatitis (1.9%), fatigue (1.7%), keratitis (1.4%), acute kidney injury (1.1%), and pneumonia (1.1%). Dose reductions of DATROWAY due to an adverse reaction occurred in 23% of patients. Adverse reactions which required dose reduction in >1% of patients included stomatitis (13%), fatigue (3.1%), nausea (2.5%), and weight decrease (1.9%). The most common (≥20%) adverse reactions, including laboratory abnormalities, were stomatitis (59%), nausea (56%), fatigue (44%), decreased leukocytes (41%), decreased calcium (39%), alopecia (38%), decreased lymphocytes (36%), decreased hemoglobin (35%), constipation (34%), decreased neutrophils (30%), dry eye (27%), vomiting (24%), increased ALT (24%), keratitis (24%), increased AST (23%), and increased alkaline phosphatase (23%). Clinically relevant adverse reactions occurring in <10% of patients who received DATROWAY included infusion-related reactions (including bronchospasm), ILD/pneumonitis, headache, pruritus, dry skin, dry mouth, conjunctivitis, blepharitis, meibomian gland dysfunction, blurred vision, increased lacrimation, photophobia, visual impairment, skin hyperpigmentation, and madarosis. Use in Specific Populations Pregnancy: Based on its mechanism of action, DATROWAY can cause embryo-fetal harm when administered to a pregnant woman because the topoisomerase inhibitor component of DATROWAY, DXd, is genotoxic and affects actively dividing cells. There are no available data on the use of DATROWAY in pregnant women to inform a drug-associated risk. Advise patients of the potential risks to a fetus. Lactation: There are no data regarding the presence of datopotamab deruxtecan-dlnk or its metabolites in human milk, the effects on the breastfed child, or the effects on milk production. Because of the potential for serious adverse reactions in a breastfed child, advise women not to breastfeed during treatment with DATROWAY and for 1 month after the last dose. Females and Males of Reproductive Potential: Pregnancy Testing: Verify pregnancy status of females of reproductive potential prior to initiation of DATROWAY. Contraception: Females: Advise females of reproductive potential to use effective contraception during treatment with DATROWAY and for 7 months after the last dose. Males: Because of the potential for genotoxicity, advise male patients with female partners of reproductive potential to use effective contraception during treatment with DATROWAY and for 4 months after the last dose. Infertility: Based on findings in animal toxicity studies, DATROWAY may impair male and female reproductive function and fertility. The effects on reproductive organs in animals were irreversible. Pediatric Use: Safety and effectiveness of DATROWAY have not been established in pediatric patients. Geriatric Use: Of the 365 patients in TROPION-Breast01 treated with DATROWAY 6 mg/kg, 25% were ≥65 years of age and 5% were ≥75 years of age. Grade ≥3 and serious adverse reactions were more common in patients ≥65 years (42% and 25%, respectively) compared to patients <65 years (33% and 15%, respectively). In TROPION-Breast01, no other meaningful differences in safety or efficacy were observed between patients ≥65 years of age versus younger patients. Renal Impairment: A higher incidence of ILD/pneumonitis has been observed in patients with mild and moderate renal impairment (creatinine clearance [CLcr] 30 to <90 mL/min). Monitor patients with renal impairment for increased adverse reactions, including respiratory reactions. No dosage adjustment is recommended in patients with mild to moderate renal impairment. The effect of severe renal impairment (CLcr <30 mL/min) on the pharmacokinetics of datopotamab deruxtecan-dlnk or DXd is unknown. Hepatic Impairment: No dosage adjustment is recommended in patients with mild hepatic impairment (total bilirubin ≤ULN and any AST >ULN or total bilirubin >1 to 1.5 times ULN and any AST). Limited data are available in patients with moderate hepatic impairment (total bilirubin >1.5 to 3 times ULN and any AST). Monitor patients with moderate hepatic impairment for increased adverse reactions. The recommended dosage of DATROWAY has not been established for patients with severe hepatic impairment (total bilirubin >3 times ULN and any AST). To report SUSPECTED ADVERSE REACTIONS, contact Daiichi Sankyo, Inc. at 1-877-437-7763 or FDA at 1-800-FDA-1088 or Please see accompanying full Prescribing Information, including the Medication Guide. About Daiichi Sankyo Daiichi Sankyo is an innovative global healthcare company contributing to the sustainable development of society that discovers, develops and delivers new standards of care to enrich the quality of life around the world. With more than 120 years of experience, Daiichi Sankyo leverages its world-class science and technology to create new modalities and innovative medicines for people with cancer, cardiovascular and other diseases with high unmet medical need. For more information, please visit
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