Prothena announces AFFIRM-AL trial did not meet primary endpoint
Prothena (PRTA) announced the Phase 3 AFFIRM-AL clinical trial evaluating birtamimab in patients with AL amyloidosis did not meet its primary endpoint. Based on these results, the company will discontinue the development of birtamimab, including stopping the open label extension of the AFFIRM-AL clinical trial. In the Phase 3 AFFIRM-AL clinical trial, the primary endpoint of time to all-cause mortality was not met for patients treated with birtamimab. In addition, neither of the secondary endpoints were met: 6-minute walk test distance and Short Form-36 version 2 Physical Component Score. Birtamimab was generally safe and well-tolerated, consistent with its established safety profile. In June, the company expects to provide details of plans to reduce ongoing operating expenses. The results of the company's review of its business options will be communicated as appropriate once the analysis and plans are finalized.
Confident Investing Starts Here:
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Fox Sports
30 minutes ago
- Fox Sports
Cristiano Ronaldo is almost certain he won't play at Club World Cup
Associated Press MUNICH (AP) — Cristiano Ronaldo says he's almost certain he will not be playing at the Club World Cup, dealing a blow to FIFA president Gianni Infantino's hopes of having one of soccer's biggest attractions at the tournament. The Portugal captain confirmed Saturday that he received 'quite a few' offers from participating clubs to play for them at the tournament starting June 14, but had decided against accepting any of them. 'Some things make sense to talk about, other things don't, and, as a person says, you can't take part in everything,' Ronaldo said. 'You have to think about the short, medium and long term. It's a decision practically made on my part not to go to the Club World Cup, but I've had quite a few invitations to go.' The 40-year-old soccer great was speaking in Munich a day before Portugal's Nations League final against Spain. Infantino had suggested last month that Ronaldo, who is still contracted to Saudi team Al-Nassr until the end of June, could switch to one of the 32 clubs taking part in the Club World Cup because of a unique transfer window created for the tournament. Ronaldo did little to quell that speculation when he posted ' this chapter is over ' after Al-Nassr's last Saudi Pro League game of the season. He was linked with several Club World Cup participants, including Brazil's Palmeiras. A switch to Al-Nassr's crosstown rival Al-Hilal – the one Saudi club that qualified – was also mooted as a potential solution to having Ronaldo play at the tournament, where his great rival Lionel Messi will be playing with Inter Miami. FIFA would have welcomed the boost that Ronaldo's presence could provide for ticket sales, though such a switch to a bitter local rival for a short period would be unthinkable for players in Europe's leagues. Both Al-Nassr and Al-Hilal are among the four big Saudi clubs backed by the country's Public Investment Fund, which has a 75% stake in each. On Thursday, FIFA announced PIF as an ' official partner ' of the Club World Cup. Saudi state money is also effectively funding the tournament's broadcasting deal that has largely backed its $1 billion prize fund being shared among the participants. 'This is irrelevant right now,' Ronaldo first said when asked Saturday about the Club World Cup. 'It makes no sense to talk about anything other than the national team.' Ronaldo fired Portugal into the Nations League final on Wednesday with a 2-1 win over host nation Germany. His winning goal was his record-extending 137th for Portugal. If he plays Sunday he will make his record-extending 221st national team appearance. ___ AP soccer:
Yahoo
14 hours ago
- Yahoo
Affirm Expands Global Footprint: Will It Deliver Sustainable Growth?
Affirm Holdings, Inc. AFRM is making a bold move beyond the United States as it seeks to fuel its next growth phase. The Buy Now Pay Later (BNPL) space has started its international expansion. It recently entered the Canadian market through an extended partnership with Williams-Sonoma and KAYAK. The company officially announced its expansion into the U.K. market, indicating its major expansion beyond North America. AFRM exited the third quarter of fiscal 2025 with strong revenue growth, reporting $783 million in total revenues — a 36% increase from the prior year, following growth of 17.3% and 46.3% in 2023 and 2024, respectively. Its active consumers boosted 21% year over year to 21.9 million in third-quarter 2025, driven by strong consumer retention, growing adoption of the Affirm Card and the addition of new users through an increase in active merchants and partnerships. It anticipates total revenues to be between $3.163 and $3.193 billion in fiscal 2025. As a pioneer-fintech company in payment solutions, it primarily focuses on providing transparent, flexible and reliable financial services. It also focuses on expanding its reach in international markets through strategic partnerships. Affirm is already scaling through its early partnerships with local merchants, setting the stage to expand its services in both the retail and travel industries, which shows the growing adoption of BNPL in today's world, especially among Gen Z and Millennials. However, achieving sustainable growth will depend on careful implementation, the ability to adapt to regulations and successful integration into local markets. Some of AFRM's competitors in the payment solutions space are PayPal Holdings, Inc. PYPL and Sezzle Inc. SEZL. PayPal reported 436 million active accounts in the first quarter of 2025, which rose 2% year over year. Its net revenues increased 1% year over year to $7.8 billion in first-quarter 2025. PayPal's total payment volume increased 3% year over year in the first quarter of 2025. Sezzle reported 2.7 million active consumers in the first quarter of 2025, which grew 5.4% year over year. Sezzle's total revenues grew 123.3% year over year to $104.9 million in the same quarter. Its gross merchandise volume increased 64.1% year over year. Over the past year, AFRM's shares have surged 85.4% compared with the industry's rise of 37%. Image Source: Zacks Investment Research From a valuation standpoint, AFRM trades at a forward price-to-sales ratio of 4.62, below the industry average of 5.61. The company carries a Value Score of F. Image Source: Zacks Investment Research The Zacks Consensus Estimate for Affirm's 2025 earnings implies 100.6% growth from the year-ago period. It witnessed five upward estimate revisions in the past 30 days against one movement in the opposite direction. Image Source: Zacks Investment Research Affirm currently carries a Zacks Rank #3 (Hold). You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report PayPal Holdings, Inc. (PYPL) : Free Stock Analysis Report Affirm Holdings, Inc. (AFRM) : Free Stock Analysis Report Sezzle Inc. (SEZL) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
19 hours ago
- Yahoo
Retailers turn to BNPL apps to ease cost-of-living strain
As rising prices squeeze household budgets on both sides of the Atlantic, major retailers in the UK and US are turning to Buy Now Pay Later (BNPL) services like Klarna, Affirm, PayPal and Afterpay to offer more flexible payment options. These services allow shoppers to split purchases into smaller instalments, often interest-free, appealing to consumers looking to manage spending without resorting to credit cards. In the UK, high street brands such as John Lewis and ASDA have integrated BNPL at checkout. In the US, companies like Walmart and Amazon have partnered with BNPL providers to help customers spread the cost of everyday purchases and big-ticket items. Retailers on both sides of the Atlantic have reported increased online conversion rates and larger order values since adopting BNPL. In the UK, John Lewis now offers Klarna as a payment method on its website, allowing customers to pay in three instalments. The retailer says this has helped boost sales of furniture and homeware, categories where customers typically spend more. In the US, Affirm is widely used by major retailers including Walmart and Peloton. Walmart enables BNPL at checkout through Affirm for purchases over $144, including electronics, home goods and sports equipment. By offering payment flexibility, the retailer has made higher-value purchases more accessible to cash-strapped consumers. Retailers receive full payment upfront from BNPL providers, while the customer repays the loan in instalments. This setup protects businesses from payment default while offering customers a way to manage costs over time. BNPL has become especially popular among younger shoppers, many of whom prefer avoiding traditional credit. In the UK, fashion brands like ASOS, H&M and JD Sports report strong uptake among Gen Z customers, who use Klarna and Clearpay (the UK version of Afterpay) to budget purchases. Similarly, in the US, Klarna and Afterpay have grown rapidly among millennial and Gen Z users, who use these services for everything from clothing to tech. Amazon introduced BNPL through Affirm in 2021, offering interest-free payments on a range of goods, from laptops to kitchen appliances. Retailers benefit from increased reach into this demographic, often using BNPL firms' marketing platforms to target shoppers directly. However, customer approval rates and loan eligibility vary, raising concerns about transparency and potential exclusion of those with weaker credit histories. While BNPL offers convenience and budgeting support, regulators and consumer advocates in both countries have warned of the risks. In the UK, the Financial Conduct Authority is planning stricter oversight of the sector after concerns about debt accumulation and lack of affordability checks. In the US, the Consumer Financial Protection Bureau has also launched investigations into BNPL providers, citing the potential for consumers to take on multiple loans across platforms without a clear understanding of repayment obligations. Retailers using BNPL must now navigate a shifting regulatory landscape. They are expected to ensure transparency around terms and conditions, and to help customers understand the consequences of missed payments. As inflation continues to impact household finances, BNPL remains a double-edged sword: a useful tool for short-term flexibility, but one that may pose longer-term financial risks if not used responsibly. "Retailers turn to BNPL apps to ease cost-of-living strain" was originally created and published by Retail Insight Network, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site.
