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Hans India
3 hours ago
- Hans India
Weight-loss drugs can lead to serious eye conditions
Drugs such as Ozempic, Wegovy, and Mounjaro (known as semaglutide and tirzepatide) have changed the way clinicians manage diabetes and obesity around the world. Collectively known as GLP-1 agonists, these drugs mimic the hormone GLP-1. This limits both hunger and interest in food, helping users lose weight, and helps control blood sugar levels. But two new studies show that people taking these drugs may have a small increased risk of serious eye conditions and vision loss. Here's what you need to know if you're taking or considering these medications. Non-arteritic anterior ischaemic optic neuropathy, or NAION, is a rare but devastating eye condition that occurs when blood flow to the optic nerve is suddenly reduced or blocked. It's also called an 'eye stroke'. The exact cause of NAION remains unclear, and there are no current treatments available. People with diabetes are at increased risk of developing NAION. Unlike other eye conditions that develop gradually, NAION causes a sudden, painless loss of vision. Patients typically notice the condition when they wake up and discover they've lost vision in one eye. Vision tends to worsen over a couple of weeks and slowly stabilises. Recovery of vision is variable, but around 70 per cent of people do not experience improvement in their vision. What has previous research shown? A previous study from 2024 found that participants prescribed semaglutide for diabetes were four times more likely to develop NAION. For those taking it for weight loss, the risk was almost eight times higher. In June, the European Medicines Agency concluded NAION represented a 'very rare' side effect of semaglutide medications: a one in 10,000 chance. However, recent studies suggest the risks may be lower than we first thought. In addition to NAION, there is also evidence to suggest GLP-1 drugs can worsen diabetic eye disease, also known as diabetic retinopathy. This occurs when high blood sugar levels damage the small blood vessels in the retina, which can lead to vision also show that patients with heart conditions who better adhere to their medication prescriptions have lower risks of NAION than those who don't. Doctors should discuss NAION risks during prescribing decisions and work with eye care providers to monitor regularly for diabetic eye disease. Patients need clear instructions to seek immediate medical attention for sudden vision loss and the need for regular eye examinations. Aggressive treatment of sleep apnoea and other heart conditions may also help reduce NAION risks. But for now, there remains an ongoing need for more research to understand how GLP-1 medications can affect the eye. (Flora Hui is with the University of Melbourne and Pete A Williams is from Karolinska Institutet)
Hans India
3 hours ago
- Hans India
Tirupati EMC to host Rs. 468-crore chip unit
TIRUPATI: The Electronics Manufacturing Cluster (EMC) shaping up near the Tirupati Airport has got a major boost with the Union Cabinet approving the establishment of a semiconductor manufacturing unit in Andhra Pradesh. The state government has proposed to set up the project at the Tirupati EMC, cementing the region's status as a hub for high-value electronics manufacturing. The semiconductor unit will be established by Advanced System in Package Technologies (ASIP) with an initial investment of Rs 468 crore. ASIP's facility will have initial capacity to produce 9.6 crore chips annually, catering to applications in mobile devices, set-top boxes, automotive electronic control units, and household electronics items. The Andhra Pradesh government, in a letter sent to ASIP on Monday, formally invited the company to set up its operations in the state and outlined a package of incentives for the firm. According to official sources, ASIP has given its consent and has plans to scale its investment over time to Rs 1,500 crore. To attract the project, the state government has offered a 25 per cent capital subsidy, land at nominal cost, a Rs 1.50 per unit electricity subsidy for five years, electricity duty exemption for the same period, a five-year interest subsidy on term loans, and full State GST reimbursement for five years. ASIP's consent was subsequently communicated to the Centre, which granted its approval, clearing the way for the unit's establishment at the Tirupati EMC. The venture marks a significant push in the state's strategy to balance its tech footprint—focusing on software investments in Visakhapatnam as well as Amaravati and positioning Rayalaseema as an electronics manufacturing hub. Tirupati was declared an electronics cluster between 2014 and 2019, and the new semiconductor unit is expected to accelerate investments in this sector. ASIP Technologies, partnered with South Korea's Apact Company Limited, will be the latest high-profile occupant of the EMC. The cluster, developed under the Ministry of Electronics and Information Technology's (MeitY) EMC scheme, already hosts major players like Dixon Technologies and Celkon in EMC-1, while EMC-2 has attracted investments from companies such as TCL and Sunny Opotech. The arrival of the semiconductor unit is expected to strengthen the electronics ecosystem in Tirupati, drawing in both domestic and foreign investors and leveling up India's position in the global semiconductor supply chain.
Time of India
12 hours ago
- Time of India
CoinDesk-Bullish IPO, Stablecoin-Circle successes pave way for crypto firms like Gemini, Grayscale to go public
Bullish IPO has hit the jackpot and so was Stablecoin giant Circle's initial public offering. With these successes, several crypto firms, including exchange Gemini and asset manager Grayscale, are now aiming to go public during an IPO window revived by robust tech earnings, along with expectations of easing tariffs and interest rates. Gemini IPO Finance Value and Valuation Masterclass - Batch 4 By CA Himanshu Jain View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program Finance Value and Valuation Masterclass - Batch 3 By CA Himanshu Jain View Program Artificial Intelligence AI For Business Professionals By Vaibhav Sisinity View Program Finance Value and Valuation Masterclass - Batch 2 By CA Himanshu Jain View Program Finance Value and Valuation Masterclass Batch-1 By CA Himanshu Jain View Program Gemini, the Winklevoss‑founded cryptocurrency exchange, has confidentially filed for a U.S. IPO with the SEC, though share count and pricing remain undecided. The move follows Circle's blockbuster listing and reflects a broader surge of crypto firms seeking public-market entry amid improving regulatory sentiment and renewed investor demand. Gemini operates a trading platform enabling investors to buy, sell and store more than 70 crypto tokens. The surge in cryptocurrency IPOs signals a turning point for the industry, reflecting growing confidence among digital asset firms to attract mainstream investors and bringing increased transparency, regulatory scrutiny and capital that could help solidify crypto's place in traditional financial markets. As the crypto sector matures financially and gains regulatory footing, firms are becoming more integrated into traditional markets. Live Events This marks a sharp turnaround for an industry that spent more than a decade under intense regulatory scrutiny worldwide. After the collapse of crypto exchange FTX in 2022, many institutional investors retreated from the digital asset market. Prices later recovered, and the sector gained fresh momentum when U.S. President Donald Trump voiced support during his campaign, pledging to be a "crypto president." Grayscale IPO Grayscale Investments, a leading crypto asset manager overseeing over $33 billion across more than 35 products, has confidentially filed for an initial public offering (IPO) with the U.S. Securities and Exchange Commission (SEC). The filing, submitted via a draft Form S‑1, keeps critical details—such as share count and pricing—undisclosed for now. Coming amid Bitcoin's rally above six‑figure levels and a pro-crypto regulatory climate under the current U.S. administration, the move follows in the footsteps of crypto firms like Circle, Gemini, and Kraken also eyeing public listings. Bullish IPO Shares of cryptocurrency exchange operator Bullish were indicated to open nearly 62 per cent above their IPO on Wednesday, signaling growing investor confidence in the sector and boosting prospects for future U.S. listings by other digital asset firms. If the stock starts to trade at the last indicated range of $55 to $60 on the NYSE, it could potentially value the billionaire venture capitalist Peter Thiel-backed company at nearly $8.77 billion. Bullish raised $1.11 billion in the largest U.S. listing by a digital assets company this year, marking another sign of mainstream adoption in a sector that recently topped $4 trillion in market value. Bullish, which acquired cryptocurrency website CoinDesk in 2023, had priced the IPO at $37 per share — above an already upsized range, and was valued at $5.41 billion. Circle IPO Stablecoin giant Circle had raised $1.05 billion in its initial public offering in June, before a blowout debut. As of last close, Circle shares were trading more than five times above their IPO price. A string of regulatory wins under a pro-crypto White House, corporate treasury adoption, and ETF inflows have prompted investors to embrace the once-scorned digital asset class, driving bellwether bitcoin to record highs. FAQs Q1. Who is 'Crypto President'? A1. Donald Trump is Crypto President. Q2. What do we know about Bullish IPO? A2. Shares of cryptocurrency exchange operator Bullish were indicated to open nearly 62 per cent above their IPO on Wednesday, signaling growing investor confidence in the sector and boosting prospects for future U.S. listings by other digital asset firms. If the stock starts to trade at the last indicated range of $55 to $60 on the NYSE, it could potentially value the billionaire venture capitalist Peter Thiel-backed company at nearly $8.77 billion.
