Applied Therapeutics to present full 12-month INSPIRE Phase 3 results
Applied Therapeutics (APLT) announced its late-breaking abstract for govorestat, or AT-007, has been selected for oral presentation at the Peripheral Nerve Society 2025 Annual Meeting, held May 17-20. The presentation will include full 12-month clinical results from the INSPIRE Phase 3 trial in SORD Deficiency, a subtype of Charcot-Marie-Tooth disease. It will also include new topline 18-month and 24-month data. The company previously shared topline 12-month data in February 2024.
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Business Insider
6 hours ago
- Business Insider
T-Mobile review: Packed with perks, but is it worth the price?
It's hard to go wrong with T-Mobile. It offers some of the best plans and value among the big three carriers in the US. Admittedly, more so if you're taking out multiple lines. Like AT&T and Verizon, T-Mobile is an ideal option for multi-line plans thanks to its multi-line discounts, especially those with three or more lines. Those with fewer lines can still enjoy T-Mobile and all its benefits, like in-person customer support at physical locations, and depending on the plan, comprehensive international features and discounts on popular streaming services. However, we'd recommend that single or dual-line accounts consider mobile-virtual-network-operator (MVNO) options, which are significantly less expensive than T-Mobile's plans, and dominate our cheap cell phone plans guide. The only way you could go wrong is if you pick T-Mobile in an area with weak coverage. This isn't a dig at T-Mobile's coverage; the same word of caution applies to all carriers, as they all have varying coverage in different parts of the country. With that said, T-Mobile has one major drawback relative to other major carriers that bears consideration — it doesn't let you mix-and-match plans (picking different plans for different lines). That could lead to unnecessarily higher monthly plan costs if other users in your account have different needs. Plans T-Mobile has three main postpaid plans — the basic Essentials (including the Essentials Saver plan), the mid-range Experience More, and the high-end Experience Beyond plans. The Essentials plan offers T-Mobile's best value with all the data most people need, even if the network may temporarily become artificially slower when it is congested (more on that in the coverage and data speeds section below). However, T-Mobile's Essentials plan lacks additional features found in the Experience plan that some may need, like high-speed mobile hotspot, satellite messaging when you're out of coverage areas, and extended international features. Experience plans also include discounts on popular streaming services and smartwatch or tablet plans, which are nice bonuses. You can get included Apple TV+ and ad-supported Netflix subscriptions on Experience More, and the Experience Beyond tier also throws in ad-supported Hulu. Prices are guaranteed for five years on both Experience plans as well. Other benefits on all three tiers include free in-flight WiFi, free months of service to SiriusXM and Pandora Streaming, and an MLS season pass (offers rotate regularly). Plus, there's T-Mobile Tuesdays to regularly mix things up by providing free Slurpees, pizza, $5 movie tickets, discounted fuel, cashback at restaurants, and more. If you've been reconsidering your home internet options lately, you'll get extra savings on T-Mobile's internet packages if you're on one of these plans. We're testing one of their 5G home internet plans right now and will have a review soon - it's pretty impressive so far. You can find plan details on T-Mobile's website, and we've included them below for your convenience: Plan features Essentials Experience More Experience Beyond Premium data 50GB Unlimited Unlimited Mobile hotspot Unlimited at 3G speeds (slow) 60GB high-speed Unlimited high-speed (capped at 250GB, then hotspot data is slow 3G speeds) Satellite messaging Beta included until July 2025 $10 per month optional extra Beta included until July 2025 $10 per month optional extra Included Smartwatch and tablet plans Optional extra, starts at $12/month Optional extra, starts at $12/month Discounted to $5/month per line Max savings of $22/month Streaming service discounts None Free Apple TV Plus and Netflix Standard with ads Savings with both subscriptions: $17.98/month Free Apple TV Plus, Netflix Standard with ads, Hulu with ads Max savings of: $27.97/month Device upgrades Can't upgrade before 24 months if bought with a deal from T-Mobile. Every two years Every year (you can trade in your phone after six or more months to upgrade) International features In Canada and Mexico: Unlimited talk, text, 128Kbps data (essentially unusably slow) Abroad: Unlimited texting in 215+ countries and destinations In Canada and Mexico: Unlimited talk, text, 15GB high-speed data Abroad: Unlimited text, 5GB high-speed data in 215+ countries and destinations Full flight texting and WiFi with streaming where available (mostly domestic US flights) In Canada and Mexico: Unlimited talk, text, 30GB high-speed data Abroad: Unlimited text, 15GB high-speed data in 215+ countries and destinations Full flight texting and WiFi with streaming where available (mostly domestic US flights) At the time of writing, T-Mobile also has a limited-time promotion for its plans where you can get a third line free (the same price as two lines). It also has the limited-time Essentials 4 Line offer for $100 per month. These promotions are outrageously good value for families or friend groups with three or more lines. Lines Essentials (including Essentials Saver, 3rd line free, and 4-line offer) Experience More (including 3rd line free offer) Experience Beyond (including 3rd line free offer) 1 $50/month $85/month $100/month 2 $40 per line ($80 total)/month $70 per line ($140 total)/month $85 per line ($170 total)/month 3 $30 per line ($90 total)/month $46.60 per line ($140 total)/month $56.60 per line ($170 total)/month 4 $25 per line ($100 total)/month $42.50 per line ($170 total)/month $53.75 per line ($215 total)/month 5 $24 per line ($120 total)/month $40 per line ($200 total)/month $52 per line ($260 total)/month T-Mobile Experience More plan T-Mobile's Experience More plan is an excellent for most people with good T-Mobile coverage, as it comes with unlimited premium data, a generous 60GB of mobile hotspot data, tempting discounts on popular streaming services like Netflix and Apple TV Plus, and comprehensive international features. Check price at T-Mobile No mix-and-match plans with T-Mobile Unlike other carriers, T-Mobile doesn't let you add differing plans under one multi-line account — every line in the account must have the same plan. That inflexibility can be somewhat mitigated by T-Mobile's 3rd-line-free promotion, but all the users in an account are still beholden to the cost of the highest-tier plan in the account. For example, if one person in an account needs the Experience Beyond plan, but the others only need the Essentials plan, everyone has to get the Experience Beyond plan and pay more than they would if they could mix and match plans. When it makes sense to get the Essentials plan If you do not need mobile hotspot data If you do not need built-in international features When it makes sense to upgrade to the Experience More plan If you need up to 60GB of fast mobile hotspot data If you need some international connectivity When it makes sense to get the Experience Beyond plan If you need up to 250GB of fast mobile hotspot data If you need lots of international connectivity You're sometimes or often off the grid and would benefit from satellite messaging, emergency services included. Note that Apple includes free Emergency SOS via satellite and Messaging via satellite free for two years after activating an iPhone 14 series or newer. The iPhone 14 is over two years old at this point, and Apple has yet to release a pricing structure for its satellite services. Don't upgrade to an Experience plan just for the streaming service and watch/tablet line discounts The maximum savings from the streaming service discounts on the Experience More plan is around $18, and up to $28 on the Experience Beyond plan. Even with all the discounts on the Experience Beyond plan combined, including streaming services and watch/tablet lines, the maximum savings amount to $50. Those discounts won't offset the added cost of the Experience plans if all you need is the Essentials plan. They are nice benefits if you also need the core features included in the Experience plans that aren't included in the Essentials plan, like fast (usable) hotspot data and extended international features. T-Mobile offers the plans with discounts for members of the military and veterans, first responders, and customers aged 55 or older. T-Mobile also offers prepaid plans, but they are poor value compared to mobile-virtual-network-operator (MVNO) options, many of which run on T-Mobile's network. MVNOs tend to offer the same amount or more data than T-Mobile's prepaid plans for lower monthly costs. The first MVNO alternative to T-Mobile's prepaid plans that comes to mind is Mint Mobile, which T-Mobile purchased back in 2024, and tops our list in our guide for the best cheap cell phone plans. Coverage T-Mobile has typically excellent coverage in many urban and suburban areas, and its rural coverage is expanding quickly. It can even serve certain areas better than other major carriers. To be sure, the opposite can be true for other areas. I can't say whether T-Mobile's coverage works for you and your area, and while T-Mobile's coverage map can give you an idea, no carrier coverage map is truly accurate. The best way to determine if T-Mobile works well in your area is to ask local friends, family, and neighbors. You can also check local groups on social media channels, like Facebook and If someone says T-Mobile's coverage isn't good, ask which carrier works for them. You might find that no carrier works well in that area, as is the case around my home. I fully realize the irony that someone writing a carrier review has poor coverage from every major carrier. Don't worry, I venture out to various spots in and out of town to test signal strength and data speeds. Data speeds T-Mobile advertises data speeds between 79 and 357 Mbps on its Essentials plans, and between 89 and 418 Mbps on its Beyond plans. Our speed tests varied wildly, regardless of plans — as high as 902 Mbps in busy parts of town, to as low as 0.97 Mbps in leafy residential areas not too far away from the busy section. Interestingly, I saw fast speeds up to 303 Mbps in sparsely populated "back-country" parts of my area. To be sure, T-Mobile data speeds will differ nationwide, and even in different parts of my town. Data speed differences between the two plans Unlike data speeds in my test areas, the difference in data speeds between the Essentials plan and the Experience Beyond plan can be translated to almost anyone across the country. T-Mobile's website has a fine-print clause beneath its plan offerings stating that the Essentials plan may deliver slower data speeds than higher-tier plans. My tests confirm that this is true. Still, while measurable, the difference in data download speeds isn't dramatic — the Essentials plan recorded 19% slower speeds on average than the Experience Beyond plan across 31 tests in various parts of town, including busy commercial areas, residential zones, parks, and backcountry. To put that into perspective, the average download speed on the Essentials plan was 220 Mbps in my tests, and 263 Mbps on the Experience Beyond plan. Both speeds are easily fast enough for most people, and the experience of using apps was identical on both the Essentials and Experience Beyond plans, whether I was in an area with slow or fast speeds. This means that those leaning toward the more affordable Essentials plan shouldn't be concerned about slower speeds or a meaningfully different experience compared to the higher-tier plans. Speeds Essentials Saver Experience Beyond Percentage difference Average download speeds (Mbps) 220 263 19% Average upload speeds (Mbps) 17 18 5% Additionally, the fastest speed test we recorded was 902 Mbps on the Essentials plan. The fastest speed test recorded on the Experience Beyond plan was 856 Mbps. Phone deals Like most major carriers in the US, T-Mobile has tempting deals for new phones. Deals differ for different phones, so you'll need to check the specific deals for the one you'd like. Still, it's possible to get even a high-end $1,000 iPhone 16 Pro for free with various condition combinations, like trading in a phone, signing up for a specific plan, or switching to T-Mobile from a different carrier. The trade-in value of your old phone depends on its generational age. For example, an iPhone 13 has a higher trade-in value than the iPhone 12. There are deals with varying conditions for almost every phone on T-Mobile, many get you a new phone for free, and some aren't even dependent on signing up for a pricey high-end plan. You generally get a better deal when signing up for higher-tier plans. The overarching phone deal condition with T-Mobile is that you must keep the phone for 24 months (two years) before you can upgrade to a new one. The exception is the Experience Beyond plan, which lets you upgrade yearly. At these times, you'll also have access to the same deals as new customers. To be sure, T-Mobile offers a shorter window before you can upgrade phones than Verizon and AT&T, which don't let you upgrade for 36 months (or three years). Should you sign up for T-Mobile? T-Mobile's plans propose some of the best value among major carriers, especially the Essentials and Experience More plans. As with most major carriers, you get better value with more lines on your account, generally around three or more lines. We recommend that those with less than three lines look at MVNOs, including Mint Mobile, which T-Mobile acquired. MVNO options often have similar features and data as the basic postpaid plans from major carriers for a lower monthly bill. For more information, take a look at our roundups of the latest Mint Mobile plans and Visible mobile deals. Still, T-Mobile's physical locations are a major benefit. They can offer superior in-person support than the phone and online-based support MVNOs offer. If you'd rather go to a physical location for anything related to your cell service, whether setting up your plan on your phone or troubleshooting an issue, you'll be better off with T-Mobile. Only rule out T-Mobile if you find it has poor coverage in your area. After all, value doesn't matter if you can't use the service. T-Mobile Essentials Plans T-Mobile's Essentials and Essentials Saver plans constitute the most affordable premium plans among the major carriers. It's a downright bargain with four or five lines on a single plan and includes 50GB of premium monthly data per line before T-Mobile slows down your data speeds. Just note that Essentials users may experience slower speeds than higher-paying T-Mobile customers during heavy network congestion. Check price at T-Mobile Shop all T-Mobile deals
Yahoo
a day ago
- Yahoo
AT&T Fiber delivers high-speed internet to thousands of Door County homes
EGG HARBOR, Wis (WFRV) – Fast, reliable internet is finally reaching more rural homes in Door County. Governor Tony Evers joined AT&T executives and local government officials Thursday morning to celebrate the launch of a $24 million public-private fiber broadband project, which will eventually serve more than 5,400 addresses across four Door County communities. New partnership provides young northeastern Wisconsinites with theater training during summer The event took place at the Kress Pavilion in Egg Harbor, where AT&T technicians provided a fiber splicing demonstration and offered tours of the company's service trucks. The first homes in the Town of Egg Harbor are now eligible to order AT&T Fiber, with other areas expected to come online in phases. The expansion includes partnerships with the towns of Egg Harbor, Sevastopol, Sturgeon Bay, and the Village of Egg Harbor. A mix of funding from AT&T, local municipalities, and the Wisconsin Public Service Commission's Capital Projects Fund helped make the project possible. 'There are residents and businesses that didn't have access to high-speed fiber — and now they do,' said Robyn Gruner, AT&T's director of external affairs in Wisconsin. 'It's a critical piece of infrastructure, not just for streaming or working from home, but for healthcare, education, and staying connected.' Gruner said more than 350 homes are now eligible to sign up for service, and more than 50 orders have already come in. Governor Evers used the opportunity to highlight his administration's commitment to broadband access, pointing to $400 million in proposed broadband investments in his latest state budget. 'With uncertainty at the federal level, momentum is more important than ever that we continue to make this a statewide issue,' Evers said. 'We've already helped over 410,000 homes and businesses get access to new or improved broadband.' Wisconsin's budget talks stall, create possible ripple effect on 2026 gubernatorial race Local leaders say the upgrades are long overdue in an area where geography and low population density have long made internet access a challenge. The broader project is expected to roll out over the coming months, connecting thousands more Door County residents to high-speed fiber. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Miami Herald
a day ago
- Miami Herald
AT&T makes generous offer to older customers
Over the past few months, AT&T (T) has made significant adjustments to its pricing, which has frustrated a few of its customers. Last year in August, AT&T increased the monthly price for most of its retired unlimited wireless plans by $10 for customers with one phone line and $20 for customers with multiple lines. Don't miss the move: Subscribe to TheStreet's free daily newsletter In November, AT&T also hiked the monthly price for its fiber and internet plans by $5. Also, in April this year, AT&T even decreased its autopay discount from $10 to $5 for phone and internet customers who pay their bills with debit cards. Related: AT&T's response to a growing threat spells trouble for customers Those who pay their bills with credit cards had their autopay and paperless billing discount completely removed. Amid these changes, AT&T revealed in its first-quarter earnings report for 2025 that it generated a net income of $4.7 billion during the quarter, which is 19% higher than what it earned during the same quarter in 2024. It also added 324,000 new postpaid phone customers and 261,000 new fiber internet customers during the first few months of the year. Image source:As AT&T sees higher profits and welcomes thousands of new customers, the phone carrier has made a bold move to attract an older group of customers who may have been discouraged by recent price increases. The phone carrier has introduced its AT&T 55+ Plan, in which customers 55 years old and older are offered one phone line for $40 a month and two phone lines for $35 a month, with autopay and paperless billing discounts activated. The plan includes unlimited talk, text, and data in and between the U.S., Canada, and Mexico. It also offers 10GB of Hotspot Data and AT&T ActiveArmor, which offers 24/7 security to help stop spam/scam calls and texts. Related: Verizon raises red flag about concerning customer behavior "Our customers remain at the center of everything we do. By listening to their needs and challenges, we recognized their growing desire for reliable and affordable connectivity - all delivered with ease," said AT&T Mass Markets Executive Vice President Jenifer Robertson in a press release. AT&T's newest plan for seniors comes at a time when one of its main competitors, T-Mobile, is offering customers who are 55 years old and older one phone line for $40 a month and two phone lines for $60 a month (with autopay enabled) through its Essentials Choice 55 plan. Verizon also offers a senior phone plan, but it is only for Florida customers. Through its 55+ Senior plan, customers can purchase one phone line for $62 a month or two phone lines for $84 a month. The move from AT&T also comes after its CEO recently issued a stern warning about the company's future phone prices, which President Donald Trump's tariff policy will impact. In April, Trump imposed a 10% baseline tariff on all countries and paused reciprocal tariffs. The pause will end in July, resulting in roughly 60 countries seeing higher tariff rates. This will likely cause U.S. consumers to see increased prices for everyday goods. More Retail: Costco quietly plans to offer a convenient service for customersT-Mobile pulls the plug on generous offer, angering customersKellogg sounds alarm on unexpected shift in customer behavior During an earnings call on April 23, AT&T CEO John Stankey said that tariffs can negatively impact several devices the company sells. "The announced tariffs could potentially increase the cost of smartphones and other devices, as well as the cost of network and technical equipment," said Stankey. "The magnitude of any increase will depend on a variety of factors, including how much of the tariffs our vendors pass on, and the impact that the tariffs have on consumer and business demand." He also warned that AT&T may have to raise prices for its devices due to Trump's tariffs. "So I think that if ultimately costs are passed to us from those that we buy handsets from, unfortunately for the customer, we're going to have to come up with some new ways for them to figure out how to digest that increase in pricing," Stankey said. Related: AT&T quietly issues stern warning to customers The Arena Media Brands, LLC THESTREET is a registered trademark of TheStreet, Inc.
