Amylyx Pharmaceuticals Gains FDA Fast Track for ALS Drug AMX0114
Amylyx Pharmaceuticals Inc. (NASDAQ:AMLX) is one of the best biotech stocks to invest in now. On June 3, Amylyx Pharmaceuticals announced that the US FDA granted Fast Track designation to AMX0114. AMX0114 is an investigational antisense oligonucleotide/ASO that is specifically designed to target calpain-2. This protein is believed to be a significant contributor to axonal degeneration, which is a key driver in the progression of amyotrophic lateral sclerosis/ALS.
ALS is a rapidly progressive and fatal neurodegenerative disorder with limited therapeutic options. The Fast Track designation is a crucial step for Amylyx in its mission to develop treatments for ALS. The FDA's decision acknowledges both the severity of ALS and the encouraging preclinical data supporting AMX0114's potential.
A medical scientist in a lab coat gazing at a microscopic view of a drug in development.
Calpain-2 is a calcium-activated protease. Research has indicated that overactive calpain-2 activity might accelerate disease progression in ALS and other neurodegenerative conditions by causing the degeneration of axons, which are vital for transmitting signals between neurons and muscles. Preclinical studies of AMX0114 have demonstrated improved neuronal survival and reduced levels of extracellular neurofilament light (NfL), which is a biomarker for neuronal damage across various disease models. AMX0114 was also well-tolerated in preclinical safety studies.
Amylyx Pharmaceuticals Inc. (NASDAQ:AMLX) is a clinical-stage pharmaceutical company that discovers and develops treatments for neurodegenerative diseases and endocrine conditions in the US.
While we acknowledge the potential of AMLX as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the .
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Disclosure: None. This article is originally published at Insider Monkey.
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Kandal M Venture Limited Announces Pricing of Initial Public Offering and Listing on Nasdaq
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The Company intends to use the net proceeds for (i) broadening its customer base by expanding its geographical reach to other key markets, including the European markets, (ii) enhancing its production capacity, (iii) establishing a new design and development center for enhancing its product development capabilities, and (iv) additional working capital and other general corporate purposes. In addition, the Company has granted the underwriters a 45-day option to purchase up to an additional 300,000 Class A Ordinary Shares of the Company, at the Offering Price, less underwriting discounts. The Offering is being conducted on a firm commitment basis. Dominari Securities LLC acted as the representative of the underwriters, and Revere Securities LLC acted as the co-underwriter (collectively, the 'Underwriters') for the Offering. Loeb & Loeb LLP acted as U.S. legal counsel to the Company and The Crone Law Group, P.C. acted as legal counsel to the Underwriters for the Offering. The Offering is being conducted pursuant to the Company's Registration Statement on Form F-1 (File No. 333-282786), as amended, previously filed with, and subsequently declared effective by the U.S. Securities and Exchange Commission (the 'SEC') on June 23, 2025. The Offering is being made only by means of a prospectus, forming a part of the registration statement, and a free writing prospectus. You may obtain these documents for free by visiting EDGAR on the SEC's website at Alternatively, electronic copies of the final prospectus relating to this Offering may be obtained from Dominari Securities LLC by email at info@ by standard mail to Dominari Securities LLC, 725 Fifth Avenue, 23rd Floor, New York, NY 10022, or by telephone at +1 (212) 393-4500; or from Revere Securities LLC by email at contact@ by standard mail to Revere Securities LLC, 560 Lexington Avenue, 16th Floor, New York, NY 10022, or by telephone at +1 (212) 688-2350. Before you invest, you should read the registration statement, the prospectus and other documents the Company has filed or will file with the SEC for more information about the Company and the Offering. This press release has been prepared for informational purposes only and shall not constitute an offer to sell or the solicitation of an offer to buy any securities, and no sale of these securities may be made in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction. About Kandal M Venture Limited Kandal M Venture Limited is a contract manufacturer of affordable luxury leather goods with its manufacturing operations in Cambodia. Kandal M Venture Limited primarily manufactures handbags, such as shoulder bags, crossbody bags, tote bags, backpacks, top-handle handbags, satchels, and other smaller leather goods, such as wallets. 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The Company cautions investors that actual results may differ materially from the anticipated results and encourages investors to read the risk factors contained in the Company's final prospectus and other reports it files with the SEC before making any investment decisions regarding the Company's securities. The Company undertakes no obligation to update or revise publicly any forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law. Contacts: Company:Kandal M Venture Limited Investor Relations Contact:Padachi Village, Prek Ho Commune, Takhmao Town, Kandal Province, Kingdom of CambodiaEmail: enquiry@ +855 23425205 Investor Relations Contact:Skyline Corporate Communications Group, LLCScott Powell, President1177 Avenue of the Americas, 5th FloorNew York, New York 10036Office: (646) 893-5835 x2Email: info@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
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Inc. 1,840,179 62.80 62.71 62.79 +0.02 Chewy Inc. 1,827,433 43.71 42.73 43.45 +0.06 Newmont Corp. 1,721,638 58.26 57.56 58.09 0.00 Merck & Co. Inc. 1,721,762 79.79 79.16 79.76 -0.56 Schlumberger N.V. (Ltd.) 1,701,733 33.615 33.30 33.495 -0.005 Chipotle Mexican Grill Inc. 1,668,589 55.325 54.63 55.055 +0.405 Citigroup Inc. 1,630,731 81.60 81.075 81.425 +0.285 CNH Industrial N.V. 1,576,768 12.91 12.67 12.675 -0.205 Endeavour Silver Corp. 1,542,033 4.78 4.68 4.7554 +0.0454 Pinterest Inc. 1,539,490 36.25 35.60 35.61 -0.13 Toast Inc. 1,541,286 45.14 43.55 43.65 -1.02 Halliburton Co. 1,498,162 20.7599 20.52 20.59 -0.19 Gamestop Corp. 1,488,996 23.69 23.25 23.38 +0.09 Fortuna Mining Corp. 1,457,585 6.54 6.44 6.5003 +0.0303 Samsara Inc. 1,453,259 41.04 40.265 40.415 +0.135 Lumen Technologies Inc. 1,435,260 4.31 4.145 4.205 -0.095 Amrize AG 1,406,336 52.98 51.37 51.965 -1.035 Western Union Co. 1,386,726 8.55 8.48 8.515 -0.045 Kinross Gold Corp. 1,371,518 15.34 15.18 15.3201 +0.0101 AMC Entertainment Holdings Inc 1,356,940 3.08 3.005 3.015 +0.015 Vertiv Holdings Co. 1,350,825 124.619 122.81 123.345 +1.025 Rubrik Inc. 1,345,476 93.64 90.70 92.93 +2.83 Rocket Companies Inc. 1,338,536 14.95 14.455 14.505 -0.445 Planet Labs PBC 1,333,207 5.74 5.50 5.525 -0.045 Paramount Group Inc. 1,323,843 6.25 6.01 6.205 -0.045 Iamgold Corp. 1,330,381 7.34 7.24 7.29 +0.04 Delta Air Lines Inc. 1,318,214 49.72 48.61 48.775 -0.785 Bristol-Myers Squibb Co. 1,317,455 47.00 46.51 46.80 -0.23 Zim Integrated 1,311,297 16.00 15.435 15.505 -0.105 Darling Ingredients Inc. 1,303,578 38.515 37.59 37.87 -0.75 Algonquin Power&Utilities Corp 1,263,270 5.71 5.64 5.665 -0.075 Salesforce Inc. 1,244,927 274.00 270.50 270.73 -0.44 Keycorp 1,242,970 16.77 16.615 16.665 -0.085 Hudson Pacific Properties Inc. 1,239,088 2.7097 2.575 2.695 -0.025 Nextera Energy Inc. 1,239,379 71.13 70.14 71.03 -0.37 Realty Income Corp. 1,237,052 57.78 57.0703 57.76 -0.22 Regions Financial Corp. 1,235,792 22.87 22.69 22.76 -0.12 CVS Health Corp. 1,228,865 67.41 66.07 66.705 -0.875 Annaly Capital Management Inc. 1,224,057 19.43 19.27 19.39 +0.03 Hewlett Packard Enterprise Co. 1,218,011 18.44 18.20 18.34 +0.19 Walt Disney Co., The 1,173,283 119.31 118.68 119.24 +0.59 Avantor Inc. 1,150,786 13.46 13.05 13.26 -0.20 NYSE American most active stocks: Stock Name Volume High Low Last Change Denison Mines Corp. 15,545,045 1.81 1.77 1.77 -0.03 Genius Group Ltd. 12,157,981 0.8257 0.7431 0.7848 +0.0878 Impact Biomedical Inc. 11,887,957 1.09 0.921 1.0303 +0.1903 B2Gold Corp. 4,849,669 3.59 3.55 3.575 +0.015 New Gold Inc. 3,573,274 4.875 4.79 4.82 -0.03 Equinox Gold Corp. 2,664,279 5.945 5.79 5.92 +0.09 Uranium Energy Corp. 2,047,524 6.80 6.53 6.61 -0.04 Energy Fuels Inc. 1,866,043 5.815 5.58 5.61 -0.04 EON Resources Inc. 1,559,910 0.41 0.3666 0.3815 -0.0514 NovaGold Resources Inc. 1,404,989 3.935 3.72 3.7293 -0.1707 Nuburu Inc. 1,359,874 0.3249 0.3133 0.3166 +0.004 Indonesia Energy Corp. Ltd. 1,281,640 3.25 3.0112 3.1899 -0.2801 Northern Dynasty Minls Ltd. 1,206,307 1.40 1.34 1.3903 +0.0503 KULR Technology Group Inc. 1,095,221 6.3934 5.765 5.765 -0.775 NORTHANN CORP. 1,085,959 0.169 0.1612 0.1676 +0.0042 Ocean Power Technologies Inc. 1,085,264 0.53 0.495 0.4959 -0.0051 Vizsla Silver Corp. 1,026,507 2.95 2.89 2.905 -0.035 Senseonics Holdings Inc. 1,024,698 0.5065 0.4961 0.4963 -0.006 Avino Silver & Gold Mines Ltd. 940,606 3.4178 3.35 3.39 -0.03 Taseko Mines Ltd. 862,295 2.905 2.84 2.845 -0.045 Silvercorp Metals Inc. 846,921 4.09 4.02 4.055 -0.005 Lineage Cell Therapeutics Inc. 725,793 1.10 1.00 1.005 -0.075 United States Antimony Corp. 635,951 2.675 2.52 2.52 -0.06 Centrus Energy Corp. 631,690 195.70 177.00 179.46 -12.72 AgEagle Aerial Systems Inc. 604,771 1.1399 1.07 1.1101 +0.0501 Unusual Machines Inc. 577,387 8.50 7.9001 7.9475 -0.2425 TMD Energy Ltd. 495,603 1.805 1.53 1.64 -0.17 Mag Silver Corp. 476,821 21.22 20.92 21.1928 +0.1328 Ryde Group Ltd. 457,907 0.32 0.2775 0.2979 -0.0141 Castellum Inc. 443,407 1.085 1.04 1.04 -0.03 Gold Resource Corp. 427,731 0.566 0.511 0.53 -0.03 Perspective Therapeutics Inc. 425,303 3.94 3.54 3.55 -0.27 Ur-Energy Inc. 413,703 1.065 1.03 1.04 -0.01 Know Labs Inc. 406,193 2.52 2.13 2.272 -0.278 TRX Gold Corp. 389,734 0.3379 0.335 0.335 -0.0014 Hyperscale Data Inc. 362,277 1.41 1.35 1.3509 -0.0791 Aeon Biopharma Inc. 341,419 0.80 0.7622 0.7795 +0.0715 331,841 12.43 10.71 11.7651 -1.0649 Trio Petroleum Corp. 310,880 1.29 1.24 1.2601 -0.0999 Ring Energy Inc. 310,522 0.7656 0.743 0.7443 -0.0166 I-80 Gold Corp. 299,932 0.6799 0.6568 0.6587 -0.0206 Hyliion Holdings Corp. 290,042 1.4375 1.36 1.365 -0.025 Americas Gold & Silver Corp. 306,853 0.78 0.7505 0.76 -0.0078 Nanoviricides Inc. 255,867 1.4553 1.39 1.45 +0.05 Credit Suisse High Yld Bd Fd 248,353 2.11 2.09 2.105 +0.005 FOXO Technologies Inc. 241,556 0.2008 0.1978 0.1987 -0.0009 Galiano Gold Inc. 235,848 1.36 1.32 1.33 -0.03 Catheter Precision Inc. 228,091 0.2502 0.24 0.2502 +0.0017 Moving iMage Technologies Inc. 226,738 0.6449 0.612 0.6248 -0.0361 Metalla Royalty&Streaming Ltd. 227,020 3.86 3.54 3.86 +0.25 Atlasclear Holdings Inc. 215,762 0.19 0.1875 0.1897 -0.0043 Battalion Oil Corp. 210,553 1.6155 1.4901 1.53 -0.10 Standard Lithium Ltd. 209,589 1.88 1.80 1.80 -0.06 Cornerstone Inc. 191,099 8.00 7.95 7.95 -0.04 Matinas BioPharma Holdings Inc 188,618 1.02 0.88 0.9725 +0.0665 Aris Mining Corp. 180,138 6.669 6.53 6.665 +0.045 Gold Royalty Corp. 168,190 2.30 2.24 2.29 +0.03 Calidi Biotherapeutics Inc. 167,797 0.2636 0.243 0.2436 -0.0165 Azitra Inc. 166,140 0.2497 0.2399 0.2477 -0.0021 Intl Tower Hill Mines Ltd. 165,588 0.92 0.8701 0.88 -0.0048 Orla Mining Ltd. (new) 137,944 10.12 9.8502 9.875 -0.235 Protalix BioTherapeutics Inc. 134,453 1.555 1.47 1.475 -0.055 Integra Resources Corp. 124,751 1.63 1.59 1.595 -0.025 Westwater Resources Inc. 108,721 0.6026 0.565 0.5672 -0.0228 Vista Gold Corp. 105,429 1.05 1.02 1.03 -0.02 Gamco 101,966 4.39 4.33 4.345 +0.005 DSS Inc. 98,880 0.9159 0.82 0.8775 +0.0175 Cornerstone Total Return Fund 96,458 7.60 7.565 7.565 -0.035 Signing Day Sports Inc. 95,149 1.09 1.04 1.0498 -0.0202 Frankl. Ltd Duration Income T. 94,642 6.41 6.38 6.40 +0.02 Credit Sui. Asset Mgmt Inc. Fd 89,651 2.92 2.887 2.915 +0.015 GoldMining Inc. 87,460 0.75 0.7371 0.7375 -0.0025 Healthy Choice Wellness Corp. 80,080 0.43 0.4001 0.41 +0.0069 Platinum Group Metals Ltd. 77,119 1.50 1.48 1.48 -0.01 KAIROS Pharma Ltd. 73,250 0.6762 0.6234 0.6398 -0.0092 Cybin Inc. 71,499 8.247 7.98 8.03 +0.19 China Pharma Holdings Inc. 70,291 1.7109 1.55 1.68 -0.04 Imperial Oil Ltd. 69,822 79.28 78.25 79.25 +0.50 Enigmatig Ltd. 69,590 2.9798 2.6393 2.7501 -0.2299 IT Tech Packaging Inc. 68,140 0.1964 0.1912 0.194 0.00 OS Therapies Inc. 67,802 1.88 1.73 1.745 +0.025 Tecogen Inc. (New) 62,540 7.22 6.82 7.01 -0.31 Inuvo Inc. 62,038 4.1996 3.81 3.9873 +0.2473 Barnwell Industries Inc. 59,482 1.2301 1.16 1.1848 -0.0552 Mexco Energy Corp. 56,976 14.01 8.81 8.81 -0.915 Pedevco Corp. 56,348 0.6686 0.6501 0.6539 -0.0073 51,900 3.26 3.2194 3.23 -0.04 SunLink Health Systems Inc. 50,849 0.935 0.9096 0.9096 -0.0126 Eaton Vance Municipal Bond Fd 50,212 9.58 9.55 9.57 +0.01 Wells Fargo Income 49,491 6.96 6.94 6.955 +0.015 New Found Gold Corp. 49,235 1.47 1.45 1.455 -0.015 BK Technologies Corp. 46,944 57.605 49.89 51.50 -3.12 Idaho Strategic Resources Inc. 46,574 13.6928 13.51 13.51 -0.23 Myomo Inc. 45,881 2.38 2.31 2.31 -0.05 Eaton Vance 45,714 10.13 10.073 10.1212 +0.0312 Exodus Movement Inc. 44,136 34.00 30.75 31.30 -2.86 Oragenics Inc. 43,245 3.83 3.61 3.82 +0.21 Ivanhoe Electric Inc. 41,105 8.645 8.44 8.57 +0.13 Planet Green Holdings Corp. 40,008 0.85 0.7481 0.7896 -0.0423 Comstock Inc. 41,146 3.59 3.45 3.455 -0.095 Sign in to access your portfolio
