Mysuru-based doctor develops affordable procedure to check rupture of membranes
Her case report was published in the International Journal of Reproductive, Female and Child Health. The therapy leverages the sealing properties of fibrin and the regenerative effects of platelets, both derived from the patient's blood, making it autologous and accessible.
This novel protocol involves injecting a mixture of autologous PRF and PRP into the amniotic cavity under ultrasound guidance to seal membrane ruptures and support fetal development.
According to Dr Sowmya, "The goal is to seal the rupture and restore a viable environment for the baby to grow." This is the first reported use of this cellular therapeutic combination for Spontaneous PV-PROM (sPV-PROM), achieving the earliest documented intervention at 14 weeks and three days gestation and the longest pregnancy continuation of 149 days in a singleton sPV-PROM case, she said.
The case involved a 26-year-old woman who lost her previous pregnancy due to sPV-PROM at 18 weeks.
In her current pregnancy at 14 weeks and 3 days, she again experienced an amniotic fluid leak. After 50 hours of the onset of the leak, the novel Intra-amniotic Fibrin and Platelet Therapy (IFPRP) halted the amniotic fluid leak completely within 36 hours. The patient delivered a healthy 3.4kg baby at 35 weeks and 4 days, with no postnatal complications for mother or baby.
Active infection control measures, including vaginal asepsis, supported the treatment, she explained.
After documenting this step, Dr Sowmya's team started a multicentric case series and has treated 14 high-risk pregnancies with IFPRP, sealing leaks in 10 cases (71% success rate), a significant improvement over the typical 90% pregnancy loss rate in sPV-PROM. The treatment resulted in 12 healthy births, including three sets of twins, with one pregnancy ongoing. No complications or infections were reported, she claimed.
"This protocol is simple, cost-effective, and feasible in resource-poor settings, making it a groundbreaking option where no curative treatment previously existed," Dr Sowmya noted.
The team includes Dr Yogitha Rao, Dr Seema SJ, Dr Srividhya NB, and Dr Praveen NS.
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