PETA claims monkey died ‘painful death' at OHSU research center, requests investigation
In a sent to the director of the National Institutes for Health's Office of Laboratory Animal Welfare, PETA urged the Division of Compliance Oversight to probe the Oregon National Primate Research Center.
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Located on Oregon Health and Science University's West campus in Beaverton, the facility has been accused of ignoring the symptoms of a Japanese macaque that died from sepsis last October. The U.S. Department of Agriculture cited this incident in its inspection report from March 4.
The a technician neglected to notify a veterinarian when the 4-year-old female monkey was found 'lying down multiple times' the day before her death.
'The failure to report unexpected signs of illness/distress such as repeatedly lying down to ensure timely delivery of veterinary medical care directly impacted the welfare of this animal,' USDA wrote.
The department further noted that several other animals spent 96 hours in an enclosure that did not meet regulators' minimum space requirements.
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Amy Meyer, associate director of PETA's primate experimentation campaigns, argued the facility is likely in noncompliance with NIH's Public Health Service Policy on Humane Care and Use of Laboratory Animals.
'We urge your office to thoroughly investigate the failures detailed in the USDA inspection report and assess whether OHSU has complied with its obligation to self-report problems in its laboratories,' Meyer wrote. 'Prompt and decisive action is warranted to address these apparent violations and to help prevent future lapses in oversight and animal welfare.'
The facility has received plenty of backlash from animal rights activists and, in response, researchers held an of their work just a few weeks ago. Oregon Gov. Tina Kotek has asked OHSU to close the center in response to the pushback, but the institution contends it is committed to providing humane treatment.
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The university also 'implemented measures to prevent a recurrence' of the death at the center of PETA's complaint, according to its statement to KOIN 6.
'Dozens of highly trained veterinary professionals engage with these animals daily to ensure their ongoing safety, enrichment, health and well-being,' OHSU said. 'These dedicated individuals develop strong bonds with the animals entrusted to their care — often for many years, and, in some cases, decades – so, the unexpected death of any animal is distressing, and their passing is grieved.'
Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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(HKEX:1672, "Ascletis") announces encouraging efficacy results from its study in diet-induced obese (DIO) mice combining ASC47, a first-in-class muscle-preserving weight loss drug candidate for the treatment of obesity, with tirzepatide. ASC47 is an adipose-targeted, once-monthly subcutaneously (SQ) injected thyroid hormone receptor beta (THRβ) selective small molecule agonist, discovered and developed in-house at Ascletis. ASC47 possesses unique and differentiated properties to enable adipose targeting, resulting in dose-dependent high drug concentrations in the adipose tissue. The objective of the DIO mouse study was to compare a low dose of ASC47 (9 mg/kg, single dose) combined with tirzepatide (3 nmol/kg, SQ, once daily) against tirzepatide monotherapy (3 nmol/kg, SQ, once daily). The treatment duration in the DIO mice was 14 days. 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ASC47 low dose demonstrated greater efficacy with tirzepatide than semaglutide Group Dosing Total body weight changefrom baseline Greater body weightreduction of combinationvs monotherapy Obese mice treatedwith tirzepatide Tirzepatide, 3 nmol/kg, SQ, QD -20.4 % - Obese mice treatedwith ASC47 lowdose combinationwith tirzepatide ASC47, 9 mg/kg, SQ, a single dose + tirzepatide, 3 nmol/kg, SQ, QD -38.1% (p<0.0001 vs tirzepatide monotherapy) 87 % Obese mice treated with semaglutide Semaglutide, 30 nmol/kg, SQ, QD -23.1 % - Obese mice treated with ASC47 low dose combinationwith semaglutide ASC47, 9 mg/kg, SQ, a single dose + semaglutide, 30 nmol/kg, SQ, QD -35.9% (p<0.0001 vssemaglutide monotherapy 55 % Note: Treatment duration: 14 days for tirzepatide monotherapy and ASC47/tirzepatide combination therapy; 28 days for semaglutide monotherapy and ASC47/semaglutide combination therapy; Obese mice: diet-induced obese mice; SQ: subcutaneous; QD: once daily. The combination of ASC47 low dose with tirzepatide also restored the body composition of obese mice to the level of healthy non-obese mice. At the end of treatment, the percentage of total muscle mass over the total body weight of obese mice treated with ASC47 low dose and tirzepatide (60.4%) was similar to healthy non-obese mice (62.0%), indicating healthy weight loss. Tirzepatide monotherapy was unable to restore body composition to healthy levels. "These preclinical data build upon a body of evidence demonstrating the potential of ASC47 as an important therapeutic approach for the treatment of obesity." said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis, "With topline data in participants with obesity from the combination study of ASC47 with semaglutide coming soon, we look forward to the combinations of ASC47 with other incretin drugs including tirzepatide in future clinical trials." About Ascletis Pharma Inc. Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potential best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) Platform and Ultra-Long-Acting Platform (ULAP), Ascletis has developed multiple drug candidates in-house, including its lead program, ASC30, a small molecule GLP-1R agonist in development as a once-daily oral tablet and once-monthly subcutaneous injection for weight management. Ascletis is listed on the Hong Kong Stock Exchange ( For more information, please visit Contact: Peter VozzoICR Healthcare443-231-0505 (U.S.) Ascletis Pharma Inc. PR and IR teams+86-181-0650-9129 (China)pr@ View original content: SOURCE Ascletis Pharma Inc. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data