Millions of diabetes patients could be given weight loss jabs sooner
SGLT-2 inhibitors, which protect the heart and kidneys, are recommended as a first-line treatment option, potentially saving nearly 22,000 lives.
The guidelines aim to address the current under-prescription of SGLT-2 inhibitors, particularly among women, older people, and black patients, to reduce health inequalities.
GLP-1 receptor agonists, including semaglutide, are also suggested for earlier use in some patients, alongside tailored recommendations for specific conditions.
This shift represents a holistic approach to type 2 diabetes management, focusing on cardiovascular and kidney health, and is open for public consultation until 2 October.
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Daily Mirror
35 minutes ago
- Daily Mirror
Nick Knowles' wife Katie 'struggling every day' in sad health update after hysterectomy
Katie Dadzie, who is the wife of presenter Nick Knowles, has revealed she's 'struggling every day' and 'feels like s**t' following a recent hysterectomy Nick Knowles ' wife, Katie Dadzie, has shared a new health update after she underwent a hysterectomy, just weeks after the couple tied the knot. Katie, 35, and TV star Nick, 62, married last month in an intimate ceremony in Essex after dating for four years. Just a few short weeks after their special day, Katie announced that she was confronting personal health battles. She revealed in early July that she underwent major surgery after suffering with Polycystic Ovary Syndrome (PCOS), endometriosis and adenomyosis. The Boa Boa lingerie founder, who has two children from a previous relationship, shared details of her health journey, bringing attention to the conditions she battled. It comes after Katie was forced to hit back at cruel trolls who labelled her 'desperate' after she posted a racy snap. The NHS says PCOS is "a common condition that affects how a woman's ovaries work", while they describe endometriosis as a condition where "cells similar to those in the lining of the womb (uterus) grow in other parts of the body. It can have a big impact on your life, but there are treatments that can help". Sharing her sad health news, Katie posted video clips showing herself in hospital, wearing a hospital gown, and laying in a hospital bed. The footage showed various bandages on her abdomen, where surgeon entered her body to remove her uterus. In a candid and personal statement alongside the video clips, Katie shared her story, writing: "I'm 35 and I've just had a hysterectomy." Giving more detail, she continued: "I've lived with pcos, endometriosis and adenomyosis since Moses wore short pants. She added: "And no, it wasn't 'just a bad period.' It was constant hospital trips. Multiple laparoscopies. Bleeding through clothes. Vomiting from the pain. Being curled up in bed, missing out on life." Sharing more painful symptoms of her condition, she wrote: "It was extreme bloating that made me look pregnant. It was migraines, stabbing pains in my legs, butt and stomach. It was chronic fatigue. It was hiding in loos, crying over another ruined day. It was my daughters terrified of getting their periods in case they end up like mummy. Years of misdiagnosis & being fobbed off. Told to take painkillers. That it was 'normal.' It wasn't." Katie went on to explain the emotional toll her condition took on her, sharing: "I've cried on bathroom floors. I've bled through clothes in public. I've had 3 surgeries. I've tried every pill, every patch, every hormone tweak. I've been put on a medical menopause just to get through uni. And still… the pain came." Now in a new update six weeks after her surgery, Katie told her fans that she still 'feels like absolute s***' and has 'gained a stone in six weeks' during her recovery from the hysterectomy. A hysterectomy is a surgical procedure which removes a woman's womb and may also involve the removal of other organs, such as the ovaries. Opening up in her honest post, Katie said that she is still struggling every day. "I keep getting messages saying, "Wow, you're out already, you look amazing, you've bounced back so fast." But honestly? It's absolute Instagram propaganda. "The truth is, I don't recognise myself at all the moment. My body feels completely foreign. I've gained a stone in six weeks, I'm constantly bloated, my boobs are bigger and sore, my face looks puffy, my skin and hair are dry. Every time I see my reflection, it feels like a stranger staring back, and I hate it." Katie went on: "On top of that, I can't even exercise to help myself feel better. My consultant has told me I have another month of no baths or gym because of the pain and bleeding. That's four more weeks of being stuck in this body I don't feel comfortable in, with no outlet, no way to feel like me again. It's like I'm trapped, waiting for permission to move forward. "The symptoms are relentless: the brain fog, forgetting names mid-sentence, going to the wrong cinema, snapping at people I love because I'm just so up and down. The CONSTANT hot flushes, the 2, 3 & 4 a.m. wake-ups, waking up drenched in sweat, terrible back pain, exhaustion that sits in my bones. And mentally… I'm low, anxious, and angry." Nick's new wife went on to explain that while she may have got all dolled up to appear on ITV's Lorraine and for the Global Champions Arabians Tour, she has been struggling behind closed doors every day. "Yes, I can throw on a dress and lipstick and smile for a picture, but it's smoke and mirrors. Behind it, I feel like absolute s***," she confessed. "I'm sharing this because I don't want anyone scrolling through their feed thinking they're failing because they're not 'bouncing back' like I seem to be. I'm not. I'm bleeding, sore, puffy, heavier, grumpy, anxious and lost in a body I don't know or like. "If you're struggling too, whether it's with recovery, hormones, or just getting through the day, you're not alone. Instagram will show you the highlight reel. But for reals? It's mostly fake news." Katie, who has two daughters from a previous relationship, previously addressed the fact her decision to undergo surgery would mean she could not carry any more children with Nick. At the time, she confessed: "I didn't want more children, my girls are everything. But that doesn't mean this is easy. Because the choice has been taken from me. And that grief is real. It feels like something in me has changed, apart from being sans uterus." Katie has a nine-year-old daughter named Savannah, and a six-year-old girl called Alex. While DIY SOS presenter Nick has four children from three different relationships - sharing daughter Tuesday and eldest son Charlie with ex-wife, Gillian Knowles, son TJ with dancer Paula Beckett, and another son named Eddie.
Daily Mail
35 minutes ago
- Daily Mail
Mysterious blue brain found in autopsy linked to RFK Jr's 'miracle cure'
A substance touted by health secretary Robert F Kennedy Jr as a 'miracle cure-all' has been found to dramatically change the color of internal organs, according to a new study. Researchers at University Hospital Frankfurt in Germany examined the bodies of 11 people and discovered that methylene blue, a synthetic dye long used to treat conditions like malaria and methemoglobinemia. Methylene blue may also help combat other health problems, including urinary tract infections and depression, experts have said. During the autopsies, researchers discovered that the brains, hearts, lungs, and pancreases had turned a striking shade of blue. Even small doses, as little as 25 milligrams, roughly a quarter of a standard aspirin tablet, were enough to alter brain pigment, the team concluded. Some individuals had received 50 to 200 milligrams intravenously for medical conditions, with multiple doses given within 10 hours of death, and all showed discoloration of the brain and heart. The researchers emphasized that while the color changes darkened upon exposure to air during autopsies, the effect was not linked to the causes of death. Instead, it highlights how methylene blue persists in the body and can dramatically affect organ appearance, raising questions for forensic and medical examinations. The individuals who received methylene blue in the hospital were generally being treated for severe medical conditions, often involving life-threatening shock or critical illnesses. Most were in intensive care units (ICUs) for issues like septic shock from infections, heart failure, complications following surgeries, or severe COVID-19 infections. Hospital staff administered the dye intravenously as a last-resort treatment to improve blood flow and oxygen delivery when standard treatments failed. The startling discovery, published in the journal Forensic Science, Medicine and Pathology, was made while researchers were conducting an autopsy on a 72-year-old man and found his brain was blue. To understand why, they searched their institute's database of 15,820 autopsy records from 2000 to 2023, looking for similar cases of doctors finding 'blue-green,' 'greenish,' or 'turquoise' organs during autopsies. They found 11 cases, including the 72-year-old, where various organs throughout the body had this unusual color. In each case, they found that six of these individuals with blue organs had ingested or been given a dosage of methylene blue shortly before their deaths. The other five had received or ingested a medical dye called toluidine blue, a sedative called Rohypnol that contains the blue dye indigocarmine, or a cleaning agent with the blue dye Brilliant Blue FCF. Study authors in Germany found 6 people who received dosages of methylene blue while in the hospital had blue brains and hearts after death The patients had taken the medical dye as a last resort treatment for various illnesses, including COVID-19 Although RFK Jr has not publicly confirmed that he uses methylene blue, a February 2025 video showed the health secretary putting droplets of a cobalt-blue liquid into what looked like water. Recent studies have explored its use in fighting early-stage COVID-19 by potentially reducing viral damage and improving oxygen delivery. It's also been investigated for its ability to boost brain health, treat shock, and potentially as an anti-aging serum. Some research has even suggested it can kill cancer cells under specific conditions. In fact, actor Mel Gibson claimed three of his friends recovered from stage four cancer after taking a supplement regimen that included methylene blue. In fact, actor Mel Gibson claimed three of his friends recovered from stage four cancer after taking a supplement regimen that included methylene blue. The Daily Mail has requested a comment from RFK Jr and the Department of Health and Human Services about the findings and is awaiting a response. While medical professionals only use the dye in extreme cases, methylene blue has taken over TikTok and Instagram with claims it can sharpen focus and boost mood. Methylene blue is FDA approved to treat the rare blood disorder methemoglobinemia, though it has also been used off label for anti-aging and cancer Influencers have dubbed it 'brain fuel' and a 'limitless pill,' with some studies claiming it can also alleviate mental health issues. However, neuroscientist Anne-Sophie Fluri told the Daily Mail in June that many of the supposed benefits being promoted online are based on preliminary research using rodents or petri dishes, not conclusive human clinical trials. The US Food and Drug Administration (FDA) has issued a public safety warning about methylene blue's potential to cause serotonin syndrome when combined with common antidepressants like Prozac, Zoloft, or Cymbalta. Serotonin syndrome is a dangerous condition caused by too much serotonin in the body, leading to symptoms like confusion, high fever, seizures, and, in rare cases, death. Methylene blue can trigger this syndrome when taken with antidepressants because it blocks an enzyme that normally breaks down serotonin, causing a harmful buildup.
Times
35 minutes ago
- Times
How eight second clip restored voice stolen by motor neurone disease
After 25 years a woman with motor neurone disease (MND) is able to speak in her own voice again thanks to an artificial intelligence programme and eight seconds of old audio. Sarah Ezekiel was left without the use of her voice and hands at the age of 34 having been diagnosed with MND shortly after the birth of her second child. Five years later, the advent of eye-gaze technology meant she could form words and sentences that would be 'spoken' by a computer. But growing up, her children Aviva and Eric only heard their mother speak through a robotic-sounding artificial voice. Voice-cloning technology and artificial intelligence that can fill in gaps in audio content mean that now, even her Cockney accent has been restored. 'After such a long time, I couldn't really remember my voice,' Ezekiel told BBC Access All. 'When I first heard it again, I felt like crying. It's a kind of miracle.'
