CERo Therapeutics Holdings, Inc. Announces Continued Enhancement of Intellectual Property Portfolio with Two Granted U.S. Patents and European Patent Application Allowance Regarding Company's Lead Compound CER-1236
SOUTH SAN FRANSCISCO, Calif., June 02, 2025 (GLOBE NEWSWIRE) -- CERo Therapeutics Holdings, Inc., (Nasdaq: CERO) ('CERo' or the 'Company') an innovative immunotherapy company seeking to advance the next generation of engineered T cell therapeutics that deploy phagocytic (i.e., target-cell eating) mechanisms alongside the array of built-in target cell destroying mechanisms used by T cells, announces two previously announced U.S. patent applications have been granted by the U.S. Patent and Trademark Office (USPTO), and one European patent application has been allowed by the European Patent Office, all of which significantly expand the Company's intellectual property portfolio.
The USPTO granted U.S. Patent No. 12,291,557, titled, 'CHIMERIC TIM4 RECEPTORS AND USES THEREOF' on May 6, 2025. The granted claims cover certain design aspects of CER-1236, the Company's lead compound. This patent provides composition of matter protection for a chimeric TIM4 receptor comprising a TIM4 binding domain and canonical T cell signaling domains.
Additionally, the European Patent Office has allowed European Patent Application No. 1882166.7 titled, 'CHIMERIC ENGULFMENT RECEPTOR MOLECULES AND METHODS OF USE' on May 16, 2025. The allowed claims encompass a chimeric engulfment receptor comprising a TIM4 binding domain and TLR2 signaling domain. The allowance of this European patent application expands protection of additional design aspects of CER-1236, which have already been granted in the U.S., Japan, and China.
Finally, the USPTO granted U.S. Patent No. 12,303,551, titled, 'CELLULAR IMMUNOTHERAPY COMPOSITIONS AND USES THEREOF,' on May 20, 2025. This patent provides coverage for combination cellular immunotherapy compositions and methods of use for CER-1236. The patent covers combination of a chimeric engulfment receptor CD4+ T cell (CD4+ CER-T cell) with a chimeric antigen receptor CD8+ T cell (CD8+ CAR-T cell) or T cell receptor CD8+ T cell (CD8+ TCR-T cell), and their use to treat cancer. This type of combination therapy could be an exciting avenue to complement the CER-T cell technology with other powerful anti-cancer therapies. CERo's intellectual property portfolio now includes 9 total patent families with protection out to 2042 in the United States.
With these additional granted patents and allowed application, CER-1236 and its platform technology is supported by 18 total issued patents and allowed patent application internationally.
Chris Ehrlich, CERo Therapeutics CEO, commented, 'We continue to aggressively expand our intellectual property portfolio, as it ensures CERo's success in the market. These patents protect the core innovations of the CER-T technology that differentiate it from other cell therapies and demonstrate the true novelty of our design . We continue to seek a robust range of patents across multiple geographies that cover this technology in general, and CER-1236 in particular. The appreciation of the novelty of the CER-T technology by the patent offices validates the innovation and therapeutic potential of this approach, and we believe that we will continue to grow the portfolio. In the near term, we anticipate updates on our clinical trial progress in AML, and the announcement of initiating human trials to treat ovarian and non-small cell lung cancers.'
About CERo Therapeutics Holdings, Inc.
CERo is an innovative immunotherapy company advancing the development of next generation engineered T cell therapeutics for the treatment of cancer. Its proprietary approach to T cell engineering, which enables it to integrate certain desirable characteristics of both innate and adaptive immunity into a single therapeutic construct, is designed to engage the body's full immune repertoire to achieve optimized cancer therapy. This novel cellular immunotherapy platform is expected to redirect patient-derived T cells to eliminate tumors by building in engulfment pathways that employ phagocytic mechanisms to destroy cancer cells, creating what CERo refers to as Chimeric Engulfment Receptor T cells ('CER-T'). CERo believes the differentiated activity of CER-T cells will afford them greater therapeutic application than currently approved chimeric antigen receptor ('CAR-T') cell therapy, as the use of CER-T may potentially span both hematological malignancies and solid tumors. CERo has commenced clinical trials for its lead product candidate CER-1236 for hematological malignancies.
Forward-Looking Statements
This communication contains statements that are forward-looking and as such are not historical facts. This includes, without limitation, statements regarding the financial position, business strategy and the plans and objectives of management for future operations of CERo. These statements constitute projections, forecasts and forward-looking statements, and are not guarantees of performance. Such statements can be identified by the fact that they do not relate strictly to historical or current facts. When used in this communication, words such as 'anticipate,' 'believe,' 'continue,' 'could,' 'estimate,' 'expect,' 'intend,' 'may,' 'might,' 'plan,' 'possible,' 'potential,' 'predict,' 'project,' 'should,' 'strive,' 'would' and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. When CERo discusses its strategies or plans, it is making projections, forecasts or forward-looking statements. Such statements are based on the beliefs of, as well as assumptions made by and information currently available to, CERo's management.
Actual results could differ from those implied by the forward-looking statements in this communication. Certain risks that could cause actual results to differ are set forth in CERo's filings with the Securities and Exchange Commission, including its most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q, and the documents incorporated by reference therein. The risks described in CERo's filings with the Securities and Exchange Commission are not exhaustive. New risk factors emerge from time to time, and it is not possible to predict all such risk factors, nor can CERo assess the impact of all such risk factors on its business, or the extent to which any factor or combination of factors may cause actual results to differ materially from those contained in any forward-looking statements. Forward-looking statements are not guarantees of performance. You should not put undue reliance on these statements, which speak only as of the date hereof. All forward-looking statements made by CERo or persons acting on its behalf are expressly qualified in their entirety by the foregoing cautionary statements. CERo undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
Contact:Chris EhrlichChief Executive Officerchris@cero.bio
Investors:CORE IRinvestors@cero.bio
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
18 minutes ago
- Yahoo
Latest Appian Platform Release Delivers Enterprise-Ready AI
SYDNEY, Aug. 20, 2025 /PRNewswire/ -- Appian (Nasdaq: APPN), the leading platform for AI process automation, today announced enhancements that help organisations work smarter with faster insights, greater scalability, and more secure AI access. Key updates include AI-powered semantic smart search, Appian AI availability for self-managed and FedRAMP environments, automatic data fabric scaling, and Process HQ reports that embed directly into sites. Smart search and AI availabilityAppian's enhanced AI smart search delivers results based on user intent—not just keywords. Its semantic capabilities—paired with access to millions of data records and documents connected by Appian's data fabric—mean it provides better, more precise results to support user queries, related case matching, and intelligent agent actions. Additionally, all Appian AI features are now available for self-managed and FedRAMP environments, giving all customers—including those in the public sector—full access to secure, enterprise-grade AI. "We've improved our quoting, claims, and underwriting processes through AI-powered process optimisation. Using Process HQ to identify bottlenecks and drive continuous improvement, powered by Appian's generative AI capabilities, I see tremendous opportunity to help us continue delivering on our strategic plans," said Sheila Evans, Chief Product and Solutions Officer at MagMutual. Data fabric autoscalingAppian's data fabric stitches together data from across many enterprise systems into a single, secure model. With this latest Appian release, high throughput query workloads now scale automatically to support growing enterprises. Autoscaling data fabric optimises performance without manual administrative support, streamlining development and reducing risk for high-volume use cases. And new asynchronous interface loading increases application responsiveness by loading slower data in the background. Users get faster app interactions, even when an interface is complex or data-heavy. Process HQ reportingWith the latest Process HQ enhancements, users can now embed reports and dashboards directly into Appian Sites, making it easier to share insights without leaving the site or relying on IT support. This release also introduces configurable drilldown reports, allowing users to explore enterprise data from multiple angles and access deeper insights with a single click. "This release makes it easier for all organisations, including our government customers, to securely leverage enterprise-grade AI," said Michael Beckley, CTO, Appian. "We're delivering AI with guardrails and transparency, without compromising on security or control." Appian is the leading platform for AI process automation, focused on improving the core processes that define businesses everywhere—from how they operate to how they serve customers and deliver value. By integrating AI into processes, Appian gives it purpose, governance, and accountability—all essential to delivering its value. And these latest enhancements make delivering value with AI easier than ever. Learn how to make AI part of your processes. About Appian Appian is The Process Company. We deliver a software platform that helps organizations run better processes that reduce costs, improve customer experiences, and gain a strategic edge. Committed to client success, we serve many of the world's largest companies across various industries. For more information, visit [Nasdaq: APPN] Follow Appian: LinkedIn, X (Twitter) Photo - Logo - View original content: SOURCE Appian Sign in to access your portfolio
Yahoo
29 minutes ago
- Yahoo
Leonardo DRS, Mercury Systems, First Solar, Kimball Electronics, and BWX Shares Plummet, What You Need To Know
What Happened? A number of stocks fell in the afternoon session after investors took some profits off the table as markets awaited signals on future monetary policy from the Federal Reserve's Jackson Hole symposium later in the week. The downturn in the market was largely attributed to a significant sell-off in megacap tech and chipmaker shares. Nvidia, Advanced Micro Devices (AMD), and Broadcom all saw notable drops, dragging down the VanEck Semiconductor ETF. Other major tech-related companies like Tesla, Meta Platforms, and Netflix were also under pressure. A key reason for this trend is that much of the recent market gains have been concentrated in the "AI trade," which includes these large technology and semiconductor companies. So this could also mean that some investors are locking in some gains ahead of more definitive feedback from the Fed. The stock market overreacts to news, and big price drops can present good opportunities to buy high-quality stocks. Among others, the following stocks were impacted: Defense Contractors company Leonardo DRS (NASDAQ:DRS) fell 3.7%. Is now the time to buy Leonardo DRS? Access our full analysis report here, it's free. Defense Contractors company Mercury Systems (NASDAQ:MRCY) fell 4.5%. Is now the time to buy Mercury Systems? Access our full analysis report here, it's free. Renewable Energy company First Solar (NASDAQ:FSLR) fell 4.9%. Is now the time to buy First Solar? Access our full analysis report here, it's free. Electrical Systems company Kimball Electronics (NASDAQ:KE) fell 3%. Is now the time to buy Kimball Electronics? Access our full analysis report here, it's free. Defense Contractors company BWX (NYSE:BWXT) fell 3.8%. Is now the time to buy BWX? Access our full analysis report here, it's free. Zooming In On First Solar (FSLR) First Solar's shares are extremely volatile and have had 36 moves greater than 5% over the last year. In that context, today's move indicates the market considers this news meaningful but not something that would fundamentally change its perception of the business. The previous big move we wrote about was 1 day ago when the stock gained 10.4% on the news that the U.S. Treasury Department and IRS released new guidance on clean energy tax credits that was more favorable than investors had feared, continuing a rally from the previous session. This move extends a surge from the previous trading session as investors reacted positively to the updated rules, which were less restrictive than many had anticipated. The guidance clarifies how solar and wind projects can qualify for valuable federal tax credits. For large utility-scale projects, a focus for First Solar, the rules now emphasize a "physical work test" to determine if a project has begun, largely replacing a previous provision. This development has cleared up policy uncertainties that weighed on the solar sector for over a year. In response to the favorable guidance, analysts at UBS designated First Solar as a top pick, citing the reduced policy risk and potential for significant earnings growth. First Solar is up 12.9% since the beginning of the year, but at $210.57 per share, it is still trading 17.7% below its 52-week high of $255.75 from September 2024. Investors who bought $1,000 worth of First Solar's shares 5 years ago would now be looking at an investment worth $2,776. Today's young investors likely haven't read the timeless lessons in Gorilla Game: Picking Winners In High Technology because it was written more than 20 years ago when Microsoft and Apple were first establishing their supremacy. But if we apply the same principles, then enterprise software stocks leveraging their own generative AI capabilities may well be the Gorillas of the future. So, in that spirit, we are excited to present our Special Free Report on a profitable, fast-growing enterprise software stock that is already riding the automation wave and looking to catch the generative AI next. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
29 minutes ago
- Yahoo
U.S. And Great Britain Move To Secure Strategic Advantage In Syria and Libya
With Russia focused on Ukraine, Washington is stepping up its efforts to ensure that Moscow cannot re-establish itself so easily in its previously vital strategic Middle East and North Africa strongholds of Syria and Libya. The U.S. and Great Britain were instrumental in the removal from power of longtime Libyan leader Muammar Gaddafi in 2011 and in the similar ousting of Syria's long-term president Bashar al-Assad in 2024. Over the 23 years, Washington and London appear to have learned that quickly putting into place a plan to ensure economic health of the country involved in an effective coup d'etat is a good idea from every angle. It minimises the chances of cultural and economic destruction wrought by unfettered migration of affected populations into Europe, it secures valuable energy rights for those countries helping to shape the new regime, and it prevents chief geopolitical rivals Russia and China from adding to their global sphere of influence. It is also crucial to note that major oil and gas projects legally entitle the international companies undertaking them to safeguard these assets in a foreign country by whatever security means they think appropriate, as agreed with the host nation. Given all this, the last few weeks have seen major moves by the U.S. and Great Britain to make sure that this time around the strategic advantage that they have engineered is both countries is not Syria, the beginning of July saw the U.S. remove Syria's Ministry of Oil and Mineral Resources from its sanctions list, together with the country's General Authority for Maritime Transport, and its two main refineries too. These actions augmented the removal of a broad range of sanctions on the country just a day earlier, including those preventing the importation of Syrian oil and oil products into the U.S. Together, the lifting of these sanctions are aimed at opening the way for the country to realise the still high potential of its oil and gas sector so that it can build a robust economy that is, according to the sanctions removal order: 'stable, unified and at peace with itself and its neighbors'. In this context it is apposite to note that before Syria's civil war began in March 2011 as part of the wider Arab Spring movement, it was a major oil producer, with output of around 400,000 barrels per day (bpd) of crude oil from proved reserves of 2.5 billion barrels. Prior to that – before the recovery rate started to decline due to a lack of enhanced oil recovery techniques being employed at the major fields -- it had been producing nearly 600,000 bpd. Europe imported over US$3 billion of oil per year from Syria up to the beginning of 2011, and many European refineries were configured to process the heavy, sour 'Souedie' crude oil that makes up much of Syria's output, with the remainder being the sweet and lighter 'Syrian Light' grade. Most of this – some 150,000-bpd combined – went to Germany, Italy, and France, from one of Syria's three Mediterranean export terminals: Banias, Tartus, and Latakia. As an adjunct to this, a multitude of international oil companies were operating in Syria's energy sector, including Great Britain's Shell, Petrofac and Gulfsands Petroleum, France's then-Total, the China National Petroleum Corporation, India's Oil and Natural Gas Corp, Canada's Suncor Energy, and Russia's Tatneft and Stroytransgaz. Russia was quick to expand its on-the-ground presence in the country's oil and gas sector as an adjunct to its launching full military support for al-Assad's regime from 30 September 2015, at the Syrian president's request, as analysed in full in my latest book on the new global oil market order. Heavy investment especially in the gas sector, allowed Moscow to leverage its influence across the country to such a degree that it became the Kremlin's key Middle Eastern outpost, with several militarily vital bases. These included the naval base at Tartus (Russia's only Mediterranean port), the air force base at Khmeimim, and the listening station just outside Latakia). However, following the 30 June and 1 July removal of sanctions on Syria by the U.S., American firms including Baker Hughes, Hunt Energy, and Argent LNG are working to revitalise the country's oil, gas and power sector, according to a senior source working in the European Union's security complex. 'They will be taking the lead here, [in Syria] alongside local [Middle Eastern] firms focusing on power generation, with British and European firms to step in after that initial work has been done,' he exclusively told last week. 'The initial focus [for the U.S.] will be on key oil-producing areas west of the Euphrates currently under control of the new Syrian government,' he added. It is a similar story for Libya, although British firms have adopted the lead role here in recent weeks. Before 2011 -- when the Arab Spring movement led to the removal of its own leader, Gaddafi -- Libya had easily been able to produce around 1.65 million barrels per day (bpd) of mostly high-quality light, sweet crude oil. Production had also been on a rising production trend at that point, up from about 1.4 million bpd in 2000. Although this output level was well below the peak levels of more than 3 million bpd achieved in the late 1960s, its National Oil Corporation (NOC) had plans in place before 2011 to roll out enhanced oil recovery techniques to increase crude oil production at maturing oil fields. There had also been plenty of interest from a slew of international oil companies to be involved in expanding production on existing fields and exploring new opportunities in oil and gas (after all, Libya still has 48 billion barrels of proved crude oil reserves – the largest in Africa). Russia was one such country, although the more chaotic conditions across the country resulting from fragmented political leadership meant Moscow was less able to cement firm control over it. Nonetheless, September 2023 saw General Khalifa Haftar – commander of the Libyan National Army (LNA) – travel to Moscow for talks with Russian President Vladimir Putin, whose Wagner mercenary soldiers provide support for LNA forces in Libya. Further talks between Haftar and senior Russian political and military figures have occurred at several points since then, according to the E.U. security source. As an adjunct to this, last year saw the arrest of Saddam Haftar -- General Haftar's son -- at Naples airport after his name appeared on an E.U. database over an arrest warrant issued in Spain for alleged weapons smuggling. This followed comments from former U.N. special envoy to Libya, Abdoulaye Bathily, that the country was becoming a mafia state dominated by gangs involved in smuggling operations, especially for arms. That said, earlier this year saw British oil giants BP and Shell sign a range of agreements with Libya's National Oil Company (NOC) aimed at boosting the country's oil and gas output recovery. BP said on 8 July that it had signed a memorandum of understanding (MoU) to evaluate options for redeveloping the giant Sarir and Messla onshore fields in the Sirte basin, and to assess potential unconventional oil and gas development. The firm's executive vice president for gas and low carbon, William Lin, stated that the agreement, 'reflects our strong interest in deepening our partnership with NOC and supporting the future of Libya's energy sector.' In the meantime, Shell is focused on exploring development possibilities for the Atshan oil field and other NOC-owned assets. Shortly afterwards during a visit to Tripoli by U.S. President Donald Trump's senior adviser for Africa, Massad Boulos, a cooperation agreement was signed between Mellitah Oil and Gas (a joint venture between the NOC and Italy's Eni), and U.S. construction consulting firm Hill International to manage a project which aims to boost Libya's gas output. More specifically, it involves the development from 2026 of two gas fields located offshore Libya with combined gas reach 750 million cubic feet per day. Perhaps the biggest sign of the U.S.'s high hopes for a new Libya was the announcement earlier this month that supermajor ExxonMobil had signed an MoU with the NOC to identify hydrocarbon resources in four offshore blocks located off Libya's northwest coast and its Sirte Basin. All of these on the-ground-developments in Libya and Syria will be very hard for Russia or China to undermine. By Simon Watkins for More Top Reads From this article on
