Leveragen Partners with Cell Signaling Technology to Advance Reagent Antibody Innovation with Proprietary Nanobody Technology
Leveragen Inc., a Boston-based biotechnology company specializing in next-generation genetic models for antibody discovery, today announced a comprehensive collaboration with Cell Signaling Technology (CST), a global leader in high-quality research antibodies and associated reagents. This collaboration will explore Leveragen's proprietary Singularity Musculus platform to expedite the development of mouse-derived nanobodies tailored for reagent antibody applications.
This press release features multimedia. View the full release here:
Leveragen Inc., a Boston-based biotechnology company specializing in next-generation genetic models for antibody discovery, today announced a comprehensive collaboration with Cell Signaling Technology (CST), a global leader in high-quality research antibodies and associated reagents. This collaboration will explore Leveragen's proprietary Singularity Musculus platform to expedite the development of mouse-derived nanobodies tailored for reagent antibody applications.
Nanobodies, or single-domain antibodies, are only about 10% the size of traditional antibodies, yet retain high target-binding affinity, exhibit enhanced tissue penetration, and can tackle structurally-challenging targets inaccessible to some full-length antibodies. Leveragen's Singularity Suite of nanobody mice harnesses cutting-edge genetic engineering technologies to remove competing conventional antibodies and preserve native immunoglobulin gene regulation, maximizing nanobody-specific immune responses and maintaining normal B-cell development. Similar to its flagship Singularity Sapiens platform of fully human single-domain antibodies developed for therapeutic applications, the Singularity Musculus platform is purpose-built to generate mouse-derived nanobodies with superior diversity, affinity, stability, and cost-efficiency—traits critical to developing high-performance reagents for research and diagnostic applications.
'We are excited to begin this partnership with CST, marking a major milestone that underscores our commitment to antibody innovation,' said Dr. Weisheng Chen, Founder and Chief Executive Officer of Leveragen Inc. 'Our Singularity Musculus platform was developed specifically to meet the growing need for versatile, diverse, and reproducible reagent antibodies. By merging our proprietary Singularity Musculus platform with CST's renowned expertise in antibody reagents, we aim to raise the bar for nanobody-based tools throughout the life sciences.'
Dr. Roberto Polakiewicz, Chief Scientific Officer at Cell Signaling Technology, commented, 'We are delighted to collaborate with Leveragen to explore the Singularity Musculus platform and its potential to advance reagent antibody development for researchers around the world.'
This partnership highlights the growing significance of nanobody-based technologies in areas including basic research, diagnostics, and therapeutic development. With their small molecular footprint, modular monomeric structure, robust binding affinity, and suitability for certain challenging antigens, nanobodies are uniquely positioned for high-throughput screening, precision imaging, and other advanced life science applications. By combining Leveragen's and CST's expertise, the collaboration aims to accelerate the creation of next-generation reagent antibodies.
About Leveragen
Leveragen is a genetic engineering company dedicated to transforming antibody discovery and development for research, diagnostics, and therapeutics. Operating exclusively from its Woburn, Massachusetts facility, the company employs advanced genome editing, synthetic biology, and chromosomal engineering technologies to develop next-generation genetic models that accelerate antibody discovery. Leveragen's proprietary collection of nanobody mice, the Singularity Suite, features Singularity Sapiens, designed to generate fully human single-domain antibodies for developing a broad range of biologic modalities, and Singularity Musculus, engineered to produce mouse-derived single-domain antibodies optimized for high-performance reagent applications. Through strategic collaborations with global pharmaceutical and biotechnology leaders, the company addresses unmet medical needs and accelerates the translation of scientific breakthroughs into practical solutions. For more information, please visit www.leveragen.com.
About Cell Signaling Technology
Cell Signaling Technology (CST), headquartered in Danvers, Massachusetts, is a global leader in the development and production of high-quality research antibodies, reagents, and related technologies. Established in 1999 by scientists committed to furthering cellular and molecular research, CST has earned a reputation for excellence through rigorous validation processes, innovative products, and dedication to reproducibility. Serving academia, pharmaceuticals, and biotechnology worldwide, CST provides tools that help researchers investigate complex signaling pathways, uncover disease mechanisms, and accelerate therapeutic discovery. With a focus on quality and customer service, CST remains at the cutting edge of life science innovation. Learn more at www.cellsignal.com.
SOURCE: Leveragen Inc.
Copyright Business Wire 2025.
PUB: 03/25/2025 08:08 AM/DISC: 03/25/2025 08:08 AM
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
31 minutes ago
- Yahoo
HOOD vs. IBKR: Which Fintech Broker is Poised for More Growth?
Robinhood Markets HOOD and Interactive Brokers Group IBKR are prominent online brokerage players offering commission-free trading platforms. Robinhood appeals to newer, mobile-first retail investors, while Interactive Brokers serves more advanced traders with its comprehensive the stock markets witnessing massive volatility and client activity, HOOD and IBKR are expected to benefit from increased trading activities. As such, investors are bullish on both. This year, shares of HOOD have soared 65.8%, while Interactive Brokers is up 18.4%. Also, stocks have fared better than the industry, the Zacks Finance sector and the S&P 500 Index in the same time frame. HOOD & IBKR YTD Price Performance Image Source: Zacks Investment Research So, the question arises: which brokerage stock — Robinhood or Interactive Brokers — offers greater upside in the evolving trading market? Let's break down their fundamentals, financial performance, growth prospects and more before taking any decision. Robinhood became extremely popular among younger generations in early 2021, riding on the meme stock wave. Nonetheless, since its IPO in July 2021, a lot has happened on the business front. It has evolved from a brokerage firm primarily trading in digital assets to a more mature and diversified entity, striving to become a one-stop shop for building generational wealth. In this context, HOOD has launched several initiatives to attract more clients and strengthen its market share. Some notable ones are Robinhood Strategies, Robinhood Banking and Robinhood Cortex to boost the wealth management offerings; the prediction markets hub; a credit card and a desktop trading platform. Additionally, Robinhood is expanding via strategic acquisitions, which are helping it foray into new businesses and complement existing ones. On Tuesday, it announced an agreement to buy Canada-based WonderFi Technologies Inc. in a C$250 million all-cash deal, which will help deepen its presence in the Canadian digital asset market. In February 2025, it completed the $300 million acquisition of TradePMR, a custodial and portfolio management platform specializing in services for Registered Investment in July 2024, Robinhood acquired Pluto Capital Inc. With the integration of Pluto's advanced capabilities, the company has revolutionized the investment experience for its users. Further, the impending buyout of Bitstamp (announced in June 2024), a globally recognized cryptocurrency exchange (featuring more than 85 tradable assets and popular in Europe and Asia), will significantly enhance the company's crypto these efforts reflect HOOD's ambition to become a full-spectrum financial services provider. HOOD Sales Estimates Image Source: Zacks Investment Research Interactive Brokers' technological superiority remains one of its strongest aspects. The company processes trades in stocks, futures, options and forex on more than 150 exchanges across several countries and technology usage has kept IBKR's compensation expense relative to net revenues (10.8% in the first quarter of 2025) below its industry peers. Further, the company has been emphasizing developing proprietary software to automate broker-dealer functions, leading to a steady rise in Brokers is expanding globally with a series of strategic moves. Earlier this month, it extended trading hours for Forecast Contracts to nearly 24 hours, after having launched them in Canada. In the U.K., it added mutual funds to its ISA offerings, enhancing tax-efficient investing. IBKR also introduced PEA accounts in France and expanded mobile trading via GlobalTrader. Other innovations include almost 24 hours of Overnight Trading on U.S. stocks and ETFs, crypto trading through Paxos with low fees and the launch of IBKR Desktop, a next-gen trading platform for Windows and Mac, underscoring its focus on advanced, global trading company's technological superiority, combined with easier regulations to improve product velocity, will support its net revenues through higher client acquisitions. Net revenues are also expected to strengthen further in the quarters ahead, given the solid Daily Average Revenue Trades (DARTs) numbers and robust trading backdrop driven by higher market participation. IBKR Sales Estimates Image Source: Zacks Investment Research The Zacks Consensus Estimate for HOOD's 2025 and 2026 earnings indicates an 11.9% and 19.4% rise for 2025 and 2026, respectively. Over the past month, earnings estimates for 2025 have remained unchanged, while for 2026, the same have been revised upward. Earnings Trend Image Source: Zacks Investment Research On the contrary, analysts are less optimistic about IBKR's prospects. The consensus mark for earnings suggests 0.4% and 7% growth for 2025 and 2026, respectively. Earnings estimates for both years have been revised lower over the past 30 days. Earnings Trend Image Source: Zacks Investment Research Hence, on earnings growth prospects, HOOD clearly has an edge over Interactive Brokers. Valuation-wise, HOOD is currently trading at the 12-month forward price-to-earnings (P/E) of 47.17X. The IBKR stock, on the other hand, is currently trading at the 12-month trailing P/TB of 28.86X. Further, both are trading at a premium to the industry average of 13.82X. P/E F12M Image Source: Zacks Investment Research While Robinhood commands a premium over Interactive Brokers, its valuation is justified, given its superior growth trajectory. Additionally, HOOD's return on equity (ROE) of 15.42% is way above IBKR's 4.97%. HOOD also outscores the industry ROE of 11.97%. This reflects Robinhood's efficient use of shareholder funds to generate profits. ROE Image Source: Zacks Investment Research HOOD has undergone a significant transformation since its IPO, evolving from a disruptive trading app into a comprehensive financial services platform. Through strategic acquisitions, it is aggressively expanding its product suite and global reach. It's also investing in advanced tools like Robinhood Cortex and Robinhood Strategies, targeting a broader investor base. These innovations, paired with a robust ROE and accelerating earnings and sales growth estimates through 2026, suggest strong long-term upside the other hand, Interactive Brokers remains a dominant, tech-driven brokerage favored by professional and institutional investors. Its global reach, low-cost model and powerful trading tools continue to support consistent revenue growth. However, while the company's innovation in areas like Forecast Contracts, GlobalTrader and IBKR Desktop is impressive, its earnings outlook is more muted, with only modest growth expected in the next two years. Combined with a lower ROE and downward revisions to earnings estimates, this suggests that while IBKR is a stable, well-run business, it may not match HOOD's upside potential in a growth-focused Robinhood appears to be the better long-term investment for solid returns. At present, Robinhood and Interactive Brokers carry a Zacks Rank #3 (Hold). You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Interactive Brokers Group, Inc. (IBKR) : Free Stock Analysis Report Robinhood Markets, Inc. (HOOD) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research
Yahoo
34 minutes ago
- Yahoo
Donald Trump's Federal Funding Freeze For Harvard University Is Having A Ripple Effect On The Cambridge Housing Market
Benzinga and Yahoo Finance LLC may earn commission or revenue on some items through the links below. President Donald Trump's $3 billion funding freeze on Harvard University is starting to have an impact on the local real estate market in Cambridge, Massachusetts, according to Trump's freeze on grants and contracts on the esteemed Ivy League institution threatens to affect the ecosystem of start-ups, entrepreneurs, and researchers in the Boston metro area, particularly in Cambridge, the area surrounding the campus. Brokers are already seeing potential homebuyers backing out of deals, including one where the buyer lost a $10,000 deposit. 'It's very unusual in my experience for someone to put down a $10,000 offer deposit and then back out,' Sage Jankowitz, a solo broker in Cambridge, told Don't Miss: Maker of the $60,000 foldable home has 3 factory buildings, 600+ houses built, and big plans to solve housing — Invest Where It Hurts — And Help Millions Heal: Trump's attempts to block Harvard from enrolling international students — currently blocked in a court action — also threaten to harm the rental economy, which relies heavily on housing for graduate students. 'These people are mostly in their 30s or 40s,' says Jankowitz, who works with a broad cross-section of buyers and sellers, including investors. 'A lot of them are married. A lot of them have one kid or multiple kids that come with them while they're here.' Boston's housing market is one of the hottest in the country and not solely reliant on Harvard to thrive, but the loss of tenants and buyers could dampen the market in the Cambridge area, which immediately surrounds Harvard. 'It's the densest concentration of academic talent in the world,' Lawrence S. Bacow, who served as president of Harvard University from 2018 to 2023 and as president of Tufts University from 2001 to 2011, told the New York Times. 'Universities and teaching hospitals are to Boston what cars are to Detroit, what energy is to Houston, or finance is to New York.' Trending: If there was a new fund backed by Jeff Bezos offering a ? University-related research is an integral part of the Boston metro area, where biotech companies have contributed to the development of flourishing neighborhoods, such as Kendall Square in Cambridge, home to the biotech company Biogen, and Boston's Seaport District, where Vertex Pharmaceuticals is based, as reported by The Times. There is a concern that if academic researchers leave, the city's economy, including housing, will suffer. 'Some will leave their science behind, and it will end — after a huge investment, it just falls off a cliff,' Dr. Wendy Chung, chief of pediatrics at Boston Children's Hospital, told the Times. 'The instability is very hard for people who are so hard-working and dedicated to their mission — they can only be pushed so far before they break.'Evan Horowitz, executive director of Tufts University's Center for State Policy Analysis, told the Wall Street Journal that if the Harvard funding freeze persists, the city could suffer a 'wealth spiral effect,' with research, real estate, and retail all affected. 'These aren't distributed jobs—they're concentrated, so we could see strong local effects,' he said. Lauren Holleran, a vice president at Gibson Sotheby's International Realty in Cambridge, has already noticed a difference with high-end clients who are holding off on buying and selling. 'They're saying, let's see how things shake out,' she told the Journal. Lower interest rates mean some investments won't yield what they did in months past, but you don't have to lose those gains. Certain private market real estate investments are giving retail investors the opportunity to capitalize on these high-yield opportunities. , which provides access to a pool of short-term loans backed by residential real estate. The best part? Unlike other private credit funds, Looking for fractional real estate investment opportunities? The features the latest offerings. Image: Shutterstock This article Donald Trump's Federal Funding Freeze For Harvard University Is Having A Ripple Effect On The Cambridge Housing Market originally appeared on
New York Times
37 minutes ago
- New York Times
Boston Legacy FC unveils new team crest: ‘It's been a learning process. We had a hiccup'
Boston Legacy FC has learned a crucial lesson before even setting foot on the field or signing a player: it's OK to try again. 'It's been a learning process and we had a hiccup when we launched the first pieces of our brand, as you know, and everyone else knows,' owner and controlling manager Jennifer Epstein told The Athletic on Friday. Advertisement While 'hiccup' might be an understatement of how the first attempt at a brand launch went for the 15th NWSL club, between the original name of BOS Nation FC and the 'Too Many Balls' campaign, everyone in Boston gave themselves time and space not just to own it and learn, but to move on. In March, the team announced its new name. When it came time to think through the launch of their first crest and brand, the club took its time. Set to begin play next year, Boston Legacy FC is ready to spread its wings, completing a five-month design process following the team's decision to rebrand. As part of that, Legacy FC hired experienced designer Matthew Wolff to lead the specific project of the new crest, with the team name already announced and the colors dating back to the team's original launch last year. The club sought an expert they could trust — enter Wolff, a known designer in the soccer world — and enlisted brand advisors in addition to their own input to ensure they had a range of viewpoints for their second attempt. 'Opening it up to a plurality of perspectives and voices really helped us drill down and do something that we think is beautiful, but also mixes older and newer and is the perfect symbol for this new legacy that we are building here in Boston,' Epstein said. Rather than using the entire team name, the crest simply says Boston. The team will celebrate the new identity with a party on Boston Common on Saturday. Wolff is no stranger to stepping into a project where a course correction is needed. His first NWSL project was in 2020 with Racing Louisville FC, following their original launch as Proof Louisville FC. Since then, he's also worked with Gotham FC and the San Diego Wave. 'Intentionality matters,' Wolff told The Athletic before getting into what he's learned from his work across the league over the past five years. 'Women's soccer fans really care about the way that their clubs look, the way that their clubs feel, what their clubs represent. There's a high standard, and there should be a high standard for this.' Advertisement As a designer, Wolff is a proponent of the idea that a club's crest and visual identity directly contribute to the growth of the game. As for the crest itself, it wasn't always a given that the swan would be the centerpiece of the design. The idea kept coming up in conversations, though, according to Wolff, and they realized it was strong enough to build the entire identity around. 'Swans have a long history in the city of Boston. They're iconic birds that populate the Charles and Mystic (rivers). Of course, they reside in the Boston Public Garden, which is in the Emerald Necklace, which extends through to where our home pitch will be at White Stadium,' Epstein said. And looking at the rest of the crests across the league, while the Washington Spirit have a nod to the eagle in theirs, a bird would stand out from the rest. 'Swans are extraordinarily fierce and extraordinarily loyal. Doesn't that sound like a Bostonian to you?' Wolff asked. 'Swans are elegant and fierce and loyal. To me, that's Boston, that's Boston sports. Early on, we realised there was some mirroring of the animal and the club's values and Bostonians' personalities. The triangulation of those three things made it feel like the right move for the center of the crest.' The team's explainer also makes a nod to 'Romeo and Juliet,' a pair of swans that summered in the Boston Public Garden for years. Both swans were female. It's a fun aside that should be popular with supporters, even if it wasn't directly an influence on the design itself. Once the swan was set, there were the smaller details to fine-tune. Each feather represents one of the original eight teams of the NWSL from its launch in 2013. The Boston Breakers were always alphabetically at the top of that list. 'The Breakers obviously are a really important part of Boston soccer, Boston sports, women's sports, women's soccer history,' Wolff said. The initial design brief always had a nod to them in some way, listed as one of the priorities. The angle of the feathers is also a nod to the Zakim Bridge, which crosses the Charles River into the North End of Boston and which was also featured on Boston's interim crest used in the early days of the expansion team. Advertisement 'When I'm working on a football crest, I want to represent the football club and the women who are going to compete on the pitch,' Wolff said. 'But of equal, if not more importance, is representing the entire city, the entire community — so I believe that a powerful football crest can really draw people that maybe weren't originally interested in the sport to the sport.' If done right, said Wolff, a crest represents the player, the club, the local, the fan, but their family too, their neighbors, the community itself. There was no ignoring the power of sports in Boston on this project, something Wolff said he thought about frequently at a time when we gather as communities less and less. Yes, there is brand power in using Boston rather than Legacy FC — an instant shortcut to the city's culture as a whole, but it also seems to be one half of a promise from the club. The critical work right now, Epstein said, is building the relationships and trust with the community of Boston and the greater area. 'This is just the beginning. We want to see that long-term pride and loyalty from our fans in the city as a whole, in what we are building. It's always at the core of what we are doing — thinking about the community and how we can bring them in.' (Top Photo: Boston Legacy FC)
