Bicara Therapeutics Announces Upcoming Presentations at AACR Annual Meeting 2025
BOSTON, March 25, 2025 (GLOBE NEWSWIRE) -- Bicara Therapeutics Inc. (Nasdaq: BCAX), a clinical-stage biopharmaceutical company committed to bringing transformative bifunctional therapies to patients with solid tumors, today announced that three abstracts relating to the company's lead product candidate, ficerafusp alfa, will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, which will be held from April 25-30, 2025 in Chicago, IL. Ficerafusp alfa is a first-in-class bifunctional antibody that combines two clinically validated targets: an epidermal growth factor receptor (EGFR) directed monoclonal antibody with a domain that binds to human transforming growth factor beta (TGF-β) and is being evaluated across multiple solid tumor types.
Details of the poster presentations are as follows:
Title: Dose expansion results of single agent ficerafusp alfa (BCA101), a bifunctional EGFR/TGF-β inhibitor in patients with metastatic or advanced cutaneous squamous cell carcinoma (cSCC)
Published Abstract #: CT034
Session Category: Clinical Trials
Session Title: Phase 0 and Phase I Clinical Trials
Session Date and Time: 4/28/2025 9:00 a.m. CT
Location: McCormick Place Convention Center, Poster Section 49
This presentation will highlight data from a Phase 1/1b dose expansion cohort of ficerafusp alfa monotherapy in second line or later cSCC patients.
Title: Dual blockade of EGFR and TGF-β with ficerafusp alfa has the potential to overcome resistance mechanisms in 1L R/M HNSCC in combination with Pembrolizumab
Published Abstract #: 3284
Session Category: Clinical Research
Session Title: Modifiers of the Tumor Microenvironment
Session Date and Time: 4/28/2025 2:00 p.m. CT
Location: McCormick Place Convention Center, Poster Section 30
This presentation will highlight a translational medicine biomarker dataset that provides insights into the effects of targeted inhibition of TGF-β with ficerafusp alfa.
Title: Ficerafusp alfa reverses acquired resistance to the KRAS-G12C inhibitor sotorasib in KRAS-G12C-mutated lung tumors
Published Abstract #: 4434
Session Category: Experimental and Molecular Therapies
Session Title: Reversal of Drug Resistance
Session Date and Time: 4/29/2025 9:00 a.m. CT
Location: McCormick Place Convention Center, Poster Section 23
This presentation will highlight a preclinical dataset that provides insights into the role of inhibiting TGF-β in overcoming acquired KRAS-G12C-inhibitor drug-resistant KRAS-G12C-mutated lung cancer.
Following the meeting, the poster presentations will be available on Bicara's website at www.bicara.com.
About Bicara Therapeutics
Bicara Therapeutics is a clinical-stage biopharmaceutical company committed to bringing transformative bifunctional therapies to patients with solid tumors. Bicara's lead program, ficerafusp alfa, is a bifunctional antibody that combines two clinically validated targets, an epidermal growth factor receptor (EGFR) directed monoclonal antibody with a domain that binds to human transforming growth factor beta (TGF-β). Through this dual-targeting mechanism, ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer cell-intrinsic EGFR survival and proliferation, as well as the immunosuppressive TGF-β signaling within the tumor microenvironment. Ficerafusp alfa is being developed in head and neck squamous cell carcinoma, where there remains a significant unmet need, as well as other solid tumor types. For more information, please visit www.bicara.com or follow us on LinkedIn or X.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, implied and express statements regarding Bicara's preclinical studies and presentation of results, the clinical development of ficerafusp alfa and presentation of data from a Phase 1/1b dose expansion cohort of ficerafusp alfa monotherapy in second line or later cSCC, clinical development of ficerafusp alfa in combination with pembrolizumab, the expected therapeutic potential and clinical benefits of ficerafusp alfa, including potential efficacy and tolerability. The words 'may,' 'might,' 'will,' 'could,' 'would,' 'should,' 'plan,' 'anticipate,' 'intend,' 'believe,' 'expect,' 'estimate,' 'seek,' 'predict,' 'future,' 'project,' 'potential,' 'continue,' 'target' and similar words or expressions, or the negative thereof, are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks and uncertainties that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, risks and uncertainties related to uncertainties inherent in the development of product candidates, including the conduct of research activities and the conduct and enrollment of clinical trials; uncertainties as to the availability and timing of results and data from clinical trials; whether results from prior preclinical studies and clinical trials will be predictive of the results of subsequent preclinical studies and clinical trials and regulatory developments in the United States and foreign countries, whether Bicara's cash resources will be sufficient to fund its foreseeable and unforeseeable operating expenses and capital expenditure requirements; as well as the risks and uncertainties identified in Bicara's filings with the Securities and Exchange Commission (SEC), including Bicara's Quarterly Report on Form 10-Q for the period ended September 30, 2024, as well as any subsequent filings that Bicara makes with the SEC. In addition, any forward-looking statements represent Bicara's views only as of today and should not be relied upon as representing its views as of any subsequent date. Bicara explicitly disclaims any obligation to update any forward-looking statements. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.
Contacts
Investors
Rachel Frank
Media
Dan Budwick
1AB
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
17 minutes ago
- Yahoo
StarRez Wins EdTech Breakthrough's 2025 'Student Safety Innovation Award'
StarRez leads the way in student safety innovation, by supporting colleges and universities worldwide in creating secure, connected, and thriving residential communities DENVER, June 10, 2025 (GLOBE NEWSWIRE) -- StarRez, global leader in housing and resident experience software that helps communities thrive - on and off-campus, today announced that it has received the 'Student Safety Innovation Award' in the 7th annual EdTech Breakthrough Awards program conducted by EdTech Breakthrough, a leading market intelligence organization that recognizes the top companies and solutions in the global educational technology market. 'At StarRez, we know that student housing plays a critical role in resident wellness, safety, and compliance. Across our global community, we're all working toward the same goal: creating safe, thriving communities where students can succeed,' said Travis Knipe, CEO of StarRez. 'While many solutions solve parts of the challenge, our focus is on delivering a unified platform that simplifies safety, compliance, and engagement, and drives real outcomes for our campus partners. We sincerely appreciate this recognition from EdTech Breakthrough reflects the incredible work of our team and customers. We remain committed to being a trusted partner on and off campus—helping deliver amazing experiences, reducing risk, automating operations, and ultimately improving student outcomes—all through one connected platform.' Safety is at the core of the StarRez platform, which equips housing teams with the tools to create secure, supportive living environments for students on and off campus. From housing applications and billing to roommate matching and off-campus education, StarRez streamlines the entire housing experience in one unified system. Beyond operational efficiency, the platform plays a vital role in enhancing student well-being and safety, helping students live, learn, and work with confidence throughout their academic journeys. StarRez equips housing teams with advanced tools to actively monitor and manage secure living environments. Features such as guest management, package tracking, digital ID scanning, and real-time communication enable staff to stay responsive and vigilant. The platform's Community Management solution fosters a sense of belonging while supporting student well-being, and its robust reporting and analytics surface key safety insights—helping teams identify trends, track incidents, automate follow ups, and take early action to maintain compliance and protect the campus community. As institutions around the world prioritize safer, smarter residential communities, StarRez continues to lead with measurable impact—empowering teams to enhance compliance, streamline safety protocols, and ensure secure access for every resident. Boosted Fire Safety Compliance: A EMEA-based university achieved a 95.75% compliance rate in fire safety activities by revamping their induction process using StarRez, ensuring students are well-informed and better prepared from day one. Streamlined Visitation Oversight: At the Fashion Institute of Technology, StarRez reduced in-person visitation-related office visits by over 60%, saving staff 12 hours a week. The platform empowers the Conduct and Public Safety teams with transparent tools to manage approvals, track policy violations, and enhance campus safety. Faster, Safer Access Control: The University of Central Arkansas cut housing access processing time by 86%—from 8 hours to just 1—through StarRez's automation capabilities, enabling secure, efficient door access for residents. 'Student needs have increased. They're requiring more attention and they're expecting better digital tools, especially in places like the housing portal', says Dante Brooks, Assistant Director of Housing at the University of Oklahoma. 'StarRez really lets us spend time with our residents and it lets us have really thoughtful interventions on everything from billing to assignments to resident well-being.' The platform makes it possible to embed compliance measures directly within the student booking experience. An interactive, automated system ensures students are informed before they even arrive on campus about rules and regulations such as fire safety. A pre-arrival fire safety video, post-move-in confirmation form, and in-person fire safety walks can ensure students actively engage with safety protocols. 'Beyond compliance, StarRez is creating a safer, more informed, and connected student experience. Universities are tasked with achieving widespread compliance in the face of challenging student engagement and ensuring student safety. However, traditional, fragmented approaches to compliance make safety training ineffective, unengaging, and hard to track,' said Steve Johansson, managing director, EdTech Breakthrough. 'StarRez is leading the way in student safety innovation, ensuring that universities worldwide can create secure, connected, and thriving residential communities. We're so pleased to be able to recognize them with 2025's 'Student Safety Innovation Award!'' As StarRez continues to advance AI capabilities within its platform, the benefits of a unified system grow exponentially—helping institutions future-proof operations while enhancing safety and student support. To learn more about StarRez's offerings and how they are leading the way in student safety innovation, visit About StarRezStarRez is the global leader in student housing software, providing innovative solutions for housing management, resident wellness and experience, and revenue generation. Trusted by 1,300+ clients across 25+ countries, StarRez supports more than 3 million beds annually with its user-friendly, all-in-one platform, delivering seamless experiences for both students and administrators. With offices in the United States, Australia, and the UK, StarRez blends the robust capabilities of a global organization with the personalized care and service of a trusted partner. For more information, visit About EdTech BreakthroughPart of Tech Breakthrough, a leading market intelligence and recognition platform for global technology innovation and leadership, the EdTech Breakthrough Awards program is devoted to honoring excellence in educational technology products, companies and people. The EdTech Breakthrough Awards provide a platform for public recognition around the achievements of breakthrough educational technology in categories including e-learning, student engagement, school administration, career preparation, language learning, STEM and more. For more information, visit Tech Breakthrough LLC does not endorse any vendor, product or service depicted in our recognition programs, and does not advise technology users to select only those vendors with award designations. Tech Breakthrough LLC recognition consists of the opinions of the Tech Breakthrough LLC organization and should not be construed as statements of fact. Tech Breakthrough LLC disclaims all warranties, expressed or implied, with respect to this recognition program, including any warranties of merchantability or fitness for a particular purpose. Media contact: Caroline Hansen [chansen@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
20 minutes ago
- Yahoo
Amid cost pressures, US employers are shifting their benefit strategy, WTW survey finds
More companies expanding choice, tackling high cost and reallocating benefit spend NEW YORK, June 10, 2025 (GLOBE NEWSWIRE) -- As U.S. employers grapple with heightened economic uncertainty and greater financial pressures on budgets, steering the right course on benefit strategy is more challenging than ever. This is according to a survey by WTW (NASDAQ: WTW), a leading global advisory, broking and solutions company. As a result, companies are turning to smarter spending, sharper focus and using benefits as a strategic tool to drive engagement, retention and purpose. The 2025 Benefits Trends Survey found rising benefit costs to be the top issue (90%) influencing U.S. employers' benefit strategies in 2025, up from 67% in 2023. Other top concerns include competition for talent (52%), expectations for an enhanced employee experience (43%), cost of living (39%) and rising mental health issues (32%). 'After a long period of high benefits inflation and in the face of a possibly weakening economy, employers are taking a step back and looking to focus on what drives real value for employees and the business. That means targeting support and spending on the benefits that matter most, enabling personalization and helping employees make better decisions,' said Jeff Levin-Scherz, Population Health Leader, North America, Health & Benefits. As the cost of medical care continues to show double digit growth in the U.S., employers face greater challenges in delivering their strategy in key areas such as health benefits (44%), wellbeing programs (44%), and leave benefits (36%). To address these concerns, employers are shifting their strategy. Few are expanding their benefit portfolio, choosing to instead focus on extracting value from their current offerings and improve financing, employee experience, analytics and administration. Compared to just 8% in the past year, 63% of employers plan to reallocate or rebalance spend in the next three years. A majority (73%) plan to tackle high costs by enhancing value or switch to better-value vendors across health, retirement and risk benefits. Just under half (44%) plan to tackle high-cost medical conditions and 37% plan to adopt a network of preferred medical providers. Eager to address employee pressure points, companies are also looking to improve the following priority areas over the next three years: maximizing value, mental health, health benefits, financial wellbeing and family support. Many plan to increase their use of communication and use nudges and navigation solutions to influence behaviors and enhance the employee experience. Regularly reviewing vendor performance, including employee feedback, is also a key action employers are taking. 'Organizations are facing more pressure than ever to deliver the right benefits strategy. Finding innovative solutions for old and new challenges and reallocating spend on benefits that deliver true value is a good start. There is still a long way to go to address these pressure points, but employers are headed in the right direction by focusing on what matters most to their employees,' said Levin-Scherz. About the survey The 2025 Benefit Trends Survey was conducted from early March to mid-April. Respondents include 696 U.S. employers, representing a broad range of industries in both the private and public sector. About WTW At WTW (NASDAQ: WTW), we provide data-driven, insight-led solutions in the areas of people, risk and capital. Leveraging the global view and local expertise of our colleagues serving 140 countries and markets, we help organizations sharpen their strategy, enhance organizational resilience, motivate their workforce and maximize performance. Working shoulder to shoulder with our clients, we uncover opportunities for sustainable success—and provide perspective that moves you. Media contactIleana Feoli: +1 212 309
Yahoo
21 minutes ago
- Yahoo
U.S. commercial insurance rates continue downward trend, dropping to 5.3% increase
Commercial Lines Insurance Pricing Survey: Q1 2025 NEW YORK, June 10, 2025 (GLOBE NEWSWIRE) -- While U.S. commercial insurance rates demonstrated an increase of 5.3% in the first quarter, the rate continued a downward trajectory compared with the prior two quarters (increases of 5.8% and 5.6%), according to the latest findings from WTW's Commercial Lines Insurance Pricing Survey (CLIPS). The survey compares premiums for policies underwritten during the first quarter of 2025 to those for the same coverage lines in the respective quarter of 2024, demonstrating a year-over-year comparison. Carriers reported an aggregate price increase of 5.3% in the first quarter, down from 6.3% recorded in the first quarter of 2024. Some coverage lines stood out with respect to price change rates in the quarter. Notably, Commercial Auto maintained a double digit increase but lower than prior quarter, while Commercial Property continued a strong downward pricing trend, with just a slight increase for the first quarter, compared to double digit increase a year prior. Additionally, Professional Liability rates displayed a higher increase this quarter but is still relatively low compared to most of the other lines. Yi Jing, Senior Director, Insurance Consulting and Technology (ICT) at WTW, commented, "In the first quarter, we witnessed some interesting trends. Overall, the continued reduction in rate increases is a positive sign for buyers. However, consistent double-digit rate jumps for areas like Commercial Auto signify continued pricing difficulty in the market. The only other coverage area maintaining double digit rate increases is Excess / Umbrella Liability." CLIPS is a retrospective look at historical changes in Commercial Property & Casualty insurance (P&C) prices and claims cost inflation. A forward-looking analysis of Commercial P&C trends, outlook, and rate predictions can be found in WTW's Insurance Marketplace Realities series. About WTW At WTW (NASDAQ: WTW), we provide data-driven, insight-led solutions in the areas of people, risk and capital. Leveraging the global view and local expertise of our colleagues serving 140 countries and markets, we help organizations sharpen their strategy, enhance organizational resilience, motivate their workforce and maximize performance. Working shoulder to shoulder with our clients, we uncover opportunities for sustainable success—and provide perspective that moves you. About CLIPS CLIPS data are based on both new and renewal business figures obtained directly from carriers underwriting the business. CLIPS participants represent a cross-section of U.S. P&C insurers that includes many of the top ten commercial lines companies and the top 25 insurance groups in the U.S. This survey compared prices charged on policies written during the first quarter of 2025, with the prices charged for the same coverage during the same quarter of 2024. For this most recent survey, 41 participating insurers representing approximately 20% of the U.S. commercial insurance market (excluding state workers compensation funds) contributed data. Media Contact Douglas +1 (516) 972-0380 Arnelle +1 (718) 208-0474Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
