C1M Biomarker May Predict Joint Damage in Early Arthritis
Higher baseline serum levels of C1M, a biochemical marker of type I collagen degradation, were associated with higher odds of progression of total joint damage in patients with early arthritis at 1 and 5 years; however, the C2M marker showed no association with progression.
METHODOLOGY:
Researchers investigated the association between baseline serum C1M and C2M levels and the radiographic progression of joint damage in a cohort of patients with early undifferentiated inflammatory arthritis and recently developed rheumatoid arthritis (the ESPOIR cohort).
They included 813 patients (mean age, 48.1 years; 76% women) having two or more swollen joints, with the swelling lasting more than 6 weeks but less than 6 months, and no previous use of disease-modifying drugs or steroids.
Radiographs of the hands, wrists, and feet were obtained and scored according to the van der Heijde-modified Sharp score (mSS), assessing erosion, joint space narrowing, and total radiographic scores for each patient; serum C1M and C2M levels were assessed using biochemical assays.
Radiographic progression was defined as an increase from baseline in the mSS score of at least 1 point at 1 year and of at least 5 points at 5 years.
TAKEAWAY:
Baseline serum levels of C1M were 42% higher in patients who had progression of total joint damage at 1 year than in those without progression (median, 68 ng/mL vs 48 ng/mL; P < .0001).
Patients with baseline serum levels of C1M in the highest quartile had increased odds of progression of total joint damage (adjusted odds ratio [aOR], 2.12; P = .03) and bone erosion (aOR, 3.80; P = .005) after adjusting for the Disease Activity Score-28, C-reactive protein levels, and anti-citrullinated protein antibody positivity.
Median baseline serum levels of C1M were 33% higher in patients with progression of total joint damage at 5 years than in those without progression (P = .0037); each ng/mL increase in baseline serum levels of C1M was associated with an increased risk for progression after adjusting for age, sex, and BMI (P = .016).
No significant associations were found between baseline serum levels of C2M and radiologic progression at either 1 or 5 years.
IN PRACTICE:
"[The] biological marker [C1M] may be combined with other biomarkers of disease activity to improve the identification of patients with early arthritis at high risk for progression," the authors wrote.
SOURCE:
This study was led by Patrick Garnero of Inserm, Lyon, France. It was published online on July 10, 2025, in RMD Open.
LIMITATIONS:
At 5 years, radiologic data were available for only 60% of patients, limiting the robustness of the findings. Relationships of C1M and C2M levels with clinical progression were not analysed using the Disease Activity Score-28. Additionally, the effect of treatment groups during follow-up was not considered.
DISCLOSURES:
This study received an unrestricted grant from Merck Sharp and Dohme, with additional support from Inserm to support part of the biological database. The ESPOIR cohort study was supported by the French Society of Rheumatology, Pfizer, Abbvie, Lilly, Fresenius, and Biogen. One author disclosed being an employee of and owning stocks in Nordic Biosciences.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
4 hours ago
- Yahoo
Fossils unearthed in Grand Canyon reveal new details of evolutionary explosion of life
Paleontologists have discovered remarkable fossils in the Grand Canyon that reveal fresh details about the emergence of complex life half a billion years ago. The newfound remains of fauna from the region suggest that it offered ideal conditions for life to flourish and diversify, in a 'Goldilocks zone' between harsh extremes elsewhere. This evolutionary opportunity produced a multitude of early animals, including oddballs with peculiar adaptations for survival, according to new research. During the Cambrian explosion, which played out in the coastal waters of Earth's oceans about 540 million years ago, most animal body types that exist today emerged in a relatively short time span, scientists believe. Back then, the Grand Canyon was closer to the equator, and the region was covered by a warm, shallow sea teeming with burgeoning life — aquatic creatures resembling modern-day shrimp, pill bugs and slugs — all developing new ways to exploit the abundant resources. Researchers turned to the Grand Canyon's layers of sedimentary rock to unlock secrets of this pivotal moment in the history of life, digging into the flaky, claylike shale of the Bright Angel Formation where most of the canyon's Cambrian-era fossils have been found. The study team expected to recover mostly the fossilized remains of hard-shelled invertebrates typical of the region. Instead, the team unearthed something unusual: rocks containing well-preserved internal fragments of tiny soft-bodied mollusks, crustaceans, and priapulids, also known as penis worms. 'With these kinds of fossils, we can better study their morphology, their appearance, and their lifestyle in much greater resolution, which is not possible with the shelly parts,' said Giovanni Mussini, the first author of the study published Wednesday in the journal Science Advances. 'It's a new kind of window on Cambrian life in the Grand Canyon.' Using high-powered microscopes, the team was able to investigate innovations such as miniature chains of teeth from rock-scraping mollusks and the hairy limbs and molars of filter-feeding crustaceans, providing a rare look into the biologically complex ways Cambrian animals adapted to capture and eat prey. The 'Goldilocks zone' for innovation For most of the planet's 4 billion-year history, simplicity reigned. Single-celled microbes remained stationary on the ocean floor, thriving on chemical compounds such as carbon dioxide and sulfur molecules to break down food. What changed? Scientists still debate what drove the Cambrian explosion, but the most popular theory is that oxygen in the Earth's atmosphere slowly began to increase about 550 million years ago, said Erik Sperling, an associate professor of Earth and planetary sciences at Stanford University. Oxygen provided a much more efficient way to metabolize food, giving animals more energy to mobilize and hunt for prey, suggested Sperling, who was not involved in the new study. 'The (emergence of) predators kicked off these escalatory arms races, and then we basically got the explosion of different ways of doing business,' Sperling said. During the Cambrian, the shallow sea covering the Grand Canyon was especially oxygen-rich thanks to its perfect, 'Goldilocks' depth, said Mussini, a doctoral student in Earth sciences at the University of Cambridge in the United Kingdom. Ranging from 40 to 50 meters (about 130 to 165 feet) in depth, the ecosystem was undisturbed by the shoreline's constant waves shifting around sediments, and sunlight was still able to reach photosynthesizing plants on the seafloor that could provide oxygen. The abundance of food and favorable environmental conditions meant that animals could take more evolutionary risks to stay ahead of their competition, Mussini said. 'In a more resource-starved environment, animals can't afford to make that sort of physiological investment,' Mussini said in a news release from the University of Cambridge. 'It's got certain parallels with economics: invest and take risks in times of abundance; save and be conservative in times of scarcity.' Many soft-bodied fossil finds before this one have come from regions with harsh environments such as Canada's Burgess Shale formation and China's Maotianshan Shales, noted Susannah Porter, a professor of Earth science at the University of California in Santa Barbara who was not involved in the study. 'It's not unlike if paleontologists far in the future only had great fossil records from Antarctica, where harsh cold environments forced people to adapt. … But then found great human fossils in New York City, where people flourished,' Porter explained. 'We have an opportunity to see different sorts of evolutionary pressures that aren't like, it's really cold, it's really hot, there's not a lot of water.' Weird adaptations of Cambrian animals While some of the feeding mechanisms uncovered in the Grand Canyon fossils are still around today, others are much more alien. Among the most freakish: penis worms that turned their mouths inside out, revealing a throat lined with hairy teeth. The worms, also known as cactus worms, are mostly extinct today, but were widespread during the Cambrian. The fossilized worm found in the Grand Canyon represents a previously unknown species. Due to its relatively large size — about 3.9 inches (10 centimeters) — and distinct teeth, it was named Kraytdraco spectatus, after the fictional krayt dragon from the Star Wars universe, Mussini said. This particular penis worm appears to have had a gradient of hundreds of branching teeth used to sweep food into an extendable mouth. 'It's a bit hard to understand how exactly it was feeding,' Mussini said. 'But it was probably eating debris on the seafloor, scraping it away with some of the most robust teeth that it had, and then using these other, more delicate teeth to filter and retain it within this long, tube-like mouth.' Rows of tiny molars, sternal parts and comblike limbs that once belonged to crustaceans were also among the findings, which all date back 507 million to 502 million years. Similar to today's brine shrimp, the crustaceans used these fine-haired limbs to capture floating food from the water and bring it to the mouth, where molars would then grind down the particles, Mussini explained. Nestled among the molars, researchers even found a few unlucky plankton. Other creatures resembling their modern counterparts included sluglike mollusks. The fossils revealed chains of teeth that likely helped them scrape algae or bacteria from along the seafloor. 'For each of these animals, there's different components, but most of what we found directly relates to the way these animals were processing their food, which is one of the most exciting parts, because it tells us a lot about their lifestyle, and as a consequence, their ecological implications,' Mussini said. Sign up for CNN's Wonder Theory science newsletter. Explore the universe with news on fascinating discoveries, scientific advancements and more. Solve the daily Crossword
Yahoo
6 hours ago
- Yahoo
Study Says That 'Micro-Walks' May Be More Effective Than Longer Ones—Even For Weight Loss
"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." For years, doctors have stressed the importance of being active during your day—after all, research has found that sitting for too long raises your risk of a slew of serious health conditions, including cardiovascular disease and type 2 diabetes. But the idea of going for hour-long walks can be overwhelming. Now, new research suggests you don't need to jam in a massive stroll into each day: Instead, you can go for 'micro-walks.' That's the main takeaway from a study published in Proceedings of the Royal Society B, which found that micro-walks may be even better for you than long ones. Here's the deal. Interested in making walks part of your regular fitness routine? Check out the exclusive WH+ 4-Week Walking Plan that burns fat and builds muscle at the same time. What are 'micro-walks'? In this study, a 'micro-walk' is defined as walking between 10 and 30 seconds at a time (with breaks in between your next walk). Are 'micro-walks' more beneficial for your health? Why? It depends on how you're looking at it. In this particular study, volunteers walked on a treadmill or climbed a short flight of stairs for different periods of time, ranging from 10 seconds to four minutes. The study participants wore masks to measure their oxygen intake (which can be used to calculate energy or calorie consumption). The researchers discovered that people who walked in short bursts used up to 60 per cent more energy than longer ones, despite the walks covering the same distance. (The more energy you expend, the more calories you can burn.) Basically, you may be able to rev up your metabolism and burn more calories if you do short bursts of walking versus longer cruises around. Albert Matheny, RD, CSCS, a co-founder of SoHo Strength Lab, says there's something to this. 'Getting activity throughout the day, in general, is better for people,' he says. 'It's better for circulation, mental health, and digestive health.' You're also more likely to have a faster pace when you do shorter bursts of walking than if you're going on, say, a five-mile walk, he points out. How many steps should I get per day? This is debatable, and research has shown that the often-quoted 10,000 steps a day may not be necessary. Instead, 7,500 steps or so is ideal—but everyone is different. If you've already been walking, Matheny says that aiming for 10,000 steps a day is great. But if not or if you don't have many opportunities to walk during your day, 7,500 steps may be a better goal. 'It's really about doing what you can,' he says. 'If you're not a big walker and you think, 'I don't want to walk five miles,' then just do 30-second bursts. It's more attainable.'DMX Comfort+ Sneaker $108.49 at 26 $109.95 at 2 $240.00 at You Might Also Like Jennifer Garner Swears By This Retinol Eye Cream These New Kicks Will Help You Smash Your Cross-Training Goals Solve the daily Crossword
Yahoo
6 hours ago
- Yahoo
Stunning Grand Canyon Fossils Reveal Evolution's Weird Experiments
A stunning new fossil find from the Grand Canyon fills in some blanks from a time when evolution began experimenting with weird new forms. About half a billion years ago, life on Earth really started cooking in an event we now call the Cambrian explosion. The fossil record from that time reveals a spike in bizarre, complex creatures appearing within a relatively short amount of time, laying the roots for most of the major animal groups that exist today. Frustratingly, fossils from later in the Cambrian period are rarer, so we don't have a clear picture of evolution's experimental second album. But a newly discovered batch of extremely well-preserved fossils could patch up that gap. These are about 505 million years old – 3 million years younger than the Burgess Shale, the layer in which fossils from the Cambrian explosion appear. Related: A team led by researchers at the University of Cambridge found more than 1,500 small, carbonaceous fossils in samples from the Bright Angel Formation (BAF) of the Grand Canyon, which was once a shallow marine environment. The vast majority of the fossils are priapulid worms, along with a couple hundred crustaceans and a few mollusks. Although ecological resources were plentiful at the time, competition was also on the rise, rewarding species that exploited new niches. Analysis of these fossils revealed a variety of adaptations to do just that. A worm species called Kraytdraco spectatus, for example, was found to be covered in teeth sporting elaborate filaments, which varied in shape and length based on where they were on the body. The researchers suggest that they used their tougher teeth to scrape and rake surfaces, kicking up food particles that they could then filter out of the water using the longer filaments. Crustacean fossils featured signs of suspension feeding by way of tiny hairs that pushed food particles towards the mouth to be ground up by molar-like structures. The mollusks, meanwhile, sported rows of shovel-shaped teeth that could have been dragged front-to-back to scrape algae or microbes from surfaces. The Cambrian explosion gets plenty of attention because it's so well-represented in the fossil record, but that was just the beginning. The newly described fossils, with their exceptional level of preserved detail, provide a fascinating glimpse into the time soon after that, when complex life was established and comfortable, and had the stability to start innovating with new forms. And we should be glad it did: most of the major groups (or phyla) of animals got their start during the Cambrian. That includes arthropoda, encompassing all insects, arachnids, and crustaceans. And there's chordata, which includes us and the rest of our backbone-bearing brethren. The competitive period of the late Cambrian could have cemented the strategies that helped animals stay successful half a billion years later. "If the Cambrian Explosion laid the foundations of modern metazoan adaptive solutions, it is the scaling up of their competitive interactions that may have enforced directional, long-term trends of functional innovation in the Phanerozoic biosphere," the researchers write. The study was published in the journal Science Advances. Related News Neither Scales Nor Feathers: Bizarre Appendage Discovered on Reptile Fossil America's Largest Crater Has Surprise Link to Grand Canyon, Study Finds 500-Million-Year-Old Fossil Suggests Ocean Origin For Spiders Solve the daily Crossword
