
Goal to end AIDS by 2030 'more off-track' after Trump cuts, UNAIDS head says
JOHANNESBURG, June 13 (Reuters) - Donald Trump's cuts to HIV/AIDS programmes will further derail an already faltering plan to end the disease as a public health threat by 2030, UNAIDS Executive Director Winnie Byanyima said on Friday.
With 1.3 million new infections in 2023, according to the latest data, the world was already "off track," Byanyima told journalists in South Africa, a country with the world's largest number of people living with HIV, at 8 million.
"Less funding means we will get more and more off-track," she said in the main city of Johannesburg, after meeting President Cyril Ramaphosa to discuss Africa's HIV/AIDS strategy in light of the U.S. president slashing billions of dollars in foreign aid in February.
"We don't know yet what that impact will be, but impact there will be: ... already you see in several countries a drop in the number of people going to clinics," Byanyima said.
Before the cuts, prevention programmes had brought down new infections, she said, but they were "not coming down fast enough to reach our target of 2023."
Now, with the shuttering of community prevention clinics across Africa, infections would surely rise, though it wasn't clear yet by how much, she said.
The administration's decision to axe swaths of U.S. foreign aid has disrupted the supply of life-saving HIV treatments, with some countries facing potentially running out. In South Africa, about a fifth of whose HIV budget was U.S.-funded, testing and monitoring of HIV patients is already falling.
Byanyima said even poor, indebted countries were managing to plug funding gaps, but called on other rich nations to step in.
"We're saying to the donors: this is one of the diseases ... without a cure, without a vaccine, yet we're seeing progress," she said. "If you've got a good success story, why drop it ... before you end it?"
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Telegraph
34 minutes ago
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NHS boss claims Nigerian mother got the ‘black service'
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Medical News Today
36 minutes ago
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Celiac disease: Is an easier way to diagnose it on the horizon?
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The test could offer another option to help with celiac disease diagnosis — importantly, one that would not require triggering symptoms to confirm the disease. The authors of the current study note that there is often a delay or lack of diagnosis when it comes to celiac disease. Diagnosis usually involves people having to eat gluten and get biopsies of the small intestine. Celiac disease also has to do with the response of a group of immune cells, CD4+ gluten-specific T-cells. For this study, researchers wanted to determine if the use of a blood test that measures interleukin-2 — a protein produced by some T-cells — release could help to accurately diagnose celiac disease. This research involved a total of 181 adult participants between 18 and 75 years old. Of these participants, 88 had celiac disease, and others were controls. Among controls, 32 participants had a non-celiac gluten sensitivity and were on a gluten-free diet. 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However, the results were less sensitive for participants with a certain, less common genotype. Analysis results also found that the WBAIL-2 assay correlated with age and the number of years participants had been following a gluten-free diet. Next, researchers tested participants' serum levels of interleukin-2 after they did an oral gluten challenge. The levels of interleukin-2 were higher for participants with celiac disease following the oral gluten challenge. Researchers also found these levels 'positively correlated with the WBAIL-2 results.' So, if the levels of interleukin-2 were elevated on one test, they were also elevated on the other. They also tested how the WBAIL-2 results related to the presence of gluten-specific T cells, which were higher among participants with celiac disease. They did find that the presence of these cells, as well as activated versions of these cells, correlated with the WBAIL-2 test. 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The results suggest that the WBAIL-2 assay can help with celiac disease diagnosis, even when people are already following a gluten-free diet. There are some limitations to this study. For one thing, it was performed out of one area, most participants were female, and there were strict inclusion criteria, so it has a limited generalizability. It also had small sample sizes for some subgroups, which means more research may be particularly necessary in these subgroups. Since researchers did not test children or people taking immunosuppressants, more research is needed to see how well this testing method would work in these populations. Researchers also acknowledge an untested 'reproducibility across laboratories.' More research is thus needed before the WBAIL-2 assay can really be used in the clinical setting. Further, the authors did not examine the cost-effectiveness of the WBAIL-2 test and how well this would stack up against current ways of diagnosing celiac disease. Then, the test was not as accurate for some participants with a specific genotype, which means it might not work for everyone. However, the number of participants with this genotype was very small in this study, and it is possible that the level of interleukin-2 response of some participants with this genotype was just not able to be detected by the test. Overall, more research is required regarding this subtype of individuals and the use of this test. Ian Storch, DO, an osteopathic physician specializing in gastroenterology and internal medicine, and an American Osteopathic Association member, who was not involved in this study, spoke to Medical News Today about its findings. 'One limitation of this study is the poor performance in the DQ8 genetic arm, which makes up 10% of celiac patients. This will decrease the sensitivity and specificity for the control group or require HLA typing before the assay is run.' 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The authors of this study also suggest that the WBAIL-2 assay could also become a first test among people following a gluten-free diet and help with symptom severity prediction. Storch said: 'I do not think that based on the data presented, removal of histology to confirm the diagnosis can be suggested.' Jeffrey D. Davis, DO, CMD, an osteopathic physician specializing in Family Medicine and Preventive Health and an American Osteopathic Association board member, who was not involved in the study, noted the following to MNT : 'I see potential for a commercially available rapid, simple, cost-effective laboratory test for physicians to use to assist in the accurate diagnosis of celiac disease. This study shows that especially in adults already on a gluten-free diet using this lab test versus currently available tests would improve our diagnostic capabilities for Celiac Disease. 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Metro
6 hours ago
- Metro
Urgent recall for vitamin gummies over 'life-threatening health risk'
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