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‘I knew it': Sign 28yo had ‘aggressive' cancer

‘I knew it': Sign 28yo had ‘aggressive' cancer

News.com.au03-06-2025
An Australian woman who was diagnosed with aggressive cancer at the age of just 28 has revealed the symptom that ultimately tipped her off that something was not quite right.
Sam Bulloch, now 30, began to notice some bleeding when she went to the toilet — something that she put down to haemorrhoids.
But, two years ago, her bathroom habits — such as a change in how many times she needed to use the restroom — made her stop and think. Ms Bulloch realised she wasn't eating as best she could as she had just switched careers and was a busy new librarian, often opting for quick and easy, cheap meals, so she put it down to the changes in her diet.
But it was Ms Bulloch's depleted energy levels that eventually made her see a doctor, thinking she was having issues with her iron levels and even possibly anaemia — which had happened previously. It got to the point where the young librarian couldn't walk up a flight of stairs without being puffed.
A GP sent her off for a blood test and an ultrasound, also under the belief that it could be to do with her iron levels. But when a tumour was found in Ms Bulloch's colon — as well as spots on her liver and lungs — doctors discovered she had stage 4 colon cancer.
'My first reaction was, 'I knew it. When I started Googling after the ultrasound, when things started to get serious, I knew something was wrong,' she told news.com.au.
Ms Bulloch said it prompted her to look back at her health history, and she realised the blood she found when she went to the bathroom likely wasn't haemorrhoids as she initially suspected.
'When I found out it was cancer, my mind when to the worst place possible. And, just because it was so advanced at the time it was found, I just didn't have a lot of hope, to be honest.'
It wasn't Ms Bulloch's first brush with a deadly cancer. Two decades prior to her diagnosis, the then 28-year-old's mother was diagnosed with breast cancer.
'There's a lot that I don't remember from most of it, and by that I just mean life felt quite normal all things considered,' she said.
Looking back, Ms Bulloch said she is now in shock and awe at how her mother handled breast cancer with such grace. Eventually, it spread to her lungs and her brain.
'I do remember when she started to decline, and I feel like that's what sticks in my mind the most — just watching her get sicker and sicker,' she recalled.
'I think the hardest part was just watching her change and not feel herself. Towards the end, it was impacting her speech and cognitive function. She just didn't feel like the mum I knew in those last months.'
It was this knowledge of how brutal chemotherapy could be that scared Ms Bulloch, as she'd had a front-row seat to her mum's decline.
With cancer such as Ms Bulloch's, there was a few lines of standardised treatment. This includes two types of chemotherapy, with the third being to combine the two treatments for a more aggressive approach. She started off with a specific chemotherapy regime, and after doing some genetic testing to see what else could be given alongside the treatment, a more targeted therapy was also applied.
Her body responded well to that, and she was treated for 10 months before its effectiveness was questioned by her doctors. Ms Bulloch was then put on a different targeted therapy before she was eligible for surgery.
'We were doing the surgeries with the intention to remove all the cancer — which, spoiler, sadly didn't happen,' she said.
The first surgery was called an high anterior resection, which saw all of her sigmoid colon and the top part of her rectum removed. Cancer was also removed from her liver. Two months later, she had another liver resection which saw the whole right lobe of her liver removed. There were plans to operate on her lungs, where cancer was also found, but at the last minute her treatment options were switched. She is now on a different chemotherapy.
Ms Bulloch is sharing her story on behalf of Australian Cancer Research Foundation's Centre for Dynamic Immuno-Oncology at The Alfred in Melbourne. The centre looks at the potentially lifesaving potential of immunotherapy, with a grant allowing researchers to watch cancer cells interact with a patient's immune system in real time.
This removes the need for things such as blood or tissue samples, and could allow researchers to find a more targeted approach for a person's individual cancer.
Ms Bulloch said one of the chemotherapies was among the first ever created and had been around for 60 years.
'That's a good thing in some ways, but it's also really rubbish to receive. It makes you so sick,' she said.
'With chemotherapy, you kill everything and so you have a lot of collateral damage with that. Whereas with targeted therapies, it looks for something specific.
'And I mean, I'm no doctor, of course, but I'm convinced that the incredible response I had to treatment at the beginning was because of the targeted therapy.'
Ms Bulloch had side effects to her treatment, such as a severe rash, but she said this was nothing compared to other types of treatment that left her bedridden and unable to have a semblance of regular life.
Carly du Toit, General Manager of Australian Cancer Research Foundation, told news.com.au that immunotherapy is one of the most important breakthroughs in cancer treatment.
'But right now, it's only effective in some patients and others experience severe side effects or minimal results,' she said.
'Until we unlock its full potential for all patients, we haven't truly delivered on its promise. At ACRF, our mission is to change that. By supporting world-leading research, like the ACRF Centre for Dynamic Immuno-Oncology, we're working to ensure that this lifesaving treatment becomes a reality for everyone who needs it.'
Colon cancer falls under the banner of bowel cancer, with the Royal Australian College of General Practitioners reporting that it was up 266 per cent from the 1980s among 15 to 24 year olds.
Ms Bulloch said no two cancers were alike, and so she believed treatment options needed to be tailored. The young librarian also said she is sharing her story to show that colon cancer can impact anyone, and it's important to be on the lookout for what the signs are. She said she's had friends confide in her, and she wants these types of conversations to be normalised.
'When it started happening to me the first thing I felt was embarrassed, which is so silly, that I was embarrassed that I was having bleeding,' she said.
'I just let the embarrassment stop me from doing anything or telling anyone about it.'
She said she will continue to advocate so that others can have full autonomy over their health. And, for Ms Bulloch, she said focusing on the everyday moments of joy while dealing with everything that has happened over the last two years is helping to get her through it all. At the beginning of this year, she met her partner Sam on Hinge when both were initially set on deleting the app for good.
'It's been a couple of months now we've done so many fun things but also he's sat with me in some really tough things,' she said.
'I went through losing my hair shortly after meeting him, getting bad scan results — like the poor things really like not come into my life at a mountain top moment.'
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Deanna tried IVF with the lot. None of the costly, unproven add-ons worked, so she went back to basics
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Four out five women accessing IVF also use add-on services during their treatment, which can greatly add to their costs as well as the profits and marketability of the clinics, but which may not increase the chances of success. An analysis of the non-core services being offered to Australian fertility patients by University of Melbourne researchers, prepared for this masthead, highlights the high costs and lack of evidence supporting services commonly upsold to potentially emotionally vulnerable patients. It reveals 44 treatment types ranging from free to $5000, and taking in everything from vitamins to plasma being injected into ovaries, genetic testing of embryos, injecting a single sperm directly into an egg and endometrial scratching, have little to no influence on the chances of having a live birth, pregnancy or miscarriage. Loading The analysis follows the launch of the Evidence-based IVF website in April, which is led by the University of Melbourne's Dr Sarah Lensen as an effort to better inform people undergoing IVF of the unproven add-ons. 'There are research articles out there on these different add-ons but the quality, broadly speaking, is really poor. Different providers are willing to draw the line in different places in terms of how much evidence they think they need before they're willing to offer or recommend something,' Lensen said. 'Sometimes there's a cost for special IVF conception vitamins or whatever, but they're probably pretty low risk, and they're not as big of a deal. 'Down the other end of the spectrum, there's the super-expensive $1000 treatment options that also come with risks because they're playing with patients' immune systems or injecting things into their ovaries that we don't really know what's going to happen. 'A lot of the add-ons that get offered slip through the cracks in terms of the existing regulatory system.' In Deanna Carr's case, she underwent two normal but unsuccessful cycles of IVF before adding steroids, blood thinners, aspirin and clexane during two further cycles. Determined more had to be done, Carr followed advice from online fertility forums and moved to one of Australia's largest clinics to seek out a specialist known for pushing the envelope. 'There's lots of conversation about which specialists to see, because these specialists are willing to be a lot more experimental – and, when we say experimental, it is literally meaning experimental. 'They're willing to try more add-ons, regardless of how inclined the research is to say that it doesn't work.' Tests at that clinic found Carr had a partial DQ Alpha gene match which may make her body more likely to attack or reject an embryo, though research suggests treatment for it does not significantly improve IVF success rates. To address the issue, a team of specialists gave Carr lymphocyte membrane immunotherapy, in which up to eight vials of blood were taken from her husband so his white blood cells could be extracted and then injected into her arm to correct her immune system with material that is genetically matched to their embryo. 'It's like weird blood brother stuff, and quite expensive,' Carr said. She was given a toxic cocktail of drugs including naltrexone and tacrolimus, which are more commonly used to treat cancer, as well as an intralipid infusion to 'knock out' her immune system. Added together, this cycle cost more than $8000. 'It didn't work. It ended up the same way all our other cycles ended,' she said. Carr's specialists then offered to step up the add-on treatments even further. They proposed a $5000 EMMA and ALICE test which would have seen Carr undergo another full IVF cycle but, rather than try for a pregnancy, the doctors would take a biopsy of her uterus to see if bacteria were present that might be impacting her pregnancies. If it found abnormalities, Carr was then to be prescribed cefalexin – a common antibiotic used for infections and cheaply available on the Pharmaceutical Benefits Scheme. 'It's what the doctor would give you for a sore throat. Why would they make me pay five grand for it? Why not just give me the medication?' Rather than spending $12,000 for another add-on-laden IVF cycle, Carr consulted the Evidence-based IVF site and realised there was little science to support the proposed treatment, then switched clinics to undergo a traditional – and successful – cycle. 'You get persuaded to add on because you obviously want it to work, and you're already spending so much, so this can financially tip you over the edge,' she said. 'A lot of these IVF companies know that. It does feel really unethical [because] a lot of the time people aren't being provided with proper information around the add-ons that are being suggested and the efficacy around them. And people are really desperate, so they'll just keep saying yes to things.' A Macquarie University professor of bioethics in the discipline of philosophy, Wendy Lipworth, last year published a study based on interviews with 31 doctors working in assisted-reproductive technology to see what their 'moral justification' for using add-ons was. The specialists' responses revealed evidence and innovation was not the driving consideration in many instances, and that regulatory reforms to only allow the use of unproven treatments in the context of formal scientific evaluation might be required. Lipworth said add-ons were often marketed as a point of difference between clinics, which may undermine individual doctors' ability not to offer them for patients. As a result, she believes any new regulation would need to focus on the clinics and what they are offering, rather than individual doctors wanting the best for their patients. 'Generally, there should be some expectation that they might at least be beneficial, even if there's no good evidence for it. That's a real balancing act,' Lipworth said. 'In fertility, the balance is going a little too far in the direction of too many things being offered without enough evidence. 'There might be room for some more regulation of how the products are advertised, how patients come to know about them, what they charge for them and so on. But the very act of using them is not in and of itself in any way unethical. 'What really matters is that people know that they're getting treatment for which there is not good evidence, and that they are able to make informed decisions about whether or not to use them. Loading 'That doesn't mean that anything goes and that patients should necessarily be able to walk into a doctor's surgery and say, 'my friend saw this on Facebook', or 'my friend used this and she got pregnant, therefore I want you to offer it to me'. 'There is still a duty of care to offer things that you, at the very, very least, are absolutely certain won't do harm.' Add-ons are not the only factor separating clinics, or the fees they charge. Lensen said premium clinics typically provide continuity of care so patients always get to see the same specialist and nurse, as well as improved customer service, which may not be provided at low-cost or public clinics. And, in many cases, the proliferation of add-on services is often more patient-driven than due to marketing by doctors or their clinics – which is why Lensen believes reforms are even more important, so regulators can step in when doctors fail to uphold their responsibility to dissuade patients from treatments that may not be in their best interests. 'The evidence is not that strong, but the patients are asking for it, or the clinic down the road is offering it, and so they end up using it too. But then when the research community does come out with robust evidence later, I think they do act,' she said. 'So it would be nice if we said from 'now on, no more offering a high dose of corticosteroids to patients. If you want to do that, they can take part in a placebo controlled trial'. 'A lot of the time, though, regulations are not aligned with the commercial interests of whoever they're trying to regulate – that's the whole reason we need them.'

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