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Ozempic Heartburn

Ozempic Heartburn

Health Line16-07-2025
Some people have reported on social media that they experience heartburn or acid reflux during Ozempic treatment. You can try some things to help prevent or lessen heartburn during Ozempic treatment.
Is heartburn typical during Ozempic treatment?
Ozempic's clinical studies didn't report heartburn. But the prescribing information notes the following mild side effects that often link to heartburn.
gastroesophageal reflux disease (GERD) (acid reflux): This can cause a burning feeling in your chest, neck, or throat. It can also cause a bitter or sour taste in the back of your mouth and regurgitation of food or liquid into your mouth. (Regurgitation involves 'bringing up' partially digested food or liquid.)
burping or belching
dyspepsia (indigestion): This side effect can cause burning or discomfort in your upper abdomen and other symptoms.
gastritis (inflammation or irritation of your stomach lining): This side effect causes nausea, vomiting, and fullness in your upper abdomen.
gas
The studies reported these side effects with the use of 5-milligram (mg) and 1-mg doses of Ozempic. Except for gas, people experienced these side effects more commonly with the 5-mg dose.
Since the drug became available, some people have reported having heartburn during Ozempic treatment. Although it can be mild, some people taking the drug reported intense heartburn. Some also reported that it affected their sleep and some everyday activities.
How do you stop heartburn during Ozempic treatment?
Some people find home remedies or practices helpful in stopping heartburn during Ozempic treatment. These include:
drinking more water
drinking a glass of water mixed with 1 teaspoon of apple cider vinegar
avoiding lying down until the heartburn passes
using a wedge pillow or elevating the head of your bed
Numerous medications are also available over the counter or by prescription for heartburn. Some of these medications help prevent heartburn or acid reflux, and others treat it once it starts. These medications include:
Antacids: Antacids neutralize your stomach acid, which may reduce or treat heartburn. Some brand-name antacid medications are:
Alka-Seltzer
Mylanta
Pepto-Bismol
Rolaids
Tums
Proton pump inhibitors (PPIs): PPIs work to reduce the amount of acid your stomach produces. Some examples are:
esomeprazole (Nexium)
pantoprazole (Protonix)
omeprazole (Prilosec)
Histamine-2 (H2) blockers: H2 blockers reduce the acid your stomach produces. Some H2 blockers are:
nizatidine (Axid)
famotidine (Pepcid, Pepcid AC)
cimetidine (Tagamet, Tagamet HB)
Your doctor may recommend a particular medication for your heartburn and acid reflux. They'll also recommend the best time to take it.
How do you prevent heartburn during Ozempic treatment?
You can do some things to help prevent or lessen heartburn during Ozempic treatment. These include:
eating smaller meals
eating slower
avoiding eating meals and snacks 3 to 4 hours before bedtime
avoiding lying down soon after meals
considering stopping smoking, if you smoke
limiting the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin
considering avoiding or limiting your intake of alcohol
reducing stress
avoiding or limiting certain foods
Foods to avoid or limit
Certain foods can contribute to the amount of acid your stomach produces, which may cause heartburn. These foods are:
certain beverages, such as carbonated drinks, tea, and coffee
fatty, greasy, or fried foods
fast foods
spicy foods
certain fruits and vegetables high in acid, such as tomatoes, pineapples, and oranges
Avoiding or limiting these foods may help prevent or reduce the heartburn you might experience during Ozempic treatment.
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