'I wish I'd known this before having a facelift': Grandmother who looks '20 years younger' has two big regrets
Peggy Lynn Marchetti, 60, has been sharing daily recovery updates with her 7,450 Instagram followers since she underwent a plethora of procedures in Guadalajara just three weeks ago.
Under the care of surgeon Dr Fabian Mendoza, she had an extended deep plane lower facelift, upper and lower blepharoplasty—when the skin around the eyes is cut and tightened—a lip lift, and fat injections to replace volume in her cheeks.
Ms Marchetti has been more than happy to answer people's questions about her staggering glow up, and surprisingly, she said the operations didn't leave her in a lot of pain.
She said: 'The first one to three days is uncomfortable. You have the headdress the bandages and I had three drains.
'You have lots of swelling, so you feel really tight, but I wouldn't consider that pain just being uncomfortable and hard to rest.'
But it was in a standalone video that Ms Marchetti revealed the things she wish she had done before having a facelift.
Speaking directly to camera, she began by explaining that she wishes she had had the op sooner—but not for the reason you'd expect.
She said: 'I would have done it a lot sooner, somewhere between the age of 50 and 54. Why? Because you heal faster, you're in overall better health, and your face and your body still match.
'Trust me, when you look 40, but your hands and your chest tell a different story, it's not good. Today's face lifts are not your mama's face lift. Cosmetic Surgery has come a long way.'
Getting into what she wishes she had known about and acted on, she said that she regrets not being more liberal with SPF as years of sun damage have left her with 'discoloration, fine lines, wrinkles and crepey skin'.
'In my younger years, I wished I would have taken sunscreen a lot more serious, not just on my face, but on my neck, my chest, my hands.
'Those UV rays as you age show up, and they rob your skin of all the radiance. I'm totally kicking myself.'
Ms Marchetti also said she wishes she had started having anti-wrinkle injections when she was younger.
'I would have started Botox and been consistent, a little consistency, and maintenance, preventative, all of those measures go a long way,' she mused.
Finally she advised others hoping to have a facelift to 'start saving early' and view it like they would a retirement pot.
'You're worth the investment in cosmetic surgery,' she said. 'No matter where you get it, it is not cheap.'
Ms Marchetti has not stated how much she has spent on her surgeries, but responded to one follower: 'The cost really depends on the procedures that you're having done. My surgeon, hospital, medications, recovery, home, clinical testing, pre-surgery, post surgery, therapies, travel, and incidentals. A good budget $20-$25k.'
Last week we revealed the similarly amazing results of a London grandmother who flew to Turkey for a facial rejuvenation procedure.
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Xeljanz (tofacitinib) is a brand-name drug prescribed for psoriatic arthritis. This article covers topics such as side effects, dosage, and how Xeljanz is available in these forms: oral tablet, oral extended-release tablet (Xeljanz XR), and an oral solution. ('Extended release' means the drug contents are slowly released into your body over time.) Throughout this article, we'll use 'Xeljanz' to refer to all forms, except where noted otherwise when specific differences belongs to a drug class called Janus kinase (JAK) inhibitors. The medication is not available in a generic version. Read on for more information about Xeljanz. You can also refer to this in-depth Xeljanz article. Xeljanz has boxed warnings. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the 'Before taking Xeljanz' section. Psoriatic arthritis explainedPsoriatic arthritis (PsA) is an autoimmune condition where your body mistakenly attacks your healthy joints. This causes inflammation and can cause permanent joint damage over time without is an autoimmune condition that causes skin cells to rapidly turn over. This creates scaly lesions, called flare-ups, on your skin. About 30% of people with psoriasis also develop PsA. People with PsA typically develop psoriasis symptoms first, although this isn't the case for of psoriatic arthritisSymptoms of psoriatic arthritis will differ for each person and range from mild to general symptoms of psoriatic arthritis include:tender, swollen joints on one or both sides of your bodyswollen fingers or toesjoint stiffness in the morningpain in your muscles and tendonsscaly skin patches that may worsen simultaneously with flaring joint painnails separating from the nail bedflaky scalpfatigueeye painWho Xeljanz is prescribed forXeljanz is prescribed to adults with psoriatic arthritis whose symptoms have not responded to treatment with, or who had intolerable side effects to, one or more tumor necrosis factor (TNF) blockers. Examples of TNF blockers used to treat psoriatic arthritis include:adalimumab (Humira) and its biosimilars, such as adalimumab-ryvk (Simlandi)certolizumab (Cimzia)infliximab (Remicade) and its biosimilars, such as Avsola (infliximab-axxq)golimumab (Simponi and Simponi Aria)How Xeljanz treats psoriatic arthritis Psoriatic arthritis (PsA) is an autoimmune, inflammatory condition. With PsA, your immune system mistakenly attacks your joints, causing pain, inflammation, and other you're prescribed Xeljanz to treat PsA, you may wonder how the medication works to treat your condition. How a drug works is also referred to as its mechanism of way Xeljanz worksXeljanz is a type of medication called a Janus kinase (JAK) inhibitor. It works by blocking an enzyme (a type of protein) called Janus kinase (JAK). The JAK enzyme plays a role in activating certain parts of your immune system, which send signals to increase inflammation that cause psoriatic arthritis (PsA) symptoms. Blocking the JAK enzyme helps decrease inflammation, easing PsA well Xeljanz works for psoriatic arthritisClinical studies found Xeljanz effective for treating psoriatic arthritis (PsA) in adults. These studies specifically evaluated how well Xeljanz worked to treat PsA symptoms in adults whose symptoms did not respond to or who had intolerable side effects to one or more tumor necrosis factor (TNF) way to gauge a medication's effectiveness is through clinical treatment guidelines. Xeljanz is a recommended treatment option for certain adults with psoriatic arthritis in guidelines from the American College of Rheumatology and National Psoriasis Foundation. Your doctor or pharmacist can provide more information on how Xeljanz fits into these treatment Xeljanz for psoriatic arthritisIf you're prescribed Xeljanz for psoriatic arthritis, it's important to understand your dosage and how to take the treating psoriatic arthritis, the following table lists recommended doses for Xeljanz and Xeljanz XR:Xeljanz (oral tablet and oral solution)Xeljanz XR (extended-release oral tablet)Recommended dosage5 milligrams (mg) twice daily11 mg once dailyYour doctor may adjust your Xeljanz dosage if you take certain other medications, have certain medical conditions, or experience certain side effects. To learn more, talk with your doctor or pharmacist. You can also learn more in the prescribing information for Xeljanz and Xeljanz In addition to treating psoriatic arthritis, Xeljanz has other uses. Keep in mind that the drug's dosage may differ when treating other conditions. 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Xeljanz is also approved to treat the following conditions: rheumatoid arthritis (RA)ankylosing spondylitis (AS)ulcerative colitispolyarticular juvenile idiopathic arthritis (JIA) It's important to note that side effects from Xeljanz may differ slightly depending on the condition it's used to lists below include some of the main side effects that have been reported with Xeljanz. For information about other potential side effects of the drug, talk with your doctor or pharmacist. You can also see our side effect article about Xeljanz or refer to Xeljanz's prescribing After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while taking Xeljanz and want to tell the FDA about it, visit MedWatch or call side effects of XeljanzMild side effects reported by people who took Xeljanz to treat psoriatic arthritis in clinical trials include:upper respiratory infection, such as sinusitisrunny nose, coughing, and sneezingdiarrheaheadacheinsomniafatigueabdominal painindigestionnausea and vomitingincreased cholesterol levelsThese side effects of Xeljanz may be temporary, lasting a few days to weeks. But if they last longer than this, bother you, or become severe, it's important to talk with your doctor or side effects of XeljanzWhile not common, serious side effects with Xeljanz are possible. These include:blood cell problems, including: low lymphocyte countlow neutrophil countlow red blood cell count (anemia)high blood pressureincreased liver enzymes, which can be a sign of drug-induced liver damageperforations (holes) in your stomach or intestinesrisk of serious infection*increased risk of death in certain people*risk of cancer and lymphoproliferative disorders*risk of serious cardiovascular side effects, in certain people*risk of blood clots*Call your doctor right away if you develop serious side effects while using Xeljanz. If the side effects seem life threatening or you think you're having a medical emergency, call 911 or your local emergency number immediately.* Xeljanz has a boxed warning for this side effect. A boxed warning is the most serious warning from the FDA. To learn more, see the 'Before taking Xeljanz' section. ALLERGIC REACTIONFor some people, Xeljanz can cause an allergic general, symptoms of allergic reaction can be mild or to manageFor mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They'll also let you know whether you should keep taking the severe allergic reaction symptoms, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care as they can become life threatening. If you've had a serious allergic reaction to Xeljanz drug, your doctor may recommend a different medication taking XeljanzBefore you take Xeljanz, there's some important information to keep in mind. The drug may not be a safe option if you have certain medical conditions or other factors that affect your health. Some of these are mentioned warningsThis drug has boxed warnings about the risk for serious infections, an increased risk of death in certain people, risk of cancer, risk of serious cardiovascular side effects in certain people, and the risk of blood clots. These are the most serious warnings from the Food and Drug Administration (FDA).Risk of serious infection: Treatment with Xeljanz lowers the ability of your immune system to fight off infections. This can raise your risk for serious infections, including herpes zoster (shingles) and tuberculosis (TB). Before you begin taking Xeljanz, your doctor will test you for TB. If you have TB or another infection, your doctor may want to treat it before you begin taking Xeljanz. If you develop symptoms of an infection while taking Xeljanz, immediately let your doctor know. 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If you experience serious cardiovascular side effects during treatment, your doctor will likely have you stop taking sure to tell your doctor if you've had a heart attack or stroke in the past before you begin treatment with Xeljanz. You're also at higher risk for serious cardiovascular side effects from taking Xeljanz if you use tobacco or have in the past. Having heart problems, including heart disease, can also increase this of blood clots: Treatment with Xeljanz may increase your risk for blood clots. Due to this risk, your doctor likely will not prescribe a Xeljanz dosage of 10 mg twice per day or a Xeljanz XR dosage of 22 mg once per day to treat your psoriatic arthritis. Get immediate medical treatment if you think you have symptoms of a blood clot while taking Xeljanz. If you experience this side effect, your doctor will likely have you stop taking you begin taking Xeljanz, let your doctor know if you have a blood clot or have had one in the past. 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