
Scientists Finally Identify Killer Microbe Behind ‘Terrifying' Sea Star Disease
Inspecting the tide pools along one of his favorite shorelines on Vancouver Island, Dr. Marley saw something new and alarming: sea stars in several stages of death, with their arms twisted or missing. The devastation went on and on. One of his favorite parts of the ecosystem — the big, colorful, 'supremely weird' sea stars — was 'dissolving away,' he recalled recently.
Since 2013, an epidemic of sea star wasting disease along the Pacific Coast of North America has caused billions of sea stars to twist and disintegrate. Sunflower sea stars, one of the world's largest starfish, lost 90 percent of its population over the last decade. Populations of sea urchins, typically preyed on by sea stars, overran and wiped out kelp forests.
The cause of the disease remained elusive. But on Monday, a new study identified the killer: a sneaky bacteria known as Vibrio pectenicida.
'I have been waiting for this for a long time,' said Dr. Harley, who was not involved with the research.
A team of scientists led by Alyssa-Lois Gehman, a marine ecologist at the Hakai Institute in British Columbia, conducted experiments over four years to find the culprit, which was 'hiding in plain sight,' Dr. Gehman said. The findings, published in Nature Ecology and Evolution, open many avenues of recovery for the sea star species that were previously unachievable without knowing the cause of the disease.
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Medscape
2 hours ago
- Medscape
Neoadjuvant vs Adjuvant Immunotherapy in Colon Cancer
The results of the phase III ATOMIC trial fired another volley in the ongoing debate over adjuvant vs neoadjuvant immunotherapy for patients with locally advanced colon cancer. But experts are divided about which treatment plan is the best. Adjuvant immunotherapy plus chemotherapy has yet to square off against neoadjuvant immunotherapy in a head-to-head trial. Even if that trial doesn't happen, post hoc analyses of ATOMIC and the neoadjuvant NICHE-2 studies may clarify whether a one-size-fits-all approach is appropriate and help determine which patients benefit more from one approach over the other, according to Christopher Lieu, MD, an investigator in the ATOMIC study. The ATOMIC study showed that adding adjuvant immunotherapy to standard-of-care chemotherapy following resection reduced the risk for disease recurrence or death by 50% compared with chemotherapy alone in the 355 patients with stage III colon cancer with mismatch repair deficiency (dMMR), who received adjuvant atezolizumab along with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy, providing those in the pro-adjuvant camp with important data. In addition, 3-year disease-free survival (DFS) was 86.4% with the combination compared with 76.6% with chemotherapy alone. The results of this trial were presented at the American Society of Clinical Oncology (ASCO) 2025. 'These data established this combination as a new standard treatment for patients with stage III colon cancer and deficient mismatch repair,' said study author Frank A. Sinicrope, MD, during a press conference at the meeting. 'We regard this as a highly impactful study that will change clinical practice, and it actually represents the first immunotherapy adjuvant study in colon cancer.' In NICHE-2, patients were given neoadjuvant ipilimumab or nivolumab followed by surgical resection. At 3 years, 100% of all 111 patients treated with ipilimumab and nivolumab prior to surgery were recurrence-free, according to a presentation at last year's annual meeting of the European Society for Medical Oncology (ESMO). The DFS beat the prespecified success threshold of 93%. Adding Immunotherapy The standard treatment for stage III colon cancer, regardless of dMMR status, is surgical resection followed by FOLFOX chemotherapy. However, about 15% of patients with stage III colon cancer have dMMR and display resistance to chemotherapy, providing a rationale for adding immunotherapies to standard treatment. 'These tumors are unable to repair their DNA and therefore accumulate mutations that trigger an immune response that is ineffective due to immune checkpoint proteins. Therefore, the use of immune checkpoint inhibitors is very attractive in this setting,' Sinicrope said during the press briefing. Sinicrope is professor of medicine and oncology, and coleader of the Gastrointestinal Cancer Program at Mayo Clinic in Rochester, Minnesota. Adjuvant Immunotherapy The ATOMIC trial is significant because it demonstrates improved DFS with the addition of immunotherapy to standard chemotherapy treatment, improving outcomes for patients with this type of locally advanced cancer over standard care. There are several rationales for adding immunotherapy following surgical resection. For example, staging relies on tumor appearance on CT scan, said Lieu, who is the codirector of Gastrointestinal Medical Oncology at the University of Colorado Cancer Center in Aurora, Colorado. There are patients with dMMR or microsatellite instability-high (MSI-H) colon cancer that appear to have stage I or II disease on their CT scan. 'In those patients, starting with immunotherapy first may not be the best idea because after a stage I or II colon cancer is resected, they don't require any further therapy because of the low risk of recurrence,' he said. 'If you think it is an early-stage cancer based of radiographic findings, you could cut out the cancer and then only offer chemotherapy and immunotherapy if it is unexpectedly stage III. I think that there's certainly rationale for that,' he continued. Other arguments for adjuvant immune checkpoint inhibitors, like atezolizumab, with chemotherapy include synergy between cytotoxic and immune mechanisms and systemic insurance against micrometastatic spread. It also avoids the potential for rare immune complications from upfront immunotherapy that could delay surgery. 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Overman, MD, Associate Vice President of Research for the MD Anderson Cancer Network in Houston, in an interview. 'Thus, I am a believer that neoadjuvant is the preferred approach for dMMR localized cancers.' Lieu said neoadjuvant immunotherapy might be more appropriate for more aggressive disease. 'What we discuss in our multidisciplinary clinic is that if these patients are diagnosed prior to surgery and particularly if they have aggressive features…those are some of the patients that I really would consider for neoadjuvant therapy,' he said. 'While it's high-risk disease, there could be some benefit to down-staging the patient, so that there isn't a positive margin. If there's pathologic complete response…and you don't have to give adjuvant chemotherapy, most people would consider that to be a win.' Overman noted that 'a big open area relates to whether the goal of neoadjuvant therapy should be operation or no operation. Likely both approaches can be done and that would be up to patient and physician.' However, 'with a nonoperative approach, we still have unknowns regarding disease assessment and surveillance for neoadjuvant therapy.' Patient-Specific Care In the absence of data from a head-to-head trial of the two approaches, a patient-specific approach may be the appropriate strategy, Lieu suggested. 'If I had a take home message, it's just that it's clear that these patients really require multidisciplinary discussion before an operation,' he said. Molecular testing has an important role to play as well, said Lieu. 'It speaks to the importance of doing biomarker testing for MMR, MSI, or both. Alarm bells should be ringing as soon as [either or both come] back positive; it should make everyone think for a second and make sure we have the right plan for the right patients.' Sinicrope reported several relationships, including with Eli Lilly, Guardant Health, Roche Holdings AG, Ventana Medical Systems, and Woven Health Collective. Lieu reported relationships with Amgen and Genentech.
Yahoo
4 hours ago
- Yahoo
Study IDs possible cause of sea star wasting disease that wreaked havoc on Oregon Coast
A leading suspect has been identified as a likely cause of sea star wasting disease, which has had a major impact on the ecology of the Oregon Coast over the past decade, according to a study published Aug. 4 in the journal Nature Ecology & Evolution. The bacterium Vibrio pectenicida was identified as being the causative agent in a disease that has killed billions of sunflower sea stars on the West Coast. The finding is critical, the study says, because the discovery "will enable recovery efforts for sea stars and the ecosystems affected by their decline." The loss of sea stars has led to a highly impactful "trophic cascade" in the ecosystem off the coast. Left unchecked by predatory sea stars, the sea urchin population has exploded, which has led to a major decline in nearshore kelp forests that serve as habitat for a wide range of fish and shellfish species. In 2021, the Center for Biological Diversity submitted a petition to list the sunflower sea star under the Endangered Species Act. The National Marine Fisheries Service proposed to protect the species as threatened in 2023 but the listing has not yet been finalized. 'Hats off to the dedicated researchers who've identified what killed billions of these extraordinary sea stars in the Pacific,' said Catherine Kilduff, a senior attorney at the Center for Biological Diversity. 'With this new information, I'm hopeful we'll be able to stop the sunflower sea star's decline and get their populations back up so they're thriving again." Kilduff said the discovery can help entire ecosystems and highlights why research funding and species protection are important. "The federal government needs to stop dragging its feet and provide the safeguards these sea stars desperately need to survive," Kilduff said. Sea star wasting disease first emerged in 2013 along the Pacific Coast and quickly became one of the largest documented marine epidemics ever recorded. Sunflower sea stars, which can grow to 3 feet across and have up to 20 arms, once ranged in high densities from Mexico to Alaska. But they were extremely susceptible to the disease, and after multiple waves of die-offs, have become functionally extinct in their southern range and have lost nearly 91% of its population overall. The identification of the bacterium causing SSWD, conducted between 2021 and 2024, is critical because it could mean treating sea stars in captivity with antibiotics or testing them in the field, Scenice News reported. "You can treat them with antibiotics [that] would target that specific bacteria,' Ian Hewson, a marine ecologist at Cornell University, told the media outlet. Any rebound in their population would be critical. The kelp forests off the Oregon Coast have been disappearing at an alarming rate as the number of sea urchins rises. The forests absorb carbon dioxide and support fish, otters, sea lions and other animals. Zach Urness has been an outdoors reporter in Oregon for 18 years and is host of the Explore Oregon Podcast. He can be reached at zurness@ or (503) 399-6801. Find him on X at @ZachsORoutdoors and BlueSky at This article originally appeared on Salem Statesman Journal: Study IDs possible cause of sea star wasting disease on Pacific coast Solve the daily Crossword
Yahoo
4 hours ago
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Are Potatoes Healthy? 3 Surprising Benefits, From Fiber to Antioxidants
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'We don't want people to fear the potato, but we want to make sure that they eat it in a healthful way and in a controlled portion size.' Research on Potatoes and Health For the 2020 study, researchers looked at the effect of eating potatoes every day, compared to eating the same number of calories in refined grains. They recruited 50 healthy adults, whose baseline blood pressure and arterial stiffness were measured at the start of the study, and whose blood samples were checked for fasting glucose, cholesterol, insulin and other markers. Those checks were repeated throughout the study. The participants were then randomly assigned to replace their usual main meal starchy side dish with a study side dish: either 200 calories worth of potatoes or refined grains, as prepared by the Metabolic Diet Study Center at Penn State. They ate this way every day for four weeks. After a break of at least two weeks, they switched to the opposite study side dish, eating it with their main meal every day for a month. Potato side dishes consisted of steamed or baked red, white and gold spuds. Refined grain options included Spanish rice, pasta, garlic bread and naan, Johnston, who is now a research assistant professor in NYU's department of medicine, said. All were prepared with minimal added salt, saturated fat or sugar, though some ingredients were minimally added for taste, including scallions, onions, breadcrumbs and cheese. There was no evidence eating potatoes increased fasting glucose levels, and there was no difference in cholesterol, insulin or other markers, the authors noted. All in all, there were no adverse cardiometabolic consequences. 'We certainly want people to eat more non-starchy vegetables because we know the average American intake is well below recommendations,' Johnston said. 'But starchy vegetables and refined grains do contribute some important nutrition as well. It's just that we need to make sure we eat them in balance.' The Alliance for Potato Research and Education, a non-profit funded by the potato industry, provided money for the study, but didn't have any say in any aspects of it, the authors wrote. Potatoes Nutrition According to the U.S. Food and Drug Administration, one medium potato contains: 100 calories 26 grams carbohydrates 2 grams of fiber 3 grams of protein 0 grams of fat 1 gram of sugar 620 milligrams of potassium (18% DV) 40 milligrams vitamin C (45% DV) Health Benefits of Potatoes Potatoes are high in many vitamins and minerals and when prepared by steaming, baking or roasting with the skin on, they can be a more nutritious option than refined carbs, research has found. Potassium Potatoes are a rich source of potassium, which is important for blood pressure regulation, but most Americans don't get enough of in their diet, Johnston said. Almost half of adults in the U.S. have hypertension, according to the Centers for Disease Control and Prevention. In Johnston's 2020 study, the participants' potassium was significantly higher when they ate potatoes, compared to refined grains Their diet quality was also higher, driven by a higher vegetable intake. Fiber White potatoes can pack in a surprising amount of fiber when eaten with the skin on. A medium potato with the skin on can have 2-4 grams of fiber, according to Mayo Clinic. The fiber is both soluble and insoluble, meaning it both feeds the good bacteria in the gut and helps keep you regular. Vitamin C A medium potato can have 20-40 milligrams of vitamin C, almost half of the daily recommended amount, according to Cleveland Clinic. Your body doesn't produce vitamin C so you need to get it from your diet. This micronutrient is an antioxidant that can reduce risk of disease, boost the immune system and increase collagen production, per UCLA Health. The Healthiest Ways to Eat Potatoes Make potatoes a side dish composing about one-fourth of your whole plate, Fernstrom advised. Be careful about the portion size: One medium potato is about the size of a computer mouse, Johnston noted. Restaurant baked potatoes can be much bigger, so consider eating half. Stick to baking, roasting or steaming: Boiling potatoes doesn't add any calories or fat, but it leaches potassium out of them. Frying is a nutritional deal-breaker. Whether you bake or microwave, keep the skin on to optimize the nutrients and fiber. Skip the extras: Don't load your potato up with butter, sour cream or bacon bits. Go easy on the salt. This article was originally published on