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Treatment for advanced womb cancer ‘major step forward'

Treatment for advanced womb cancer ‘major step forward'

Just 15% of women live for five years if they have been diagnosed with advanced (stage four) endometrial cancer – a cancer which usually starts in the lining of the womb.
The treatment, pembrolizumab, can slow down cancer growth and improve survival odds, health officials said.
The National Institute for Health and Care Excellence (Nice) estimates that around 2,100 women will benefit from the treatment each year.
It said that its approval of the treatment for the NHS in England marks a 'major step forward' in treatment for women with this type of cancer.
The treatment, also known as Keytruda and made by Merck Sharp and Dohme, is an immunotherapy drug and is delivered in a drip alongside chemotherapy drugs carboplatin and paclitaxel and can be given for up to two years.
Nice said that clinical trials show the combination of treatments reduced the risk of death by 26% compared to chemotherapy alone.
The treatments can also slow down cancer progression, it added.
'For people with advanced endometrial cancer, this innovative combination offers a powerful new treatment option,' said Helen Knight, director of medicines evaluation at Nice.
'It marks a major step forward, and we're pleased to recommend it as part of our commitment to getting the best care to people, fast, while ensuring value for the taxpayer.'
Around 9,700 women are diagnosed with endometrial cancer each year, Nice said, making it the most common gynaecological cancer in the UK.
Helen Hyndman, lead nurse at the charity Eve Appeal's information service Ask Eve, said: 'Primary advanced or recurrent womb (endometrial) cancer has a huge impact on the quality of life for those diagnosed.
'It is great news that this new treatment has been approved.
'It will offer hope, a better quality of life and improve outcomes for those affected.'
Professor Peter Johnson, NHS England's national clinical director for cancer, said: 'Getting this treatment to many more NHS patients as quickly as possible will help thousands of women live longer, allowing them to spend more time with loved ones and give them a better quality of life.
'Thanks to the NHS's Cancer Drugs Fund, it is now being fast-tracked into routine use, with treatment available to more patients from today.'
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Majority of British public back prostate screening
Majority of British public back prostate screening

Telegraph

time30 minutes ago

  • Telegraph

Majority of British public back prostate screening

Nine in ten Britons want to see prostate cancer screening introduced, polling has found. A survey of 2,000 adults found widespread problems around the current system, which relies on men to come forward and ask GPs for tests when they already have concerns. Polling of the British public found one in five have had a male family member or close friend die from the disease. Among those, more than three quarters believed earlier diagnosis could have saved the life of their loved one. And more than one quarter of those polled had no trust, or not much trust at all, in the current NHS system to detect prostate cancer at an early stage. The poll found 91 per cent of participants thought the NHS should introduce routine screening for prostate cancer screening in men as it does for breast cancer in women. Women aged between 50 and 70 are offered mammograms every five years. More than half of those polled said their opinion of their local MP would worsen if they opposed the introduction of screening. Targeted screening The research by OnePoll was commissioned by charity Prostate Cancer Research, which is calling for the introduction of targeted screening. The survey found a strong desire among its respondents for the NHS to be more proactive about collecting and sharing information about medical history. In total, 69 per cent of those polled said in the event they were diagnosed with prostate cancer, they would want their male family members' NHS records to be automatically updated to reflect this. Having a family history of the disease – like breast and ovarian disease – means an increased risk. There was also considerable appetite for technological innovation, with 60 per cent supporting the use of artificial intelligence (AI) to improve prostate cancer diagnosis, for example, by reading MRI scans faster and more accurately. The call for targeted screening has been backed by MPs including Rishi Sunak, the former prime minister, Sir James Cleverly, the former home secretary, and Calvin Bailey, a Labour MP and the chairman of the all-party parliamentary group on prostate cancer. Wes Streeting, the Health Secretary, has applauded The Telegraph's campaign, saying he would like to see a screening programme in place if the evidence supports it. David James, the director of patient projects and influencing at Prostate Cancer Research, said: 'These poll results send an unequivocal message to policymakers: the public overwhelmingly supports the introduction of a national prostate cancer screening programme. 'The current system is clearly failing to meet the public's expectations for early detection and proactive management of genetic risk. 'With such strong support for investment and participation, it's time for the NHS to prioritise a targeted screening programme that could save countless lives and alleviate the long-term burden on our healthcare system.' Prostate Cancer Research is calling for urgent improvements to screening provision to tackle rising prostate cancer deaths and health inequality in the UK. The charity's research suggests targeted screening – focused on black men, those with BRCA1/2 mutations and those with a family history of the disease – could mean an extra 775 additional early diagnoses per year for those aged between 45 and 69. The research also suggests these changes could spare almost 300 men a year from a stage 4 diagnosis, in which prostate cancer becomes incurable. A Department for Health and Social Care spokesman said: 'Every life lost to prostate cancer is a tragedy. 'We're working to strengthen cancer services across the NHS and will carefully consider the evidence on prostate cancer screening to ensure we're doing everything possible to catch this disease early and save lives. 'This Government has been clear we would like to see screening in place, but the decision must be evidence-led. 'The UK National Screening Committee is looking at this as a priority, including reviewing the evidence for screening men with a family history of prostate cancer and other high-risk groups. 'While this review takes place, we're getting on with improving cancer treatment and prevention – investing £16m in the TRANSFORM trial to find better detection methods, and deploying cutting-edge technology to personalise medicine, catch sickness sooner, and save lives.'

I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs
I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs

Scottish Sun

time4 hours ago

  • Scottish Sun

I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs

After a brutal wake-up call which could have left her two sons without a mum, Suzanne shed two thirds of her body weight - without resorting to £150-a-month Ozempic or Mounjaro SHAPESHIFTER I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs 'SUGAR addict' mum-of-two Suzanne Evans was a chronic overeater who couldn't resist sweets and chocolate. She quickly soared to 31st and was forced to use a wheelchair just to move around. Then, she got the brutal wake-up call she needed; if she didn't slim down, and fast, she would be dead in four weeks. Suzanne eventually shed two thirds of her body weight - but it wasn't jabs like Ozempic that saw her do it. 13 Suzanne Evans before losing 20st without using jabs like Ozempic Credit: Jam Press/Suzanne Evans 13 The mum-of-two after her incredible transformation, sparked by doctors giving her four weeks to live Credit: Jam Press/Suzanne Evans Suzanne was always larger than her friends. But six years ago, unable to walk more than a few steps, she had to start using a wheelchair due to her size. After a trip to the doctor, the 40-year-old was told that her kidneys and liver were shutting down. Her heart was also under near-unbearable strain, and medics estimated that she had just four weeks to live due to imminent organ failure. Suzanne, from Hereford, Herefordshire, knew something had to change - and quickly. READ MORE ON WEIGHT LOSS JABS UP Can you get free fat jabs on the NHS? The 4 key criteria plus exact weight revealed 'I was terrified,' she tells Sun Health. 'When you look in the doctor's eyes and see they're scared, you know you're in trouble. 'It was the worst feeling and I was in the worst place. I didn't want to be 31st. 'Doctors said I was so ill because of my weight, but they didn't have faith in me that I would fight so hard to lose it. They thought the damage had been done.' Suzanne's health was in serious decline in 2018, with her being 'rushed into hospital every other week' for a year. 'Every single part of my body radiated pain,' she adds. 'I could hardly breathe or move without excruciating pain.' I was sick of trying fad diets and not losing weight but now I've shed FIVE STONE without fat jabs or silly eating plans The mum was terrified by the prospect of dying – with her sons just 10 and 13 at the time. 'I recorded videos for them to watch if I wasn't there any more,' Suzanne says. 'It was emotional. But I was determined to slim down and improve my health for them.' After her dad, Tony, died in hospital, she was hell-bent on not having the same outcome, and signed herself out in February 2019. Upon coming home, Suzanne vowed to turn things around for sons Gethin, now 19, and 16-year-old Evan. The mum had tried diets in the past but had always reverted to binge eating. I'd eat all day and all night. There was always something in my hand. I had drawers by my bedside full of sweets and crisps and chocolates Suzanne Evans 'My weight gain started after my father died unexpectedly when I was pregnant in 2008,' Suzanne says. 'I comfort ate and then suffered postnatal depression after giving birth. 'I became addicted to sugar – I would just eat anything sweet. 'My mum eventually became my carer when I became wheelchair-bound in 2014. 'I'd eat all day and all night. There was always something in my hand. 'I would have whatever I could get my hands on. I had drawers by my bedside full of sweets and crisps and chocolates. 'If I woke up in the night, I would gorge on them.' 13 After hitting 31st, Suzanne was forced to use a wheelchair to get around Credit: Jam Press/Suzanne Evans 13 She says she was addicted to sugar and couldn't resist sweets and chocolate Credit: Jam Press/Suzanne Evans 13 Doctors telling her she was on the brink of organ failure was the wake-up call she needed Credit: Jam Press/Suzanne Evans 13 Suzanne joined Simming World and the weight soon started to drop off Credit: Jam Press/Suzanne Evans But the stark warning from doctors proved to be the push she needed to, once and for all, drop the weight. Suzanne followed the Slimming World plan, which puts an emphasis on whole foods without counting calories. It costs £5.95 per week (or £23.80 per mont) - far less than injections which start at around £150 a month. Just one week into her weight loss journey, she had dropped 1st, and by the end of her first month she was 2st 7lbs lighter. But it wasn't all easy. 'I had the shakes from the sugar withdrawal,' she says. 'I'd had 11 years of overeating, but I had hope at last. I really was fighting for my life and I felt so proud. 'I started incorporating walking into my daily routine - just a few steps at first until I could do more. 'Eventually I was able to take the dog for a walk and it felt great. 'My doctor cried a year later when I walked into the surgery; it was the first time they'd seen me walk in a long time.' 'It saved my life' Suzanne has now lost an incredible 20st and weighs 11st 4lbs. She is careful to maintain her svelte size, having two healthy meals a day - including overnight oats with fruit for breakfast and a chicken or beef stir fry for dinner. Suzanne adds: 'People have noticed my weight loss and ask me what I have done to lose so much. 'I tell them it is all down to determination, willpower and Slimming World. 'They ask me what else I did and the answer is nothing. I just made the decision to change my life and live. 'I am so grateful to Slimming World because their food plan saved my life. 'And I am so proud of myself for making it happen.' 13 The 40-year-old lost a staggering 20st in total - two thirds of her body weight Credit: Jam Press/Suzanne Evans 13 She overhauled her diet and started exercising Credit: Jam Press/Suzanne Evans 13 Suzanne with her dad Tony, who died in 2008, when she was a child Credit: Jam Press/Suzanne Evans 13 When people ask how she slimmed down, she tells them it was 'determination, willpower and Slimming World' Credit: Jam Press/Suzanne Evans As well as spicy stir fries and oats, the mum is a big fan of tuna pasta salad, ham and mushroom omelettes and Italian pork with beans and greens. Suzanne says: 'These are my weekly must-haves - I always have to have all the ingredients to create these meals at home. 'Every week I go out on a Sunday to shop for the week ahead. 'For me, preparation is key - whether it's quick and easy tuna pasta, which has serious filling power, leaving you fuller for longer, or my favourite gluten-free vegetable and beef stir fry. 'I love that I can have unlimited amounts and stay slim. 'These meals are also so tasty that I never get bored - and best of all, I can eat them guilt-free. 'When you optimise your food, you are guaranteed to lose weight. I just wish I knew that, and how important having a slimming group can be, earlier. 'When I was on my own, I was too embarrassed and ashamed to be around anyone. I needed a community of people who understood me, and now I have that. 'I never miss a week; we're all there for each other, supporting one another all the way to our targets and beyond. 'It's essential to have that beautiful support, especially on days when you're struggling.' How to lose weight safely Losing weight should be a long-term commitment to healthier living, rather than any drastic measures. The NHS tips - which can be adopted slowly - include: Get active for 150 minutes a week – you can break this up into shorter sessions Aim to get your 5 A Day – 80g of fresh, canned or frozen fruit or vegetables count as 1 portion Aim to lose 1 to 2lbs, or 0.5 to 1kg, a week Read food labels – products with more green colour coding than amber and red are often a healthier option Swap sugary drinks for water – if you do not like the taste, add slices of lemon or lime for flavour Cut down on food that's high in sugar and fat – start by swapping sugary cereal for wholegrain alternatives Share your weight loss plan with someone you trust – they can help motivate you when you have a bad day Read about: The five fat loss foundations The calorie formula for weight loss The perfect portion sizes for meals to lose weight Sun Health's 8-week weight loss kick start plan Suzanne is particularly conscious to emphasise that losing weight is a marathon, not a sprint. She says: 'Quick fix diets are not the answer as they don't help with the underlying problem. 'I've tried most diets but they didn't work because I needed help changing my mindset to help me overcome my overeating. 'I couldn't do that alone; I needed a consultant to guide me. 'It has taken me seven years to overcome all of my obstacles. 'But now, because of all my hard work, I'm more than confident I can stay at my target weight for the rest of my days.' 13 The mum-of-two with her sons, who inspired her weight loss journey Credit: Jam Press/Suzanne Evans 13 'Slimming World saved my life,' Suzanne says Credit: Jam Press/Suzanne Evans

Struggling doctors left in ‘recurring cycle of debt'
Struggling doctors left in ‘recurring cycle of debt'

The Independent

time4 hours ago

  • The Independent

Struggling doctors left in ‘recurring cycle of debt'

Newly qualified doctors and medical students are taking on part-time jobs, such as driving Ubers or working in bars, to cope with financial difficulties. The British Medical Association (BMA) reports an average £3,674 drop in funding for final-year undergraduates and post-graduate medical students due to reduced student loans and NHS bursaries. This funding gap is forcing students into a 'recurring cycle of debt,' with many maxing out overdrafts and credit cards to complete their medical degrees. Students from poorer backgrounds and those on longer, six-year programmes or post-graduate degrees are disproportionately affected, facing up to three years of reduced funding. The BMA is calling on the government to provide full student finance maintenance for the entire duration of medical courses, estimating the cost at £24 million.

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