Jennifer Aniston Shares Heartbreaking Confession About Matthew Perry's Death
The 56-year-old actress and Perry were incredibly close, since they were first cast on the hit NBC sitcom. In the years that followed, Aniston and the rest of the cast -- Matt LeBlanc, Lisa Kudrow, David Schwimmer and Courtney Cox -- had a heartbreaking front-row seat to Perry's turbulent years as he struggled with addiction.
For years, Aniston and the cast tried to help their good friend. Sometimes they were successful, other times they faced increasing challenges. When the season finally came to an end after 10 seasons in 2004, the crew went their separate ways. Some found stardom while others struggled for some time to shake off the roles that launched them to immense stardom.
The cast reunited in 2021, and that's when the world got a glimpse of Perry's struggles as he struggled even just to talk. And while the world would also mourn his shocking death some two years later, Aniston was among those who had, in sense, come to terms with Perry's tragic demise.
'We did everything we could when we could,' Aniston told Vanity Fair. 'But it almost felt like we'd been mourning Matthew for a long time because his battle with that disease was a really hard one for him to fight. As hard as it was for all of us and for the fans, there's a part of me that thinks this is better ... I'm glad he's out of that pain.'
Perry, who earned fame playing the role of the lovable and funny Chandler Bing, was found dead at his home on Oct. 28. He was 54. The Los Angeles County Medical Examiner's Office later released Perry's autopsy report, which listed Perry's cause of death as acute effects of ketamine.
In his 2022 memoir, Friends, Lovers, and the Big Terrible Thing, Perry opened up about taking ketamine infusions while in rehab in Switzerland.
"Ketamine was a very popular street drug in the 1980s," Perry wrote. "There is a synthetic form of it now, and it's used for two reasons: to ease pain and help with depression."
Perry would go on to describe the drug as a "giant exhale" and that it had his name "written all over it."
Even still, Perry admitted, at the time, that it was "not for me."
According to the autopsy report, Perry received ketamine infusion therapy for depression and anxiety. His last known treatment was more than a week before his untimely death.
Jennifer Aniston Shares Heartbreaking Confession About Matthew Perry's Death first appeared on Men's Journal on Aug 11, 2025
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