Semler Scientific Inc. (SMLR) Investors Who Lost Money – Contact Law Offices of Howard G. Smith About Securities Fraud Investigation
BENSALEM, Pa.--(BUSINESS WIRE)--Law Offices of Howard G. Smith announces an investigation on behalf of Semler Scientific Inc. ('Semler' or the 'Company') (NASDAQ: SMLR) investors concerning the Company's possible violations of federal securities laws.
IF YOU ARE AN INVESTOR WHO SUFFERED A LOSS IN SEMLER SCIENTIFIC INC. (SMLR), CONTACT THE LAW OFFICES OF HOWARD G. SMITH ABOUT POTENTIALLY PURSUING CLAIMS TO RECOVER YOUR LOSS.
Contact the Law Offices of Howard G. Smith to discuss your legal rights by email at howardsmith@howardsmithlaw.com, by telephone at (215) 638-4847 or visit our website at www.howardsmithlaw.com.
What Happened?
On February 28, 2025, Semler filed its annual report for full year 2024 and disclosed that "there is a risk that [U.S. Department of Justice ('DOJ')] will file a complaint or complaint in intervention in a civil False Claims Act lawsuit seeking damages." The Company also revealed it had received an initial civil investigative demand from the DOJ in July 2017 regarding Semler's claims for reimbursement related to its peripheral artery disease QuantaFlo device. The Company further stated that it had participated in settlement discussions with the DOJ in February 2025, which were unsuccessful.
On this news, Semler's stock price fell $4.03, or 9.4%, to close at $38.89 per share on March 3, 2025, thereby injuring investors.
Contact Us To Participate or Learn More:
If you purchased Semler securities, have information or would like to learn more about these claims, or have any questions concerning this announcement or your rights or interests with respect to these matters, please contact us:
Law Offices of Howard G. Smith,
3070 Bristol Pike, Suite 112,
Bensalem, Pennsylvania 19020,
Telephone: (215) 638-4847
Email: howardsmith@howardsmithlaw.com
Visit our website at: www.howardsmithlaw.com.
This press release may be considered Attorney Advertising in some jurisdictions under the applicable law and ethical rules.
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
28 minutes ago
- Yahoo
Travere Therapeutics to Present New FILSPARI® (sparsentan) Data at the 62nd ERA Congress
Data from SPARTACUS and PROTECT OLE to show significant proteinuria reduction when replacing RASi with FILSPARI and when FILSPARI is used in combination with SGLT2i New mechanistic data to show FILSPARI protects against IgA deposition in the kidney SAN DIEGO, June 03, 2025--(BUSINESS WIRE)--Travere Therapeutics, Inc., (Nasdaq: TVTX) today announced that the Company will present seven abstracts at the upcoming European Renal Association (ERA) Congress in Vienna, Austria, June 4-7. Presentations will include new data on the use of FILSPARI in IgA nephropathy (IgAN) from the Phase 2 SPARTACUS Study which demonstrated that FILSPARI provided clinically meaningful benefits in adults with IgAN who replaced their renin-angiotensin system inhibitor (RASi) with FILSPARI while receiving stable sodium-glucose cotransporter-2 inhibitor (SGLT2i) therapy. A presentation on results from the open label extension (OLE) of the Phase 3 PROTECT Study will show that patients previously treated with maximum labeled irbesartan experienced significant proteinuria reduction after switching to FILSPARI in the study. In a preclinical model of IgAN, FILSPARI protected from mesangial deposition of IgA, suggesting a potential role of endothelin-1 and angiotensin II as modulators of disease activity in IgAN. Data from the gddY mouse model of IgAN will offer new insight into the pathogenesis of IgAN as a tissue-specific autoimmune disease. In focal segmental glomerulosclerosis (FSGS), the Company will share a data analysis from the Phase 3 DUPLEX Study showing that partial and complete proteinuria remission were achieved earlier and more frequently with FILSPARI than irbesartan. The Company will also present preclinical data in an animal model of immune-mediated FSGS showing that optimized dual endothelin and angiotensin blockade with FILSPARI helps protect the integrity of the glomerular filtration barrier, reducing glomerular permeability and lowering albuminuria. "The breadth of data we're presenting underscores our confidence in the role FILSPARI can serve as foundational therapy for rare kidney diseases," said Jula Inrig, M.D., chief medical officer of Travere Therapeutics. "These findings provide further evidence that FILSPARI can decrease the risk of IgAN disease progression. We are deeply committed to advancing research and delivering innovative therapies that can make a meaningful difference for people living with IgAN and FSGS." European Renal Association Congress Presentations Sparsentan Added to Stable Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2is) in Adults with IgA Nephropathy (IgAN) in the Phase 2 SPARTACUS Trial Abstract: No. 1916Session: Glomerular & Tubulointerstitial DiseasesDate: June 6, 2025, 9:00-9:05 CESTLocation: Focused Oral Room 3 Effects of Sparsentan After Maximized Angiotensin Receptor Blocker (ARB) Treatment in Patients with IgA Nephropathy (IgAN) in the PROTECT Trial Abstract: No. 1920Session: Glomerular & Tubulointerstitial DiseasesDate: June 6, 2025, 9:05-9:10 CESTLocation: Focused Oral Room 3 Patients with Focal Segmental Glomerulosclerosis (FSGS) Achieved Low Proteinuria Targets Earlier and More Often with Sparsentan (SPAR) vs. Irbesartan (IRB) in DUPLEX Abstract: No. 2444Session: Glomerular & Tubulointerstitial DiseasesDate: June 6, 2025, 16:40-16:45 CESTLocation: Focused Oral Room 2 Kidney Outcomes and Effects of Proteinuria in Alport Syndrome: a Longitudinal Analysis of Using Data from the National Registry of Rare Kidney Diseases (RaDaR) Abstract: No. 2883Session: FC 12: Membranous Nephropathy and Other Rare DiseasesDate: June 5, 2025, 18:12-18:24 CESTLocation: Hall K Population Modeling Depicts the Mutational Burden of NPHS2 (Podocin) Nephropathy and Reveals an Undiagnosed Adult-Onset Genetic Cohort Abstract: No. 1346Session: Glomerular & Tubulointerstitial DiseasesDate: June 5, 2025, 15:00-15:06 CESTLocation: XWall I Mozart Eine Kleine Nachtmusik Sparsentan Reversibly Decreases Mesangial IgA Deposition in gddY Mice; A Possible Role for Mesangial-Cell-Surface Autoantigen Expression Abstract: No. 733Session: Glomerular & Tubulointerstitial DiseasesDate: June 5, 2025, 8:33-8:39 CESTLocation: Focused Oral Room 2 Sparsentan Reduces Glomerular Dysfunction and Proteinuria in a Rat Model of Serum-Factor-Induced Nephrotic Syndrome Abstract: No. 272Session: Glomerular & Tubulointerstitial DiseasesDate: June 5, 2025, 9:48-9:51 CESTLocation: Hall K About IgA Nephropathy IgA nephropathy (IgAN), also called Berger's disease, is a rare progressive kidney disease characterized by the buildup of immunoglobulin A (IgA), a protein that helps the body fight infections, in the kidneys. The deposits of IgA cause a breakdown of the normal filtering mechanisms in the kidney, leading to blood in the urine (hematuria), protein in the urine (proteinuria) and a progressive loss of kidney function. Other symptoms of IgAN may include swelling (edema) and high blood pressure. IgAN is the most common type of primary glomerulonephritis worldwide and a leading cause of kidney failure due to glomerular disease. IgAN is estimated to affect up to 150,000 people in the U.S. and is one of the most common glomerular diseases in Europe and Japan. About Focal Segmental Glomerulosclerosis Focal segmental glomerulosclerosis (FSGS) is a rare proteinuric kidney disorder in both children and adults that is estimated to affect more than 40,000 patients in the U.S. with similar prevalence in Europe. The disorder is defined by progressive scarring of the kidney and often leads to kidney failure. FSGS is characterized by proteinuria, where protein leaks into the urine due to a breakdown of the normal filtration mechanism in the kidney. Once in the urine, protein is considered to be toxic to other parts of the kidney, especially the tubules, and is believed to contribute to further disease progression. Other common symptoms include swelling in parts of the body, known as edema, as well as low blood albumin levels, abnormal lipid profiles and hypertension. Sparsentan is not approved for use in FSGS. There is currently no approved pharmacologic indicated for the treatment of FSGS. About Travere Therapeutics At Travere Therapeutics, we are in rare for life. We are a biopharmaceutical company that comes together every day to help patients, families and caregivers of all backgrounds as they navigate life with a rare disease. On this path, we know the need for treatment options is urgent – that is why our global team works with the rare disease community to identify, develop and deliver life-changing therapies. In pursuit of this mission, we continuously seek to understand the diverse perspectives of rare patients and to courageously forge new paths to make a difference in their lives and provide hope – today and tomorrow. For more information, visit FILSPARI® (sparsentan) U.S. Indication FILSPARI (sparsentan) is indicated to slow kidney function decline in adults with primary immunoglobulin A nephropathy (IgAN) who are at risk for disease progression. IMPORTANT SAFETY INFORMATION BOXED WARNING: HEPATOTOXICITY AND EMBRYO-FETAL TOXICITY Because of the risks of hepatotoxicity and birth defects, FILSPARI is available only through a restricted program called the FILSPARI REMS. Under the FILSPARI REMS, prescribers, patients and pharmacies must enroll in the program. Hepatotoxicity Some Endothelin Receptor Antagonists (ERAs) have caused elevations of aminotransferases, hepatotoxicity, and liver failure. In clinical studies, elevations in aminotransferases (ALT or AST) of at least 3-times the Upper Limit of Normal (ULN) have been observed in up to 3.5% of FILSPARI-treated patients, including cases confirmed with rechallenge. Measure transaminases and bilirubin before initiating treatment and monthly for the first 12 months, and then every 3 months during treatment. Interrupt treatment and closely monitor patients who develop aminotransferase elevations more than 3x ULN. FILSPARI should generally be avoided in patients with elevated aminotransferases (>3x ULN) at baseline because monitoring for hepatotoxicity may be more difficult and these patients may be at increased risk for serious hepatotoxicity. Embryo-Fetal Toxicity FILSPARI can cause major birth defects if used by pregnant patients based on animal data. Therefore, pregnancy testing is required before the initiation of treatment, during treatment and one month after discontinuation of treatment with FILSPARI. Patients who can become pregnant must use effective contraception before the initiation of treatment, during treatment, and for one month after discontinuation of treatment with FILSPARI. Contraindications FILSPARI is contraindicated in patients who are pregnant. Do not coadminister FILSPARI with angiotensin receptor blockers (ARBs), ERAs, or aliskiren. Warnings and Precautions Hepatotoxicity: Elevations in ALT or AST of at least 3-fold ULN have been observed in up to 3.5% of FILSPARI-treated patients, including cases confirmed with rechallenge. While no concurrent elevations in bilirubin >2-times ULN or cases of liver failure were observed in FILSPARI-treated patients, some ERAs have caused elevations of aminotransferases, hepatotoxicity, and liver failure. To reduce the risk of potential serious hepatotoxicity, measure serum aminotransferase levels and total bilirubin prior to initiation of treatment and monthly for the first 12 months, then every 3 months during treatment. Advise patients with symptoms suggesting hepatotoxicity (nausea, vomiting, right upper quadrant pain, fatigue, anorexia, jaundice, dark urine, fever, or itching) to immediately stop treatment with FILSPARI and seek medical attention. If aminotransferase levels are abnormal at any time during treatment, interrupt FILSPARI and monitor as recommended. Consider re-initiation of FILSPARI only when hepatic enzyme levels and bilirubin return to pretreatment values and only in patients who have not experienced clinical symptoms of hepatotoxicity. Avoid initiation of FILSPARI in patients with elevated aminotransferases (>3x ULN) prior to drug initiation because monitoring hepatotoxicity in these patients may be more difficult and these patients may be at increased risk for serious hepatotoxicity. Embryo-Fetal Toxicity: FILSPARI can cause fetal harm when administered to a pregnant patient and is contraindicated during pregnancy. Advise patients who can become pregnant of the potential risk to a fetus. Obtain a pregnancy test prior to initiation of treatment with FILSPARI, monthly during treatment, and one month after discontinuation of treatment. Advise patients who can become pregnant to use effective contraception prior to initiation of treatment, during treatment, and for one month after discontinuation of treatment with FILSPARI. FILSPARI REMS: Due to the risk of hepatotoxicity and embryo-fetal toxicity, FILSPARI is available only through a restricted program called the FILSPARI REMS. Prescribers, patients, and pharmacies must be enrolled in the REMS program and comply with all requirements ( Hypotension: Hypotension has been observed in patients treated with ARBs and ERAs. There was a greater incidence of hypotension-associated adverse events, some serious, including dizziness, in patients treated with FILSPARI compared to irbesartan. In patients at risk for hypotension, consider eliminating or adjusting other antihypertensive medications and maintaining appropriate volume status. If hypotension develops, despite elimination or reduction of other antihypertensive medications, consider a dose reduction or dose interruption of FILSPARI. A transient hypotensive response is not a contraindication to further dosing of FILSPARI, which can be given once blood pressure has stabilized. Acute Kidney Injury: Monitor kidney function periodically. Drugs that inhibit the renin-angiotensin system (RAS) can cause kidney injury. Patients whose kidney function may depend in part on the activity of the RAS (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute kidney injury on FILSPARI. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in kidney function while on FILSPARI. Hyperkalemia: Monitor serum potassium periodically and treat appropriately. Patients with advanced kidney disease, taking concomitant potassium-increasing drugs (e.g., potassium supplements, potassium-sparing diuretics), or using potassium-containing salt substitutes are at increased risk for developing hyperkalemia. Dosage reduction or discontinuation of FILSPARI may be required. Fluid Retention: Fluid retention may occur with ERAs, and has been observed in clinical studies with FILSPARI. FILSPARI has not been evaluated in patients with heart failure. If clinically significant fluid retention develops, evaluate the patient to determine the cause and the potential need to initiate or modify the dose of diuretic treatment then consider modifying the dose of FILSPARI. Most common adverse reactions The most common adverse reactions (≥5%) are hyperkalemia, hypotension (including orthostatic hypotension), peripheral edema, dizziness, anemia, and acute kidney injury. Drug interactions Renin-Angiotensin System (RAS) Inhibitors and ERAs: Do not coadminister FILSPARI with ARBs, ERAs, or aliskiren due to increased risks of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure). Strong and Moderate CYP3A Inhibitors: Avoid concomitant use of FILSPARI with strong CYP3A inhibitors. If a strong CYP3A inhibitor cannot be avoided, interrupt FILSPARI treatment. When resuming treatment with FILSPARI, consider dose titration. Monitor blood pressure, serum potassium, edema, and kidney function regularly when used concomitantly with moderate CYP3A inhibitors. Concomitant use with a strong CYP3A inhibitor increases sparsentan exposure which may increase the risk of FILSPARI adverse reactions. Strong CYP3A Inducers: Avoid concomitant use with a strong CYP3A inducer. Concomitant use with a strong CYP3A inducer decreases sparsentan exposure which may reduce FILSPARI efficacy. Antacids and Acid Reducing Agents: Administer FILSPARI 2 hours before or after administration of antacids. Avoid concomitant use of acid reducing agents (histamine H2 receptor antagonist and PPI proton pump inhibitor) with FILSPARI. Sparsentan exhibits pH-dependent solubility. Antacids or acid reducing agents may decrease sparsentan exposure which may reduce FILSPARI efficacy. Non-Steroidal Anti-Inflammatory Agents (NSAIDs), Including Selective Cyclooxygenase-2 (COX-2) Inhibitors: Monitor for signs of worsening renal function with concomitant use with NSAIDs (including selective COX-2 inhibitors). In patients with volume depletion (including those on diuretic therapy) or with impaired kidney function, concomitant use of NSAIDs (including selective COX-2 inhibitors) with drugs that antagonize the angiotensin II receptor may result in deterioration of kidney function, including possible kidney failure. CYP2B6, 2C9, and 2C19 Substrates: Monitor for efficacy of concurrently administered CYP2B6, 2C9, and 2C19 substrates and consider dosage adjustment in accordance with the Prescribing Information. Sparsentan decreases exposure of these substrates, which may reduce efficacy related to these substrates. P-gp and BCRP Substrates: Avoid concomitant use of sensitive substrates of P-gp and BCRP with FILSPARI. Sparsentan may increase exposure of these transporter substrates, which may increase the risk of adverse reactions related to these substrates. Agents Increasing Serum Potassium: Monitor serum potassium frequently in patients treated with FILSPARI and other agents that increase serum potassium. Concomitant use of FILSPARI with potassium-sparing diuretics, potassium supplements, potassium-containing salt substitutes, or other drugs that raise serum potassium levels may result in hyperkalemia. Please see the full Prescribing Information, including BOXED WARNING, for additional Important Safety Information. Forward Looking Statements This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995. Without limiting the foregoing, these statements are often identified by the words "on-track," "positioned," "look forward to," "will," "would," "may," "might," "believes," "anticipates," "plans," "expects," "intends," "potential," or similar expressions. In addition, expressions of strategies, intentions or plans are also forward-looking statements. Such forward-looking statements include, but are not limited to, references to: statements relating to the clinical studies and models described herein, and data to be presented; statements regarding the potential role of FILSPARI as foundational therapy for rare kidney diseases; statements regarding the impact of FILSPARI on IgAN disease progression; statements regarding the goal of advancing research and delivering innovative therapies that can make a meaningful difference for people living with IgAN and FSGS; and statements related to the estimated sizes of patient populations. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes and results to differ materially from current expectations. No forward-looking statement can be guaranteed. Among the factors that could cause actual results to differ materially from those indicated in the forward-looking statements are risks and uncertainties related to the Company's sNDA for FILSPARI in FSGS, including the timing and outcome thereof. There is no guarantee that the FDA will grant approval of FILSPARI for FSGS on the anticipated timeline, or at all. The Company also faces risks and uncertainties related to its business and finances in general, the success of its commercial products, risks and uncertainties associated with its preclinical and clinical stage pipeline, risks and uncertainties associated with the regulatory review and approval process, risks and uncertainties associated with enrollment of clinical trials for rare diseases, and risks that ongoing or planned clinical trials may not succeed or may be delayed for safety, regulatory or other reasons. Specifically, the Company faces risks associated with the ongoing commercial launch of FILSPARI in IgAN, the timing and potential outcome of its and its partners' clinical studies, market acceptance of its commercial products including efficacy, safety, price, reimbursement, and benefit over competing therapies, risks related to the challenges of manufacturing scale-up, risks associated with the successful development and execution of commercial strategies for such products, including FILSPARI, and risks and uncertainties related to the new administration, including but not limited to risks and uncertainties related to tariffs and the funding, staffing and prioritization of resources at government agencies including the FDA. The Company also faces the risk that it will be unable to raise additional funding that may be required to complete development of any or all of its product candidates, including as a result of macroeconomic conditions; risks relating to the Company's dependence on contractors for clinical drug supply and commercial manufacturing; uncertainties relating to patent protection and exclusivity periods and intellectual property rights of third parties; risks associated with regulatory interactions; and risks and uncertainties relating to competitive products, including current and potential future generic competition with certain of the Company's products, and technological changes that may limit demand for the Company's products. The Company also faces additional risks associated with global and macroeconomic conditions, including health epidemics and pandemics, including risks related to potential disruptions to clinical trials, commercialization activity, supply chain, and manufacturing operations. You are cautioned not to place undue reliance on these forward-looking statements as there are important factors that could cause actual results to differ materially from those in forward-looking statements, many of which are beyond our control. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Investors are referred to the full discussion of risks and uncertainties, including under the heading "Risk Factors", as included in the Company's most recent Form 10-K, Form 10-Q and other filings with the Securities and Exchange Commission. View source version on Contacts Media:888-969-7879mediarelations@ Investors:888-969-7879IR@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
39 minutes ago
- Yahoo
Edison Lithium Provides Further Update on Sale of Interest in Resource Ventures S.A.
Vancouver, British Columbia--(Newsfile Corp. - June 3, 2025) - Edison Lithium Corp. (TSXV: EDDY) (OTC Pink: EDDYF) (FSE: VV0) ("Edison" or the "Company") is pleased to provide an update on the previously announced proposed sale of its Argentina subsidiary, Resource Ventures S.A. ("ReVe"), to Mava Gasoil LLC ("Mava") (the "Proposed Transaction"). To facilitate the completion of the Proposed Transaction, the Company has granted Mava an extension, and the parties now anticipate the completion of the closing on or before June 30, 2025. In consideration for the extension, Mava has agreed to pay an advance payment of US$100,000, which will be credited against the total purchase price of US$3,500,000 upon closing. The Company previously received an initial deposit of USD$100,000 from Mava and further payments of USD$3,100,000, USD$100,000 and USD$100,000 are payable by Mava to the Company and the two other shareholders of ReVe, respectively, upon closing. As previously disclosed, the proposed transaction contemplates Mava acquiring all of the issued and outstanding shares of ReVe for total consideration of USD$3,500,000. The completion of the Proposed Transaction remains subject to, among other conditions, TSX Venture Exchange final acceptance, and receipt of the balance of the purchase price. About Edison Lithium Corp. Edison Lithium Corp. is a Canadian-based junior mining exploration company focused on the procurement, exploration and development of cobalt, lithium, alkali and other energy metal properties. The Company's acquisition strategy is based on acquiring affordable, cost-effective, and highly regarded mineral properties in areas with proven geological potential. Edison is building a portfolio of quality assets capable of supplying critical materials to the battery industry and intends to capitalize on and have its shareholders benefit from the renewed interest in the battery metals space. On behalf of the Board of Directors: "Nathan Rotstein" Nathan RotsteinChief Executive Officer and Director For more information, please contact:Tel: 416-526-3217Email: info@ Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. Forward-Looking Disclaimer: This news release contains certain forward-looking statements. Statements that are not historical facts, including statements about Edison's beliefs and expectations, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties and a number of factors could cause actual results to differ materially from those contained in any forward-looking statement. In some cases, forward-looking statements can be identified by words or phrases such as "may," "will," "will be", "expected," "anticipate," "target," "aim," "estimate," "intend," "plan," "believe," "potential," "continue,", "proposes", "contemplates", "is/are likely to" or other similar expressions. All information provided in this news release is as of the date of this news, and the Company undertakes no duty to update such information, except as required under applicable law. Forward-looking statements in this press release relate to, among other things: the proposed sale of ReVe, the anticipated timing and completion of the Proposed Transaction, the receipt of final TSX Venture Exchange approval for the disposition, the closing of the Proposed Transaction, and the receipt of the purchase price. Actual future results may differ materially. There can be no assurance that such statements will prove to be accurate, and actual results and future events could differ materially from those anticipated in such statements. Forward-looking statements reflect the beliefs, opinions and projections of management on the date the statements are made and are based upon a number of assumptions and estimates that, while considered reasonable by the respective parties, are inherently subject to significant business, economic, competitive, political and social uncertainties and contingencies. Many factors, both known and unknown, could cause actual results, performance or achievements to be materially different from the results, performance or achievements that are or may be expressed or implied by such forward-looking statements and the parties have made assumptions and estimates based on or related to many of these factors. Such factors include, without limitation: receipt of final TSXV approval required for the Proposed Transaction, and receipt of the purchase price. Readers should not place undue reliance on the forward-looking statements and information contained in this news release concerning these times. Except as required by law, the Company does not assume any obligation to update the forward-looking statements of beliefs, opinions, projections, or other factors, should they change, except as required by law. To view the source version of this press release, please visit Sign in to access your portfolio
Yahoo
an hour ago
- Yahoo
Meet 5 Republicans in Congress who defined Trump's first 100 days
WASHINGTON – While President Donald Trump spent his first 100 days in office issuing executive orders and paring down the size of the federal government, Republicans in Congress were making moves of their own. The House reelected Speaker Mike Johnson, temporarily putting aside frustrations carried over from the last Congress. The Senate confirmed Trump's nominees despite skepticism from some in the conference and one tie-breaking vote cast by Vice President JD Vance. And both chambers built a blueprint for what will become the president's policy package to extend tax cuts and beef up spending on border security, defense and domestic energy production. In each case, GOP lawmakers grappled with narrow margins of control in both chambers. In the House, there was almost no room for error, as Republican vacancies early in the year made an already narrow majority as small as a one-vote margin in some cases. (Republicans have a three-vote margin in the House as two Democratic seats are vacant.) Republican House and Senate leaders, Johnson and Senate Majority Leader John Thune, and their leadership teams shepherded their conferences through these challenging votes. But there were several other Republicans who had outsized influence, shaping policy or nearly blocking it. Here are five Republican members of Congress who made a significant mark on Capitol Hill during Trump's first 100 days in office: Few members of Congress have had more impact on the shape of Trump's agenda than Jason Smith, the Missouri Republican who leads the powerful House Ways and Means Committee and who advocated for the one "big, beautiful bill" approach to Trump's agenda that Congress is pursuing. Trump has big ambitions for the tax policy in his marquee bill: Extending the tax cuts implemented during his first term while eliminating tax on tips, overtime and Social Security benefits. More: What to know as Congress starts working on Donald Trump's 'big beautiful bill' The president has also supported an effort by a handful of key Republicans from high-tax states like New York and California to end, or at least raise, the cap on state and local tax deductions known as SALT. Implementing those changes will be complicated – and expensive. All told, nonpartisan analysts estimate the tax cuts will cost between $5 trillion and $11 trillion over the next decade. Smith's committee will be the hatching ground for this policy fight. Tax bills must start in the House, per the U.S. Constitution, giving the tax committee chairman plenty of leverage over the debate. As Congressional Republicans began hashing out the big picture of what Trump's agenda would look like, Smith was an advocate for rolling all of Trump's priorities – taxes, along with border and energy policies – into one 'big, beautiful bill,' as the president would come to call it. Smith is an attorney who started his political career as the youngest member of the Missouri House of Representatives at 25. He argued that to start Trump's second term that the single-bill strategy would stand the best chance at ensuring all of the president's priorities get passed, given the extremely tight Republican margins in the House. Smith and House leadership were at odds with Republicans in the Senate, which wanted Congress to pass two separate bills, one for taxes and one for other policy ‒ to put wins on the board quickly. "That's why we need one big, beautiful bill," Smith told The Washington Reporter earlier this year. "It is our opportunity to deliver, to ensure we get as much (as) possible of President Trump's agenda enacted into law as soon as possible." Trump wavered for weeks between the two strategies. Smith and other House leaders lobbied Trump on their plan and eventually won. Trump backed the one-bill strategy in February, setting the framework for what's playing out now. The House Freedom Caucus formed 10 years ago ‒ an outgrowth of the 2000s-era Tea Party that had sought to push other fellow Republicans toward limited government and fiscal responsibility. Over the years, it developed a reputation as a hardline faction willing to blow up the best-laid plans of GOP leadership. Now the invite-only group has realigned itself around Trump – and has surprisingly provided the needed support to clinch tough votes over and over since Republicans took control of both chambers of Congress at the start of 2025. More: House Speaker Mike Johnson's victory came with a warning from hardline Republicans The Freedom Caucus threatened to stop Johnson, the House speaker, from winning reelection to leadership in January, to block a government funding extension in March, and to stop a budget blueprint that would kick off work on Trump's legislative agenda in April over spending concerns. In each case, at Trump's behest, they backed down and voted with the rest of the GOP. In April, the caucus successfully delayed a House vote on the budget blueprint until Congressional leadership committed to finding at least $1.5 trillion in spending cuts. Maryland Rep. Andy Harris, the former anesthesiologist who now chairs the Freedom Caucus, played a crucial role in leading negotiations. 'In the end, the Freedom Caucus has always been willing to say no when it had to,' Harris said in an interview with USA TODAY. In these cases, the group was 'able to pull the conference in a direction that it needed to go in order to get a final product that the entire Freedom Caucus could agree with and, therefore, deliver the votes necessary in a tight majority.' Harris pushed back on the idea that the caucus has moved away from its roots to support the president's preferences, and said each of these tough votes eventually was 'consistent with the principles that we have espoused for 10 years.' 'I think the Trump administration realizes that we're the group that most strongly supports President Trump and his agenda,' Harris said. While the Freedom Caucus' hardliners are in Trump's good graces, there is one fiscal conservative in the House who is not: Thomas Massie, the Kentucky Republican who has repeatedly bucked GOP leadership over concerns about government spending. Massie is no stranger to being a thorn in his party's side, defending small-government principles. But amid this year's tight margins, he has single-handedly complicated each tight vote leadership sought to squeeze through. The former technology entrepreneur was the only Republican who did not vote for Johnson as speaker, arguing he wasn't up to the task and would cost the GOP's majority during the midterm elections. Johnson was only able to clinch the gavel after he flipped two other Republican holdouts. More: Who is Thomas Massie? Trump lashes out at House Republicans' squeaky wheel Republicans only had one vote to spare in February when they first attempted to pass a budget blueprint that would unlock the process to craft Trump's legislative agenda. When Massie said he was a no, Johnson was forced to engage in a dramatic whip operation on the floor to flip the remaining holdouts. Massie again cited concerns about the national debt when he forced Johnson to do the same thing in March to avoid a government shutdown. In April, Republican leaders didn't even bother including Massie in their overtures on another critical Trump agenda vote; he sided against the bill. Trump has noticed all along the way. In March, the president slammed Massie "of beautiful Kentucky" in a post on Truth Social, saying he "is an automatic 'NO' vote on just about everything." "HE SHOULD BE PRIMARIED, and I will lead the charge against him," Trump wrote. Massie says he's not worried. He defeated a primary challenger in 2020 after Trump criticized his objection to a COVID-19 response bill, though his opponents argue they stand a better chance of unseating him this time. "Someone thinks they can control my voting card by threatening my re-election. Guess what? Doesn't work on me," Massie wrote on X. "Three times I've had a challenger who tried to be more MAGA than me. None busted 25% because my constituents prefer transparency and principles over blind allegiance." Sen. Markwayne Mullin has a reputation for getting into the mix. The 47-year-old Oklahoman is a former mixed martial arts fighter who tried to help Capitol police barricade the House doors during the attack on the Capitol on Jan. 6, 2021; sought to rescue U.S. citizens from Afghanistan in an unauthorized helicopter mission as American troops pulled out of the country in 2021; and attempted to fight Teamsters President Sean O'Brien during a committee hearing in 2023. Since Republicans took the House, Senate and White House, Mullin has taken on a new role as an informal liaison between the bodies as they seek to pass GOP priorities in the as quick as they can. More: Big spending, big cuts: House Republicans scramble to strike a deal on Trump's agenda Mullin served five terms in the House before being elected to the Senate in 2022. He's kept his finger on the pulse of the House GOP conference throughout the beginning of this year, attending their meetings and checking in with House Speaker Johnson. "It's only roughly 100 yards to the other side of the Capitol, but a lot of times we're not talking like we should," Mullin said in a brief interview with USA TODAY. "A lot of times, when we're talking about things, it's a misunderstanding. And when you can at least get that out of the way and just deal with the issue itself, then you're able to get to a positive spot." Mullin is also one of Trump's closest allies in the Senate. He enjoys a strong relationship with the president, fostered through his personal connection and his public profile of defending Trump's policies while attacking detractors. As Senate Republicans sought to keep their conference together on some of Trump's more controversial Cabinet nominees, Mullin played a role in helping "open doors" for meetings between Hegseth and other senators. He was an advocate for Defense Secretary Pete Hegseth during his confirmation hearings and continued to support Hegseth as he came under fire for his use of Signal to communicate intelligence information. Sen. Mitch McConnell and Trump's tense relationship is no secret, dating back to the president's first term and even earlier. McConnell and Trump worked together to pass the 2017 Tax Cuts and Jobs Act and transform the makeup of the U.S. Supreme Court. They also clashed over efforts to repeal the Affordable Care Act, a coronavirus aid package, and the attack on the Capitol on Jan. 6, 2021. Things have changed for the longtime Senate Republican leader, who rejoined the rank-and-file at the beginning of the year and announced he plans to retire when his term ends in 2027. More: McConnell called Trump 'despicable' and a 'narcissist,' cried after Capitol riot, new book says Now out of GOP leadership, McConnell has emerged as the most obstinate member of a loose cohort of Republican senators willing to criticize the president's policies and nominees. McConnell is the only GOP senator to oppose four Cabinet nominees: Labor Secretary Lori Chavez-DeRemer, Director of National Intelligence Tulsi Gabbard, Health and Human Services Secretary Robert F. Kennedy Jr., and Defense Secretary Pete Hegseth. In his statements opposing the nominees, he gave unsparing assessments, saying they were incapable of doing the job. He called Gabbard's appointment an 'unnecessary risk' for national intelligence and said Kennedy has 'a record of trafficking in dangerous conspiracy theories.' McConnell's surprise opposition to Hegseth forced Vance to come to the Capitol to cast a tie-breaking vote – the closest any of Trump's nominees have come to failing. He has also been one of the most vocal Republicans on Capitol Hill in criticizing select administration actions, including tariffs and negotiations with Russia to end the war in Ukraine. In a Courier-Journal op-ed, McConnell argued Trump's tariffs would "heap on the pain" and cost average Kentuckians. "I think Sen. McConnell feels a degree of freedom that he never had before," Sen. John Cornyn, R-Texas, who served as McConnell's No. 2 as GOP whip for six years, told USA TODAY earlier this year. "I would expect there will be more disagreements down the road, but he's representing his state and voting his conscience – something I would think we all would do." This article originally appeared on USA TODAY: 5 Republicans in Congress who defined Trump's first 100 days
