
Simple reason why women get worse hangovers than men - it's not what you think
If you think your tolerance for alcohol is worse than the men in your life, you're right - we ask the experts why ladies can't handle booze was well as lads...
Men and women may look like they operate the same on the outside, but research shows we are very different when it comes to some things... from healing to heartbeats and even the amount we blink. Here are just a few ways that men and women differ in surprising ways...
Men fall in love faster than women
Despite their reputation for being the less romantic gender, a new study has found men fall in love twice as fast as women. A team of researchers quizzed more than 800 young people aged 18 to 25 in 33 countries who described themselves as being in love for a study in the Biology of Sex Differences earlier this month.
They found that the men tended to fall in love about a month before women on average – over around four weeks, compared to two months for females. Not only did the men in the age group fall in love more quickly, they also reported falling in love more often: 2.6 times, compared to 2.3 times for women.
Researchers have put the reason down to our hunter-gatherer past, when women had to be more careful about committing to a mate who would stick around to help care for their offspring.
According to study author, biological anthropologist Adam Bode, from The Australian National University: 'Men will have fallen in love sooner than females because the male fitness landscape favours quantity of potential mates over quality, whereas the opposite is true for females.'
Women get drunk more quickly
We've all been through it. The throbbing headache. The dry mouth. The feeling you could throw up at any moment. But if after a heavy night your male partner feels back to normal sooner than you do, it's not because you've drunk more. It may be down to your gender.
Research has found women feel the effects of alcohol sooner because they have much less of the enzyme alcohol dehydrogenase in their stomachs, which breaks down alcohol before it enters the bloodstream. This means more alcohol, a toxin, enters the bloodstream unprocessed.
The result is that women feel its effects more on their brains – and their livers have to work harder to process it. 'Females have only about one-fifth as much of this enzyme… so women literally get more effect, ounce for ounce, than men,' explains Columbia University's Dr Marianne Legato, founder of The Foundation for Gender-Specific Medicine in New York.
Women have hangovers for longer
To make matters worse, women also suffer with hangovers longer. In 2003, researchers at the University of Missouri, US, surveyed over 1,230 students. Women complained of tiredness, dehydration, headaches, nausea, and vomiting more severely the next day than men who'd drunk similar amounts, and it took them longer to shake off symptoms.
One reason is that as well as having less of the enzyme they need to break down alcohol, they also have smaller livers. This means their bodies have to work harder for longer to remove the alcohol from their systems.
Psychologist Wendy Slutske, who led the research, says: 'This finding makes biological sense –women tend to weigh less and have lower percentages of body water. So they achieve higher degrees of intoxication and more hangovers per alcoholic unit.'
Men's wounds heal slower than women's
Cut your finger? If you're a man, you may find it takes longer to heal than a similar injury would for your female partner. This is because men have slower healing rates than women at all ages, according to a 2009 study in the Journal of Dermatological Science.
One possible reason is that men's skin is around 20 to 25% thicker than women's. This means there is more skin thickness for the body to repair before a wound is healed fully. However, while men's wounds may take longer to heal, the downside is that women's skin ages faster, particularly after menopause.
This is because men's skin is thicker due to the effect of the male hormone testosterone. This hormone helps give male skin a higher density of the elastin and collagen scaffolding that keeps skin firm – and this gives male complexions more resilience over time.
By contrast, women owe much of their skin thickness, moisture and suppleness more to the effect of the female sex hormone oestrogen. When this drops off after menopause, it leads to a drop in collagen at a rate of about 2% per year, while men's collagen levels decline much more slowly. Combined with a thinner skin, this means women's skin is ageing faster by the time both genders hit their 50s.
Men get hungry faster
If your male partner complains he's already hungry while you're still full after your last meal, he's not just being greedy – he really does digest his food faster. Researchers have found that men's food moves about a fifth more quickly through their bodies than it does in women.
Men's stomachs also empty faster because they have bigger volume and make more acid to break food down. According to gastroenterologists, it takes a woman around 28 hours to completely digest and excrete a meal, compared to around 24 hours for men.
Women also have fewer bowel movements. Part of the reason is that women have a slightly longer colon than men, with an added 10 centimetres, so their food has to travel further. Research has also found that female sex hormones alter the make-up of the digestive bile – so women have fewer salts to dissolve foods compared with men.
The female heart beats faster
The heart has its own electrical system that sends signals telling it when to contract and pump blood. These signals originate from a group of cells in the right atrium, called the sinus node, the heart's pacemaker.
The female heart is about two-thirds the size of a man's, weighing around 120g compared to 180g. However, because the female organ is smaller, it has to beat slightly faster to make up for it and distribute the blood around the body: 78 and 82 beats for an adult woman, compared to between 70 and 72 beats per minute for a man of the same age, according to a 2014 study in the Journal of Clinical and Diagnostic Research.
According to the researchers: 'This is largely due to the size of the heart, typically smaller in females than males. The smaller female heart, pumping less blood with each beat, needs to beat at a faster rate to match the larger male heart's output.'
Women blink more often and faster
Every minute we blink repeatedly to spread optical fluids over the surface of our eyes to keep them moist. However, women tend to blink slightly more often and more quickly than men, around 19 times a minute for females versus 11 for males, according to a 2008 study in the journal Ophthalmic and Physiological Optics.
Experts believe the reason is down to hormone differences, which contribute to the different make-up of this lubrication, which is made up of mucus, water and oil. According to eye surgeon Glenn Carp of the London Vision Clinic: 'Men have more testosterone which holds these tears together better and keeps their eyes well moistened.'
Female hormones may be another reason women blink more. We don't know why but studies have found women blink the most when they are taking contraceptive pills containing oestrogen.
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The Independent
22-05-2025
- The Independent
This experimental drug could help young people with a rare and aggressive form of ALS
An experimental drug could help young people with a rare form of ALS, researchers at New York's Columbia University Irving Medical Center announced on Thursday. Known as 'ulefnersen,' the therapy showed promise in treating patients with FUS-ALS, which is caused by a genetic mutation in a gene called FUS. The gene provides instructions for making a protein and plays a crucial role in cellular processes. While the mutations are only responsible for between one and two percent of ALS cases, they cause some of the most aggressive forms of ALS that begin in adolescents and young adults. Fewer than 30,000 people in the U.S. are living with ALS, which is also known as amyotrophic lateral sclerosis or Lou Gehrig's disease, while 5,000 people are diagnosed each year. The nervous system disease affects nerve cells in the brain and spinal cord, leading to a loss of muscle control that gets progressively worse. The exact cause of the disease remains unknown, but a small number of cases are genetic. There is no cure and it is, eventually, fatal. 'When testing new drugs for ALS, we do not expect to see clinical improvement,' neurologist and scientist Neil Shneider said in a statement. 'What we've seen in one patient is really unprecedented functional recovery. It's surprising and deeply motivating for us, the ALS research community, but also the community of ALS patients.' Shneider, who developed the drug in collaboration with the biotech company Ionis Pharmaceuticals, published his findings in the peer-reviewed journal The Lancet. Starting as an effort to help a single patient, the case series was small, including just 12 patients who were treated with the drug. Two of the patients showed a remarkable response to the drug. A young woman who had received injections of ulefnersen since late 2020 regained the ability to walk unaided and to breathe without the use of a ventilator, both previously lost to ALS. The medical center said she has lived longer with this disease than any other known patient with this juvenile-onset form of FUS ALS. A man in his mid-thirties was asymptomatic when he began treatment, but tests of electrical activity in his muscles indicated that symptoms would likely emerge imminently. However, after three years of treatment, he has yet to develop FUS-ALS symptoms and the abnormal electrical activity in his muscles has improved. Lastly, the researchers found patients experienced an up to 83 percent decrease in a protein called neurofilament light — a biomarker of nerve damage — following six months on the drug. 'These responses show that if we intervene early enough and go after the right target at the right time in the course of disease, it's possible to not only slow disease progression, but actually reverse some of the functional losses,' said Shneider. 'It's also a wonderful example of precision medicine and therapeutic development based on science and an understanding of the biology of disease.' While most of the other symptomatic patients did not survive their disease, Shneider said that 'several apparently benefited from the treatment. The progression of their disease slowed, and they lived a longer life as a consequence.' There were no serious adverse events related to the drug and a global clinical trial is now in progress. At least 25 patients have been treated with the drug around the world, including the dozen in Shneider's case studies. It was first tested six years ago in an Iowa patient named Jaci Hermstad. The drug was originally named for her. 'Now we are eagerly awaiting those results, which we hope will lead to the approval of ulefnersen,' Shneider said.


Medical News Today
20-05-2025
- Medical News Today
Heart attack: More sleep, exercise, less sitting can help lower risk
Written by Corrie Pelc on May 20, 2025 — Fact checked by Kevin Cyr, MD To prevent a second heart attack, replace 30 minutes' sitting time with exercise, a new study suggests. Image credit: Maskot/Getty Images. About one in five people who have experienced a heart attack will have another within 5 years. Heart attack survivors are also at an increased risk for other cardiovascular issues, such as heart failure, which can be lowered through lifestyle changes like exercising more. A new study says people who are too sedentary after experiencing a heart attack are at a higher risk of having another one or another cardiovascular event. Researchers report the risk of a secondary cardiovascular event can be lowered by replacing 30 minutes of sedentary behavior with light-intensity or moderate-to-vigorous-intensity physical activity, or sleep. 'The risks for heart attack survivors are still substantial,' Keith Diaz, PhD, the Florence Irving Associate Professor of Behavioral Medicine at Columbia University Medical Center in New York City, a certified exercise physiologist, a volunteer member of the AHA's Physical Activity Science Committee, and lead author of a new study told Medical News Today . 'Even those survivors who receive the most advanced treatments and medications still have significant risk. That's why it's urgent to find additional ways to reduce this risk,' Diaz explained. Adding to this list is a new study recently published in the journal Circulation: Cardiovascular Quality and Outcomes — for which Diaz is the lead author — which reports that people who are too sedentary after experiencing a heart attack are at a higher risk of having another one or another cardiovascular event. However, they can lower their risk of a secondary cardiovascular event by replacing 30 minutes of sedentary behavior with light-intensity or moderate to vigorous-intensity physical activity, or sleep. For this study, researchers recruited more than 600 adults between the ages of 21 to 96 who had been treated at a hospital for a heart attack or chest pain. Study participants were asked to wear a wrist accelerometer for an average of 30 consecutive days after leaving the hospital to measure how much time they spent sedentary vs moving. 'In our previous research, we noticed that a number of heart attack survivors were quite fearful of exercise,' Diaz said. 'Many of the bodily sensations of intense exercise can remind survivors of their heart attack, causing them to fear and avoid it. As a result, we were finding that many survivors were extremely sedentary, spending over 13 hours a day sitting.' 'Given all that has been learned from research on the health hazards of sitting, we were concerned that heart attack survivors were unknowingly increasing their risk of having another event,' he continued. 'That's why we decided to investigate the link between sedentary behavior and secondary heart attack risk.' At the study's conclusion, Diaz and his team found that study participants who spent an average of more than 14 hours a day being sedentary more than doubled their chances of having another cardiac event or to be hospitalized again within a year after their first cardiac event. 'This finding highlights that sedentary behavior is a toxic, harmful behavior which can impact recovery and future health risk after a heart event,' he explained. 'A big misconception among both patients and physicians is that sedentary behavior doesn't matter as long as you are getting your exercise in. Many people focus solely on meeting exercise recommendations, treating it like a checkbox. 'I got my 30 minutes in, so I'm good and don't need to move [for] the rest of the day.' But exercise is just the tip of the iceberg. It only accounts for [approximately] 2% of the day for those who actually do it.' – Keith Diaz, PhD 'Our study found that patients who spent more time sitting after a heart event had a higher risk of cardiac events and death within a year, irrespective of exercise levels,' Diaz added. 'In other words, even if you're exercising, long periods of sitting can still pose a serious health risk. Reducing sedentary time throughout the day is really important for optimal recovery after a heart event,' he emphasized. On the flip side, researchers discovered that participants who replaced 30 minutes of sedentary behavior with light-intensity physical activity daily lowered their secondary heart event or death risk by 50%. Furthermore, substituting 30 minutes of sitting with moderate to vigorous activity every day cut their risk by 61%. 'The large reduction in risk from replacing sedentary time with light-intensity activity really underscores an important public health message: doing something is better than doing nothing,' Diaz said. 'Movement itself, regardless of intensity, can be beneficial after hospitalization. This is especially relevant for people recovering from a heart event who may find moderate or vigorous activity difficult or scary,' he added. 'While exercise still provides the best 'bang for your buck' in terms of the greatest health benefits, our findings are good news for people who may not have the time, ability or desire to exercise,' he continued. 'The road to a healthy lifestyle after a heart event is more accessible and achievable than we thought and is not just for gym regulars.' Diaz and his team also found that if participants replaced 30 minutes of sedentary time with an extra 30 minutes of sleep, they slashed their secondary cardiac event risk by 14%. 'Sleep is healthier than sitting,' Diaz explained. 'It's a restorative behavior that helps the body and mind recover which is especially important after a serious health event like a heart attack. Many patients struggle to find time or feel too intimidated to engage in intense physical activity.' 'Our findings offer an encouraging message,' he added. 'Even getting an extra half hour of sleep, rather than spending that time sitting on your phone or watching one more episode on Netflix, can support recovery and reduce risk. For all the couch potatoes out there, this is a small, doable step that can still make a meaningful difference for your health.' MNT also had the opportunity to speak with Christopher Berg, MD, a board certified cardiologist at MemorialCare Heart and Vascular Institute at Orange Coast Medical Center in Fountain Valley, CA, about this study, who commented that the results are concerning, but not all that surprising. 'We've long known that too much sitting is bad for cardiovascular health,' Berg, who was not involved in this study, explained. 'But this research adds an important layer: It's not just how much time patients are sedentary — it's also how that time is accumulated. Long, uninterrupted periods of inactivity appear particularly harmful.' 'What really stood out to me was the authors' statistical approach that suggested that even replacing 30 minutes of sedentary time with light activity, moderate exercise, or even sleep was associated with a lower risk of heart events and death,' he continued. 'That's a powerful message that I'll be using in [the] clinic to encourage patients to stay active.' 'Still, it's important to be cautious with these results,' Berg added. 'This was an observational study, so we can't say for sure that [more] sedentary behavior caused the bad outcomes. People in the most sedentary group were generally older and had more health problems, which may have contributed to their risk. That said, the message is still a good one: if you've had a heart attack — or even just a scare — staying active in some form is likely beneficial.' Heart Disease Cardiovascular / Cardiology Sports Medicine / Fitness


The Independent
19-05-2025
- The Independent
You can reduce your risk for another heart attack with one simple step
Someone in the U.S. has a heart attack every 40 seconds, and heart disease is the nation's leading cause of death. But researchers now say people who have suffered a heart attack can significantly reduce the risk of another one by following a seemingly simple course of action: get up and get moving. 'Sitting less and moving or sleeping a little more can make a real difference,' said Dr. Keith Diaz, a professor at Columbia University Medical Center and a volunteer member of the American Heart Association's Physical Activity Science Committee, in a statement Monday. 'More physical activity and more sleep are healthier than sitting, so we hope these findings support health professionals to move toward a more holistic, flexible and individualized approach for physical activity in patients after a heart attack or chest pain.' Diaz was one of the coauthors of the study, which was funded by a National Institutes of Health grant and published in the American Heart Association's peer-reviewed scientific journal Circulation: Cardiovascular Quality and Outcomes. What they found To reach these conclusions, the authors examined the health of approximately 600 people between the ages of 21 to 96 who had been treated for a heart attack or chest pain at New York City's Columbia University Irving Medical Center. They used wrist accelerometers to track the amount of time each participant spent moving for an average of around a month after they were discharged from a hospital's emergency department. The accelerometer's measurements allowed researchers to infer the intensity of a participant's physical activity. Any additional cardiac events or associated deaths were evaluated a year after they were discharged from the hospital the first time using phone surveys, electric health records, and the Social Security Death Index. Within the year, 8.2 percent of patients experienced a cardiac event or died. They found that those in the group with the lowest activity levels – defined as spending more than 14 hours each day being sedentary – had a 2.58 times higher risk of having another heart problem or dying within the next year. Researchers also found that 30 minutes of moderate-to-vigorous activity a day reduces the risk of adverse cardiovascular events or death by 61 percent. Even 30 minutes of light-intensity physical activity slashed the risk in half. 'These findings suggest sitting less and doing anything else – like taking a walk, cooking, playing with your dog or gardening – will help you stay healthier,' Dr. Bethany Barone Gibbs, a professor at West Virginia University, explained. Getting 30 minutes of sleep also lowered the risk by 14 percent. Poor sleep is a known risk factor for cardiovascular disease, which claims more lives each year in the U.S. than all forms of cancer and chronic lower respiratory disease combined, according to the American Heart Association's 2025 Statistical Update. 'We were surprised that replacing sedentary time with sleep also lowered risk. Sleep is a restorative behavior that helps the body and mind recover, which is especially important after a serious health event like a heart attack,' Diaz said.