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Fisherfolk at higher risk of chronic kidney disease, says nephrologist

Fisherfolk at higher risk of chronic kidney disease, says nephrologist

Time of India29-06-2025
Panaji:
For over two decades, a high incidence of chronic renal disease has been reported in the coastal villages of Canacona. Dr Narayan Prasad, head of the nephrology department of Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, said the occurrence of the disease among the fishing community, people working in salt pans and those living in coastal areas has been peculiar.
He was speaking on 'Renal healthcare in India: Understanding environmental exposures and social determinants' at an event organised by the Goa University.
He listed heat stress and dehydration as the key causes. 'Coastal people often tend to skip water consumption, exposing themselves to the disease,' said Prasad in his talk.
A health official of the community health centre, Canacona, said that currently, there are more than 190 people listed for dialysis.
Citing a study on chronic kidney disease of uncertain aetiology (CKDu), Prasad said that a 2009 medical camp in Canacona indicated a high prevalence of CKDu in residents. As many as 298 urine samples were collected, and nearly 24% of the participants showed urinal abnormalities, he quoted the study.
'The disease can also be attributed to the presence of mycotoxin in mouldy cereals, food products and aromatic compounds found in drinking water,' the research found.
Prasad also presented other case studies that analysed the prevalence of CKDu in coastal people of Andhra Pradesh, Odisha, Goa, and union territories of Puducherry and Daman and Diu.
Prasad said by virtue of their occupation, which is likely to be either agriculture or fisheries, or both, people are likely to be more susceptible to having CKDu. 'Coastal areas and agricultural lands are high-heat areas. Spending long hours here leads to dehydration, slowly affecting the kidneys. Similarly, exposure to toxic agro chemicals, pesticides and fertilisers further exacerbates the problem,' he said.
'With rest and adequate water consumption, kidney injury markers can be reduced. A multi-disciplinary approach to sociological, occupational, legal and policy framework can be helpful to bring down CKDu cases,' the doctor said.
Excess uric acid doesn't just lead to kidney stones— over time, it can also damage tissues in the kidney. Studies show that high uric acid levels are linked with a higher risk of developing chronic kidney disease (CKD). In this health condition, one's kidney function declines slowly and progressively. For the unversed, the kidneys help filter out waste from the blood and it is removed along with urine from the body. However, when the kidneys don't function properly it could lead to build of toxins— including uric acid— in the blood. CKD may not show any early symptoms, it can cause high blood pressure (BP), fatigue, and even kidney failure in extreme cases. Managing uric acid early through lifestyle changes, exercise, hydration, and regular health check-ups is important to protect long-term kidney health.
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Drug Approvals Hit an FDA Wall
Drug Approvals Hit an FDA Wall

Hindustan Times

time4 days ago

  • Hindustan Times

Drug Approvals Hit an FDA Wall

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America's drug regulator is in turmoil
America's drug regulator is in turmoil

Hindustan Times

time11-08-2025

  • Hindustan Times

America's drug regulator is in turmoil

TO APPRECIATE the dilemmas the Food and Drug Administration (FDA) faces when it reviews new drugs targeting rare diseases, consider the recent rollercoaster ride of Sarepta Therapeutics, a biotech firm. In 2023 the FDA granted accelerated approval for its gene therapy for Duchenne muscular dystrophy, a rare genetic disorder that typically causes death in early adulthood. Peter Marks, director of the FDA's biologics centre at the time, approved the treatment despite reviewers' concerns about limited clinical data. Some hailed that as proof the FDA could be nimble in cases where sufferers had few options. The treatment costs an eye-watering $3.2m per patient, so the drug's approval delivered Sarepta a major payday. But in the past four months three patients on Sarepta's treatments have died from acute liver failure. On July 18th the FDA asked the firm to suspend distribution. Within days its stock lost nearly half of its value (see chart 1). 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One reviewer who works on rare diseases notes that during evaluations of proposed treatments for them, the science can be less familiar, the clinical trials smaller, and approval may hinge on less conventional intermediate evidence. This uncertainty can breed scepticism initially. What often persuades reviewers of a treatment's safety and efficacy is statistical stress-testing and other scrutiny of the evidence that can take months. Speeding this up risks causing reviewers to err on the side of caution, which could lead to fewer approvals, not more. Side effects may include Congress is another source of uncertainty. Lawmakers have so far failed to reauthorise a voucher programme that encouraged drugmakers to pursue treatments for rare pediatric diseases. In exchange, companies received a voucher granting expedited FDA review for another drug. The vouchers are transferable and can be sold for tens of millions of dollars on a secondary market (see chart 3). 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Rollercoasters are no fun when you have no choice but to ride them. America-s-drug-regulator-is-in-turmoil

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