New drug can help stop certain breast cancer tumours early, trial shows
It is the first worldwide study to show that using blood tests to find early signs of cancer resistance to treatment helps patients, scientists say.
The study looked at patients who had hormone-positive, HER2-negative breast cancer, which is about 70% of cases.
Results showed patients given camizestrant reduced their chances of cancer progression by 56%, compared with just standard therapies.
Doctors used a simple blood test to spot changes in the cancer's DNA that show whether current treatments might soon stop working.
When they found these signs, some patients were given camizestrant, while others stayed on their usual treatment.
Those on camizestrant had their cancer stay the same and not get worse for much longer, 16 months on average, compared with about nine months for the others.
The drug was safe for most patients but 1% stopped taking it because of side effects.
More than 3,000 patients from 23 countries took part in the study, which was funded by AstraZeneca and co-led by researchers at The Institute of Cancer Research in London.
Co-principal investigator Professor Nick Turner, group leader in molecular oncology at The Institute of Cancer Research, London, said the drug is 'a pivotal moment in breast cancer care'.
Professor Kristian Helin, chief executive of The Institute of Cancer Research said: 'The results of the Serena-6 trial represent more than a clinical milestone, they represent a transformational shift in how we approach precision medicine.'
About 55,000 women are diagnosed with breast cancer in the UK every year and 11,500 will die from the disease, The Institute of Cancer Research said.
The Serena-6 trial results were to be presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago on Sunday.
Dr Catherine Elliott, director of research at Cancer Research UK, said: 'This study is a clear example of how blood tests are starting to transform cancer treatment.
'By tracking tiny traces of tumour DNA in the blood, researchers were able to spot early signs of treatment resistance and switch therapies before cancer had a chance to grow.
'It shows how circulating tumour DNA, or ctDNA, could help doctors make smarter, more timely treatment decisions.
'This approach could become an important part of how we personalise care for people with advanced breast cancer.'
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The Independent
12 hours ago
- The Independent
You can now give yourself an at-home flu vaccine
For the first time, Americans can get their seasonal flu vaccine at home. Starting Friday, eligible adults in 34 states can order the FluMist Home - a nasal spray - online ahead of the upcoming flu season, European drugmaker AstraZeneca announced, calling it a 'transformational moment in the evolution of influenza protection.' FluMist was previously only available at pharmacies or doctors' offices. Now, interested people can go to to order the sprays, potentially saving time spent at a clinic or drug store. Once received, the vaccine should be stored in the refrigerator until it is used. Then, people between the ages of 18 and 49 years old can self-administer the vaccine. FluMist Home can be given to children and teens between the ages of two and 17 years old. A full dose is one spray in each nostril. FluMist may not prevent infection in everyone who takes it, but it works similarly to vaccines for measles and chickenpox. It contains weakened versions of viruses that trigger the immune system in the nose and throat, teaching it to build up immunity without causing infection. In rare cases, FluMist may cause serious side effects, including allergic reactions. But the most common side effects are a runny or stuffy nose, a sore throat and a fever of over 100 degrees. Some people should not take FluMist, including those with severe allergies to eggs, the vaccine's ingredients, or other flu vaccines, and kids who take aspirin or medicines containing aspirin. Children should also not take aspirin for four weeks after they get FluMist, unless told to do so by a healthcare provider. The spray, which was initially approved by the Food and Drug Administration in 2003 and was approved for at-home use without a healthcare professional last September, should be free for people with insurance, though there is an $8.99 shipping and processing fee. AstraZeneca said it hopes that all of the lower 48 states will have access to the spray in future flu seasons, although when that may be is unclear. The announcement comes on the heels of the worst flu season in 15 years, fueled by a cold winter, the spread of H5N1 bird flu, Covid, and other respiratory illnesses, and declining vaccine rates. Falling vaccination was 'a major cause of the surge,' Dr. Elizabeth Mack, the head of the pediatric critical care unit at the Medical University of South Carolina's Children's Health, told National Geographic. 'As influenza vaccination rates decline, especially among younger populations, this first-of-its-kind, at-home, needle-free option offers a critical opportunity to help make protection more accessible, convenient, and better aligned with the realities and current preferences of people's lives,' Dr. Ravi Jhaveri, the division head of infectious diseases at Northwestern University School of Medicine, said of FluMist Home, in a statement shared by AstraZeneca.
BBC News
6 days ago
- BBC News
Do wellness drinks really do what they say?
Calm in a can. Relaxation after a few what some drinks companies are promising with beverages formulated specifically to help you chill and Serena swear by them. 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The "functional beverage" market - that's drinks with additional health benefits - is booming, with British supermarkets seeing sales jump by 24.5% in the last 12 months, according to one market research firm. Almost 30% of UK households now buy these functional drinks, Worldpanel by Numerator what's actually in them that's supposed to help you feel more mellow or give your health a boost? Well, that's where things can get complicated, as each brand takes a different with Trip's Mindful Blend, other companies like Rheal, Grass&Co, Goodrays and supermarket own-brands, advertise that their drinks contain supplements including:Lion's Mane extract – a type of mushroom found in east Asian countriesL-theanine – an amino acid found primarily in green and black teaAshwagandha – a herb cultivated in areas of Asia, Africa, and EuropeMagnesium – a mineral the human body needs to function properlyThese supplements are all commonly found in many health and wellbeing products and are associated with enhancing mood, boosting energy, supporting cognition, and helping with how robust is the evidence for that? It's tricky because there are many studies of varying credibility each suggesting different levels of advert, which suggested its ingredients were stress and anxiety busters, breached the Advertising Standards Agency's (ASA) code, with the ASA ruling that Trip's claims their drinks could "prevent, treat or cure disease" were a step too told BBC News the ruling related to "a single page on the website" and it has made the "changes requested". It says it's confident it's ingredients permit the use of the word "calm" which is "widely and lawfully used by many brands". Dietitian Reema Patel is concerned the amount of supplement in these drinks may not give consumers the emotional balance, feelings of calm, or stress relief that is advertised across the industry. She highlights a growing body of evidence around the funghi Lion's Mane, but says there are no conclusive findings about whether it can have any impact - as yet."The research is still very much in its infancy," she says. 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Dr Sinead Roberts, a performance nutritionist, says supplements can make a difference, but they tend to work for certain groups of people in specific circumstances - such as high-performing athletes who want that extra edge, or people who are deficient in a certain nutrient - not necessarily for the general you enjoy the taste, "crack on", Dr Roberts says, but if you want to reduce stress and anxiety you're probably best saving your £2 or £3 and putting it towards a "therapy session or a massage at the end of the month"."A trace of Lion's Mane or Ashgawanda in a fizzy drink is not going to make any difference," she May, 25, first discovered these drinks at Glastonbury a couple of years ago. She's not overly bothered about trying to reach a state of zen through them - she just likes the taste."I'm ADHD," Emily says, "so I would definitely need a lot more than one of those drinks to calm me down." There is a fine line between advertising that a product will give you a feeling of calm and quiet, and claiming these kinds of drinks will help with mental health Natasha Tiwari says mental health and well-being are "increasingly conflated" in the wellness sector, creating a "toxic mix". There can be a positive - yet temporary - change in mood and consumers might feel a buzz, she says, not because of the ingredients necessarily, but because "everything around the experience of the product is real"."So you've bought a drink which, let's say, is a little bit pricier than the alternatives in the market. Therefore you make a commitment to sit down quietly and enjoy it nicely," she says. "You look at the branding - which is lovely and calming - you're processing your environment in the moment, and then actually what you're experiencing truly is a calm moment in your otherwise busy day. That's not fake."And it's that little window of peace that Lucy and Serena yearn for - and for a few minutes a fizzy drink in a can gives them that, whether the science really agrees, or News contacted all the brands mentioned in this article. Grass&Co told us it's their mission "to deliver high-strength natural adaptogen and vitamin-packed blends formulated by experts... which are supported by approved health claims."
Daily Mail
7 days ago
- Daily Mail
Our lives changed forever after my husband had the Covid jab...a stroke left him blind and paralysed - and the stress has broken our marriage
When Vicky O'Neill casts her mind back to life during the pandemic, one date remains forever etched in her memory. For it was on May 17, 2021, that husband John awaited his turn to have the newly-approved AstraZeneca Covid vaccine. The doting father-of-two from Althorne, Essex, was considered more at risk from Covid-19 because of his asthma and was optimistic the jab could offer a 'return to normality.' Still, moments before his appointment, the then 41-year-old turned to his wife and said he was worried about the possible side-effects. 'We were sitting in the car, just the two of us. And he said to me, "I'm going to go in and have AstraZeneca, and you're going to have the Pfizer. That means if there's any problems - because we don't know much about these vaccines - at least there is still one of us here for the kids." 'I told him not to be stupid. He went in, had his jab and didn't think anything of it.' But the IT contractor's words turned out to be a chilling foretelling of events that would forever change their lives. Within the next 10 days, John suffered a devastating stroke that would leave him blind in his left eye, paralysed down his right side and 60 per cent brain damaged, among other permanent disabilities. As he and his family would later discover, John had suffered an extremely rare reaction to the Covid jab that causes blood clots with a low platelet count. Known as VITT - vaccine-induced immune thrombocytopenia and thrombosis - medical experts said such a reaction would only happen to one in 50,000 people. Four years on, John and his loved ones acknowledge just how lucky he is to even be alive - but the repercussions continue. Now aged 46, John has been left a shadow of the man he once was, unable to work and needing full-time care. The financial impact on the family has also been immense - with John confessing they have been 'living on nothing', and their beloved four-bed detached home is now up for sale. Having received an 'inadequate' compensation payment from the Government, John fears he has become one of the 'forgotten' individuals whose lives changed immeasurably after they had the vaccine - and he has added his name to a 50-strong class action currently going through the courts. In the latest consequence of this tragedy, the tremendous stress endured by the couple has brought an end to John and Vicky's 16-year marriage, with the pair taking the difficult decision to divorce. It's a decision borne more out of necessity than desire, with both clearly devastated that events have turned out this way. But after 25 years together, both agree it is the right thing to do for their children and are determined to remain heavily involved in each other's life. 'As you can see, we get on but everything has changed. John's changed. I've had to change, and life is so very different,' said a tearful Vicky, who has cared for her husband full-time over the last four years. John, who still struggles with his speech in the aftermath of his stroke, simply nodded while dabbing away his tears. Looking around the lounge of their comfortable home, vibrant family photos point to an array of happier times in their life. Vicky had just turned 18 when she met John, an ambitious IT contractor who previously earned a six-figure salary. 'We were very lucky. John worked really hard and we had a good life, like we've never asked for anything. I was working as a graphic designer for an architect in London. 'We were both very career-minded, but we knew what we wanted. We bought a house together in Romford while we were still very young and we had our own cars. We done it all ourselves. You know, we had a good life.' The couple married in 2008, and four years later had their daughter, Freya, now aged 13, followed by their son, Mason, now eight. 'He's been diagnosed with autism and ADHD so he's 100 miles an hour, but the most amazing kid,' Vicky enthused. 'We had everything we wanted - life was good.' Five years ago, the couple decided to move from Romford to the more rural surrounds of Althorne to provide 'a better life for the kids'. They bought their current home and planned to renovate and extend the property, but plans were halted after the world was plunged into the Covid pandemic. Both John and Mason, who was aged just four at the time, suffered from severe asthma and out of caution the family shuttered themselves off from seeing anyone. 'We were extreme, we didn't want anyone to visit because they both had asthma and we worried about the virus. 'When this jab came out, we thought this is what we needed to get us back into the world again.' At first, none of John's initial concerns about the vaccine came to fruition. He experienced the typical flu-like symptoms reported by others after the first 24 hours, but otherwise seemed fine. But as the days went on, Vicky noted that John seemed 'extremely tired' and had experienced fleeting moments of feeling sick. Ten days after his vaccination, John awoke in the morning and complained of an intense pain in his left eye. After calling 111, he was advised by a doctor that he likely had a sinus infection and a prescription was issued over the phone. Vicky recalled that she left the house to go and pick up the medication, only to find John saying the pain was 'unbearable' when she returned. Within hours, he began saying there was something wrong with his jaw and decided to return to bed. But when he got up around 6pm, Vicky could see her husband was seriously unwell. 'He walked in here, and he was grey and clammy. He said his vision had gone in one eye and couldn't stop being sick. He pleaded with me to call an ambulance.' A first responder arrived within minutes and suspected John, who by now was also slurring his words, was having a heart attack or stroke. When the ambulance arrived, he was taken off to Broomfield Hospital in Chelmsford. Despite the severity of his symptoms, the doctors believed at first that John simply had a migraine. But overnight he suffered a major stroke, originating in his optic nerve, that damaged 60 per cent of his brain. Consultants then discovered his left carotid artery had become 'completely occluded'. John would need to be transferred to the Royal London Hospital for a life-saving procedure to insert a stent, with Vicky warned by medics 'he might not make it'. She was told hours later that despite an initial problem the stent had been successfully inserted, but when Vicky went to visit her husband the next day she found him 'in a state'. 'He had a temperature. His left eye was completely shut. He was thrashing around and kept pulling his left leg up and groaning.' Vicky had previously noted at Broomfield that John's leg had a strange 'mottling' around the ankle, but was reassured by doctors that this would be assessed after he was transferred to the Royal London. However, when she asked if this had been done, a doctor seemed to be unaware of the issue. 'I'd looked at his leg again and now he had these red blanches all the way up his skin. The doctor pulled the sheet back, and said "Oh my God. He's got a haematoma." He began shouting for the team and said John needed to be scanned quickly.' Within hours, Vicky was approached by a haematologist consultant, who delivered devastating news: John had developed a condition known as VITT as a result of the Covid vaccine, which had caused his blood to start clotting in all the main arteries of his body. The rash on his left leg was a major clot that had formed. Vicky was asked to make a choice between John having his leg amputated or to start anticoagulation treatment including a plasma transfusion, but both procedures were 'extremely life threatening.' 'John was already paralysed on the right side by the stroke. He could not move, he couldn't sit up, he couldn't do anything for himself. He couldn't even lift his own head. 'The only thing he could do was lift this leg - and now they might amputate it.' Devastated by such a decision, Vicky said she believed John would not want to go ahead with amputation but would be guided by the doctors. They agreed to go ahead with the plasma exchange, with John reacting well to the treatment. He remained in intensive care for weeks before finally being transferred back to Broomfield Hospital and a short rehabilitation stint at Homerton Hospital. In all, John spent four months in hospital before coming home - but life would never be the same again. He presently takes 17 tablets a day and remains 'under every consultant possible'. 'John struggles with his speech and has aphasia. He also has difficulties reading and writing and recognising numbers. He's blind in his left eye. His carotid artery is now completely blocked, so doctors have to monitor him constantly to ensure he has no issues there. 'The artery in his left leg is blocked. So he has no pulse below the left knee and that causes a lot of problems. If he walks even 10 metres he gets pins and needles because of the restricted blood flow. 'His right leg was affected by the stroke and is now his weak leg. 'He's also now on the border of heart failure as a result of the stroke and we are getting him assessed for possible dementia.' Lifting his right arm and hand, John shakes his head before letting it drop. 'That arm is nothing', he added, showing he had lost the use of his limb. With the benefit of hindsight, Vicky acknowledges that at the point John returned home in September 2021 - and she became his full-time carer - the challenges had only just begun. 'Mason was starting school, and then Freya went back for the first time since the pandemic began - and we had to just try and be normal. 'But when I look back now, I didn't ever have any downtime. I had gone from my husband nearly dying to having to come home to look after the children and get them to be understanding of what was going on. And in all of this, I was still learning what was going on with John.' There were also new concerns for Vicky around their finances. 'John had been the main breadwinner, and all of a sudden he wasn't there. We would be OK for a little while due to savings, but my husband has had a stroke and he's not going to get better. I kept thinking what are we going to do?' John has been eligible to claim Personal Independence Payment and Employment and Support Allowance, while Vicky has claimed Carer's Allowance and been able to work a few hours each week to supplement her income. 'But for a family of four, you just can't survive on that,' explained Vicky, who said they had struggled over the last four years and the couple have had no other option than to sell their home. John was found to fit the criteria for the Government's Vaccine Damage Payment Scheme (VDPS), which offers a one-off financial payment of £120,000 in the event that a vaccine likely caused at least 60 per cent disablement. In John's case, that figure was found to be 90 per cent - but that money alone will not be enough to financially secure the family for the years ahead. He has now joined a class action launched by Leigh Day solicitors against AstraZeneca, which was indemnified during the pandemic, and the Government, which would likely pay out if their claim is successful. Lawyers representing victims and families are suing AstraZeneca under the Consumer Protection Act 1987. They argue the vaccine was 'a defective product' that was 'not as safe as consumers generally were reasonably entitled to expect'. AstraZeneca has strongly denied these claims. Health officials first identified cases of VITT linked to AstraZeneca's jab in Europe as early as March 2021, just over two months after the vaccine was first deployed in the UK. On its website, Leigh Day stressed it was not an 'anti-vaccination' case. 'It is however a case about fairness – a case in which we are trying to secure fair compensation for those families who paid the ultimate personal price for agreeing to be vaccinated during the pandemic.' Vicky said if they were to be successful, the money would take away their financial stress - but tragically it would never bring back the life they once had. 'I was lucky that we didn't lose John, and our children were lucky that they didn't lose their dad, but they have lost him in a huge way, in every way possible. He is still here, but he's not the man he was. 'It worries me going forward, because John has lots of issues and we don't know how they are going to progress. 'Money can't buy happiness. It can make things stable, which is great, but it's not going to change what happened. It's not like having a broken arm that you can fix and go back to enjoying life, doing your job and taking the kids to the park. 'It's never going to happen for us. 'John has been robbed of his life, and he can try and make another life for himself, but it's always going to be limited because of what happened.' Vicky is keen to stress that she and her family are not against vaccinations, but feels saddened their lives were upended simply because they tried to 'do what was right'. 'We just wanted to do right by our family, our friends, the country. We just wanted to do our part in getting back to normal. 'But life is far from normal for us - and we just don't know what the future holds.' In a statement to MailOnline, Leigh Day partner Sarah Moore said: 'As a result of his injuries, John will never be able to work again, or be the husband and father that he once was for Vicky and their children. 'Presently the Government scheme provides them with a one-off payment of £120,000. That is less than John's annual earnings prior to his injuries and is wholly inadequate to provide him with the specialist care that he needs to live with his injuries let alone provide for his family. 'John stepped forward for vaccination at the Government's request, along with thousands of others, and yet when he needs the Government to stand with him and his family by providing meaningful financial support they are nowhere to be seen. 'John and others like him do not want to have to bring a legal claim, they want to put their energies into putting their lives back together. 'The fact that they are having to do so should be a cause of national shame, the pandemic was a period of national solidarity and yet, in the aftermath when the country has moved on, those injured like John have been forgotten.' Official data shows at least 81 Brits have died from blood clot complications apparently linked to the AstraZeneca jab, according to figures collected by the UK's drug watchdog, the Medicines and Healthcare products Regulatory Agency. A further unconfirmed number have been injured and/or disabled. Further Covid vaccine rollouts have either minimised use of the AstraZeneca jab and/or phased it out entirely in favour of mRNA alternatives like those made by rival pharma giants Pfizer and Moderna. However, AstraZeneca's jab is credited with saving some 6million lives globally during the Covid pandemic. AstraZeneca previously said in a statement: 'Our sympathy goes out to anyone who has lost loved ones or reported health problems. 'Patient safety is our highest priority, and regulatory authorities have clear and stringent standards to ensure the safe use of all medicines, including vaccines. 'From the body of evidence in clinical trials and real-world data, the AstraZeneca-Oxford vaccine has continuously been shown to have an acceptable safety profile and regulators around the world consistently state that the benefits of vaccination outweigh the risks of extremely rare potential side effects.'
