logo
New antibiotic that could save millions of lives enters final testing

New antibiotic that could save millions of lives enters final testing

Independent6 days ago

Roche, a Swiss drugmaker, is advancing zosurabalpin, a new antibiotic developed with Harvard University, into the third and final phase of testing.
Zosurabalpin will be tested against drug-resistant acinetobacter baumannii bacteria, which the CDC identifies as an "urgent threat" and has not been addressed by new antibiotics in over 50 years.
The Phase 3 trial will involve approximately 400 patients worldwide, comparing zosurabalpin to standard treatment.
Roche aims to combat antimicrobial resistance with this innovation, potentially revealing new insights into bacterial membranes for future antibiotic discovery.
The experimental drug is hoped to be approved by the end of the decade, addressing the global issue of Sepsis, which causes approximately 11 million deaths annually, and community-acquired pneumonia, which kills three to four million people each year.

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Arsenal target Rodrygo handed deadline to 'convince everyone' at Real Madrid he deserves his place
Arsenal target Rodrygo handed deadline to 'convince everyone' at Real Madrid he deserves his place

Daily Mail​

time33 minutes ago

  • Daily Mail​

Arsenal target Rodrygo handed deadline to 'convince everyone' at Real Madrid he deserves his place

Arsenal target Rodrygo has been handed a deadline to convince everyone he belongs at Real Madrid, as per a report. The 24-year-old developed into an integral player for Madrid since joining from Brazilian side Santos for €45million (£37.9m) in 2019. The forward, who has also won 33 caps for Brazil, may have a lower profile than fellow attackers Kylian Mbappe and Vinicius Jnr, yet he still has a hugely impressive record at the Bernabeu. Rodrygo has 68 goals and 50 assists in 267 appearances for Los Blancos but after a difficult campaign, reports have linked him with a move away this summer, with Arsenal believed to be one of many Premier League clubs interested. And with speculation rampant, Madrid have told Rodrygo he must prove he can fit into Xabi Alonso 's system at the upcoming Club World Cup, according to Spanish outlet Marca. The revamped 32-team tournament runs through mid-June to mid-July, meaning the Brazilian forward has around seven weeks to get back to his best. Teams are expected to take this year's Club World Cup more serious than ever before, considering the mammoth prize pool at stake. The side that takes the trophy home will receive a windfall of $40m (£30m), while a team winning of their games could see them land up to $125m (£92m). For reference, the winner of the Champions League earns around £120m, while the Premier League champions typically earn between £38m and £40m for finishing first. Sky Sports Germany previously claimed Arsenal are in talks with the 24-year-old over a move and that he is at the top of their list of targets on the wing, although he has also been touted with a move to Man City, Man United and Liverpool. Mikel Arteta was pressed on these links prior to Arsenal's final game of the campaign against Southampton - which saw them win 2-1. 'If you want to win titles, you have to be the best in the market,' Arteta said, as he refused to confirm or deny the links. 'The teams that win have the best players. 'It's a matter of pride. It shows we've brought the club to a level where people expect us to challenge for trophies. 'What is clear with the amount of injuries that we had in the front line is that we need a goal threat and we need firepower'. Rodrygo scored 18 goals and claimed nine assists in the 2023-24 season as Madrid won the treble. But he has failed to follow it up this season, only bagging six times and providing six assists in LaLiga. He has scored just once in his last 22 matches, last netting against Atletico Madrid in March. Rodrygo was not called up for Carlo Ancelotti's inaugural Brazil squad, whom the former Madrid boss now manages.

Deco on Barca's future, challenging Real and Yamal
Deco on Barca's future, challenging Real and Yamal

BBC News

time33 minutes ago

  • BBC News

Deco on Barca's future, challenging Real and Yamal

Barcelona sporting director Deco denies the club have financial problems and says they do not need to sell players - despite La Liga's restrictive financial 47, has overseen a revival of Barcelona since his appointment in 2023, culminating in a domestic treble while also reaching the semi-finals of the Champions Catalans have renewed the contracts of superstar teenager Lamine Yamal, Raphinha and manager Hansi Flick, while they were cleared by Spain's National Sports Council (CSD) to register midfielder Dani Olmo amid a dispute with La Liga. When asked whether the world should see Barcelona as a well-run club in 2025, Deco told BBC Sport: "Barcelona is my club, I love Barcelona. I saw what happened from the outside and always thought I could help put Barca at the same high level. "I knew it would be difficult when I joined with the financial rules - it is not a financial problem, but the financial fair play rules in Spain are more difficult than the Premier League and in other countries. "It is a problem for a lot of clubs, you just hear about Barca because we are a big club. You need to work with it, see how you can improve the team and the combination of La Masia [academy] players and experienced players has been important."The former Portugal midfielder, who played for the Catalans - as well as Chelsea and Porto - stresses Barcelona are happy working with La Liga but have faith the rules will continue to improve. Even if they do not, Barcelona are excited to have "one of the biggest contracts in history" with Nike, and the newly renovated 100,000-seater Nou Camp will be the biggest stadium in Europe and improve insists Barcelona will "not sell our best players", adding the team's recent success means they can "grow with many of the same players". But he says they are in looking for "two, three or four signings", without needing to enter the market "like crazy" thanks to the stability at the core of the asked if it includes the option of signing Manchester United's Marcus Rashford, thought to be available for £40m, or Liverpool's Luis Diaz, he added: "We have been focusing on renewing contracts, after that, we'll discuss players to come. "Of course, these two players, like you mentioned, they are good but have contracts in their clubs, so we won't speak because it's not fair. But when you decide to go to the market, for sure, we find some names. In my opinion, we don't need to bring many players."He added: "When I speak with the agents of the players, everyone wants to come or stay. So this is important. The image of the club is still good. We are proud because Barcelona is still such a big club, and the way we are playing football makes players want to come."Deco is aware of the constant threat of Real Madrid, who will look to improve under new head coach Xabi have also agreed deals for right-back Trent Alexander-Arnold, who will leave Liverpool, and Bournemouth centre-back Dean Huijsen. Benfica left-back Alvaro Carreras is understood to be next on the club's shortlist."Next season is not going to be easy, because I know that first Real Madrid has a lot of top players," he said. "In my opinion they have a big team. They have a lot of fantastic players. Of course they want to improve."It's very important to have a strong Madrid. It's very important to have strong players, top players, players that the people want to see. I think Madrid has these kinds of players, like us."Now it's important to keep the top players in La Liga. So for us it's important that Madrid are strong, that Atletico is strong, and we need to be there." 'Yamal can make history like Messi' Barcelona have already signed perhaps their most important deal of the summer, keeping 17-year-old Spanish sensation Yamal at the club on a new six-year deal until made his debut at 15 and has already made 106 appearances for the club. He was part of Spain's European Championship-winning team, is the reigning Golden Boy and Kopa winner - awards given to the best young player in the world - and was heavily involved in Barcelona's four El Clasico wins against Madrid this season. All this success has led him to be compared to Barcelona legend Lionel Messi, widely regarded as among the world's greatest ever players. Deco continued: "Lamine is Lamine. Leo is Leo. Leo was the best player in the history of this club, for me, the best player in history. "Everyone becomes crazy when they see Lamine playing football, you would pay to go watch him in the stadium, he's special and he wanted to stay because he believes in the project. He deserves an improved salary. "He's going to be one of the best players in the world. We need to respect him as a player, but not forget he is 17 years old."Deco added: "It's not easy to compare, but Lamine, in terms of quality, can make history like Leo. But of course, to make history, he needs to have a good team behind him."Barcelona managed Messi mania and would know how to give Yamal the degree of protection he needs to shine."We try to not let him do everything, because, you know, sometimes the sponsors, and everyone wants his shirt or time," Deco continued. "Sometimes we can't control everything, but people see his magic, on and off the pitch. "They want to have a piece of him and we need to help him manage that."

BREAKING NEWS Alice Liveing is pregnant! Fitness influencer is congratulated by Carrie Johnson and Vicky Pattison as she reveals she's expecting first child - after concerning fans with A&E dash
BREAKING NEWS Alice Liveing is pregnant! Fitness influencer is congratulated by Carrie Johnson and Vicky Pattison as she reveals she's expecting first child - after concerning fans with A&E dash

Daily Mail​

time41 minutes ago

  • Daily Mail​

BREAKING NEWS Alice Liveing is pregnant! Fitness influencer is congratulated by Carrie Johnson and Vicky Pattison as she reveals she's expecting first child - after concerning fans with A&E dash

Fitness influencer Alice Liveing has revealed she's pregnant. The vlogger, 32, shared the joyous news in an Instagram post on Sunday, with a video of herself cradling her growing baby bump and cuddling up to husband Patrick Murphy. Alongside the sweet video, Alice penned: 'Some news we wanted to share with you. 'I appreciate that the journey to get here can be a hard one. And seeing this news isn't always easy. My heart, and love go to anyone still there. 'I haven't wanted to hide this from you, but for various reasons and anxieties which I won't go in to now we've wanted to wait a little longer and I hope you can understand that.' From A-list scandals and red carpet mishaps to exclusive pictures and viral moments, subscribe to the DailyMail's new Showbiz newsletter to stay in the loop. Alice continued: 'We're both so excited, and filled with hope and love for our next chapter, and can't wait to take you along with us. I'm due October so the countdown is truly on. 'Big big love and I cannot wait to get back to sharing so much more soon.' Alice was immediately inundated with well-wishes from her celebrity pals, with Vicky Pattison writing: 'Oh wow!!! This is incredible news congratulations ♥️'. while Boris Johnson's wife Carrie commented: 'Oh I'm so so so pleased for you Alice ❤️'. Katie Piper added: 'Huge congratulations so happy for you ❤️'; as Kirsty Gallagher penned: 'Congratulations lovely news ❤️' and Frida Redknapp commented: 'Wonderful and exciting news.' Alice's joyous news comes after she concerned fans by revealing that she was rushed to A&E after a routine GP check-up. The blogger, who rose to fame with her Alice-with-the-abs persona, took to Instagram Story last week to share the health update with fans. Alice revealed she had been taking to Accident and Emergency after a mystery ailment arose during a routine appointment. Sharing a snap from her hospital bed with a cannula in her arm, Alice wrote: 'What a weird old day. Routine GP appointment turned a quick trip to A&E. The NHS is amazing and I'm always in awe of everyone who keeps it running.' Alice added with another selfie: 'Not the dramatic day I was expecting, but also makes you 10x more grateful for everything.' Sharing that she had since been discharged, Alice posted a photo of lunch of anchovies, dill and caper on toast with the caption: 'Home and grateful for health.' But on Tuesday, Alice said the 'saga' was continuing as doctors were unsure what was wrong with her - but assured fans it wasn't life-threatening. 'The saga continues today because basically they're not quite sure what's going on,' she said. 'At some point I'll obviously talk about it all, but only when I've actually got a clue what the situation is. 'Anyway, it's not crazily dramatic or life-threatening so I'm fine. I'm just obviously worried and want some answers.' Getting candid about her health last year with The Sunday Times, she reflected on her previous 'Alice-with-the-abs' persona, which saw her front her Instagram content with a muscular yet tiny frame. But Alice revealed that her weight dropped so low, her periods stopped. Despite becoming a hugely successful cookbook author and receiving publishing deals that celebrity chefs would envy, Alice has revealed that her dedication to so-called 'clean eating'; left her sleeping badly, with thinning hair and 'terrible' skin. She has revealed she was 25 years old and had just met her now-husband Paddy when she visited a fertility specialist to find out why her periods had stopped; but she was shocked by the doctor's assessment. 'She told me, "You're not eating enough and doing too much exercise, your body is in a state of stress and if you carry on you won't be able to have children." Those words changed my life,' Alice said. But on Tuesday, Alice said the 'saga' was continuing as doctors were unsure what was wrong with her - but assured fans it wasn't life-threatening Following the news she might struggle to conceive, Alice began following a programme to gain 10kg which saw her exercising less and eating more. However, as she slowly put on weight, the influencer has revealed she struggled to always stick to the programme and fell back into 'bad behaviours' from time to time. As she changed her life, so too did her career, and Alice dropped 'Clean Eating' from her Instagram title in 2017. Now Alice's page is full off encouraging images of a woman of a healthy weight encouraging others to improve their strength and fuel their bodies accordingly. She has just penned her newest book, Give Me Strength (which is also the name of her fitness app) but has revealed the process of writing it was 'painful'. Alice said: 'I bear a lot of responsibility for perpetuating a potentially damaging narrative.' She added she didn't realise what she was doing was 'wrong' but added she can now 'own her mistakes'. Looking back on her life as Clean Eating Alice, the influencer revealed she was often exhausted and in private, avoided social events that involved food or made excuses about having already eaten when she did attend dinners. Despite this, Alice would pretend differently online and sometimes posted snaps of enjoying pizza with her friends on Instagram (even though she had ordered a salad for dinner). 'That's the bit I feel guiltiest about — I was lying, being disingenuous,' she said, adding that her previous Instagram life was 'smoke and mirrors'. The influencer tracks her issues with food back to being a student at theatre school. After a year of boozing and eating junk food, as many students do, Alice claims one of her tutors told her she should be 'conscious of her body' if she ever wanted to pursue showbusiness seriously. The words clearly stung as Alice took a personal training course, began dieting, and dropped from a size 12 to a size 8 within months. She opened her Instagram account alongside her body transformation and it rapidly gained several thousands of followers. At 22, and, in her words, with 'no qualifications to write a book', she was offered 'life changing money' to author books on clean eating and weight loss. Now, as Alice embarks upon a new mission encouraging people to be healthy rather than to 'eat clean' she has suggested that some people within the 'fitspo' community are struggling with the same food issues she once had to deal with. However for Alice herself, she finds 'joy' in both life and food.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store