
VC Digest: First half of 2025: By Igor Kostyuchenok
Time flies and the first half of the year 2025 is almost over. It's time to reflect on the past 6 months and make some predictions about the next two quarters. While the world is slowly sliding into the World War III most investors try to look away and decide to invest in the most hype areas.
1. AI-Native Applications
ANI (Artificial Narrow Intelligence)
GenAI
AGI (Artificial General Intelligence)
ANI has already penetrated most of the areas of our everyday lives. Most of the children see ANI as a commodity - something they've gotten used to from the very early age. ANI is one type of artificial intelligence we've mastered and since AGI is still too far away, most investors concentrate on the GenAI startups
• What's hot: Autonomous agents, AI copilots, verticalized LLM tools (e.g., for legal, medical, customer support).
• Why now: Widespread integration of GPT-4/5, Claude, Gemini, etc. is pushing software toward automation, not just augmentation.
• Example startups: Cognosys, Rewind AI, Harvey
2. Embedded & Decentralized Finance (DeFi 2.0)
The idea of DeFi is at least 10 years old, so it took the decentralized finance idea almost a decade to slowly start becoming mainstream. Nowaydas we tokenize anything we can and finally start using stablecoins for bank rated cross border money transfer. The regulators in many jurisdictions are coming up with crypto legislations like MiCA in the EU.
• What's hot: Real-world asset (RWA) tokenization, embedded payments, DePIN (Decentralized Physical Infrastructure Networks)
• Why now: Regulatory frameworks (e.g., MiCA in the EU) are becoming clearer, enabling institutional involvement.
• Example startups: Centrifuge, Ondo Finance, Lemonade Crypto
3. Mental Health & Neurotech
The ever earlier tech adoption, the growing urbanisation, the constant rise of technology and the slow death of attraction to nature are all having effects on our mental health. Since people are still the most important money making force, their mental health is quite important and thus the health related startups will continue grown for at least the next decade.
• What's hot: AI therapy tools, neurostimulation wearables, psychedelic-assisted therapy platforms.
• Why now: Rising mental health awareness + regulatory openings for novel treatments.
• Example startups: Flow Neuroscience, MindMaze, Happify Health
4. Synthetic Biology & Precision Medicine
We are already at 70-80 years lifespan, which is unprecedented for a human body. We are already half biorobots when we reach 60 and it's only the beginning. People keep pushing the boundaries of human bodies and will soon start pushing the boundaries of human mind - biological programming is the next stage of human evolution. Whoever is not playing the game is destined to lose it.
• What's hot: Biofoundries, cell programming platforms, gene editing services (CRISPR 3.0).
• Why now: Lab automation, AI-driven drug discovery, and regulatory support in the U.S. and China.
• Example startups: Ginkgo Bioworks, Elegen, SyntheX
5. Industrial Automation & Robotics
The capitalism is all about maximizing the profit. At the same time people are expensive and hard to deal with, so e.g. for Tesla to build 20.000,00 dollars car and be able to compete with cheap workforce from China they need to automate as much production as possible. The same is true for all other industries that want to stay competitive.
• What's hot: AI-powered robotics for logistics, agriculture, and construction.
• Why now: Labor shortages + computer vision advances = tipping point for adoption.
• Example startups: Covariant, FarmWise, Dusty Robotics
What topics else are VC hot:
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