Latest news with #ADC
New York Post
16 hours ago
- New York Post
Former Arkansas police chief's prison escape offers unique challenges: experts
The former Arkansas police chief who escaped prison on Sunday may have an 'edge' compared to other escapees due to his past in law enforcement, experts say. Former Gateway Police Department Chief Grant Hardin, 56, escaped from the North Central Unit, a medium-security prison, Sunday afternoon in Calico Rock, according to the Arkansas Department of Corrections (ADC). Nicknamed the 'Devil in the Ozarks,' Hardin was serving decades in prison for murder and rape. Advertisement Eric Brown, a 24-year U.S. Army Special Forces veteran and CEO of Imperio Consulting, told Fox News Digital that a former police chief like Hardin 'has a working knowledge of law enforcement procedures, patrol routines and how search operations are typically structured.' 'That gives him an initial edge. He knows how law enforcement thinks,' Brown told Fox News Digital. Law enforcement officials 'will likely lean on geo-fencing, license plate readers, and known associate surveillance,' Brown added. 'If he's on foot, dogs, drones and thermal imaging tighten the noose,' Brown said. Advertisement 'Establishing a perimeter means thinking like the fugitive, assessing terrain, choke points and logical escape routes. Officials are watching for movement: stolen vehicles, property break-ins, supply thefts, even unusual local chatter. The key is pattern disruption.' It took less than 30 minutes for prison officials to notice that Hardin had disappeared from prison. 4 Former Gateway Police Department Chief Grant Hardin, 56, in Arkansas, has escaped from prison, and may have an 'edge' compared to other escapees. Stone County Sheriff's Office Photos that the Stone County Sheriff's Office posted to social media show Hardin wearing an ADC-style uniform during his escape through a sally port, though ADC communications director Rand Champion said the uniform he was wearing was not official. Advertisement Angelo Brown, Ph.D., assistant professor of criminology at Arkansas State University, similarly told Fox News Digital that law enforcement officials will likely be using drones and infrared camera technology to search heavily wooded areas in Stone County, where Hardin escaped, which is located just east of the Ozark Mountains. Hardin has ties to Garfield, Eureka Springs, Holiday Island and Huntsville, according to the FBI. Angelo Brown said Hardin's police chief experience means he likely has ties to law enforcement officials who may help him, and he will avoid making 'simple mistakes that a lot of people on the run make, like going to relatives' homes, using… cellphones, credit cards, things like that.' 4 Experts say the ex-police chief may have an 'edge' compared to other escapees due to his past in law enforcement. AP Advertisement 'Getting away, that's still very unlikely. Especially now, even if it is state-level corruption… the federal government's involved in this search and investigation, the state police, various agencies are working on this. So, I think law enforcement is doing everything they can to keep people safe,' he said, noting, however, that it is impossible to 'mitigate the risk completely' with a fugitive on the run. Champion said during a Wednesday news conference that authorities are fairly confident in the route they believe Hardin took when he escaped and his current location. 'Based on the information that we have and the experience of our teams, they feel fairly confident that he is still fairly close to this region,' Champion said, noting that 'all it takes is one vehicle' for Hardin to use to travel elsewhere, though officials have established a perimeter around Stone County. 4 Law enforcement officials have already said they will rely on 'geo-fencing, license plate readers, and known associate surveillance' in order to track down Hardin. AP 'As of this time, they are still very confident that he is in the area,' Champion said. Champion said the public should assume Hardin is 'a very dangerous individual,' and there is a risk he may commit more crimes while he is on the run. Hardin was sentenced to 30 years for murder plus additional time for rape. He pleaded guilty to the 2017 murder of James Appleton, 59, a city water employee who was found shot in the face inside his work truck, KNWA reported. Advertisement 4 KNWA reported that Hardin pleaded guilty to the 2017 murder of James Appleton, 59, a city water employee who was found shot in the face inside his work truck. AP While Hardin was being booked into the state prison around that time, officials submitted his DNA sample into a database. His DNA linked him to the rape cold case of a teacher in 1997, the outlet reported. Hardin ended up pleading guilty in that case in 2019, according to KNWA. Advertisement The former police chief's escape came two days after 10 prisoners escaped a correctional facility in New Orleans, eight of whom have since been recaptured while two remain at large. Hardin is described as a 6-foot White male, weighing approximately 259 pounds. The FBI is offering a $20,000 reward for information leading to his recapture and is asking tipsters to call 1-800-CALL-FBI with any information concerning the escapee.
Business Recorder
16 hours ago
- Politics
- Business Recorder
CM condemns terrorist attack in Sorab
LAHORE: Chief Minister Punjab Maryam Nawaz Sharif has strongly condemned a terrorist attack in Sorab, under the banner of Fitna-ul-Hindustan. She paid tribute to the immortal sacrifices of ADC Revenue Hidayat Buledi, who was martyred in the defence of motherland, and said, 'Hidayat Buledi created an unforgettable chapter of fulfilling her duty by sacrificing her life.' She added, 'This attack by pro-India terrorists is highly detestable and intolerable.' Madam Chief Minister offered condolences and extended her heartfelt sympathies to the bereaved family. She said,' By bringing the enemies to justice, they are sending a message that the brave sons of Pakistan will never back down.'
Yahoo
17 hours ago
- Business
- Yahoo
ASCO25: MSD's ADC candidate achieves 56.3% ORR in lymphoma trial
Zilovertamab vedotin, an antibody drug conjugate (ADC) developed by Merck & Co (MSD) to treat diffuse large B-cell lymphoma (DLBCL), has demonstrated promise in a Phase II/III study, as the company looks to catch up with ADC Therapeutics' marketed drug. When administered in combination with standard of care, rituximab and gemcitabine-oxaliplatin (R-GemOx), zilovertamab vedotin achieved an objective response rate (ORR) of 56.3%. At this pre-planned analysis, there were eight complete responses (CR) and one partial response (PR). The median follow-up in this 1.75mg/kg cohort was 9.9 months. ADC Therapeutics' Zynlonta (loncastuximab tesirine-lpyl) is the only ADC approved by the US Food and Drug Administration (FDA) for DLBCL. In the Phase II LOTIS-2 trial, Zynlonta – administered as a monotherapy – produced an ORR of 48.3%. MSD published a snapshot of the results from the ongoing waveLINE-003 study (NCT05139017) ahead of a presentation on 30 May at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, held from 30 May to 3 June in Chicago, Illinois. The positive efficacy results came despite a patient dying in the highest dose cohort due to treatment-related sepsis. MSD's randomised, multicenter, open-label, dose confirmation and expansion waveLINE-003 study is investigating the zilovertamab vedotin triplet combination therapy as a treatment for relapsed or refractory DLBCL. Patients with blood cancer who have already tried one more line of therapy are eligible for the treatment, administered intravenously every three weeks up to six cycles at three different doses. MSD disclosed that treatment-related adverse events (TRAEs) were reported in 98% of patients (n=40), with those at Grade 3 or higher occurring in 63% of patients. At the highest dose of 2.0mg/kg, three patients discontinued treatment due to adverse events, one patient withdrew due to a physician's decision, and one patient died after discontinuing treatment due to related sepsis. At this dose, three patients completed the treatment, compared to the eight from the 1.75mg/kg dose. MSD said that based on safety and efficacy data, the recommended Phase II dose is 1.75g/kg. Zilovertamab vedotin is an ADC that targets ROR1, which is a transmembrane protein overexpressed in multiple haematologic malignancies. The ADC market was valued at $8.6bn in 2023, with it forecast to exceed $45bn by 2030, according to analysis by GlobalData. MSD's data arrived on the same day that Germany-based Merck KGaA, also presenting at ASCO, revealed positive Phase I results for its ADC candidate for metastatic colorectal cancer treatment. GlobalData is the parent company of Pharmaceutical Technology. MSD Research Laboratories' oncology clinical research vice president Dr Gregory Lubiniecki said: 'In the Phase II portion of the waveLINE-003 trial, the 1.75mg/kg dose of zilovertamab vedotin with rituximab, gemcitabine and oxaliplatin demonstrated a promising response rate, complete response rate and manageable safety profile in combination with standard of care. 'The Phase III portion of this trial is already enrolling, and as we continue to advance our research of this investigational ROR1-directed ADC, these promising results amplify our belief in the potential of zilovertamab vedotin to treat multiple hematologic malignancies.' Zilovertamab vedotin is also currently being evaluated in patients with previously untreated DLBCL in the Phase III waveLINE-010 study (NCT06717347) and the Phase II waveLINE-007 study (NCT05406401). ADC content on Pharmaceutical Technology (Or Clinical Trials Arena) is supported by Syngene. Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content. "ASCO25: MSD's ADC candidate achieves 56.3% ORR in lymphoma trial" was originally created and published by Clinical Trials Arena, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Hindustan Times
a day ago
- Hindustan Times
Op Shield: Punjab all set for mock drills today
With a statewide civil defence mock drill scheduled for Saturday, Punjab's special director general of police (DGP) Sanjeev Kalra said large-scale emergency situations will be simulated in all districts, starting 6 pm. Kalra said, 'The mock drill is a part of Operation Shield and is being conducted in all districts of states on the Western border.' Additional deputy commissioner (ADC), urban development, Amritsar, Amit Sareen, said, 'A blackout drill will be conducted in the district from 8 pm to 8.30 pm. Inner areas of the district will be exempted.' In Ferozepur, deputy commissioner Deepshikha Sharma said sirens will be sounded in the city and cantonment areas between 6 pm and 6.30 pm, followed by a voluntary blackout from 9 pm to 9.30 pm in the same zones. In Fazilka, DC Amarpreet Kaur Sandhu said the drill will be carried out from 6 pm to 7 pm. ADC Sareen appealed to residents to switch off all exterior lights, including automatic lights on cameras and lights running on inverters, as soon as the sirens go off at 8 pm. 'If you need to keep lights on inside the house, make sure to use heavy curtains or similar arrangements so that light does not escape outside through windows. During the blackout, the safest place is the ground floor or basement. So, practice sitting in the middle of a room on the ground floor. Try to sit in a place where there is no glass window nearby,' said Sareen. He added, 'Do not go to the rooftop, street, or any open space during the blackout. Those who are driving on the road at that time should turn off their vehicle's lights — whether it's a car, scooter, or motorcycle — and pull over to the side of the road'. Authorities of all three districts assured residents that it is a routine preparedness exercise aimed at enhancing public awareness and readiness in case of emergencies and said that there is no reason to panic.
Express Tribune
a day ago
- Politics
- Express Tribune
Govt official martyred in Surab terror siege
During the attack, Additional Deputy Commissioner (Revenue) Hidayat Baloch Buledi stood his ground to protect others, ultimately sacrificing his life in the line of duty. PHOTO: Listen to article A senior district administration official was martyred after heavily armed terrorists, belonging to Fitna al Hindustan, launched a coordinated attack on a bank and the residences of government officers in Surab, Balochistan, officials said on Friday. Shahid Rind, a spokesperson for the provincial government, and Hamza Shafqaat, the commissioner of Quetta, confirmed that Hidayatullah Buledi, the additional deputy commissioner (ADC) of Surab district, was martyred while fighting the terrorists. Officials and witnesses stated that 20 to 30 terrorists of Fitna al Hindustan entered the market of Surab city on motorcycles in the evening and targeted soft civilian areas such as banks and markets. Ordinary Baloch women and children were also attacked in the market, they added. "Heavily armed militants launched a coordinated assault on a bank and the residences of senior government officers in Surab Bazaar," spokesperson Rind said in a statement. "The attackers looted the bank and set fire to several official residences," he added. During the attack, Rind said, ADC Revenue Hidayatullah Baloch Buledi was martyred while resisting the terrorists. He said that women and children were present in the ADC's residence at the time of the assault. However, despite the presence of his family members, Buledi stood firm against the attackers. He paid rich tribute to Buledi, saying that the ADC fought valiantly to protect Baloch children and women from the terrorists and ultimately laid down his life in the line of duty. "He has set a new example of bravery by sacrificing his life for the nation," Rind said. "Deputy Commissioner Surab compound was attacked. Unfortunately, Additional Deputy Commissioner Mr Hidayat Buledi embraced martyrdom. The attack was carried out by Fitna al Hindustan. Mr Buledi was a LUMS alumnus. Levies and other law enforcement agencies valiantly fought them back," Shafqaat tweeted. According to Rind, the attack was not a random act of violence but part of a calculated attempt to destabilise the province. "This operation was carried out by Indian-backed proxies. It is a clear effort to challenge the state's authority and spread fear," he asserted. "By targeting Baloch areas and Baloch women and children, Fitna al Hindustan has once again proven that these Indian-sponsored terrorists have no connection with Balochistan and Baloch traditions," the spokesperson stated. "Indian proxies have taken action on their orders." Security forces, including the Frontier Corps (FC), police and Levies, promptly reached the spot and launched a joint clearance operation. "Search and clearance operations are ongoing, and the enemies of peace will be brought to justice," the spokesperson said. Prime Minister Shehbaz Sharif strongly condemned the cowardly attack on innocent citizens, officers of the administration, and a bank by terrorists in Surab. He paid tribute to ADC Hidayatullah Buledi for embracing martyrdom while defending his area from terrorists. The prime minister expressed sympathy with the bereaved family members of the martyr. "ADC Hidayatullah Buledi set an example of bravery while fighting against the terrorists. The sympathies of the whole nation are with the family of the martyred," he said in a statement. Shehbaz said that terrorists had targeted innocent and unarmed citizens, including children and women. "The attack by cowardly terrorists on the citizens and their properties is openly and evidently reflective of their animosity towards the people and the progress of Balochistan," he said. "The war against terrorists will continue until their complete elimination from the country. The armed forces of Pakistan are working day and night to exterminate the proxies who are spreading terrorism in Pakistan under the patronage of India," the prime minister stated. "The whole nation stands shoulder to shoulder with the armed forces in completely wiping out the elements involved in terrorism with the abetment of India." He directed that the persons involved in the incident be identified and given exemplary punishment. (WITH INPUT FROM APP)
