Latest news with #ADDF
Yahoo
a day ago
- Health
- Yahoo
Next Era of Alzheimer's Care Will be Defined by Precision Prevention
New U.S. study reflects growing role of lifestyle interventions, further highlighting need to study lifestyle and drugs in combination NEW YORK, July 28, 2025 /PRNewswire/ -- Results from the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) released today strengthen the case for precision prevention, a strategy set to revolutionize Alzheimer's care by combining lifestyle changes with targeted therapeutics based on individual risk factors. "The future lies in precision prevention," said Dr. Howard Fillit, Co-Founder and Chief Science Officer of the Alzheimer's Drug Discovery Foundation. "We have seen this model succeed in cancer and heart disease, and with a growing body of evidence showing neither lifestyle nor drugs can stop Alzheimer's alone, now is the time to double down on studying the two in combination, which will lay the path for precision medicine." The ADDF is driving a new era of clinical trials that look at lifestyle and therapeutic interventions in tandem, including Dr. Miia Kivipelto's MET-FINGER study, which has created a blueprint for combination therapy studies going forward. The U.S. POINTER study, released during the Alzheimer's Association International Conference (AAIC) and published simultaneously in the Journal of the American Medical Association (JAMA), found multidomain lifestyle interventions supported cognitive health in aging populations. This builds on previous findings from Dr. Miia Kivipelto's original FINGER trial, the first to show the critical role of lifestyle changes in preventing dementia. U.S. POINTER showed its structured high-intensity lifestyle interventions benefitted participants regardless of their APOE4 carrier status, a genetic risk factor for Alzheimer's disease. This contrasts findings from the FINGER study, which showed benefit especially in carriers of APOE4, and further highlights the wide-reaching impacts of lifestyle changes. "The U.S. POINTER results validate the findings of the FINGER study in a more diverse U.S. population," said Dr. Kivipelto. "This is yet another proof point that lifestyle can have a tremendous impact on the brain. By developing personalized scientific approaches to match each patient's unique biomarker profile with a combined drug and prevention plan, we are redefining how we treat and prevent Alzheimer's." About The Alzheimer's Drug Discovery Foundation (ADDF)Founded in 1998 by Leonard A. and Ronald S. Lauder, the Alzheimer's Drug Discovery Foundation is dedicated to rapidly accelerating the development of drugs to prevent, treat, and cure Alzheimer's disease. The ADDF is the only public charity solely focused on funding the development of drugs for Alzheimer's, employing a venture philanthropy model to support research in academia and the biotech industry. The ADDF's leadership and contributions to the field have played a pivotal role in bringing the first Alzheimer's PET scan (Amyvid®) and blood test (PrecivityAD®) to market, as well as fueling the current robust and diverse drug pipeline. Through the generosity of its donors, the ADDF has awarded more than $370 million to fund 765 Alzheimer's drug development, biomarker, and prevention programs in 21 countries. To learn more, please visit: View original content to download multimedia: SOURCE Alzheimer's Drug Discovery Foundation Inicia sesión para acceder a tu cartera de valores
Yahoo
10-07-2025
- Health
- Yahoo
The Best Foods For Your Brain Health After Age 40
Like most people over 40, I've noticed that my memory can sometimes be a little sluggish, and my mind doesn't always seem to be as quick and sharp as it was when I was, say, in my 20s. This cerebral slowdown is even more likely to be true for those of us who have other medical issues, particularly conditions like long COVID or menopause that can be notorious for causing 'brain fog.' I've mostly chalked this up to an inevitable part of getting older. But I never really stopped to consider that what I'm putting in my fridge or on my dinner plate might be partly to blame. Our brains, like many other parts of our bodies, undergo significant changes as we age. 'As we age, our brain naturally goes through changes,' said Dr. Alexander Zubkov, a board-certified neurologist and part of the Scientific Advisory Board of 1MD Nutrition. 'Blood flow to the brain tends to slow down, and there's often a gradual decline in neurotransmitter levels, especially those related to memory, mood, and focus — like dopamine, acetylcholine and serotonin.' Zubkov says oxidative stress and chronic low-grade inflammation, both of which are known contributors to cognitive decline, also build up over time. On the upside, age can also bring some positive changes to our cognitive abilities. 'As we get older, learning and memory tend to become more difficult,' said Yuko Hara, the director of aging and Alzheimer's prevention at the Alzheimer's Drug Discovery Foundation (ADDF). 'However, not everything goes downhill with aging. Vocabulary increases with age, and so does wisdom. Crystallized intelligence (the total knowledge gained over time) increases with age, allowing older people to reflect on and examine situations more effectively and to make informed decisions.' Our diet affects virtually every part of our body, including our brain. 'A healthy diet is important for brain function and cognitive health,' Hara said. She says you can maximize the positive ways a healthy diet influences brain health by incorporating foods with antioxidant and anti-inflammatory properties into your diet. Zubkov says a nutrient-dense diet 'provides the building blocks for neurotransmitters, supports cellular repair, reduces inflammation, and protects against oxidative damage.' Experts have recommendations for foods you might want to include on your grocery list to help support your brain health. Registered dietitian nutritionist (RDN) Lauren Manaker cites these foods that are known for their brain-boosting benefits: True tea — which, unlike herbal tea, is derived from the Camellia sinensis plant — includes varieties such as green tea, black tea, white tea and oolong tea. Manaker says this kind of tea is a natural source of antioxidants like catechins and flavonoids, which help protect brain cells from oxidative stress and inflammation. In addition, she notes, true tea contains L-theanine — an amino acid that helps you relax without feeling drowsy — and caffeine, which enhances alertness and cognitive performance. 'Together, these elements may support focus, memory, and overall mental clarity.' Studies have shown that frequent tea consumption, particularly drinking green tea, can have a positive cognitive effect on older people. Manaker says it's fitting that walnuts look somewhat like tiny brains — take it as a hint from Mother Nature that this tree nut is good for our brain. 'Walnuts are often hailed as a superfood for brain health due to the nutrients they naturally contain, including antioxidants and magnesium,' Manaker said. Walnuts are the only tree nut that is an excellent source of ALA omega-3 fatty acids, Manaker said, adding that data shows that higher levels of ALA in the blood were linked to better energy usage in brain regions typically affected in Alzheimer's Disease (AD). These links were even stronger in individuals carrying certain genetic markers for AD risk. Mushrooms are increasingly recognized as a superfood for brain health, Manaker said, thanks to their rich nutritional profile and unique compounds. This includes ergothioneine, a powerful antioxidant and anti-inflammatory agent. 'Ergothioneine helps protect brain cells from oxidative stress and inflammation, both of which are linked to cognitive decline and neurodegenerative diseases,' Manaker said. 'Additionally, mushrooms contain essential nutrients like B vitamins and amino acids, which support overall brain function and energy metabolism.' Other foods that Zubkov recommends for supporting brain health include fatty fish like salmon and sardines, which are rich in omega-3 DHA, considered essential for brain cell structure; blueberries, because they're packed with anthocyanins, which fight oxidative stress and improve memory; and leafy greens like spinach and kale, which are high in folate, vitamin K, and lutein, all linked to slower cognitive decline. Some foods, on the other hand, may not be so beneficial for your brain health — and may not be great for your health overall — so you may want to limit their role in your daily diet. Dr. Joshua Helman, a Harvard-trained physician specializing in reversing and preventing cognitive decline, easily identifies one category of foods of concern. 'Highly processed foods, especially those high in added sugars, refined grains, trans fats, and omega-6–heavy oils, promote inflammation and insulin resistance in the brain.' Helman notes this connection between unhealthy processed foods and cognitive health has led some researchers to refer to Alzheimer's as 'type 3 diabetes.' 'I also advise people to be cautious with foods high in sodium, nitrates or artificial additives,' Helman said. 'These can contribute to vascular damage, which is a major driver of cognitive impairment. Many people are surprised to learn that even moderate exposure to pesticides, plastics, and heavy metals in food and water can interfere with memory and focus over time.' Nutritionists Rank The Best (And Worst) Packaged Deli Meats For Your Health Doctors Who Specialize In Women's Health Share The 9 Things They Would Never, Ever Do 11 Foods Experts Say Can Boost Your Brain Health And Help Ward Off Dementia
Yahoo
07-07-2025
- Health
- Yahoo
The Best Foods For Your Brain Health After Age 40
Like most people over 40, I've noticed that my memory can sometimes be a little sluggish, and my mind doesn't always seem to be as quick and sharp as it was when I was, say, in my 20s. This cerebral slowdown is even more likely to be true for those of us who have other medical issues, particularly conditions like long COVID or menopause that can be notorious for causing 'brain fog.' I've mostly chalked this up to an inevitable part of getting older. But I never really stopped to consider that what I'm putting in my fridge or on my dinner plate might be partly to blame. Our brains, like many other parts of our bodies, undergo significant changes as we age. 'As we age, our brain naturally goes through changes,' said Dr. Alexander Zubkov, a board-certified neurologist and part of the Scientific Advisory Board of 1MD Nutrition. 'Blood flow to the brain tends to slow down, and there's often a gradual decline in neurotransmitter levels, especially those related to memory, mood, and focus — like dopamine, acetylcholine and serotonin.' Zubkov says oxidative stress and chronic low-grade inflammation, both of which are known contributors to cognitive decline, also build up over time. On the upside, age can also bring some positive changes to our cognitive abilities. 'As we get older, learning and memory tend to become more difficult,' said Yuko Hara, the director of aging and Alzheimer's prevention at the Alzheimer's Drug Discovery Foundation (ADDF). 'However, not everything goes downhill with aging. Vocabulary increases with age, and so does wisdom. Crystallized intelligence (the total knowledge gained over time) increases with age, allowing older people to reflect on and examine situations more effectively and to make informed decisions.' Our diet affects virtually every part of our body, including our brain. 'A healthy diet is important for brain function and cognitive health,' Hara said. She says you can maximize the positive ways a healthy diet influences brain health by incorporating foods with antioxidant and anti-inflammatory properties into your diet. Zubkov says a nutrient-dense diet 'provides the building blocks for neurotransmitters, supports cellular repair, reduces inflammation, and protects against oxidative damage.' Experts have recommendations for foods you might want to include on your grocery list to help support your brain health. Registered dietitian nutritionist (RDN) Lauren Manaker cites these foods that are known for their brain-boosting benefits: True tea — which, unlike herbal tea, is derived from the Camellia sinensis plant — includes varieties such as green tea, black tea, white tea and oolong tea. Manaker says this kind of tea is a natural source of antioxidants like catechins and flavonoids, which help protect brain cells from oxidative stress and inflammation. In addition, she notes, true tea contains L-theanine — an amino acid that helps you relax without feeling drowsy — and caffeine, which enhances alertness and cognitive performance. 'Together, these elements may support focus, memory, and overall mental clarity.' Studies have shown that frequent tea consumption, particularly drinking green tea, can have a positive cognitive effect on older people. Manaker says it's fitting that walnuts look somewhat like tiny brains — take it as a hint from Mother Nature that this tree nut is good for our brain. 'Walnuts are often hailed as a superfood for brain health due to the nutrients they naturally contain, including antioxidants and magnesium,' Manaker said. Walnuts are the only tree nut that is an excellent source of ALA omega-3 fatty acids, Manaker said, adding that data shows that higher levels of ALA in the blood were linked to better energy usage in brain regions typically affected in Alzheimer's Disease (AD). These links were even stronger in individuals carrying certain genetic markers for AD risk. Mushrooms are increasingly recognized as a superfood for brain health, Manaker said, thanks to their rich nutritional profile and unique compounds. This includes ergothioneine, a powerful antioxidant and anti-inflammatory agent. 'Ergothioneine helps protect brain cells from oxidative stress and inflammation, both of which are linked to cognitive decline and neurodegenerative diseases,' Manaker said. 'Additionally, mushrooms contain essential nutrients like B vitamins and amino acids, which support overall brain function and energy metabolism.' Other foods that Zubkov recommends for supporting brain health include fatty fish like salmon and sardines, which are rich in omega-3 DHA, considered essential for brain cell structure; blueberries, because they're packed with anthocyanins, which fight oxidative stress and improve memory; and leafy greens like spinach and kale, which are high in folate, vitamin K, and lutein, all linked to slower cognitive decline. Some foods, on the other hand, may not be so beneficial for your brain health — and may not be great for your health overall — so you may want to limit their role in your daily diet. Dr. Joshua Helman, a Harvard-trained physician specializing in reversing and preventing cognitive decline, easily identifies one category of foods of concern. 'Highly processed foods, especially those high in added sugars, refined grains, trans fats, and omega-6–heavy oils, promote inflammation and insulin resistance in the brain.' Helman notes this connection between unhealthy processed foods and cognitive health has led some researchers to refer to Alzheimer's as 'type 3 diabetes.' 'I also advise people to be cautious with foods high in sodium, nitrates or artificial additives,' Helman said. 'These can contribute to vascular damage, which is a major driver of cognitive impairment. Many people are surprised to learn that even moderate exposure to pesticides, plastics, and heavy metals in food and water can interfere with memory and focus over time.' Nutritionists Rank The Best (And Worst) Packaged Deli Meats For Your Health Doctors Who Specialize In Women's Health Share The 9 Things They Would Never, Ever Do 11 Foods Experts Say Can Boost Your Brain Health And Help Ward Off Dementia
Yahoo
07-07-2025
- Health
- Yahoo
The Best Foods For Your Brain Health After Age 40
Like most people over 40, I've noticed that my memory can sometimes be a little sluggish, and my mind doesn't always seem to be as quick and sharp as it was when I was, say, in my 20s. This cerebral slowdown is even more likely to be true for those of us who have other medical issues, particularly conditions like long COVID or menopause that can be notorious for causing 'brain fog.' I've mostly chalked this up to an inevitable part of getting older. But I never really stopped to consider that what I'm putting in my fridge or on my dinner plate might be partly to blame. Our brains, like many other parts of our bodies, undergo significant changes as we age. 'As we age, our brain naturally goes through changes,' said Dr. Alexander Zubkov, a board-certified neurologist and part of the Scientific Advisory Board of 1MD Nutrition. 'Blood flow to the brain tends to slow down, and there's often a gradual decline in neurotransmitter levels, especially those related to memory, mood, and focus — like dopamine, acetylcholine and serotonin.' Zubkov says oxidative stress and chronic low-grade inflammation, both of which are known contributors to cognitive decline, also build up over time. On the upside, age can also bring some positive changes to our cognitive abilities. 'As we get older, learning and memory tend to become more difficult,' said Yuko Hara, the director of aging and Alzheimer's prevention at the Alzheimer's Drug Discovery Foundation (ADDF). 'However, not everything goes downhill with aging. Vocabulary increases with age, and so does wisdom. Crystallized intelligence (the total knowledge gained over time) increases with age, allowing older people to reflect on and examine situations more effectively and to make informed decisions.' Our diet affects virtually every part of our body, including our brain. 'A healthy diet is important for brain function and cognitive health,' Hara said. She says you can maximize the positive ways a healthy diet influences brain health by incorporating foods with antioxidant and anti-inflammatory properties into your diet. Zubkov says a nutrient-dense diet 'provides the building blocks for neurotransmitters, supports cellular repair, reduces inflammation, and protects against oxidative damage.' Experts have recommendations for foods you might want to include on your grocery list to help support your brain health. Registered dietitian nutritionist (RDN) Lauren Manaker cites these foods that are known for their brain-boosting benefits: True tea — which, unlike herbal tea, is derived from the Camellia sinensis plant — includes varieties such as green tea, black tea, white tea and oolong tea. Manaker says this kind of tea is a natural source of antioxidants like catechins and flavonoids, which help protect brain cells from oxidative stress and inflammation. In addition, she notes, true tea contains L-theanine — an amino acid that helps you relax without feeling drowsy — and caffeine, which enhances alertness and cognitive performance. 'Together, these elements may support focus, memory, and overall mental clarity.' Studies have shown that frequent tea consumption, particularly drinking green tea, can have a positive cognitive effect on older people. Manaker says it's fitting that walnuts look somewhat like tiny brains — take it as a hint from Mother Nature that this tree nut is good for our brain. 'Walnuts are often hailed as a superfood for brain health due to the nutrients they naturally contain, including antioxidants and magnesium,' Manaker said. Walnuts are the only tree nut that is an excellent source of ALA omega-3 fatty acids, Manaker said, adding that data shows that higher levels of ALA in the blood were linked to better energy usage in brain regions typically affected in Alzheimer's Disease (AD). These links were even stronger in individuals carrying certain genetic markers for AD risk. Mushrooms are increasingly recognized as a superfood for brain health, Manaker said, thanks to their rich nutritional profile and unique compounds. This includes ergothioneine, a powerful antioxidant and anti-inflammatory agent. 'Ergothioneine helps protect brain cells from oxidative stress and inflammation, both of which are linked to cognitive decline and neurodegenerative diseases,' Manaker said. 'Additionally, mushrooms contain essential nutrients like B vitamins and amino acids, which support overall brain function and energy metabolism.' Other foods that Zubkov recommends for supporting brain health include fatty fish like salmon and sardines, which are rich in omega-3 DHA, considered essential for brain cell structure; blueberries, because they're packed with anthocyanins, which fight oxidative stress and improve memory; and leafy greens like spinach and kale, which are high in folate, vitamin K, and lutein, all linked to slower cognitive decline. Some foods, on the other hand, may not be so beneficial for your brain health — and may not be great for your health overall — so you may want to limit their role in your daily diet. Dr. Joshua Helman, a Harvard-trained physician specializing in reversing and preventing cognitive decline, easily identifies one category of foods of concern. 'Highly processed foods, especially those high in added sugars, refined grains, trans fats, and omega-6–heavy oils, promote inflammation and insulin resistance in the brain.' Helman notes this connection between unhealthy processed foods and cognitive health has led some researchers to refer to Alzheimer's as 'type 3 diabetes.' 'I also advise people to be cautious with foods high in sodium, nitrates or artificial additives,' Helman said. 'These can contribute to vascular damage, which is a major driver of cognitive impairment. Many people are surprised to learn that even moderate exposure to pesticides, plastics, and heavy metals in food and water can interfere with memory and focus over time.' Nutritionists Rank The Best (And Worst) Packaged Deli Meats For Your Health Doctors Who Specialize In Women's Health Share The 9 Things They Would Never, Ever Do 11 Foods Experts Say Can Boost Your Brain Health And Help Ward Off Dementia
Yahoo
16-06-2025
- Business
- Yahoo
Leonard Lauder, former CEO of beauty empire Estée Lauder, dies at 92
Leonard Lauder, CEO emeritus of the multibillion-dollar Estée Lauder beauty empire founded by his parents and named after his mother, has died. He was 92. The Estée Lauder Companies Inc. announced his death Sunday 'with deep sadness' and said Lauder, the eldest son of Estée and Joseph Lauder, had died at home 'surrounded by family.' The New York City native graduated from the Bronx High School of Science and studied business at Columbia University, among other prominent schools, the company said. After formally joining the family business in 1958, he expanded the single brand 'handful of products' into a global beauty empire during six decades at the company. He served as president from 1972-1995, as CEO from 1982-1999, and as chairman from 1995 through June 2009, and was 'deeply involved' in company acquisition strategy until his death. The 'true visionary, fearless leader, and cherished friend to so many' was 'the beacon of our company and the north star of an entire industry,' the company said. 'Throughout his life, my father worked tirelessly to build and transform the beauty industry, pioneering many of the innovations, trends, and best practices that are foundational to the industry today,' said William Lauder, his son and the current chairman of Estée Lauder's board of directors. 'Above all, my father was a man who practiced kindness with everyone he met. His impact was enormous.' Lauder was known as much for his philanthropy as for his business acumen, and championed health causes such as Alzheimer's disease and breast cancer. He pledged $1 billion in Cubist works to the Metropolitan Museum of Art, donated $125 million to the University of Pennsylvania School of Nursing and gave $10 million to Hunter College's nursing school in New York City. Lauder helped his late wife Evelyn Lauder launch the famous Pink Ribbon campaign, an awareness initiative of the Breast Cancer Research Foundation, which she founded in 1993. In 1998, Lauder and his brother Ronald Lauder co-founded the Alzheimer's Drug Discovery Foundation, which 'reshaped the Alzheimer's research landscape,' ADDF co-founder and chief science officer Dr. Howard Fillit said, adding that 'Lauder's legacy is woven into the very fabric of the ADDF and the progress it has driven toward understanding, treating, and ultimately curing Alzheimer's.' ___________
