Latest news with #ATH
The Australian
28-07-2025
- Health
- The Australian
Alterity reports positive trial results
Special Report: Alterity Therapeutics has reported positive topline results from its open-label phase II clinical trial of lead drug ATH434, offering encouraging signs for the treatment of multiple system atrophy (MSA). Alterity reports positive topline data from open-label phase II trial of ATH434 in multiple system atrophy ATH434 demonstrated clinical benefit on Unified MSA Rating Scale and global measures of neurological symptoms Neuroimaging biomarkers showed target engagement and slowed brain atrophy with drug well tolerated and having a favourable safety profile The study, conducted in a patient population with more advanced disease than in the Alterity Therapeutics' (ASX:ATH) double-blind phase II trial, showed ATH434 was well tolerated and provided measurable clinical benefits, including stabilisation of neurological symptoms and slowed brain atrophy. Over the 12-month treatment period, results indicated patients treated with ATH434 showed ~50% less disease progression on the Modified Unified MSA Rating Scale (UMSARS I) compared to historical controls. Notably, 30% of participants reported stable or improved symptoms – an uncommon result in this advanced patient group. In further encouraging results, 30% of participants also stabilised or improved on the Patient Global Impression of Change (PGIC) scale, which asks the patient to evaluate their overall neurological symptoms as compared to immediately before starting therapy. ATH434 also helped stabilise symptoms of orthostatic hypotension, a common and serious drop in blood pressure when standing, in study participants. Notably, the overall results suggest that ATH434 was just as effective in this more advanced group of MSA patients as it was in earlier-stage patients from the previous phase II double-blinded trial. Neuroimaging data provided further support, showing a slowing of brain volume loss in MSA-affected regions and reduced iron accumulation – both consistent with the proposed mechanism of ATH434, which targets excess brain iron thought to drive MSA pathology. Novel approach could provide much-needed therapy Alterity's lead indication, MSA, is a rare and aggressive parkinsonian disorder with up to 50,000 patients in the US, driven by excess iron and aggregation of a protein called alpha-synuclein in the central nervous system. ATH434 takes a novel approach to MSA by addressing iron imbalance and protein aggregation, offering what could be the first disease-modifying therapy. The drug has been granted both fast track and orphan drug designations by the US Food and Drug Administration, as well as orphan drug status in the EU. Backed by promising phase II and open-label phase II results, Alterity is chasing a market opportunity exceeding US$1.1 billion with ATH434. About the open-label study The phase II open label trial (ATH-434-202) was an open-label study in advanced MSA. The trial enrolled participants diagnosed with MSA using a multimodal approach (clinical, neuroimaging, fluid biomarkers), who were treated with oral ATH434 75mg twice daily for 12 months. The study assessed the safety and efficacy of ATH434 treatment on clinical and biomarker endpoints. The pre-specified key clinical endpoints included the modified UMSARS I, the clinical global impression of change, and the patient global impression of change. Enrolled participants were more advanced than those in the double-blind ATH434-201 phase II trial based on baseline variables including duration of motor symptoms, UMSARS I score, frequency of severe orthostatic hypotension, and plasma NFL levels. Based on the observed clinical and neuroimaging data, ATH434 improved overall neurological symptoms and slowed disease progression compared to historical data. 'Strongly support advancing our ATH434 program' CEO Dr David Stamler said he was very encouraged by the positive results from the ATH434-202 trial, as they reinforce the robust efficacy we observed in its phase II study. 'The data from our phase II studies are consistent and strongly support advancing our ATH434 program in MSA,' he said. 'With the favourable clinical and biomarker outcomes we have seen, we continue to believe that ATH434 has the potential to slow the progression of this devastating disease. 'We are committed to bringing this new therapy to patients as soon as possible.' The trial's lead investigator, professor Daniel Claassen from Vanderbilt University Medical Centre said the results were very helpful in establishing the clinical response to therapy. He said the consistent changes in UMSARS, along with quantitative measures in imaging, support the findings noted in the phase II trial. 'Currently, there are no disease modifying medications for the treatment of MSA, and these data encourage the continued development of ATH434 to treat this disease,' he said. 'We are indebted to the study participants and their families who contributed to this study.' This article was developed in collaboration with Alterity Therapeutics, a Stockhead advertiser at the time of publishing. This article does not constitute financial product advice. You should consider obtaining independent advice before making any financial decisions.
NBC Sports
20-07-2025
- Sport
- NBC Sports
Fantasy Baseball Waiver Wire: Zebby Matthews returns, Caleb Durbin remains hot
Welcome to Waiver Wire Watch, where I review my favorite waiver wire adds and drops for each week of the MLB season. The premise is pretty straightforward. I'll try to give you some recommended adds each week based on recent production or role changes. When I list a player, I'll list the category where I think he'll be helpful or the quick reason he's listed. I hope it will help you determine if the player is a fit for what your team needs. For a player to qualify for this list, he needs to be UNDER 40% rostered in Yahoo! formats. I understand you may say, 'These players aren't available in my league,' and I can't help you there. These players are available in over 60% of leagues and some in 98% of leagues, so they're available in many places, and that can hopefully satisfy readers who play in all league types. Matthew Pouliot, THERE WILL BE A FAIR AMOUNT OF SIMILARITY BETWEEN THIS WEEK AND LAST WEEK SINCE WE'VE ONLY HAD TWO GAMES PLAYED BETWEEN THE TIME OF THOSE ARTICLES. JUST KEEP THAT IN MIND. MUCH OF LAST WEEK'S ANALYSIS WILL HOLD TRUE BECAUSE WE CAN'T LET TWO GAMES DRASTICALLY CHANGE OUR OPINIONS. Waiver Wire Hitters Otto Lopez - 2B/SS, MIA: 38% rostered (POWER BOOST, BATTING AVERAGE UPSIDE) During the All-Star break, I wrote an article highlighting some hitters that I think are in for much better second halves than what we saw from them in the first half. Lopez was one of the hitters I mentioned there. He's been pretty good already this season, slashing .249/.318/.393 with 10 steals and a surprising 10 home runs. The power is not something I expected from a guy with just an 88 mph average exit velocity; however, his xSLG of .495 is much higher than his current slugging percentage, and his Pull Air% is not great, but better than anything he's posted before. His 8.8% barrel rate is the best of his career, and his .293 xBA might be closer to what we see from him in the second half. Max Muncy - 2B/SS/3B, ATH (6% rostered) was another player I highlighted, who is mostly relevant in deeper formats. Over his last 16 games, Muncy is slashing .267/.313/.517 with four home runs, eight runs scored, seven RBI, and a 13.6% barrel rate. If you use Statcast's Swing Path data, you can see that Muncy's Ideal Attack Angle has skyrocketed to nearly 60% in July. Some of that could be tied to adjusting how far out in front of the plate he's making contact and also how wide his stance is, opening it up slightly after closing it off a lot in June. This could all be nothing, but we've seen young players adjust as the season goes on, so maybe that's what Muncy is doing. Chandler Simpson - OF, TB: 36% rostered (RETURN FROM MINORS, SPEED WINNER) Simpson is back up because, I guess, he became a much better defender in three weeks in the minors. Since being recalled, Simpson is hitting .371/.400/.443 with nine runs scored and eight steals in 20 games. People will tell you that fantasy managers misunderstand Simpson's actual value, and it's not really that high, but his speed is a legit issue. He's going to hit for a strong batting average and post elite stolen base totals. If Tampa Bay keeps running hot like this, he'll chip in some runs even from the bottom of the order. Colt Keith - 1B/2B, DET: 31% rostered (FULL-TIME JOB PROSPECT GROWTH) A couple of weeks ago, I covered Colt Keith as a potential breakout thanks to his impressive Process+ score, which ranks 6th in all of baseball since June 1st. Process+ is a Pitcher List stat that shows 'The combined value of a hitter's Decision Value, Contact Ability, and Power.' At that point, he was rostered in 7% of leagues, and the stats hadn't shown up yet, but his process has been rewarded. Over his last 20 games, Keith is hitting .299/.368/.478 with two home runs, 11 runs scored, and six RBI, and his roster rate has shot up. We know prospect growth isn't linear, so it's time to jump back on board with Keith. Jac Caglianone - 1B/OF, KC: 27% rostered (PROSPECT GROWTH, POWER UPSIDE) We've seen a bunch of prospects this year start slow and then begin to figure it out. Cam Smith and Nick Kurtz are just two of the most recent examples. Caglianone's two mammoth home runs the week before the All-Star break could signal that he's the next one. I recorded a video on him last week explaining my thoughts, but I would add him if he's been cut in your leagues. Carlos Narvaez - C, BOS: 20% rostered (BATTING AVERAGE UPSIDE, PLAYING TIME UPSIDE) Narvaez remains a fringe option in one-catcher formats because he plays regularly on a good offense, but he is a must-roster in two-catcher leagues. He cooled a bit in the middle of June, but over his last 16 games, he's hitting .267/.303/.417 with two home runs, eight runs scored, and eight RBI. He's been solid for Boston all year long and could be a solid option while they're running hot. If you're looking for an option in a two-catcher format, you can go with Victor Caratini - C/1B, HOU (11% rostered), who has continued to play regularly in Houston with Yordan Alvarez suffering a setback in his rehab from a hand fracture. In his last 25 games, Caratini has seven home runs and 23 RBI to go along with a .283/.293/.543 slash line. I'm not sure how long the power will remain this helpful, but he's making a lot of contact, and the home park can help. A final option is Adrian Del Castillo - C, ARI (1% rostered), who was called up on Friday and served as the designated hitter for both games, going 5-for-8 with two RBI and two runs scored. The Diamondbacks don't seem to want him to catch, even with Gabriel Moreno hurt, which could hurt Del Castillo's playing time when Pavin Smith is back. However, we saw how impactful his bat could be last year. He battled injuries this season and has played just 14 games in the minors, but he seems healthy now and could eventually be a regular part of this lineup if the Diamondbacks trade away players at the deadline. Austin Hays - OF, CIN: 20% rostered (POWER UPSIDE, EVERY DAY JOB) Austin Hays continues to produce when healthy this season, going 2-for-5 with two home runs, three RBI, and four runs scored in two games against the Mets since the All-Star Break. On the season, he's slashing .290/.338/.546 with 10 home runs and 40 RBI in 49 games. He hits in the middle of the order every game he plays in, and the ball is going to carry in these hot months in Cincinnati. Evan Carter - OF, TEX: 18% rostered (POST HYPE PROSPECT, HOT STRETCH) Kennedi Landry had a good piece on Evan Carter a few weeks ago, highlighting some of the changes that have led to his strong performance since coming off the He admitted to putting a lot of pressure on himself after his injury, and cited playing looser and feeling like he had a better mental approach at the plate. Since June 1st, Carter has hit .283/.372/.453 in 38 games with three homers, 15 RBI, 19 runs scored, and nine steals. The batting average hasn't carried over into July, but those stolen bases are great to see with the injuries he's had in the past, and Carter has a real five-category skillset. He's unlikely to play against many lefties, but he can be a really solid option in all fantasy leagues. If you're looking primarily for speed in the outfield, you could turn to Jake Mangum - OF, TB (7% rostered), who is playing most days and hitting third for Tampa Bay. I'll admit that I've never been a huge Mangum believer, and I'm still not, but he is hitting .297/.333/.396 over his last 25 games with 7 RBI, 11 runs scored, and four steals. That's not doing a ton to help you outside of batting average, so I think he's more of a deep-league play, but he's making a lot of contact and has 14 steals on the year, so there is a case to be made for adding him. Tyler Freeman - SS/OF, COL: 16% rostered (REGULAR STARTING ROLE, BATTING AVERAGE UPSIDE) Colorado still start the week off in Coors, but even apart from games at home, Freeman has been valuable in fantasy. He's hitting .340/.415/.436 over his last 25 games with 12 runs scored and seven steals. The stolen base value is a bit surprising given his previous results, but he has 12 steals this season while hitting leadoff for the Rockies. Freeman had a solid enough season last year for Cleveland, and moving to Colorado should help him. Freeman makes a lot of contact, but the hard contact is limited, and his BABIP has been low in years past. Coors Field tends to boost BABIP, so Freeman could emerge as a .270 hitter with some decent speed and multi-position eligibility. Freeman is also 15th in Process+ since June 1st, so the stats are backed up by a strong approach. You could also look to add his teammate, Mickey Moniak - OF, COL (11% rostered), who has taken playing time from Brenton Doyle by hitting .357/.400/.757 over his last 21 games with six home runs, 13 runs scored, 17 RBI, and three steals, The former number one overall pick may have found a home and a home environment that suits his skillset and covers up some of his contact issues. Caleb Durbin - 2B/3B/SS, MIL: 15% rostered (BATTING AVERAGE UPSIDE, HOT STRETCH) Durbin has turned it on of late, hitting .366/.430/.524 over his last 25 games with three home runs, 13 RBI, 18 runs scored, and four steals. As I mentioned with Caglianone, it takes rookies some time to adjust to the big leagues, and we're now seeing Durbin start to get a bit more comfortable in the box. I would like to see more steals than the nine he has on the season right now, since that's been Durbin's calling card in the minors, but it's nice to see the rookie adjusting to MLB pitching and starting to get on base more often. I think the steals will come. A deeper league multi-position option is Mauricio Dubon - 1B/2B/3B/SS/OF, HOU (4% rostered). Dubon can play pretty much anywhere, and with the injury to Isaac Paredes on Saturday, it seems like Dubon is going to basically play every day for the Astros by shifting around the field. Since June 20th, Dubon has had only three fewer plate appearances than Jose Altuve and has hit .254/.293/.451 with three home runs, 10 runs scored, and five RBI in 22 games. That's a little bit of production in four of the five offensive categories, and while he won't carry your team, he's a great bench piece to fill in anywhere you have a gap in your lineup. Masataka Yoshida - OF, BOS (7% rostered) (RECENT IL RETURN, BATTING AVERAGE UPSIDE) Yoshida came back from the IL the week before the All-Star break and has gone 6-for-19 with two doubles, an RBI, a run scored, and one steal in his first six games of the season. He's a career .286/.343/.433 hitter in Major League Baseball with just a 13% strikeout rate in 254 games. He's going to provide a great batting average and the potential for solid counting stats while hitting near the middle of Boston's lineup. Well, we think. When the Red Sox bring back Yoshida, they will have only four lineup spots for Yoshida, Ceddanne Rafaela, Roman Anthony, Jarren Duran, and Wilyer Abreu. They have managed it so far by rotating days off, but I think a trade has to be coming. Another platoon bat I've always been a fan of is Jesus Sanchez - OF, MIA (6% rostered). He's hitting just .261 on the season with eight home runs, but his 112 Process+ from May 12th on is well above the 100 league average mark. He has a 92 mph average exit velocity and 11.7% barrel rate, so he's making tons of strong contact. He is also chasing far less outside of the zone and making a career-high 76% contact rate. It would not surprise me if we see a power surge from Sanchez in the second half. Andrew Vaughn - 1B, MIL: 7% rostered (POTENTIAL STARTING JOB, APPROACH CHANGE?) With Rhys Hoskins landing on the IL for the next six to eight weeks, Andrew Vaughn is emerging as a starting option in Milwaukee, and I'm intrigued by an approach change he made in the minors since being traded. I recorded a video this week explaining why I think Vaughn might be a decent gamble in deeper formats. Another deeper league corner infield target is Otto Kemp - 1B/2B/3B/OF, PHI (1% rostered). Now that Alec Bohm is headed to the IL, it seems like Kemp is going to be the starting third baseman in Philadelphia. He's hitting .250/.324/.348 in 28 games so far with just one home run and one steal, but he had 14 home runs and 11 steals in 58 games at Triple-A, so there is power and speed in this profile. He's 6-for-23 (.261) to start July, so maybe he's starting to settle in a bit more. There will always be strikeouts, but this is an offense that you want a part of. Ha-Seong Kim - SS, TB: 6% rostered (RETURN FROM IL, SPEED UPSIDE) Kim returned from the IL the week before the All-Star break, suffered a calf cramp, but returned and has emerged as the starting shortstop of Tampa Bay. He's gone 7-for-28 in eight games with one double, one home run, three runs scored, three RBIs, and two steals. I think his value will be primarily in stolen bases, but I recorded a video on Kim last week, so you can check it out for my detailed thoughts. Josh Bell - 1B, WAS: 5% rostered (HOT STREAK, POTENTIAL TRADE CANDIDATE) Bell has a Process+ score of 116 since June 15th, which is far better than the league average score of 100. Over that stretch, Bell is hitting .308/.379/.451 with two home runs, eight runs scored, and 11 RBI in 27 games. The power numbers aren't great there, but we have seen Bell be a consistent 20 home run hitter before, so maybe the ball starts to fly a bit in the summer, or he gets traded into a better lineup. Brady House - 3B, WAS: 5% rostered (HOT STREAK, PROSPECT GROWTH) Another prospect starting to figure it out a little bit is Brady House. The rookie has gone 14-for-48 (.292) in July with two home runs, six runs scored, and seven RBI. Since being promoted, he has 23 strikeouts in 25 games with a 17.5% swinging strike rate, so I'm a little concerned about the contact, but it hasn't bit him yet. While his first two MLB home runs just came the Saturday before the break, he had 13 in Triple-A this season with a 46% hard hit rate, so there is some power in that bat. I have liked his approach of late, and the results are solid for deeper formats. If we're just using Process+, we should note that Hose's teammate, Daylen Lile - OF, WAS (0% rostered), has a Process+ score of 112 since June 15th, which is pretty solid work from a young rookie. Over that span, he's hitting .244/.293/.349 in 24 games with two home runs, 12 runs scored, and three steals, but he also has just 13 strikeouts to six walks in that span. The process is there, and the contact has been there, so maybe the results will also start to tick up in the coming months. Nick Gonzales: 2B/SS, PIT: 4% rostered (BATTING AVERAGE ASSET, STARTING JOB) Gonzales was another hitter I highlighted in my article over the break as a potential batting average asset. His 110 Process+ from May 12th on tells us that Gonzales could be a batting average asset in the second half of the season. In July, Gonzales has taken a pretty drastic opposite field approach, making contact -4.4 inches behind the front of the plate after being out over 10 inches in front of the plate earlier in the season. That has led to a massive spike in his Ideal Attack Angle%, and while it will limit his power ceiling, it could mean more line drives and hits fall in. If you wanted another multi-position option for deeper leagues, Lenyn Sosa - 1B/2B/3B, CWS (4% rostered) has jumped on the Process+ leaderboard with a score of 107 since June 15th, which is above the league average of 100. Over that same stretch, he's hitting .274/.317/.505 with five home runs, 14 runs scored, 17 RBI, and one steal in 26 games. That's not bad production across the board in deeper formats. Tommy Pham - OF, PIT: 2% rostered (STARTING JOB, HOT STREAK) We all talked a lot about Max Muncy's glasses, but perhaps we need to pay attention to Tommy Pham's contacts. There is a great video from Logan Arblaster that shows Pham discussing a difficult situation with his contact lenses based on a rare eye condition that he has. The video was taken on June 23rd, and Pham mentions in the video that he has made contact lens changes throughout the year, but has 'felt better the last week.' If we take Pham's stats from June 16th, we see that he's hitting .359/.394/.609 in 20 games with four home runs, nine runs scored, and 17 RBIs. That will play in any league type. A name to keep an eye on in deeper leagues is Nathan Lukes - OF, TOR (1% rostered). Lukes has recently moved into the leadoff spot against right-handed pitching and is hitting .325/.400/.500 in 12 games in July with one home run, seven runs scored, and seven RBI. His role may change when Daulton Varsho comes back in a couple of weeks, so I'm not saying this is a breakout for the 31-year-old, but his approach is great for a leadoff hitter, and the Blue Jays have been playing really good baseball lately, so perhaps this is a solid multi-week add. Dominic Canzone - OF, SEA: 2% rostered (PLAYING TIME OPPORTUNITY, POWER UPSIDE) Canzone has been putting up tremendous production since being called up and ranks 14th in Process+ among all hitters with at least 200 pitches faced since June 15th. Over that stretch, he's hitting .347/.364/.613 with five home runs, nine runs scored, and eight RBI in 23 games. Canzone is not going to play against lefties, and he doesn't have quite the track record of success, but Canzone has always made impressive quality of contact throughout his MLB career, so there is some upside here in deeper formats. Another option would be Isaac Collins - OF, MIL (2% rostered), who has been on a bit of a heater since June 1st, hitting .300/.413/.500 in 34 games with five home runs, 22 runs scored, 17 RBI, and four steals. He has good plate discipline overall and is pulling the ball near 50% of the time, mostly on the ground and on a line, which is good for his batting average but might cap the overall power upside. His average exit velocity is also only 88.5 mph over that span, so this is not a hitter you're adding for power, but he has a solid approach that should lead to plenty of doubles and decent counting stats, hitting fifth or sixth in Milwaukee. Waiver Wire Pitchers Zach Eflin - SP, BAL: 44% rostered Eflin is technically rostered in too many leagues to count for this article, but I wanted to highlight him here because I think he's being overlooked due to some early-season struggles. Eflin has been a solid starter for the last few years, posting an ERA of 3.59 or better in each of the last two years and keeping his ERA under 4.00 most years. He had a lat injury earlier in the season and then a back injury that landed him on the IL, but I think he can be a solid starter in the second half if he's healthy and may even be traded into a slightly better situation since he's a free agent at the end of the season. If you're open to a longer-term stash, I like Spencer Arrighetti - SP, HOU (30% rostered). The right-hander is beginning his rehab assignment next week and will likely begin at around 40-50 pitches. Unlike pitchers like Shane McClanahan and Cristian Javier, Arrighetti has not had any arm issues this season; he's on the IL due to a broken thumb suffered when he was hit by a batted ball during batting practice. He might need three or four rehab starts, but if you can wait until early August, he should be back and healthy. Edward Cabrera - SP, MIA: 36% rostered I have to mention Cabrera here because I'm a big fan of what he's doing this year, but I'm worried about his injury. I know he was cleared to pitch next week, but being removed from the game last week with a shoulder injury doesn't give me warm and fuzzy feelings, especially with his injury track record. I'm not dropping him yet if he's on my team, but I'm also probably not starting him against the Padres next week since I have some questions about his health. Emmett Sheehan - SP, LAD: 29% rostered Sheehan started on Saturday and wasn't his best, but I still believe in the talent. I'm not sure if he will continue to piggyback with Shohei Ohtani once the Dodgers get back into their normal schedule, and with Blake Snell also nearing a return and Ohtani getting closer to being ready to pitch a full five innings, there may not be many weeks left of Sheehan in this rotation. However, even when that happens, the Dodgers could decide to limit Clayton Kershaw's workload to save him for the playoffs. At this point, I'm not ready to drop Sheehan from fantasy rosters just yet; his upside is too high. Zebby Matthews - SP, MIN: 26% rostered I wrote about Zebby Matthews as a pitcher I think could end the season in the top 25 starting pitchers, so clearly I've been in the bag for him all season. He looked really good in his rehab start last Sunday, sitting 97.4 mph on his fastball and striking out nine batters in four innings, so I'm not going to let a rough first start back in Coors Field put me off of bidding on him in fantasy leagues. He has also deserved better in his big league innings with a 12.1% SwStr% and 20.5% K-BB% in 19 innings since May 15th. That has helped him post a 3.39 SIERA despite his 5.21 ERA. He looked electric in his Triple-A rehab start last week, and I'd be stashing him now. Brandon Walter - SP, HOU: 18% rostered Walter is another pitcher I covered in that article on second-half breakouts and breakthroughs. In that article, I said: 'Walter is another pitcher I wrote about earlier this season, and I've been impressed with what he's done so far. He's registered just an 11.9% SwStr% but a 23% K-BB% and 2.98 SIERA in 40.2 innings this season. He relies more on command and deception than overpowering stuff, which makes him a bit riskier than some of the other names on this list, but I think his spot in the rotation is rather secure, and I could see him being a streamer in 12-team leagues and a locked-in option in deeper formats.' Blake Treinen - RP, LAD: 11% rostered Trienen has made two rehab performances during this week and looks pretty good, commanding the zone while sitting 96 mph on his sinker. He seems healthy and could be called up after the weekend. With Tanner Scott struggling to close out games, Treinen could emerge as an option in a closer committee in Los Angeles. Joey Cantillo - SP, CLE: 9% rostered Cantillo was another pitcher I had mentioned in my article from earlier in the week. He seems to have a rotation spot locked up with Luis L. Ortiz undergoing an MLB investigation for a gambling infraction. Since coming back as a starter, Cantillo has a 14.9% SwStr% and 20.7% K-BB% in 12.2 innings with a 3.33 SIERA. His changeup can be a truly dominant pitch, and he gets elite extension on his fastball, so there is enough here to tie up right-handed hitters and make Cantillo a good high-upside play for the second half. Richard Fitts - SP, BOS: 3% rostered I'm also fully in the bag for Fitts and have been since he showed increased velocity and an expanded pitch mix this spring. Since coming off the IL, he has been sitting 97 mph on his four-seam fastball with his secondaries starting to get more consistent. He's posted a 13.2% SwStr% in 16.2 innings since May 15th, with a 3.84 SIERA that is much better than his 5.40 ERA. I think he was done a disservice by the Red Sox rushing him back from the IL, and it wouldn't shock me if he keeps his rotation spot for the remainder of the season. The schedule isn't great for him next week, but that might be a way you can get some really cheap exposure to him. STREAMING STARTER PITCHERS MUST BE 40% ROSTERED ON YAHOO OR UNDER (ranked in loose order) Week of 7/21 Strong Preference Fairly Confident Some Hesitation Desperate / Uncertain Health
Yahoo
14-07-2025
- Business
- Yahoo
Bitcoin tops $121K, boosting Satoshi Nakamoto's fortune to $132B
Bitcoin tops $121K, boosting Satoshi Nakamoto's fortune to $132B originally appeared on TheStreet. It seems nothing can get in the way of Bitcoin's fresh rally as it surpassed the $121,000 price mark to hit a new all-time high (ATH) on July 14. President Donald Trump hailed the crypto rally for hitting "through the roof" after Bitcoin surpassed the $112,000 mark for the first time on July 10. Since then, the king coin has been hitting record highs one day after another. Launched in 2009, Bitcoin is the world's largest cryptocurrency. It has a market cap of $2.4 trillion and accounts for more than 60% of the total crypto market on-chain analytics platform Arkham Intelligence recently reported that Satoshi Nakamoto, the pseudonymous creator of Bitcoin, has become the world's 12th wealthiest person, thanks to their BTC holdings. Satoshi Nakamoto's net worth soared to more than $132.6 billion at the time of writing. As per the on-chain analytics platform Coinglass, $235 million in short positions have been liquidated in the crypto market in the last hour. Needless to say, Bitcoin made up the bulk of these liquidations, as $205 million in BTC short positions have been liquidated in the last hour. Bitwise's Jeff Park credited Bitcoin treasury purchases and exchange-traded fund (ETF) inflows for the surge in BTC's price of late. 'It's over $15 billion, and that number is bigger than the first half of Bitcoin ETF flows that we experienced in 2024,' Park said. 'And the other thing I love about these Bitcoin treasury companies, for the most part, these are never gonna sell Bitcoin.' Park predicted that Bitcoin will hit the price of $200,000 by the end of 2025. Bitcoin was trading at $121,209.01 at the time of writing, as per Kraken's price feed. Bitcoin tops $121K, boosting Satoshi Nakamoto's fortune to $132B first appeared on TheStreet on Jul 14, 2025 This story was originally reported by TheStreet on Jul 14, 2025, where it first appeared. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
12-07-2025
- Business
- Yahoo
Bitcoin Hits New All-Time High at $116k, Nearly $1B Shorts Get Liquidated: Markets Liveblog
Bitcoin just breached $116k after blowing past $113,800 on Thursday, setting a new all-time high. The oldest digital asset has been on a tear for the last several months — and has nearly doubled over the past year, climbing from $57,899 a year ago today. CoinDesk analysts and industry experts are watching closely to see if bitcoin (BTC) can rise to $120,000, or if this week's price action is just an ephemeral gasp. This liveblog will be updated regularly. Scroll down for the latest. Unknown block type "divider", specify a component for it in the ` option Tough day for the shorts: Thursday's move higher in prices liquidated over $950 million in leveraged short trading positions across all assets on exchanges, the largest amount in a day this year, CoinGlass data shows. Shorts are bearish bets anticipating prices will decline. Bettors in the prediction market Kalshi are pricing in bitcoin hitting $141,000 by the end of this year. The forecasted BTC price is based on the price of recent trades that were put on the tape in the platform, according to Kalshi. This isn't the first time the $140K price prediction showed up during today's ATH rally. Earlier, Gerry O'Shea, head of global market insights at Hashdex, said in a note: "While the macro environment will continue to remain uncertain, we believe the bull market is far from over and new catalysts, including more institutional platforms allowing access to bitcoin, may help drive the price of BTC to $140,000 or higher this year."Michael Saylor now has $69 billion reason to celebrate:Michael Saylor, the executive chairman of Strategy (MSTR), gloated in Thursday's price rise. Strategy has accumulated 597,325 Bitcoin since 2020, when his company first started buying up bitcoin, almost acting as a de facto exchange-traded fund before such products were available to U.S. investors. At today's new all-time high prices, his holdings are worth $69.29 billion. And as a reminder, here are the top public bitcoin treasury companies, according to The vibes on Thursday felt eerily similar to mid-December 2017, when bitcoin's price soared to just under $20,000 for the first time. The digital asset had gone on a tear in 2017, rising from just under $1,000 over the course of those 12 months. Of course, the broader environment is dramatically different in July 2025: Interest rates, the amount of capital invested into digital assets, the types of institutions involved, the regulatory interest and the sheer number of people in crypto are all different than eight years ago. Here is at least one industry observer calling for a potential $120K for bitcoin. Ryan Gorman, chief strategy officer at Uranium Digital, said: "Bitcoin accumulation through companies deploying treasury strategies is continuing to pick up momentum across all sectors and geographic regions, and shows no sign of slowing down. This, coupled with President Trump's bullish Truth Social post earlier today, and the administration's declared Crypto Week next week in D.C., leads to a situation where buyers outnumber sellers and continues a virtuous cycle where higher prices beget more buys in anticipation of further positive news. "Additionally, when looking at open options interest, positioning is rather bullish with calls outnumbering puts - the smart (institutional) money is expecting a further move to the upside. Where this rally extends to is anyone's guess, but, seasonally light trading volumes lead to less liquidity and the opportunity for prices to gap quickly to the upside. This is creating a perfect storm where it would not surprise me if we see Bitcoin hit $120,000 before the end of next week regardless of uncertainty around tariffs and their impact on the global economy." We are reopening the live blog to update for the new, fresh record for BTC. The price just hit $116,221 on Coinbase and is hitting new all-time highs above $116k on other exchanges. Just the wild 24-hour nature of crypto! The live blog will be wrapping up for today as the market seems to have calmed down for now. Bitcoin is trading around $113,400, while the Nasdaq and S&P 500 closed 0.1% and 0.3% higher, respectively. The U.S. dollar index (DXY) inched slightly higher to 97.6. Speaking of USD weakness and risk assets, let's quickly look at a story written by CoinDesk contributor Siamak Masnavi based on an analysis by Kobeissi Letter. This may partially explain why BTC hit a fresh high. The Kobeissi Letter estimated that if the federal funds rate is cut by at least 3% (something that Trump suggested in his social media post), it could reduce U.S. interest costs by up to $2.5 trillion over five years, but warned that it would be unprecedented outside a recession. They cautioned it could reignite inflation above 5%, sink the USD more than 10%, and send asset prices soaring, including gold to $5,000 and the S&P 500 past 7,000. The precious metal is currently trading around $3,324/oz, and SPX just closed at 6,280.47. Adding to market volatility, rumors have emerged that Trump might attempt to remove Powell for cause before his term ends in 2026, potentially replacing him with a more compliant successor. Such a move could accelerate interest rate cuts, further weakening the dollar and boosting demand for alternative assets like bitcoin. Looking at derivatives, perp funding rates are at or below neutral for all major cryptos across the board. No immediate signs of speculative froth so far. As ByteTree chief investment officer Charlie Morris said in a market note this week, "crypto feels quiet," but "the quiet bulls are the best." On the altcoin front, things have remained relatively muted, with most large caps only rising 2%-5%. Notable exceptions among the top 50 coins by market capitalization include sui (SUI), pepe (PEPE) and dogecoin (DOGE), which are up 12.4%, 8.6% and 6.3% respectively. The CoinDesk 20, meanwhile, is up 3.2%. Bitcoin is now in a "negative dealer gamma zone" between $112,000 and $120,000, Deribit options data tracked by Amberdata shows. This means that to maintain a net direction-neutral portfolio exposure, which they strive to do per mandate, market makers will have to buy the underlying asset as the market moves higher, adding to upside volatility. In short, the trend could accelerate. Some are attributing bitcoin's all-time high to global currency fluctuations, saying that while $113,800 is indeed the highest BTC has been relative to USD, it's not the highest it's been relative to other currencies. And indeed, valuing BTC in terms of the U.S. dollar as opposed to other currencies or even other cryptocurrencies has long spurred debate within the industry. Crypto-linked stocks are on fire, with crypto exchanges such as Robinhood (HOOD) and Coinbase (COIN) rising more than 3% on Thursday. Meanwhile, the miners such as Hut 8, Bitfarms, and HIVE Digital are up more than 4%. Interestingly, the stablecoin issuer Circle (CRCL), the hottest new crypto IPO stock, is only up by 0.4%. The 2021 bull run's second half was purely leverage and derivatives-driven. It had a 50% hash rate correction, and all on-chain metrics were bearish, plus we had incoming fed rate hikes for the first time. Market cycle is completely different with a new buyer in the market, a new Fed chair potentially incoming with cuts and a crypto-pro U.S. president. Also, don't forget the swath of bitcoin buying treasury companies. Net accounts are still short (CoinDesk's Omkar Godbole mentioned this was a retail indicator). This is interesting, as in previous cycles, we had retail euphoria, but not so much this time. However, while a record high for bitcoin is almost certainly bullish on the surface, a number of technical indicators paint a different picture: the daily RSI has now made three lower highs, an example of bearish divergence indicating the move could be short-lived. Trading volume has also dropped off since the initial record high in January, and BTC is still below its respective record highs against EUR and GBP, indicating dollar weakness over BTC strength. Also, the trading firms I speak to are bearish, but it is worth noting that they were also bearish from BTC's $30k to $70k run in the last cycle's double in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Forbes
11-07-2025
- Business
- Forbes
Crypto Analyst: Bitcoin's Latest High A Sign That Market Is 'Maturing Fast'
Bitcoin prices hit their latest record, this time above $116,000. Bitcoin reached a fresh, all-time high above $116,000 on Thursday, July 10, a development that one analyst highlighted as a clear sign of rapid evolution. 'Bitcoin's new ATH high is a signal that this market is maturing fast,' Doug Colkitt, a founding contributor at Fogo, stated via email. He offered this interpretation after the world's most prominent digital currency rose to more than $116,600, according to Coinbase data from TradingView. 'Every breakout like this pulls more liquidity into the ecosystem, and traders are already looking past BTC toward performance assets deeper in the onchain stack,' he said. 'The next wave of gains won't come from narrative alone, but from platforms that solve real trading problems and move serious volume.' Mike Cahill, CEO of Douro Labs, also weighed in on the implications of these latest price movements. 'Bitcoin breaking $114K is particularly significant because it reflects growing institutional confidence, deepening integration with traditional markets, and a global search for financial infrastructure that isn't shackled to legacy intermediaries,' he said through emailed commentary. 'The real story here goes far beyond price,' Cahill emphasized. 'The narrative that has been driving finance in 2025 is the notion that DeFi and TradFi are converging, and this new all-time high just underscores the dawn of the next era for finance as a whole.' 'As Bitcoin continues to gain new ground, what matters most is how this capital gets redeployed: into new blockchains, better infrastructure, and decentralized systems with real-world impact,' he concluded. Tom Bruni, editor-in-chief & VP of community at Stocktwits, offered his thoughts on the strength of bitcoin's latest upward movement. 'Bitcoin broke out to fresh all-time highs today, begging the question of whether this is the real deal or a fakeout,' he said through email. 'Today's breakout to new highs and strength in the altcoin market suggest risk appetite remains strong.' 'In the absence of any negative catalysts, people are comfortable buying stocks, crypto, and other risk assets…at least until earnings season kicks off Tuesday and picks up in the following weeks,' stated Bruni. 'But for now, sentiment suggests there's more room to run, and retail seems to be sticking with the trade.' 'From both a sentiment and technical perspective, the recent reset is being viewed by traders as a healthy development,' he emphasized. 'More broadly, Bitcoin's consolidation over the last six weeks has allowed sentiment to reset and provide a more sustainable backdrop for prices to rally against,' Bruni continued. 'The first time prices reached $110k, Bitcoin had experienced a 50% rally off its April lows in just six weeks, making it difficult for bulls to get on board,' he added. 'Now, with prices resetting at this higher range, it's clear to buyers that they won't be getting a bargain at lower levels.' 'Essentially, they feel more confident in buying a fresh breakout vs. chasing a long-in-the-tooth rally.'
