Latest news with #AZN
Yahoo
a day ago
- Business
- Yahoo
Astrazeneca (AZN) Stock Declines While Market Improves: Some Information for Investors
The latest trading session saw Astrazeneca (AZN) ending at $71.93, denoting a -1.24% adjustment from its last day's close. The stock fell short of the S&P 500, which registered a gain of 0.41% for the day. Meanwhile, the Dow experienced a rise of 0.08%, and the technology-dominated Nasdaq saw an increase of 0.67%. Shares of the pharmaceutical witnessed a gain of 0.54% over the previous month, beating the performance of the Medical sector with its loss of 3.74% and underperforming the S&P 500's gain of 6.13%. Investors will be eagerly watching for the performance of Astrazeneca in its upcoming earnings disclosure. On that day, Astrazeneca is projected to report earnings of $1.11 per share, which would represent year-over-year growth of 12.12%. Our most recent consensus estimate is calling for quarterly revenue of $14.03 billion, up 8.42% from the year-ago period. For the full year, the Zacks Consensus Estimates project earnings of $4.49 per share and a revenue of $57.68 billion, demonstrating changes of +9.25% and +6.67%, respectively, from the preceding year. It is also important to note the recent changes to analyst estimates for Astrazeneca. These recent revisions tend to reflect the evolving nature of short-term business trends. As a result, upbeat changes in estimates indicate analysts' favorable outlook on the company's business health and profitability. Research indicates that these estimate revisions are directly correlated with near-term share price momentum. To exploit this, we've formed the Zacks Rank, a quantitative model that includes these estimate changes and presents a viable rating system. The Zacks Rank system, spanning from #1 (Strong Buy) to #5 (Strong Sell), boasts an impressive track record of outperformance, audited externally, with #1 ranked stocks yielding an average annual return of +25% since 1988. Over the past month, the Zacks Consensus EPS estimate has moved 0.35% lower. As of now, Astrazeneca holds a Zacks Rank of #3 (Hold). In terms of valuation, Astrazeneca is currently trading at a Forward P/E ratio of 16.2. This valuation marks a discount compared to its industry's average Forward P/E of 20.51. It is also worth noting that AZN currently has a PEG ratio of 1.34. The PEG ratio is akin to the commonly utilized P/E ratio, but this measure also incorporates the company's anticipated earnings growth rate. AZN's industry had an average PEG ratio of 1.47 as of yesterday's close. The Medical - Biomedical and Genetics industry is part of the Medical sector. This industry currently has a Zacks Industry Rank of 74, which puts it in the top 30% of all 250+ industries. The Zacks Industry Rank gauges the strength of our individual industry groups by measuring the average Zacks Rank of the individual stocks within the groups. Our research shows that the top 50% rated industries outperform the bottom half by a factor of 2 to 1. Don't forget to use to keep track of all these stock-moving metrics, and others, in the upcoming trading sessions. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report AstraZeneca PLC (AZN) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research Sign in to access your portfolio
Business Insider
2 days ago
- Business
- Business Insider
AstraZeneca, Daiichi announce results from three trials on DATROWAY
Results from three trials continue to demonstrate the potential of DATROWAY in combination with various immunotherapies to improve outcomes in patients with non-small cell lung cancer, NSCLC, across multiple stages of the disease. These results from TROPION-Lung02, TROPION-Lung04 and NeoCOAST-2 were presented at the 2025 American Society of Clinical Oncology Annual Meeting. DATROWAY is a specifically engineered TROP2 directed DXd antibody drug conjugate, ADC, discovered by Daiichi Sankyo and being jointly developed and commercialized by Daiichi Sankyo and AstraZeneca (AZN). In 42 patients receiving first-line doublet DATROWAY plus pembrolizumab, an objective response rate of 54.8% was observed. In 54 patients receiving first-line triplet DATROWAY plus pembrolizumab and platinum chemotherapy, an ORR of 55.6% was observed. This analysis included patients enrolled during the dose escalation phase of the trial, where 4.8% and 40.7% of patients treated with the doublet and triplet regimens, respectively, received DATROWAY at a dose of 4 mg/kg versus 6 mg/kg. First results from cohort 5 of the TROPION-Lung04 phase 1b trial, presented during a poster session on Saturday, May 31, showed DATROWAY plus AstraZeneca's PD-1/TIGIT bispecific antibody rilvegostomig as a first-line treatment demonstrated an ORR of 57.5%, including one complete response and 22 partial responses in 40 patients with advanced or metastatic NSCLC. A disease control rate of 95% was seen. Final results from Arm 4 of the NeoCOAST-2 phase 2 platform trial evaluating neoadjuvant DATROWAY plus AstraZeneca's anti-PD-L1 therapy IMFINZI and single-agent platinum chemotherapy were presented during a poster session on Saturday, May 31 and showed the combination demonstrated a pathologic complete response rate of 35.2%
Business Insider
2 days ago
- Health
- Business Insider
AstraZeneca announces results from SERENA-6 Phase III trial
Positive results from the SERENA-6 Phase III trial showed that AstraZeneca's (AZN) camizestrant in combination with a cyclin-dependent kinase 4/6 inhibitor demonstrated a highly statistically significant and clinically meaningful improvement in progression-free survival, PFS. The trial evaluated switching to the camizestrant combination versus continuing standard-of-care treatment with an aromatase inhibitor in combination with a CDK4/6 inhibitor in the 1st-line treatment of patients with hormone receptor-positive, HER2-negative advanced breast cancer whose tumors have an emergent ESR1 mutation. These results will be presented today during the Plenary Session at the 2025 American Society of Clinical Oncology, ASCO, Annual Meeting in Chicago, IL and simultaneously published in The New England Journal of Medicine. Results showed the camizestrant combination reduced the risk of disease progression or death by 56% compared to standard-of-care treatment as assessed by investigator. Median PFS was 16.0 months for patients who switched to the camizestrant combination versus 9.2 months for the comparator arm. Importantly, a consistent PFS benefit was observed across all CDK4/6 inhibitors and clinically relevant subgroups in the trial, including analysis by age, race, region, time of ESR1 mutation detection and type of ESR1 mutation. Confident Investing Starts Here:
Business Insider
2 days ago
- Health
- Business Insider
AstraZeneca, Daiichi announces results from DESTINY-Gastric04 phase 3 trial
Positive results from the DESTINY-Gastric04 phase 3 trial showed ENHERTU demonstrated a statistically significant and clinically meaningful improvement in overall survival, OS, compared to ramucirumab plus paclitaxel in patients with second-line HER2 positive unresectable and/or metastatic gastric or gastroesophageal junction, GEJ, adenocarcinoma. ENHERTU is a specifically engineered HER2 directed DXd antibody drug conjugate, ADC, discovered by Daiichi Sankyo and being jointly developed and commercialized by Daiichi Sankyo and AstraZeneca (AZN). In the primary endpoint analysis of OS, ENHERTU reduced the risk of death by 30% versus ramucirumab plus paclitaxel. Median OS was 14.7 months with ENHERTU versus 11.4 months with ramucirumab plus paclitaxel. In the secondary endpoint analysis of progression-free survival, ENHERTU demonstrated a 26% reduction in the risk of disease progression or death versus ramucirumab plus paclitaxel as assessed by investigator. Median PFS was 6.7 months with ENHERTU versus 5.6 months with ramucirumab plus paclitaxel. A confirmed objective response rate of 44.3% was seen in patients treated with ENHERTU with seven complete responses and 97 partial responses versus an ORR of 29.1% with three CRs and 66 PRs in the ramucirumab plus paclitaxel arm. Median duration of response was 7.4 months in the ENHERTU arm and 5.3 months in the ramucirumab plus paclitaxel arm. Disease control rate was 91.9% with ENHERTU versus 75.9% with ramucirumab plus paclitaxel. Improvements in OS and PFS with ENHERTU were consistent across subgroups
Business Insider
2 days ago
- Business
- Business Insider
AstraZeneca announces results from MATTERHORN Phase III trial of IMFINZI
Positive results from the MATTERHORN Phase III trial showed perioperative treatment with AstraZeneca's (AZN) IMFINZI in combination with standard-of-care FLOT chemotherapy demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of event-free survival, EFS, versus chemotherapy alone. Patients were treated with neoadjuvant IMFINZI in combination with chemotherapy before surgery, followed by adjuvant IMFINZI in combination with chemotherapy, then IMFINZI monotherapy. The trial evaluated this regimen versus perioperative chemotherapy alone for patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction, GEJ, cancers. In a planned interim analysis, patients treated with the IMFINZI-based perioperative regimen showed a 29% reduction in the risk of disease progression, recurrence or death versus chemotherapy alone. Estimated median EFS was not yet reached for the IMFINZI arm versus 32.8 months for the comparator arm. For the secondary endpoint of overall survival, a strong trend was observed in favor of the IMFINZI-based perioperative regimen. The trial will continue to follow OS, which will be formally assessed at the final analysis. Confident Investing Starts Here:
